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1. Stable isotope and compositional analysis of Alaska caribou teeth embedded in polymethyl-methacrylate (PMMA)

Author:
Harmston, Nathan I.; Linduska, Erik J.; Tomco, Patrick L.
Source:
Journal of archaeological science 2019 v.111 pp. 105016
ISSN:
0305-4403
Subject:
Rangifer tarandus; acetone; archaeology; carbon; collagen; enamel; grinding; humans; isotope labeling; nitrogen; paleoecology; polymethylmethacrylate; stable isotopes; tissues; tooth enamel; Alaska
Abstract:
... Stable isotopic analysis (SIA) of incremental dental tissues from archaeological specimens provides unique insight into the paleoecology of animals utilized by humans in the past. Unfortunately, many archaeological specimens are too fragile to survive the mechanical processes necessary to accurately identify and sample incremental dental tissues. Polymethyl-methacrylate (PMMA) is an organic polyme ...
DOI:
10.1016/j.jas.2019.105016

2. The use of geospatial information as support for Disaster Risk Reduction; contextualization to Baalbek-Hermel Governorate/Lebanon

Author:
Der Sarkissian, Rita; Zaninetti, Jean-Marc; Abdallah, Chadi
Source:
Applied geography 2019 v.111 pp. 102075
ISSN:
0143-6228
Subject:
assets; case studies; developing countries; disasters; geographic information systems; humans; models; planning; research and development; risk; risk reduction; rural areas; spatial data; zoning; Lebanon
Abstract:
... Given that natural hazards, vulnerabilities, and the resulting disasters are spatial phenomena; the application of geographical information systems (GIS) has proven to be a convenient and reliable tool for the Disaster Risk Reduction (DRR) process. Nevertheless, effective use of these technologies is context-specific and requires research and development, especially in developing countries like Le ...
DOI:
10.1016/j.apgeog.2019.102075

3. Induction of RNA interference to block Zika virus replication and transmission in the mosquito Aedes aegypti

Author:
Magalhaes, Tereza; Bergren, Nicholas A.; Bennett, Susan L.; Borland, Erin M.; Hartman, Daniel A.; Lymperopoulos, Konstantinos; Sayre, Richard; Borlee, Bradley R.; Campbell, Corey L.; Foy, Brian D.; Olson, Kenneth E.; Blair, Carol D.; Black, William; Kading, Rebekah C.
Source:
Insect biochemistry and molecular biology 2019 v.111 pp. 103169
ISSN:
0965-1748
Subject:
Aedes aegypti; Chikungunya virus; RNA interference; Zika virus; arboviruses; blood meal; dengue; double-stranded RNA; expectorants; genes; habitat conservation; humans; insecticide resistance; insecticides; larvae; nucleotide sequences; pesticide application; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; saliva; transcription (genetics); viral load; virus replication; yellow fever; Puerto Rico; Senegal; Uganda
Abstract:
... The yellow fever mosquito, Aedes aegypti, serves as the primary vector for epidemic transmission of yellow fever, dengue, Zika (ZIKV), and chikungunya viruses to humans. Control of Ae. aegypti is currently limited to insecticide applications and larval habitat management; however, to combat growing challenges with insecticide resistance, novel genetic approaches for vector population reduction or ...
DOI:
10.1016/j.ibmb.2019.05.004
PubMed:
31103782
PubMed Central:
PMC7012353

4. Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme

Author:
Wiatr, Marie; Merle, Nicolas S.; Boudhabhay, Idris; Poillerat, Victoria; Rossini, Sofia; Lecerf, Maxime; Kaveri, Srini V.; Lacroix-Desmazes, Sébastian; Roumenina, Lubka T.; Dimitrov, Jordan D.
Source:
Molecular immunology 2019 v.111 pp. 205-208
ISSN:
0161-5890
Subject:
anti-inflammatory activity; complement; endothelial cells; humans; intravenous injection; heme; immunomodulators; immunoglobulins
Abstract:
... Therapeutic intravenous immunoglobulin preparations (IVIg) are used for treatment of wide range of autoimmune and inflammatory diseases. Versatile mechanisms have been reported to contribute to the immunomodulatory effects of IVIg. Here we demonstrate that IVIg has a strong potential to inhibit pro-inflammatory effect of extracellular heme. Indeed, the presence of immunoglobulins reduced the poten ...
DOI:
10.1016/j.molimm.2019.04.020
PubMed:
31078967
PubMed Central:
PMC6560225

5. Effects of extracellular Hsp70 and cigarette smoke on differentiated THP-1 cells and human monocyte-derived macrophages

Author:
Hulina-Tomašković, Andrea; Somborac-Bačura, Anita; Grdić Rajković, Marija; Bosnar, Martina; Samaržija, Miroslav; Rumora, Lada
Source:
Molecular immunology 2019 v.111 pp. 53-63
ISSN:
0161-5890
Subject:
Toll-like receptor 2; Toll-like receptor 4; apoptosis; blood; cell lines; cytotoxicity; gene expression; humans; inflammation; interleukin-8; macrophages; messenger RNA; mitogen-activated protein kinase; models; patients; respiratory tract diseases; secretion; transcription factor NF-kappa B
Abstract:
... Extracellular Hsp70 (eHsp70) can act as pro-inflammatory mediator and is elevated in blood of chronic obstructive pulmonary disease (COPD) patients. Most of those patients are smokers, and it was suggested previously that cigarette smoke might induce Hsp70 secretion from the circulating cells. Therefore, we aimed to explore inflammation-associated effects of cigarette smoke extract (CSE) and its c ...
DOI:
10.1016/j.molimm.2019.04.002

6. IFN-β secretion is through TLR3 but not TLR4 in human gingival epithelial cells

Author:
Teixeira, Hellen; Zhao, Jiawei; Kinane, Denis F.; Benakanakere, Manjunatha R.
Source:
Molecular immunology 2019 v.111 pp. 27-31
ISSN:
0161-5890
Subject:
Toll-like receptor 2; Toll-like receptor 3; Toll-like receptor 4; bacteria; epithelial cells; epithelium; humans; interferon regulatory factor-3; interferon-beta; ligands; mouth; pathogens; phosphorylation; polyinosinic-polycytidylic acid; secretion; viruses
Abstract:
... The oral cavity is home for a plethora of bacteria and viruses. Epithelial barriers encounter these micro-organisms and recognize them via pathogen recognition receptors (PRRs) that instigate antibacterial and antiviral responses. We and others have shown that human gingival epithelial cells (HGECs) express PRRs to defend invading pathogens. Among these PRRs, TLR2, TLR3 and TLR4 are highly express ...
DOI:
10.1016/j.molimm.2019.03.006

7. Immunogenicity and protective efficacy of mucosal delivery of recombinant hcp of Campylobacter jejuni Type VI secretion system (T6SS) in chickens

Author:
Singh, Ankita; Nisaa, Khairun; Bhattacharyya, Sudipta; Mallick, Amirul Islam
Source:
Molecular immunology 2019 v.111 pp. 182-197
ISSN:
0161-5890
Subject:
Campylobacter jejuni; Escherichia coli; antibodies; chickens; chitosan; digestive tract mucosa; food chain; genes; hemolysins; human diseases; humans; immunization; immunogenicity; immunoglobulin Y; interferon-gamma; interleukin-17; interleukin-1beta; interleukin-6; interleukin-8; intestines; nanoparticles; tripolyphosphates; type VI secretion system; vaccines; virulence
Abstract:
... The type VI secretion system (T6SS) has recently emerged as a new pattern of protein secretions in Campylobacter jejuni (C. jejuni). Within the T6SS cluster, hemolysin co-regulated protein (hcp) is considered as a hallmark of functional T6SS and holds key role in bacterial virulence. As poultry is the primary reservoir of C. jejuni and the major sources for human infection, we evaluated the capaci ...
DOI:
10.1016/j.molimm.2019.04.016

8. Structural variants of Salmonella Typhimurium lipopolysaccharide induce less dimerization of TLR4/MD-2 and reduced pro-inflammatory cytokine production in human monocytes

Author:
Aldapa-Vega, Gustavo; Moreno-Eutimio, Mario Adán; Berlanga-Taylor, Antonio J.; Jiménez-Uribe, Alexis P.; Nieto-Velazquez, Goreti; López-Ortega, Orestes; Mancilla-Herrera, Ismael; Cortés-Malagón, Enoc Mariano; Gunn, John S.; Isibasi, Armando; Wong-Baeza, Isabel; López-Macías, Constantino; Pastelin-Palacios, Rodolfo
Source:
Molecular immunology 2019 v.111 pp. 43-52
ISSN:
0161-5890
Subject:
Salmonella Typhimurium; adjuvants; cytokines; dimerization; genes; humans; immune response; immunomodulators; innate immunity; lipid A; mice; microRNA; microarray technology; monocytes; phosphates; transcription (genetics); transcription factor NF-kappa B
Abstract:
... Salmonella enterica serovar Typhimurium (S. Typhimurium) changes the structure of its lipopolysaccharide (LPS) in response to the environment. The two main LPS variants found in S. Typhimurium correspond to LPS with a hepta-acylated lipid A (LPS 430) and LPS with modified phosphate groups on its lipid A (LPS 435). We have previously shown that these modified LPS have a lower capacity than wild typ ...
DOI:
10.1016/j.molimm.2019.03.003

9. The effect of DNA methylation on the miRNA expression pattern in lipopolysaccharide-induced inflammatory responses in human dental pulp cells

Author:
Mo, Zehuan; Li, Qimeng; Cai, Luhui; Zhan, Minkang; Xu, Qiong
Source:
Molecular immunology 2019 v.111 pp. 11-18
ISSN:
0161-5890
Subject:
DNA; DNA methylation; epigenetics; gene expression; high-throughput nucleotide sequencing; humans; inflammation; interleukin-6; interleukin-8; lipopolysaccharides; messenger RNA; methyltransferases; microRNA; protein content; pulp; tooth pulp
Abstract:
... Endodontic infection is a widespread oral problem. DNA methylation is a key epigenetic modification that plays important roles in various inflammatory responses, but its role in dental pulp inflammation is poorly understood. In this study, we assessed the expression of DNA methyltransferases (DNMTs) in human dental pulp cells (hDPCs) during lipopolysaccharide (LPS)-induced inflammation and found th ...
DOI:
10.1016/j.molimm.2019.03.012

10. Accumulation and fate of nano- and micro-plastics and associated contaminants in organisms

Author:
Ribeiro, Francisca; O'Brien, Jake W.; Galloway, Tamara; Thomas, Kevin V.
Source:
Trends in analytical chemistry 2019 v.111 pp. 139-147
ISSN:
0165-9936
Subject:
aquatic invertebrates; birds; environmental impact; humans; insects; marine mammals; mechanism of action; nanoplastics; sea turtles; tissues
Abstract:
... Following a decade of research on the environmental impacts of microplastics, a knowledge gap remains on the processes by which micro and nanoplastics pass across biological barriers, enter cells and are subject to biological mechanisms. Here we summarize available literature on the accumulation of microplastics and their associated contaminants in a variety of organisms including humans. Most dat ...
DOI:
10.1016/j.trac.2018.12.010

11. Metabolization of pharmaceuticals by plants after uptake from water and soil: A review

Author:
Klampfl, Christian W.
Source:
Trends in analytical chemistry 2019 v.111 pp. 13-26
ISSN:
0165-9936
Subject:
biosolids; drug residues; environmental assessment; fertilizers; humans; irrigation; metabolites; sewage treatment; soil
Abstract:
... Residues of pharmaceuticals are ubiquitous in the environment, due to the increased use of drugs for treating humans and animals. If in agriculture water or biosolids from sewage treatment plants or manure from treated animals are used for irrigation or as a fertilizer respectively, drug residues may come into contact with plants. Subsequently these substances may be taken up, be translocated and ...
DOI:
10.1016/j.trac.2018.11.042

12. A coupled flood-agent-institution modelling (CLAIM) framework for urban flood risk management

Author:
Abebe, Yared Abayneh; Ghorbani, Amineh; Nikolic, Igor; Vojinovic, Zoran; Sanchez, Arlex
Source:
Environmental modelling & software 2019 v.111 pp. 483-492
ISSN:
1364-8152
Subject:
case studies; computer software; decision making; environmental models; humans; issues and policy; risk; risk reduction; urban areas; Saint Maarten
Abstract:
... In this paper, we describe a modelling framework that allows the integration of human and physical components of flood risk. Within this framework, flood risk management is conceptualized as a coupled human-flood system. The human subsystem includes individuals and their behaviour and institutions that shape human-flood interaction. The framework presents a dynamic integration between agent-based ...
DOI:
10.1016/j.envsoft.2018.10.015

13. Adrenomedullin: Continuing to explore cardioprotection

Author:
Tsuruda, Toshihiro; Kato, Johji; Kuwasako, Kenji; Kitamura, Kazuo
Source:
Peptides 2019 v.111 pp. 47-54
ISSN:
0196-9781
Subject:
aldosterone; amino acids; angiogenesis; apoptosis; biomarkers; calcitonin; cardioprotective effect; clinical trials; cyclic AMP; disulfide bonds; embryogenesis; gene transfer; half life; heart failure; humans; hypertrophy; myocardial infarction; myocardium; oxidative stress; rodents; secretion; therapeutics; vasodilation
Abstract:
... Adrenomedullin (AM), a peptide isolated from an extract of human pheochromocytoma, comprises 52 amino acids with an intramolecular disulfide bond and amidation at the carboxy-terminus. AM is present in various tissues and organs in rodents and humans, including the heart. The peptide concentration increases with cardiac hypertrophy, acute myocardial infarction, and overt heart failure in the plasm ...
DOI:
10.1016/j.peptides.2018.03.012

14. A linked modelling framework to explore interactions among climate, soil water, and land use decisions in the Argentine Pampas

Author:
García, Guillermo A.; García, Pablo E.; Rovere, Santiago L.; Bert, Federico E.; Schmidt, Federico; Menéndez, Ángel N.; Nosetto, Marcelo D.; Verdin, Andrew; Rajagopalan, Balaji; Arora, Poonam; Podestá, Guillermo P.
Source:
Environmental modelling & software 2019 v.111 pp. 459-471
ISSN:
1364-8152
Subject:
climate; cover crops; drainage; export tax; grains; groundwater; humans; issues and policy; land use; models; soil water; surface water; topography; water table; Pampas region
Abstract:
... In flat environments, groundwater is relatively shallow, tightly associated with surface water and climate, and can have either positive and negative impacts on natural and human systems depending on its depth. A linked modelling and analysis framework that seeks to capture linkages across multiple scales at the climate/water/crop nexus in the Argentine Pampas is presented. This region shows a str ...
DOI:
10.1016/j.envsoft.2018.10.013

15. Apelin and Elabela/Toddler; double ligands for APJ/Apelin receptor in heart development, physiology, and pathology

Author:
Kuba, Keiji; Sato, Teruki; Imai, Yumiko; Yamaguchi, Tomokazu
Source:
Peptides 2019 v.111 pp. 62-70
ISSN:
0196-9781
Subject:
G-protein coupled receptors; adults; angiotensin II; cardiovascular diseases; endoderm; heart; homeostasis; humans; ligands; morphogenesis; peptidyl-dipeptidase A; sequence homology; therapeutics
Abstract:
... Apelin is an endogenous peptide ligand for the G protein-coupled receptor APJ/AGTRL1/APLNR and is widely expressed throughout human body. In adult hearts Apelin-APJ/Apelin receptor axis is potently inotropic, vasodilatory, and pro-angiogenic and thereby contributes to maintaining homeostasis in normal and pathological hearts. Apelin-APJ/Apelin receptor is also involved in heart development includi ...
DOI:
10.1016/j.peptides.2018.04.011

16. Atrial and brain natriuretic peptides: Hormones secreted from the heart

Author:
Nakagawa, Yasuaki; Nishikimi, Toshio; Kuwahara, Koichiro
Source:
Peptides 2019 v.111 pp. 18-25
ISSN:
0196-9781
Subject:
atrial natriuretic peptide; brain; cyclic GMP; glycosylation; heart; heart failure; humans; metabolites; myocytes; patients; secretion; signal transduction; tissues
Abstract:
... The natriuretic peptide family consists of three biologically active peptides: atrial natriuretic peptide (ANP), brain (or B-type) natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Among these, ANP and BNP are secreted by the heart and act as cardiac hormones. Both ANP and BNP preferentially bind to natriuretic peptide receptor-A (NPR-A or guanylyl cyslase-A) and exert similar effec ...
DOI:
10.1016/j.peptides.2018.05.012

17. Endothelin and the heart in health and diseases

Author:
Miyauchi, Takashi; Sakai, Satoshi
Source:
Peptides 2019 v.111 pp. 77-88
ISSN:
0196-9781
Subject:
DNA; G-proteins; amino acids; antagonists; cardiomyocytes; endothelial cells; endothelins; heart failure; humans; hypertension; hypertrophy; kidney diseases; patients; receptors; swine
Abstract:
... Endothelin-1 (ET-1), a 21-amino acid peptide, was initially identified in 1988 as a potent vasoconstrictor and pressor substance isolated from the culture supernatant of porcine aortic endothelial cells. From human genomic DNA analysis, two other family peptides, ET-2 and ET-3, were found. They showed different effects and distribution, suggesting that each peptide may play separate roles in diffe ...
DOI:
10.1016/j.peptides.2018.10.002

18. Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model

Author:
Chen, Hainan; Liu, Yijian; Gui, Qingjun; Zhu, Xiao; Zeng, Lin; Meng, Jun; Qing, Jina; Gao, Ling; Jackson, Ampadu O.; Feng, Juling; Li, Yi; He, Jin; Yin, Kai
Source:
Peptides 2019 v.111 pp. 118-126
ISSN:
0196-9781
Subject:
animal models; blood serum; coronary vessels; endothelial cells; fibrosis; gastrointestinal system; ghrelin; heart; humans; myocardial infarction; phosphorylation; rats
Abstract:
... Ghrelin, a peptide hormone produced in the gastrointestinal tract, has recently been found to be associated with the onset of myocardial fibrosis (MF). The exact mechanism, however, remains elusive. This study sought to identify the function and mechanism of ghrelin on MF after acute myocardial infarction (AMI). AMI was established in Spraque-Dawley rats by ligation of the left anterior descending ...
DOI:
10.1016/j.peptides.2018.09.001

19. Glucagon-like peptide-1 receptor action in the vasculature

Author:
Almutairi, Malak; Al Batran, Rami; Ussher, John R.
Source:
Peptides 2019 v.111 pp. 26-32
ISSN:
0196-9781
Subject:
agonists; blood flow; blood glucose; cardiomyocytes; cardioprotective effect; cardiovascular diseases; clinical trials; endothelial cells; endothelium; glucagon-like peptide 1; humans; insulin secretion; mortality; nitric oxide; noninsulin-dependent diabetes mellitus; oxidative stress; smooth muscle
Abstract:
... Glucagon-like peptide-1 receptor (GLP-1R) agonists augment insulin secretion and are thus used clinically to improve glycemia in subjects with type 2 diabetes (T2D). As recent data reveal marked improvements in cardiovascular outcomes in T2D subjects treated with the GLP-1R agonists liraglutide and semaglutide in the LEADER and SUSTAIN-6 clinical trials respectively, there is growing interest in d ...
DOI:
10.1016/j.peptides.2018.09.002

20. Map based discovery of hydrologic data in the HydroShare collaboration environment

Author:
Xue, Zhaokun; Couch, Alva; Tarboton, David
Source:
Environmental modelling & software 2019 v.111 pp. 24-33
ISSN:
1364-8152
Subject:
computer software; data collection; humans; hydrologic data; laboratory experimentation
Abstract:
... Data discovery refers to the process of locating pre-existing data for use in new research. In the HydroShare collaboration environment for water science, there are more than twenty kinds of data that can be discovered, including data from specific sites on the globe, data corresponding to regions on the globe, and data with no geospatial meaning, such as laboratory experiment results. This paper ...
DOI:
10.1016/j.envsoft.2018.09.014