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- Gryko, Dorota, et al. Show all 6 Authors
- Chemical communications 2019 v.55 no.6 pp. 763-766
- DNA; Escherichia coli; RNA; Salmonella Typhimurium; alkynes; antibiotics; bacteria; chemical reactions; genes; oligonucleotides; protein synthesis; therapeutics; vitamin B12
- ... Specifically designed, antisense oligonucleotides are promising candidates for antibacterial drugs. They suppress the correct expression of bacterial genes by complementary binding to essential sequences of bacterial DNA or RNA. The main obstacle in fully utilizing their potential as therapeutic agents comes from the fact that bacteria do not uptake oligonucleotides from their environment. Herein, ...