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CD8-positive T-lymphocytes
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- Author:
- Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
- Source:
- Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
- ISSN:
- 0006-291X
- Subject:
- CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
- Abstract:
- ... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
- DOI:
- 10.1016/j.bbrc.2019.03.002
- https://doi.org/10.1016/j.bbrc.2019.03.002
- Author:
- Rodolfo Cordeiro Giunchetti; Patricia Silveira; Lucilene Aparecida Resende; Jaqueline Costa Leite; Otoni Alves de Oliveira Melo-Júnior; Marina Luiza Rodrigues- Alves; Laís Moreira Costa; Daniel Ferreira Lair; Vinícius Rossi Chaves; Ingrid dos Santos Soares; Ludmila Zanandreis de Mendonça; Mariana Ferreira Lanna; Helen Silva Ribeiro; Ana Alice Maia-Gonçalves; Thaiza Aline Pereira Santos; Bruno Mendes Roatt; Rodrigo Dian Oliveira Aguiar-Soares; Juliana Vitoriano-Souza; Nádia das Dores Moreira; Fernando Augusto Siqueira Mathias; Jamille Mirelle de Oliveira Cardoso; Wendel Coura-Vital; Alexsandro Sobreira Galdino; Kelvinson Fernandes Viana; Olindo Assis Martins-Filho; Denise da Silveira-Lemos; Walderez Ornelaz Dutra; Alexandre Barbosa Reis
- Source:
- Veterinary parasitology 2019 v.271 pp. 87-97
- ISSN:
- 0304-4017
- Subject:
- B-lymphocytes; CD8-positive T-lymphocytes; Leishmania infantum; animal models; antibody formation; biomarkers; cell differentiation; coculture; dogs; employment; histopathology; immunogenicity; industry; interferon-gamma; interleukin-10; interleukin-4; macrophages; natural history; parasite load; parasitism; tissues; transforming growth factor beta; tumor necrosis factor-alpha; vaccine development; vaccines; visceral leishmaniasis
- Abstract:
- ... The natural history of canine visceral leishmaniasis (CVL) has been well described, particularly with respect to the parasite load in different tissues and immunopathological changes according to the progression of clinical forms. The biomarkers evaluated in these studies provide support for the improvement of the tools used in developing vaccines against CVL. Thus, we describe the major studies u ...
- DOI:
- 10.1016/j.vetpar.2019.05.006
- https://doi.org/10.1016/j.vetpar.2019.05.006
- Author:
- Fei Geng; Jie Guo; Qian-Qian Guo; Yu Xie; Ling Dong; Yi Zhou; Chen-Lu Liu; Bin Yu; Hui Wu; Jia-Xin Wu; Hai-Hong Zhang; Wei Kong; Xiang-Hui Yu
- Source:
- Vaccine 2019 v.37 no.31 pp. 4382-4391
- ISSN:
- 0264-410X
- Subject:
- CD8-positive T-lymphocytes; animal models; antigens; antineoplastic activity; breast neoplasms; chemokine CCL2; chemokine CXCL12; clinical trials; codons; fibroblasts; humans; immune response; immunogenicity; metastasis; mice; recombinant vaccines; secretion; signal peptide; suppressor cells; t-plasminogen activator
- Abstract:
- ... Cancer-associated fibroblasts (CAFs), major components of the tumor microenvironment (TME), promote tumor growth and metastasis and inhibit the anti-tumor immune response. We previously constructed a DNA vaccine expressing human FAPα, which is highly expressed by CAFs, to target these cells in the TME, and observed limited anti-tumor effects in the 4T1 breast cancer model. When the treatment time ...
- DOI:
- 10.1016/j.vaccine.2019.06.012
- https://doi.org/10.1016/j.vaccine.2019.06.012
- Author:
- Yuan Zhang; Xin Bush; Bingfang Yan; Justin A. Chen
- Source:
- Biomaterials 2019 v.189 pp. 48-59
- ISSN:
- 0142-9612
- Subject:
- CD8-positive T-lymphocytes; animal models; apoptosis; calcium phosphates; disease course; drug resistance; drug therapy; engineering; growth retardation; immune response; immunosuppression; macrophages; melanoma; nanoparticles; phenotype; suppressor cells
- Abstract:
- ... Myeloid-derived suppressor cells (MDSCs) promote tumor-mediated immunosuppression and cancer progression. Gemcitabine (Gem) is a MDSC-depleting chemotherapeutic agent; however, its clinical use is hampered by its drug resistance and inefficient in vivo delivery. Here we describe a strategy to formulate a Gem analogue gemcitabine monophosphate (GMP) into a lipid-coated calcium phosphate (LCP) nanop ...
- DOI:
- 10.1016/j.biomaterials.2018.10.022
- PubMed:
- 30388589
- PubMed Central:
- PMC6281175
- https://doi.org/10.1016/j.biomaterials.2018.10.022
- Author:
- David Wolski; Georg M. Lauer
- Source:
- Viruses 2019 v.11 no.8 pp. -
- ISSN:
- 1999-4915
- Subject:
- CD8-positive T-lymphocytes; Hepatitis C virus; animal models; gene expression; gene regulatory networks; human diseases; humans; immune response; metabolism; patients; transcription (genetics); viruses
- Abstract:
- ... The hepatitis C virus is unique among chronic viral infections in that an acute outcome with complete viral elimination is observed in a minority of infected patients. This unique feature allows direct comparison of successful immune responses with those that fail in the setting of the same human infection. Here we review how this scenario can be used to achieve better understanding of transcripti ...
- DOI:
- 10.3390/v11080683
- PubMed:
- 31357397
- PubMed Central:
- PMC6723887
- https://doi.org/10.3390/v11080683
- Author:
- Mohadetheh Moulana
- Source:
- Life sciences 2019 v.220 pp. 44-49
- ISSN:
- 0024-3205
- Subject:
- CD8-positive T-lymphocytes; animal models; animal ovaries; breast neoplasms; dihydrotestosterone; etiology; females; inflammation; kidneys; laboratory animals; mast cells; patients; pellets; polycystic ovary syndrome; rats; spleen
- Abstract:
- ... The immune etiology of polycystic ovary syndrome (PCOS) is an intriguing area. However, whether there is alteration in the leukocyte populations in different tissues remain ambiguous. Aim: To characterize the leukocyte populations of hyperandrogenemic female (HAF) rat tissues. Methods: Female Sprague Dawley rats at 3 weeks of age were implanted subcutaneously with dihydrotestosterone (DHT) or plac ...
- DOI:
- 10.1016/j.lfs.2019.01.048
- PubMed:
- 30708097
- PubMed Central:
- PMC6392450
- https://doi.org/10.1016/j.lfs.2019.01.048
- Author:
- Ivana Dalila Montironi; Elina Beatriz Reinoso; Valentina Croce Paullier; María Inés Siri; María Julia Pianzzola; Melina Moliva; Noelia Campra; Guillermo Bagnis; Isabel Ferreira LaRocque-de-Freitas; Debora Decote-Ricardo; Celio Geraldo Freire-de-Lima; José María Raviolo; Laura Noelia Cariddi
- Source:
- Research in veterinary science 2019 v.125 pp. 333-344
- ISSN:
- 0034-5288
- Subject:
- CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Enterococcus faecium; Minthostachys verticillata; adaptive immunity; animal models; anti-inflammatory activity; antibodies; bacteria; bovine mastitis; essential oils; females; gene expression; humans; immunomodulators; interleukin-10; interleukin-1beta; macrophages; mammary glands; mice; milk; milk quality; neutrophils; pathogens; phagocytosis; plate count; protective effect; reactive oxygen species; therapeutics; tumor necrosis factor-alpha
- Abstract:
- ... Minthostachys verticillata essential oil (EO) is a natural product that reports immunomodulatory effects on human T cells as well as anti-inflammatory activity. Bovine mastitis is a worldwide disease, mainly caused by bacteria, affecting milk quality and yield, leading to high economic losses. Environmental pathogens, as Enterococcus faecium, are implicated in the disease. Antibiotic therapy is ad ...
- DOI:
- 10.1016/j.rvsc.2019.07.015
- https://doi.org/10.1016/j.rvsc.2019.07.015
- Author:
- Georgia Kalodimou; Svenja Veit; Sylvia Jany; Ulrich Kalinke; Christopher C. Broder; Gerd Sutter; Asisa Volz
- Source:
- Viruses 2019 v.12 no.1 pp. -
- ISSN:
- 1999-4915
- Subject:
- CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Nipah henipavirus; Vaccinia virus; animal models; antibodies; cell-mediated immunity; encephalitis; epitopes; glycoproteins; immune response; interferons; major histocompatibility complex; mice; peptides; respiratory tract diseases; vaccination; vaccines; viruses; zoonoses
- Abstract:
- ... Nipah virus (NiV) is an emerging zoonotic virus that is transmitted by bats to humans and to pigs, causing severe respiratory disease and often fatal encephalitis. Antibodies directed against the NiV-glycoprotein (G) protein are known to play a major role in clearing NiV infection and in providing vaccine-induced protective immunity. More recently, T cells have been also shown to be involved in re ...
- DOI:
- 10.3390/v12010026
- https://doi.org/10.3390/v12010026
- Author:
- Diane M. Da Silva; Joseph G. Skeate; Elena Chavez-Juan; Kim P. Lühen; Jiun-Ming Wu; Chia-Mao Wu; W. Martin Kast; KinKai Hwang
- Source:
- Vaccine 2019 v.37 no.22 pp. 2915-2924
- ISSN:
- 0264-410X
- Subject:
- Human papillomavirus type 16; humans; neoplasms; oligodeoxyribonucleotides; vaccines; therapeutics; vaccine adjuvants; animal models; chemical bonding; immune response; immunogenicity; oncogene proteins; exotoxins; CD8-positive T-lymphocytes
- Abstract:
- ... Persistent human papillomavirus (HPV) infection is causally linked to the development of several human cancers, including cervical, vulvar, vaginal, anal, penile, and oropharyngeal cancers. To address the need for a therapeutic vaccine against HPV-associated diseases, here we test and compare the immunogenicity and therapeutic efficacy of a bacterial exotoxin fusion protein covalently linked to th ...
- DOI:
- 10.1016/j.vaccine.2019.04.043
- PubMed:
- 31010714
- PubMed Central:
- PMC6586561
- https://doi.org/10.1016/j.vaccine.2019.04.043
10. Utilizing VEGF165b mutant as an effective immunization adjunct to augment antitumor immune response
- Author:
- Huiyong Zhang; Enchao Jia; Wenjiao Xia; Tanyu Lv; Chengui Lu; Zhenping Xu; Wuling Zhu
- Source:
- Vaccine 2019 v.37 no.15 pp. 2090-2098
- ISSN:
- 0264-410X
- Subject:
- CD8-positive T-lymphocytes; angiogenesis; animal models; cancer vaccines; epitopes; humoral immunity; immune response; immunization; immunosuppression; mice; monoclonal antibodies; mutants; neoplasms; peptides; vascular endothelial growth factors
- Abstract:
- ... Compelling evidence has shown that blocking VEGF via monoclonal antibodies may be beneficial in that it not only inhibits tumor angiogenesis but also reduces immune suppression and promotes T cell infiltration into tumors. Herein, we determined whether our recently generated VEGF165b mutant could be used as a co-immunization adjunct to augment the peptide cancer-vaccine- induced immune response in ...
- DOI:
- 10.1016/j.vaccine.2019.02.055
- https://doi.org/10.1016/j.vaccine.2019.02.055
- Author:
- Alfredo Amador-Molina; Cesar Trejo-Moreno; Damaris Romero-Rodríguez; Isabel Sada-Ovalle; Enrique Pérez-Cárdenas; Edmundo Lamoyi; José Moreno; Marcela Lizano
- Source:
- Vaccine 2019 v.37 no.9 pp. 1219-1228
- ISSN:
- 0264-410X
- Subject:
- CD8-positive T-lymphocytes; Papillomaviridae; adjuvants; animal models; cell-mediated immunity; cross immunity; cytotoxicity; enzymes; growth retardation; immune response; melanoma; mice; proteins; protocols; vaccination; vaccines; virus replication; women
- Abstract:
- ... CD8+ T cell-mediated immune response plays a major role in the clearance of virus-infected cells, including human papillomavirus (HPV). The effective treatment of women with normal cytology but persistent high risk-HPV infection or with low-grade intraepithelial lesions could take advantage of novel strategies based on vaccination with viral immunological targets with a wide spectrum of cross-prot ...
- DOI:
- 10.1016/j.vaccine.2018.12.036
- https://doi.org/10.1016/j.vaccine.2018.12.036
- Author:
- Jeffrey M. Plume; Dylan Todd; Daniel J. Bonthius
- Source:
- Viruses 2019 v.11 no.6 pp. -
- ISSN:
- 1999-4915
- Subject:
- CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Lymphocytic choriomeningitis mammarenavirus; animal models; brain; cytokines; disease course; fetus; geotaxis; humans; immune response; neonates; neuroglia; neurons; neuropathology; pregnancy; pups; rats; viruses
- Abstract:
- ... When infection with lymphocytic choriomeningitis (LCMV) occurs during pregnancy, the virus can infect the fetus and injure the fetal brain. However, type, location, and severity of neuropathology differ among cases. One possible explanation for this diversity is that fetuses are infected with different viral strains. Using a rat model of congenital LCMV infection, we investigated how differences i ...
- DOI:
- 10.3390/v11060552
- PubMed:
- 31207945
- PubMed Central:
- PMC6631398
- https://doi.org/10.3390/v11060552