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1. Preliminary results from structural systems biology approach in Tetrahymena thermophila reveal novel perspectives for this toxicological model

Author:
Chasapis, Christos T.
Source:
Archives of microbiology 2019 v.201 no.1 pp. 51-59
ISSN:
0302-8933
Subject:
Tetrahymena thermophila; cadmium; databases; eukaryotic cells; genes; human diseases; models; protein-protein interactions; proteins; topology; toxicity; toxicology; yeasts
Abstract:
... Tetrahymena is a unicellular microbial eukaryotic organism that has been used extensively in toxicology and environmental research. This work attempts to model for the first time the wiring of proteins involved in cellular mechanisms of Cd toxicity in Tetrahymena thermophila. 1975 high-confidence PPIs between 68 Cd-binding proteins and 422 partners were inferred through a novel structural systems ...
DOI:
10.1007/s00203-018-1571-6

2. Regulation of the inositol transporter Itr1p by hydrogen peroxide in Saccharomyces cerevisiae

Author:
Santos, Tomás; Marinho, H. Susana; Cyrne, Luisa
Source:
Archives of microbiology 2019 v.201 no.1 pp. 123-134
ISSN:
0302-8933
Subject:
Saccharomyces cerevisiae; culture media; genes; hydrogen peroxide; myo-inositol; phenotype; phospholipids; plasma membrane; sphingolipids; transporters; yeasts
Abstract:
... Myo-inositol is a precursor of several membrane phospholipids and sphingolipids and plays a key role in gene regulation in Saccharomyces cerevisiae (S. cerevisiae). Here, we tested whether H₂O₂ was affecting the levels of the inositol transporters and thus inositol uptake. In S. cerevisiae cells adapted to H₂O₂ Itr1–GFPp accumulated in the plasma membrane until 20 min, concomitantly with an inhibi ...
DOI:
10.1007/s00203-018-1584-1