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- Author:
- Aya I. Abdelaziz; Eman M. Mantawy; Amany M. Gad; Hala M. Fawzy; Samar S. Azab
- Source:
- Food and chemical toxicology 2019 v.132 pp. 110719
- ISSN:
- 0278-6915
- Subject:
- agonists; antioxidant activity; antioxidants; apoptosis; autoimmune diseases; caspase-3; cyclic AMP; glucagon-like peptide 1; hepatocytes; hepatotoxicity; inflammation; interleukin-6; liver; methotrexate; neoplasms; oxidative stress; protective effect; rats; toxicology; transcription (genetics); transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Methotrexate (MTX) is commonly used to treat several types of cancer and autoimmune diseases. However, there is increasing concern over its organs toxicities particularly liver toxicity. Liraglutide, a glucagon like peptide-1 agonist, possesses antioxidant and anti-inflammatory features. This study aimed to explore the potential protective effect of liraglutide pre-treatment in ameliorating MTX-in ...
- DOI:
- 10.1016/j.fct.2019.110719
- https://doi.org/10.1016/j.fct.2019.110719
2. Adaptive responses to low doses of radiation or chemicals: their cellular and molecular mechanisms
- Author:
- Yann Guéguen; Alice Bontemps; Teni G. Ebrahimian
- Source:
- Cellular and molecular life sciences 2019 v.76 no.7 pp. 1255-1273
- ISSN:
- 1420-682X
- Subject:
- DNA repair; aggression; antioxidant activity; apoptosis; autophagy; cell cycle; cell viability; death; defense mechanisms; humans; inflammation; ionizing radiation; models; neoplasms; occupational exposure; risk; risk estimate; stress response; therapeutics; transcription factor NF-kappa B; unfolded protein response
- Abstract:
- ... This article reviews the current knowledge on the mechanisms of adaptive response to low doses of ionizing radiation or chemical exposure. A better knowledge of these mechanisms is needed to improve our understanding of health risks at low levels of environmental or occupational exposure and their involvement in cancer or non-cancer diseases. This response is orchestrated through a multifaceted ce ...
- DOI:
- 10.1007/s00018-018-2987-5
- https://doi.org/10.1007/s00018-018-2987-5
- Author:
- Azam Hosseinzadeh; Gholamreza Houshmand; Mehdi Goudarzi; Seyed Hashem Sezavar; Saeed Mehrzadi; Esrafil Mansouri; Mojtaba Kalantar
- Source:
- Life sciences 2019 v.217 pp. 91-100
- ISSN:
- 0024-3205
- Subject:
- adults; antioxidant activity; arsenic; blood serum; catalase; creatine; free radical scavengers; gallic acid; glutathione; glutathione peroxidase; heart; histopathology; hypertension; laboratory animals; males; medicinal properties; neoplasms; nitric oxide; oxidative stress; rats; skin lesions; sodium arsenite; spleen; superoxide dismutase; tissues; toxic substances
- Abstract:
- ... Arsenic is an important toxic chemical affecting millions of people around the world. Exposure to inorganic arsenic results in various health problems including skin lesions, hypertension, hematological disturbance, cardiovascular disease, spleen enlargement and cancer. Gallic acid (GA) is an important phenolic compound possessing various pharmacological properties including anti-inflammatory, ant ...
- DOI:
- 10.1016/j.lfs.2018.11.050
- https://doi.org/10.1016/j.lfs.2018.11.050
- Author:
- Conor Slattery; Paul D. Cotter; Paul W. O’Toole
- Source:
- Nutrients 2019 v.11 no.6 pp. -
- ISSN:
- 2072-6643
- Subject:
- Lactobacillus; antimicrobial properties; antioxidant activity; beverages; cholesterol metabolism; glycemic effect; immunomodulation; kefir; microorganisms; neoplasms
- Abstract:
- ... Lactobacilli are among the most common microorganisms found in kefir; a traditional fermented milk beverage produced locally in many locations around the world. Kefir has been associated with a wide range of purported health benefits; such as antimicrobial activity; cholesterol metabolism; immunomodulation; anti-oxidative effects; anti-diabetic effects; anti-allergenic effects; and tumor suppressi ...
- DOI:
- 10.3390/nu11061252
- PubMed:
- 31159409
- PubMed Central:
- PMC6627492
- https://doi.org/10.3390/nu11061252
- Author:
- Jessica CeramellaThese authors have contributed equally to the manuscript.; Monica Rosa Loizzo; Domenico Iacopetta; Marco Bonesi; Vincenzo Sicari; Teresa Maria Pellicanò; Carmela Saturnino; Aurélie Malzert-Fréon; Rosa TundisJoint senior authors.; Maria Stefania Sinicropi
- Source:
- Food & function 2019 v.10 no.7 pp. 4280-4290
- ISSN:
- 2042-650X
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Anchusa azurea; aerial parts; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; caffeic acid; caspase-3; catechin; cell death; cell lines; chemical composition; chlorogenic acid; cytoskeleton; death; high performance liquid chromatography; inhibitory concentration 50; menadione; methanol; mice; neoplasm cells; neoplasms; oxidative stress; toxicity
- Abstract:
- ... The present study aimed to determine the chemical composition, antioxidant effects and antitumor properties of a methanol extract of Anchusa azurea Mill. (Boraginaceae) aerial parts against four tumour cell lines (MCF-7, MDA-MB-231, RKO, and R₂C). The antioxidant effects were assessed by using β-carotene bleaching, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl ...
- DOI:
- 10.1039/c9fo00582j
- https://doi.org/10.1039/c9fo00582j
- Author:
- Luan He; Yong Zhang; Naixin Kang; Yaner Wang; Ziyu Zhang; Zhengxia Zha; Shilin Yang; Qiongming Xu; Yanli Liu
- Source:
- Phytomedicine 2019 v.56 pp. 136-146
- ISSN:
- 0944-7113
- Subject:
- Anemone chinensis; Western blotting; adverse effects; anti-inflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; blood; body weight; catalase; cell viability; cisplatin; creatinine; drug therapy; flow cytometry; glutathione; histopathology; in vivo studies; kidneys; mice; models; neoplasms; nephrotoxicity; protective effect; reactive oxygen species; renal failure; saponins; superoxide dismutase; urea nitrogen
- Abstract:
- ... Cisplatin is a highly effective chemotherapeutic agent commonly used in the treatment of a wide variety of malignancies. However, its clinical usage is severely limited by its serious side effects, especially nephrotoxicity. Anemoside B4, is a major saponins, rich in root of Pulsatilla chinensis (Bunge), has anti-inflammation in vitro. However, the antioxidant or anti-inflammatory effects of anemo ...
- DOI:
- 10.1016/j.phymed.2018.10.035
- https://doi.org/10.1016/j.phymed.2018.10.035
- Author:
- Rui Jia; Zhengyan Gu; Qin He; Jinliang Du; Liping Cao; Galina Jeney; Pao Xu; Guojun Yin
- Source:
- Fish & shellfish immunology 2019 v.93 pp. 395-405
- ISSN:
- 1050-4648
- Subject:
- NAD (coenzyme); NAD(P)H dehydrogenase (quinone); Oreochromis niloticus; alkaline phosphatase; anti-inflammatory activity; antioxidant activity; blood serum; catalase; complement; diet; fish; gene expression; gene expression regulation; glutathione transferase; growth performance; heat shock proteins; heme oxygenase (biliverdin-producing); hepatoprotective effect; herbal medicines; hydrogen peroxide; inflammation; interleukin-1beta; interleukin-8; intraperitoneal injection; lipid peroxidation; liver; messenger RNA; necrosis; neoplasms; plant extracts; quinones; signal transduction; transaminases; tumor necrosis factor-alpha
- Abstract:
- ... Radix Bupleuri extract (RBE) is one of the most popular oriental herbal medicines, which has anti-oxidative and anti-inflammatory properties. However, its protective effects and underlying molecular mechanisms on oxidative damage in tilapia are still unclear. The aims of the study were to explore the anti-oxidative, anti-inflammatory and hepatoprotective effects of RBE against oxidative damage, an ...
- DOI:
- 10.1016/j.fsi.2019.07.080
- https://doi.org/10.1016/j.fsi.2019.07.080
- Author:
- Adriana Nowak; Anna Paliwoda; Janusz Błasiak
- Source:
- Critical reviews in food science and nutrition 2019 v.59 no.21 pp. 3456-3467
- ISSN:
- 1549-7852
- Subject:
- Bifidobacterium; Lactobacillus; antineoplastic activity; antioxidant activity; antioxidant enzymes; apoptosis; bacteria; carcinogens; cell cycle; cell proliferation; molecular weight; neoplasm cells; neoplasms; proteins; reactive oxygen species; therapeutics; transition elements
- Abstract:
- ... Lactobacillus and Bifidobacterium strains, their isolated constituents and substances that they secrete exert various anti-cancer actions, resulting from their anti-proliferative, pro-apoptotic and anti-oxidant properties. They can express and secrete anti-oxidant enzymes, bind reactive oxygen species, release small molecular weight anti-oxidants and chelate transition metals, preventing detriment ...
- DOI:
- 10.1080/10408398.2018.1494539
- https://doi.org/10.1080/10408398.2018.1494539
- Author:
- E. R. Prudêncio; C. M. Cardoso; R. N. Castro; C. J. Riger
- Source:
- Applied biochemistry and microbiology 2019 v.55 no.3 pp. 264-269
- ISSN:
- 0003-6838
- Subject:
- Saccharomyces cerevisiae; antioxidant activity; atherosclerosis; caffeic acid; cell membranes; cell viability; chlorogenic acid; diet; glutathione; lipid peroxidation; mutants; neoplasms; neurodegenerative diseases; oxidative stress; stress tolerance; superoxide dismutase; viability assays; yeasts
- Abstract:
- ... Hydroxycinnamic acids have received particular attention because they are the most abundant phenolic class in our diet and because of the increasing interest in reducing oxidative damages. These damages are related to diseases such as cancer and atherosclerosis, as well as neurodegenerative disorders. The objective of this study was to evaluate the antioxidant protection of chlorogenic and caffeic ...
- DOI:
- 10.1134/S0003683819030116
- https://doi.org/10.1134/S0003683819030116
- Author:
- S. Karakaya; M. Koca; O. Sytar; B. Dursunoglu; H. Ozbek; H. Duman; Z. Guvenalp; C.S. Kılıc
- Source:
- South African journal of botany 2019 v.121 pp. 536-542
- ISSN:
- 0254-6299
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; acetylcholinesterase; aerial parts; antioxidant activity; aphrodisiacs; chlorogenic acid; cholinesterase; coumarin; enzyme activity; flavor; fruits; immunostimulants; methylene chloride; neoplasms; propyl gallate; roots; rutin; sedatives; skin diseases; umbelliferones
- Abstract:
- ... Ferulago species are utilized as flavor, sedative, tonic, aphrodisiac, peptic, immunostimulant, antibronchitis, vermicidal, carminative and for the curation of cancers and skin disorders in Middle Eastern region. The presented research reports anticholinesterase and antioxidant capacities of aerial parts, fruits, flowers, roots extracts and isolated coumarins of roots from of Ferulago cassia Boiss ...
- DOI:
- 10.1016/j.sajb.2019.01.020
- https://doi.org/10.1016/j.sajb.2019.01.020
- Author:
- Zahra Rafiee; Mohammad Nejatian; Marjan Daeihamed; Seid Mahdi Jafari
- Source:
- Trends in food science & technology 2019 v.88 pp. 445-458
- ISSN:
- 0924-2244
- Subject:
- antimicrobial properties; antioxidant activity; antioxidants; bacterial infections; bioavailability; biological half-life; cosmetics; curcumin; dispersibility; drugs; encapsulation; gastrointestinal system; hydrophilicity; industrial applications; nanocapsules; nanocarriers; nanoparticles; neoplasms; neurodegenerative diseases; processed foods; turmeric; water solubility
- Abstract:
- ... Curcumin, the major bioactive material of turmeric, has wide functional features such as anti-diabetic, anti-cancer, anti-inflammatory, and antioxidant activities. However, curcumin exhibits some major limitations including low water solubility, degradation during processing or within the gastrointestinal tract and alkaline conditions, leading to decrease of its bioavailability. For these reasons, ...
- DOI:
- 10.1016/j.tifs.2019.04.017
- https://doi.org/10.1016/j.tifs.2019.04.017
- Author:
- A.B. Oyenihi; C. Smith
- Source:
- Journal of ethnopharmacology 2019 v.229 pp. 54-72
- ISSN:
- 0378-8741
- Subject:
- active ingredients; adverse effects; antineoplastic agents; antioxidant activity; antioxidants; chronic diseases; mechanism of action; medicinal plants; neoplasms; pharmaceutical industry; plant products; polyphenols; therapeutics; toxicity; traditional medicine
- Abstract:
- ... Given the severe side effects associated with most of the conventional cancer medications, as well as the expanding body of evidence indicating secondary toxicity of these drugs, individuals with cancer are increasingly turning to natural alternatives. Similarly, the pharmaceutical industry is in search of natural products to treat cancer. An understanding of the specific active components in plan ...
- DOI:
- 10.1016/j.jep.2018.09.037
- https://doi.org/10.1016/j.jep.2018.09.037
- Author:
- Byoung Wook Bang; Dongsun Park; Kye Sook Kwon; Don Haeng Lee; Min-Jung Jang; Sun Kyu Park; Jeom-Yong Kim
- Source:
- Journal of medicinal food 2019 v.22 no.2 pp. 140-151
- ISSN:
- 1557-7600
- Subject:
- Lonicera japonica; animal models; anti-inflammatory activity; antioxidant activity; antioxidants; catalase; chlorogenic acid; gastritis; gene expression regulation; glutathione; hexosamines; hydrochloric acid; interleukin-1beta; malondialdehyde; mucus; neoplasms; oral administration; oxidation; oxidative stress; prostaglandins; quantitative polymerase chain reaction; sialic acid; stomach ulcers; superoxide dismutase; tissues; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... The gastroprotective effects of BST-104 (a water extract of Lonicera japonica) and the mechanisms involved were investigated in murine models of gastritis and peptic ulcer. The gastroprotective effects of BST-104 and its active components were evaluated in rat models of HCl/ethanol-induced gastritis and acetic acid-induced gastric ulcer. After orally administering BST-104, chlorogenic acid, rebami ...
- DOI:
- 10.1089/jmf.2018.4231
- https://doi.org/10.1089/jmf.2018.4231
- Author:
- Huifeng Li; Chang Xu; Li Zhou; Yangfan Dong; Yujie Su; Xiaodan Wang; Jian G. Qin; Liqiao Chen; Erchao Li
- Source:
- Fish & shellfish immunology 2019 v.91 pp. 315-324
- ISSN:
- 1050-4648
- Subject:
- Flavobacterium; Geobacillus; Litopenaeus vannamei; Microbacterium; Mycobacterium; Toll-like receptors; Vibrio; amylases; antioxidant activity; beta-glucans; condition factor; diet; digestibility; enzyme activity; glutathione peroxidase; growth performance; health status; heat-shock protein 70; hepatopancreas; immunity; intestines; lectins; messenger RNA; microbial communities; myostatin; necrosis; neoplasms; pathogens; probiotics; proteinases; salinity; superoxide dismutase; tumor necrosis factor-alpha
- Abstract:
- ... An 8-week trial was conducted to evaluate the effect of dietary β-glucan supplement (0, 0.01%, 0.02%, or 0.04%) on growth and health of Pacific white shrimp Litopenaeus vannamei at low salinity of 3 practical salinity unit (psu). The L. vannamei fed 0.02% and 0.04% β-glucan gained more weight and showed higher activities of protease, amylase, superoxide dismutase, and glutathione peroxidase in the ...
- DOI:
- 10.1016/j.fsi.2019.05.052
- https://doi.org/10.1016/j.fsi.2019.05.052
- Author:
- Birendra Nath Karan; Tapan Kumar Maity; Bikash Chandra Pal; Tanushree Singha; Snehasis Jana
- Source:
- Natural product research 2019 v.33 no.22 pp. 3287-3292
- ISSN:
- 1478-6427
- Subject:
- Fourier transform infrared spectroscopy; Nyctanthes arbor-tristis; anti-inflammatory activity; antineoplastic activity; antioxidant activity; betulinic acid; carbon; cytotoxicity; ethyl acetate; fractionation; human cell lines; humans; in vitro studies; inhibitory concentration 50; leaves; mass spectrometry; neoplasm cells; neoplasms; nitrites; nuclear magnetic resonance spectroscopy; spectral analysis; stable isotopes; tumor necrosis factor-alpha
- Abstract:
- ... Betulinic acid was first time isolated via bioactivity-guided fractionation from ethyl acetate extract of Nyctanthes arbor-tristis leaves. Its structure was established by FTIR, ¹H and ¹³C- nuclear magnetic resonance and high-resolution mass spectrometry. It had shown excellent inhibition of anti-inflammatory properties with IC₅₀ of 10.34 μg/mL (COX-1), 12.92 μg/mL (COX-2), 15.53 μg/mL (5-LOX), 15 ...
- DOI:
- 10.1080/14786419.2018.1470171
- https://doi.org/10.1080/14786419.2018.1470171
- Author:
- Davide Tagliazucchi; Serena Martini; Lisa Solieri
- Source:
- Fermentation 2019 v.5 no.4 pp. -
- ISSN:
- 2311-5637
- Subject:
- antimicrobial properties; antioxidant activity; chronic diseases; health services; healthy diet; humans; lactic acid bacteria; lifestyle; milk; milk proteins; neoplasms; patients; peptides; probiotics; proteolysis; sensory properties; shelf life; therapeutics; yogurt
- Abstract:
- ... With rapidly ageing populations, the world is experiencing unsustainable healthcare from chronic diseases such as metabolic, cardiovascular, neurodegenerative, and cancer disorders. Healthy diet and lifestyle might contribute to prevent these diseases and potentially enhance health outcomes in patients during and after therapy. Fermented dairy foods (FDFs) found their origin concurrently with huma ...
- DOI:
- 10.3390/fermentation5040096
- https://doi.org/10.3390/fermentation5040096
- Author:
- Margherita Lavorgna; Elena Orlo; Roberta Nugnes; Concetta Piscitelli; Chiara Russo; Marina Isidori
- Source:
- Plant foods for human nutrition 2019 v.74 no.2 pp. 164-170
- ISSN:
- 0921-9668
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Capsicum; analgesics; antioxidant activity; apoptosis; capsaicin; cations; cytotoxicity; fibroblasts; fruits; hot peppers; human cell lines; humans; neoplasm cells; neoplasms; raw fruit; secondary metabolites; toxicity testing; traditional medicine
- Abstract:
- ... Capsaicin is a spicy capsaicinoid, produced as secondary metabolite by Capsicum fruits. This alkaloid has been used for years in folk medicine for its analgesic and antinflammatory properties although most data is referred to the raw fruit. In this study, the antiradical activity of the pure capsaicin has been studied using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazo ...
- DOI:
- 10.1007/s11130-019-00722-0
- https://doi.org/10.1007/s11130-019-00722-0
- Author:
- Sheng‐I Chen; Chia‐Chien Hsieh
- Source:
- International journal of food science & technology 2019 v.54 no.5 pp. 1460-1466
- ISSN:
- 0950-5423
- Subject:
- antioxidant activity; chemoprevention; computational methodology; epidemiological studies; genome; lectins; medical treatment; neoplasms; nutrients; nutritional intervention; peptides; proteinase inhibitors; soy protein; soybeans
- Abstract:
- ... Epidemiological studies have shown that soy consumption is associated with lower incidence of various diseases, such as cancer. Over the past decades, soy proteins and derived peptides have been considered as potential preventive agents against the initiation, promotion and progression of cancer. Additionally, soybeans provide essential nutrients and abundant peptides and proteins with multiple bi ...
- DOI:
- 10.1111/ijfs.14053
- https://doi.org/10.1111/ijfs.14053
- Author:
- Wenfeng Li; Jing Zhang; Si Tan; Qiaoran Zheng; Xin Zhao; Xiaoxv Gao; Yalong Lu
- Source:
- Journal of food biochemistry 2019 v.43 no.12 pp. e13046
- ISSN:
- 0145-8884
- Subject:
- Citrus; antioxidant activity; black tea; cardiovascular system; citric acid; epigallocatechin gallate; neoplasms; neurodegenerative diseases; obesity; polyphenols; risk reduction; tea (beverage)
- Abstract:
- ... This study examined the dissolution kinetics and antioxidant activity of tea polyphenols during the soaking of white, yellow, green, oolong, black, and dark teas. All these teas were, respectively, soaked with either freshly boiled distilled water (DW) or 10 mmol/L citric acid–water solution. The residue obtained from one extraction was used for the next extraction and this process was performed c ...
- DOI:
- 10.1111/jfbc.13046
- https://doi.org/10.1111/jfbc.13046
- Author:
- Mingming Zhou; Pei Chen; Yuan Lin; Shengzuo Fang; Xulan Shang
- Source:
- Forests 2019 v.10 no.8 pp. -
- ISSN:
- 1999-4907
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Cyclocarya paliurus; antioxidant activity; antioxidants; bioactive compounds; colorimetry; dietary supplements; ethanol; flavonoids; high performance liquid chromatography; human cell lines; ingredients; leaves; metabolites; neoplasm cells; neoplasms; polyphenols; solvents; trees; triterpenoids; China
- Abstract:
- ... Cyclocarya paliurus (Batal.) Iljinskaja is an indigenous and multifunction tree species in China, but it is mainly used in pharmaceutical and nutraceutical ingredients. To make a comprehensive evaluation on its bioactive metabolites, antioxidant and antitumor potentials of C. paliurus leaves, the leaf samples were collected from 15 geographic locations (natural populations) throughout its distribu ...
- DOI:
- 10.3390/f10080625
- https://doi.org/10.3390/f10080625
- Author:
- André Luis Rodrigues de Souza; Flavia dos Santos Gomes; Renata Valeriano Tonon; Luiz Fernando Menezes da Silva; Lourdes Maria Corrêa Cabral
- Source:
- Journal of food processing and preservation 2019 v.43 no.11 pp. e14164
- ISSN:
- 0145-8892
- Subject:
- antioxidant activity; bioactive compounds; fruits; human health; lycopene; microfiltration; molecular weight; neoplasms; odors; pulp; reverse osmosis; temperature; tomatoes; total soluble solids
- Abstract:
- ... Lycopene is a carotenoid found in tomatoes and other red fruits and vegetables. It is known for its antioxidant properties, which is associated with the prevention of cancer. Raw tomatoes and tomato‐based products are important sources of dietary lycopene. This study aimed to evaluate the integration of diafiltration and reverse osmosis processes to concentrate tomato pulp and to obtain a lycopene ...
- DOI:
- 10.1111/jfpp.14164
- https://doi.org/10.1111/jfpp.14164
- Author:
- Mardi M. Algandaby
- Source:
- Journal of food biochemistry 2019 v.43 no.7 pp. e12895
- ISSN:
- 0145-8884
- Subject:
- acid phosphatase; adults; adverse effects; alkaline phosphatase; animal models; anti-inflammatory activity; antioxidant activity; bioavailability; blood glucose; blood pressure; blood serum; body weight changes; bone formation; bone resorption; carotenoids; collagen; crosslinking; enzyme activity; epiphyses; fasting; femur; histology; hyperinsulinemia; interleukin-6; metabolic syndrome; neoplasms; osteocalcin; osteoporosis; oxidative stress; rats; triacylglycerols; tumor necrosis factor-alpha
- Abstract:
- ... In the current study, anti‐osteoporotic activities of crocin were evaluated in a rat model of metabolic syndrome‐induced osteoporosis. Metabolic syndrome was confirmed by increased body weight gain, increased fasting blood glucose, hyperinsulinemia, elevated mean arterial blood pressure, and increased serum triglycerides level. Crocin (5 or 10 mg/kg) protected against histological and architectura ...
- DOI:
- 10.1111/jfbc.12895
- https://doi.org/10.1111/jfbc.12895
- Author:
- Sameh Soliman Tawfik; Ahmed Amer Elkady; Wael Aly El khouly
- Source:
- Environmental science and pollution research international 2019 v.26 no.15 pp. 15414-15419
- ISSN:
- 0944-1344
- Subject:
- alanine transaminase; alkaline phosphatase; anti-inflammatory activity; antioxidant activity; antioxidants; aspartate transaminase; bioactive compounds; blood serum; catalase; gamma radiation; glutathione peroxidase; hepatocytes; hepatotoxicity; histopathology; interleukin-1beta; lipid peroxidation; liver; liver function; necrosis; neoplasms; protective effect; rats; saffron; superoxide dismutase; tissues; tumor necrosis factor-alpha
- Abstract:
- ... Crocin (C₄₄H₆₄O₂₄) is an isolated bioactive molecule of saffron extract. It has different pharmacological effects such as antioxidant and anti-inflammatory activities. In the present study, radioprotective property of crocin was investigated in the rat liver. Thirty-two rats were equally divided into four groups: (1) control (normal saline), (2) crocin (200 mg/kg), (3) γ-rays (6Gy), and (4) crocin ...
- DOI:
- 10.1007/s11356-019-04724-y
- https://doi.org/10.1007/s11356-019-04724-y
- Author:
- Nor Hisam Zamakshshari; Gwendoline Cheng Lian Ee; Intan Safinar Ismail; Zalikha Ibrahim; Siau Hui Mah
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Calophyllum; antioxidant activity; antioxidants; bark; computer simulation; cytotoxicity; enzymes; ethyl acetate; hexane; human diseases; inhibitory concentration 50; methanol; methylene chloride; neoplasm cells; neoplasms; nitric oxide; plant extracts; xanthones
- Abstract:
- ... The stem bark of Calophyllum depressinervosum and Calophyllum buxifolium were extracted and examined for their antioxidant activities, together with cytotoxicity towards human cancer cells. The methanol extract of C. depressinervosum exhibited good DPPH and NO scavenging effects. The strongest BCB inhibition and FIC effects were shown by dichloromethane and ethyl acetate extracts of both species. ...
- DOI:
- 10.1016/j.fct.2019.110800
- https://doi.org/10.1016/j.fct.2019.110800
- Author:
- Rosa Tundis; Monica R. Loizzo; Marco Bonesi; Lorenzo Peruzzi; Thomas Efferth
- Source:
- Natural product research 2019 v.33 no.12 pp. 1809-1812
- ISSN:
- 1478-6427
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Daphne mezereum; aerial parts; antineoplastic agents; antioxidant activity; beta-carotene; bleaching; gas chromatography-mass spectrometry; hexane; humans; inhibitory concentration 50; maceration; methanol; methylene chloride; neoplasm cells; neoplasms; phytochemicals; statistics
- Abstract:
- ... In this study, we investigated for the first time the anti-proliferative and antioxidant properties of D. mezereum and D. striata. The aerial parts were extracted by maceration with n-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxida ...
- DOI:
- 10.1080/14786419.2018.1437432
- https://doi.org/10.1080/14786419.2018.1437432
- Author:
- Pooran Golkar; Marzieh Taghizadeh; Seyed Amir Hossein Jalali
- Source:
- Journal of food biochemistry 2019 v.43 no.11 pp. e13036
- ISSN:
- 0145-8884
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Chrozophora; anthocyanins; antineoplastic activity; antioxidant activity; antioxidants; cancer therapy; carotenoids; carvacrol; catechin; dietary supplements; ellagic acid; enzyme activity; enzymes; eugenol; hesperetin; hesperidin; high performance liquid chromatography; human cell lines; kaempferol; neoplasms; quercetin; rosmarinic acid; thymol; Iran
- Abstract:
- ... The present study was conducted to determine the total phenolics, flavonoids, flavonols, anthocyanin, and carotenoids as well as the antioxidant activity of 10 different Crozophora tinctoria accessions originated from Iran. The highest contents of total phenolics, flavonoids, flavonols, anthocyanin, and carotenoids were detected in C.t (2), C.t (10), C.t (10), C.t (9), and C.t (3) accessions, resp ...
- DOI:
- 10.1111/jfbc.13036
- https://doi.org/10.1111/jfbc.13036
- Author:
- Shahab Khosravi; Mohammad Safari; Zahra Emam‐Djomeh; Mohammad‐Taghi Golmakani
- Source:
- Journal of food processing and preservation 2019 v.43 no.2 pp. e13872
- ISSN:
- 0145-8892
- Subject:
- antioxidant activity; antioxidants; black tea; brix; cardiovascular diseases; cellulose; diabetes; fermentation; financial economics; flavor; kombucha; microsymbionts; neoplasms; pH; starter cultures; syrups; titratable acidity; yeasts
- Abstract:
- ... In the present study, date syrup (DS) was used as a medium for preparation of Kombucha beverage. Fermentation of DS with different Brix values and also sweetened black tea were performed using Kombucha starter culture (KSC) and cultivation was accomplished after 15 days at 30°C. The results indicated that by increasing the Brix value of DS from 6 to 10, a rise in the titratable acidity, phenolic c ...
- DOI:
- 10.1111/jfpp.13872
- https://doi.org/10.1111/jfpp.13872
- Author:
- Mihir Parikh; Thane G. Maddaford; J. Alejandro Austria; Michel Aliani; Thomas Netticadan; Grant N. Pierce
- Source:
- Nutrients 2019 v.11 no.5 pp. -
- ISSN:
- 2072-6643
- Subject:
- animal health; anti-inflammatory activity; antioxidant activity; bioactive compounds; brain; cardiovascular diseases; human health; humans; lignans; linolenic acid; linseed; menopause; neoplasms; omega-3 fatty acids; women
- Abstract:
- ... Flaxseed is a rich source of the omega-3 fatty acid, alpha linolenic acid, the lignan secoisolariciresinol diglucoside and fiber. These compounds provide bioactivity of value to the health of animals and humans through their anti-inflammatory action, anti-oxidative capacity and lipid modulating properties. The characteristics of ingesting flaxseed or its bioactive components are discussed in this ...
- DOI:
- 10.3390/nu11051171
- PubMed:
- 31130604
- PubMed Central:
- PMC6567199
- https://doi.org/10.3390/nu11051171
- Author:
- Chunchun Wang; Shuting Cao; Qianhui Zhang; Zhuojun Shen; Jie Feng; Qihua Hong; Jianjun Lu; Fei Xie; Yan Peng; Caihong Hu
- Source:
- Journal of agricultural and food chemistry 2019 v.67 no.5 pp. 1409-1417
- ISSN:
- 1520-5118
- Subject:
- adenosine triphosphate; antioxidant activity; average daily gain; blood serum; butyric acid; copper; dextran; diamine oxidase; diquat; electrical resistance; enzyme activity; inflammation; interferon-gamma; interleukin-6; intestines; lactic acid; malondialdehyde; membrane potential; messenger RNA; mitochondria; mitochondrial membrane; mitophagy; necrosis; neoplasms; occludins; oxidative stress; piglets; reactive oxygen species; superoxide dismutase; tributyrin; tumor necrosis factor-alpha; zinc
- Abstract:
- ... The study evaluated the effects of butyric acid, in the form of tributyrin on the oxidative stress, inflammation, and mitochondrial function in diquat-challenged pigs. Twenty-four weaned pigs were allocated to four treatments in a 2 × 2 factorial arrangement with the main effects of tributyrin supplementation and diquat challenge. The results showed that supplemental tributyrin increased (P < 0.05 ...
- DOI:
- 10.1021/acs.jafc.8b06208
- https://doi.org/10.1021/acs.jafc.8b06208
- Author:
- Weihao Ou; Haibin Hu; Pei Yang; Jihong Dai; Qinghui Ai; Wenbing Zhang; Yanjiao Zhang; Kangsen Mai
- Source:
- Fish & shellfish immunology 2019 v.94 pp. 132-141
- ISSN:
- 1050-4648
- Subject:
- Prevotella; Scophthalmus maximus; antioxidant activity; daidzein; experimental diets; feed conversion; feed intake; fish feeding; gene expression; gene expression regulation; growth performance; interleukin-1beta; intestinal microorganisms; intestines; juveniles; lactic acid bacteria; messenger RNA; necrosis; neoplasms; occludins; short chain fatty acids; tight junctions; transforming growth factor beta 1; tumor necrosis factor-alpha; turbot; virulent strains
- Abstract:
- ... A 12-week feeding trial was conducted to investigate the effect of dietary daidzein on the intestinal mucosal barrier function and the intestinal microbiota profile of juvenile turbot (Scophthalmus maximus L.). Three isonitrogenous and isolipidic experimental diets were formulated to contain 0 (FM), 40 (D.40) and 400 (D.400) mg kg⁻¹ daidzein, respectively. Fish fed D.400 had significantly lower gr ...
- DOI:
- 10.1016/j.fsi.2019.08.059
- https://doi.org/10.1016/j.fsi.2019.08.059
- Author:
- Seong-Ah Kim; Hyojee Joung; Sangah Shin
- Source:
- Nutrition journal 2019 v.18 no.1 pp. 37
- ISSN:
- 1475-2891
- Subject:
- National Health and Nutrition Examination Survey; adults; antioxidant activity; beans; cardiovascular diseases; cross-sectional studies; diet recall; eating habits; fish; fruits; hypercholesterolemia; hypertriglyceridemia; kimchi; lipemic effect; metabolic syndrome; neoplasms; nutrients; nuts; oils; risk factors; sweets; vegetables; Korean Peninsula
- Abstract:
- ... BACKGROUND: Abnormal diet is considered to be an important risk factor for dyslipidemia. However, so far, most studies have focused on the association between single factors only, such as specific nutrients, foods, or dietary patterns, and dyslipidemia risk. This study aimed to examine the association of the joint interaction between dietary pattern and dietary total antioxidant capacity (TAC) wit ...
- DOI:
- 10.1186/s12937-019-0459-x
- PubMed:
- 31301735
- PubMed Central:
- PMC6626369
- https://doi.org/10.1186/s12937-019-0459-x
32. Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity
- Author:
- A. Rosa; D. Caprioglio; R. Isola; M. Nieddu; G. Appendino; A. M. Falchi
- Source:
- Food & function 2019 v.10 no.3 pp. 1629-1642
- ISSN:
- 2042-650X
- Subject:
- antineoplastic activity; antioxidant activity; antioxidants; apoptosis; cholesterol; droplets; fatty acid composition; fluorescence; free radicals; ginger; lipid peroxidation; mitochondria; mitochondrial membrane; neoplasm cells; neoplasms; oleic acid; oxidation; oxidative stress; palmitic acid; phospholipids; sesquiterpenoids; staining; stearic acid
- Abstract:
- ... The dietary sesquiterpene dienone zerumbone (ZER) selectively targets cancer cells, inducing mitochondrial dysfunction and apoptosis, and protects non-cancerous cells towards oxidative stress and insult. This study examines the in vitro effects of ZER on lipid peroxidation in biological systems (cholesterol and phospholipid membrane oxidation) and explores its antitumor action in terms of its abil ...
- DOI:
- 10.1039/c8fo02395f
- https://doi.org/10.1039/c8fo02395f
- Author:
- Kyung Hye Seo; Ji Yeon Lee; Jeong-Yong Park; Gwi Yeong Jang; Hyung Don Kim; Young- Seob Lee; Dong Hwi Kim
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 89
- ISSN:
- 1472-6882
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Rubus coreanus; alternative medicine; ambient temperature; anti-inflammatory activity; anti-inflammatory agents; antioxidant activity; asthma; diarrhea; ethanol; fruits; inducible nitric oxide synthase; inhibitory concentration 50; interleukin-6; introduced species; lipopolysaccharides; macrophages; necrosis; neoplasms; nitric oxide; polymerase chain reaction; prostaglandin synthase; signal transduction; solvents; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha; China; Japan; Korean Peninsula
- Abstract:
- ... BACKGROUND: Rubus coreanus fruit (RF) has been used as a traditional medicine formulation to treat various diseases including diarrhea, asthma, and cancer in East Asia (Korea, China, and Japan). RF, which is native to Korea, has a larger fruit size than that of exotic species. In this study, we aimed to compare the anti-inflammatory activities of immature and mature RF extracted with different sol ...
- DOI:
- 10.1186/s12906-019-2496-6
- PubMed:
- 31023273
- PubMed Central:
- PMC6485102
- https://doi.org/10.1186/s12906-019-2496-6
- Author:
- Shuyun Ji; Xi Qi; Shuxue Ma; Xing Liu; Yuna Min
- Source:
- Animals 2019 v.9 no.10 pp. -
- ISSN:
- 2076-2615
- Subject:
- antioxidant activity; antioxidant genes; antioxidants; broiler chickens; carcinogenicity; cecum; gene expression regulation; homeostasis; immunity; jejunum; metabolites; mucosa; neoplasms; nutrient requirements; signal transduction; threonine; transcription (genetics); viruses
- Abstract:
- ... This study aimed to determine the effects of different dietary threonine levels on the antioxidant and immune capacity and the immunity of broilers. A total of 432 one-day-old Arbor Acres (AA) broilers were randomly assigned to 4 groups, each with 6 replicates of 18 broilers. The amount of dietary threonine in the four treatments reached 85%, 100%, 125%, and 150% of the NRC (Nutrient Requirements ...
- DOI:
- 10.3390/ani9100739
- PubMed:
- 31569385
- PubMed Central:
- PMC6826648
- https://doi.org/10.3390/ani9100739
- Author:
- Ji-Wei Li; Jian Hu; Ming Wei; Ying-Ying Guo; Pei-Shi Yan
- Source:
- Animals 2019 v.9 no.8 pp. -
- ISSN:
- 2076-2615
- Subject:
- antioxidant activity; backfat; bioinformatics; biosynthesis; carbohydrates; fetus; inflammation; interleukin-6; lipid metabolism; malondialdehyde; mitochondria; models; necrosis; neoplasms; obesity; oxidative stress; placenta; pregnancy; proteome; proteomics; steroid hormones; triacylglycerols
- Abstract:
- ... Maternal obesity is associated with impaired maternal metabolism and affects the developmental programming of the fetus. The placenta is dysfunctional when exposed to an obese intrauterine environment and can transduce and mediate detrimental maternal impacts to the fetus through mechanisms that remain largely unknown. The main objective of this study was to investigate the effects of maternal obe ...
- DOI:
- 10.3390/ani9080546
- PubMed:
- 31408947
- PubMed Central:
- PMC6720507
- https://doi.org/10.3390/ani9080546
- Author:
- Xudong Gao; Cong Wang; Zhongqin Chen; Yue Chen; Ramesh Kumar Santhanam; Zihan Xue; Qiqi Ma; Qingwen Guo; Wei Liu; Min Zhang; Haixia Chen
- Source:
- Food and chemical toxicology 2019 v.130 pp. 130-141
- ISSN:
- 0278-6915
- Subject:
- antioxidant activity; apoptosis; cytotoxicity; flow cytometry; functional foods; garlic; human cell lines; hydrogen peroxide; inhibitory concentration 50; mitochondria; neoplasms; protective effect; therapeutics
- Abstract:
- ... Laba garlic is a kind of processed garlic products, it is the traditional Chinese food with a long history. In this study, the antitumor, antioxidant and cytotoxic properties of the blue pigment (BP) from Laba garlic were investigated. N-trans-feruloyltyramine (FLA) was isolated and identified from BP. The protective effects of FLA against H2O2-induced oxidative damages in L02 cells were also asse ...
- DOI:
- 10.1016/j.fct.2019.05.021
- https://doi.org/10.1016/j.fct.2019.05.021
- Author:
- Mu-Yang Li; Xin-Ming Zhu; Xiao-Tian Niu; Xiu-Mei Chen; Jia-Xin Tian; Yi-Di Kong; Dong-Ming Zhang; Lei Zhao; Gui-Qin Wang
- Source:
- Molecular biology reports 2019 v.46 no.2 pp. 2221-2230
- ISSN:
- 0301-4851
- Subject:
- Allium; Channa argus; albumins; antioxidant activity; blood proteins; diet; feed conversion; genes; globulins; glutathione transferase; heat-shock protein 70; heat-shock protein 90; immune response; interleukin-1beta; lysozyme; mortality; necrosis; neoplasms; polysaccharides; protective effect; specific growth rate; superoxide dismutase; tumor necrosis factor-alpha; weight gain
- Abstract:
- ... The present study evaluated the effects of dietary Allium mongolicum Regel polysaccharide (AMRP) on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus. A basal diet was supplemented with AMRP at 0, 1, 1.5 or 2 g/kg feed for 56 days. After the 56 days feeding period, weight gain (WG), specific growth rate (SGR) and feed conversion ratio (FCR) were signific ...
- DOI:
- 10.1007/s11033-019-04677-y
- https://doi.org/10.1007/s11033-019-04677-y
- Author:
- Ke Ji; Hualiang Liang; Mingchun Ren; Xianping Ge; Bo Liu; Bingwen Xi; Liangkun Pan; Heng Yu
- Source:
- Fish & shellfish immunology 2019 v.93 pp. 474-483
- ISSN:
- 1050-4648
- Subject:
- Megalobrama amblycephala; alanine transaminase; albumins; alkaline phosphatase; antioxidant activity; antioxidants; aspartate transaminase; catalase; complement; copper; dietary protein; fish; fish feeding; gene expression; glutathione; glutathione peroxidase; growth performance; heme oxygenase (biliverdin-producing); immune response; immunoglobulin M; interleukin-10; interleukin-1beta; interleukin-8; juveniles; malondialdehyde; messenger RNA; necrosis; neoplasms; non-specific serine/threonine protein kinase; phosphatidylinositol 3-kinase; rapamycin; regression analysis; superoxide dismutase; target of rapamycin signaling pathways; transcription factor NF-kappa B; transforming growth factor beta; tryptophan; tumor necrosis factor-alpha; zinc
- Abstract:
- ... Dietary administration of tryptophan has been proved improving growth performance of fish. An 8-week feeding trial was conducted to investigate the effects of dietary tryptophan level on antioxidant capacity and immune response through Nrf2 and TOR signaling pathway. The results showed that, 0.08% tryptophan level significantly increased plasma aspartate aminotransferase (AST), while immunoglobuli ...
- DOI:
- 10.1016/j.fsi.2019.08.006
- https://doi.org/10.1016/j.fsi.2019.08.006
- Author:
- Nadia M. El-Beih; Gamal Ramadan; Enas A. El-Husseiny; Aya M. Hussein
- Source:
- Molecular biology reports 2019 v.46 no.4 pp. 3701-3711
- ISSN:
- 0301-4851
- Subject:
- adverse effects; animal disease models; antioxidant activity; aril; blood serum; body weight changes; glycemic effect; hyperglycemia; insulin receptor substrate proteins; insulin resistance; juices; lipid peroxidation; liver; medicinal plants; mitogen-activated protein kinase; necrosis; neoplasms; nitric oxide; noninsulin-dependent diabetes mellitus; pomegranates; rats; skeletal muscle; tumor necrosis factor-alpha
- Abstract:
- ... Nowadays, medicinal plants have been widely used everywhere to provide essential care for many disorders including diabetes. Recent reports assumed that the antidiabetic activities of pomegranate aril juice (PAJ) may be ascribed to its punicalagin (PCG). Therefore, the present study evaluated and compared the antidiabetic activities of PAJ and its PCG, and monitored some mechanisms of their action ...
- DOI:
- 10.1007/s11033-019-04813-8
- https://doi.org/10.1007/s11033-019-04813-8
- Author:
- Junjiang Xiao; Bingtong Liu; Yongliang Zhuang
- Source:
- Food and chemical toxicology 2019 v.129 pp. 30-37
- ISSN:
- 0278-6915
- Subject:
- Nephelium lappaceum; additive effect; anti-inflammatory activity; antioxidant activity; antioxidants; collagen; enzyme activity; glutathione; histology; hyaluronic acid; interleukin-6; malondialdehyde; metalloproteinases; mice; neoplasms; oxidants; phenolic compounds; phosphorylation; photoaging; protective effect; rambutans; toxicology; ultraviolet radiation
- Abstract:
- ... Rambutan peel phenolics (RPP) have high antioxidant and anti-inflammatory activities. Leu-Ser-Gly-Tyr-Gly-Pro (LSGYGP) possesses good radical scavenging activity and matrix metalloproteinase (MMPs) inhibitory ability. These underlying mechanisms indicated that RPP and LSGYGP may be used for antiphotoaging. Few data on the effects of RPP and LSGYGP on in vivo photoaging are available. We evaluated ...
- DOI:
- 10.1016/j.fct.2019.04.020
- https://doi.org/10.1016/j.fct.2019.04.020
- Author:
- Ting Zhang; Zhuo Wang; Xiaoxu Wang; Weili Sun; Xuezhe Cui; Rende Li; Guangyu Li
- Source:
- Italian journal of animal science 2019 v.18 no.1 pp. 98-104
- ISSN:
- 1828-051X
- Subject:
- Cervus nippon; acetates; antioxidant activity; blood serum; body weight; deer; glutathione peroxidase; growth performance; immunoglobulin A; interleukin-1; interleukin-2; males; necrosis; neoplasms; reactive oxygen species; superoxide dismutase; vitamin A; Switzerland
- Abstract:
- ... The present study examined the effects of dietary vitamin A (VA) on antioxidant functions, immune functions and production performance in farmed sika deer. Forty healthy male sika deer (initial body weight (BW): 47.07 ± 4.75 kg; 8 months of age) were randomly assigned to four treatments on the basis of BW. The dietary treatments included a basal diet (containing 330 U/kg VA) supplemented with 0 (c ...
- DOI:
- 10.1080/1828051X.2018.1456978
- https://doi.org/10.1080/1828051X.2018.1456978
- Author:
- Joungyoun Noh; Eunkyeong Jung; Jeonghun Lee; Hyejin Hyun; Seri Hong; Dongwon Lee
- Source:
- Biomacromolecules 2019 v.20 no.2 pp. 1109-1117
- ISSN:
- 1526-4602
- Subject:
- antineoplastic activity; antioxidant activity; apoptosis; aqueous solutions; bilirubin; body weight changes; heme oxygenase (biliverdin-producing); homeostasis; micelles; neoplasm cells; neoplasms; oxidation; oxidative stress; polymers; protoporphyrin; reactive oxygen species; therapeutics; toxicity
- Abstract:
- ... Cancer cells have a large amount of ROS (reactive oxygen species) because of disturbed ROS homeostasis. Cancer cells therefore undertake redox adaptation to drive proliferation in tumor environments and even survive during anticancer treatment by upregulating endogenous antioxidants. As one of antioxidant defense systems, heme oxygenase-1 (HO-1) acts as an essential role in tumor development by of ...
- DOI:
- 10.1021/acs.biomac.8b01802
- https://doi.org/10.1021/acs.biomac.8b01802
- Author:
- Baltasar Mayo; Lucía Vázquez; Ana Belén Flórez
- Source:
- Nutrients 2019 v.11 no.9 pp. -
- ISSN:
- 2072-6643
- Subject:
- antioxidant activity; biochemical pathways; biosynthesis; cardiovascular diseases; clinical trials; daidzein; enzymes; genetic background; health effects assessments; human health; humans; intestinal microorganisms; intestines; mechanism of action; menopause; meta-analysis; metabolites; neoplasms; osteoporosis; women
- Abstract:
- ... Epidemiological data suggest that regular intake of isoflavones from soy reduces the incidence of estrogen-dependent and aging-associated disorders, such as menopause symptoms in women, osteoporosis, cardiovascular diseases and cancer. Equol, produced from daidzein, is the isoflavone-derived metabolite with the greatest estrogenic and antioxidant activity. Consequently, equol has been endorsed as ...
- DOI:
- 10.3390/nu11092231
- PubMed:
- 31527435
- PubMed Central:
- PMC6770660
- https://doi.org/10.3390/nu11092231
- Author:
- Khezina Rafiq; Nazia Shaheen; Munir H. Shah
- Source:
- Environmental monitoring and assessment 2019 v.191 no.11 pp. 650
- ISSN:
- 0167-6369
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; antioxidant activity; atomic absorption spectrometry; cadmium; calcium; chromium; cobalt; copper; fruits; grapefruits; health effects assessments; human health; human nutrition; hydroxyl radicals; iron; lead; magnesium; manganese; neoplasms; nickel; nitric acid; pollutants; potassium; risk; sodium; strontium; tangerines; toxicity; zinc; Pakistan
- Abstract:
- ... Fruits are important components of human diet, and their contamination by environmental pollutants is an emerging challenge nowadays. The present study is based on the measurement of selected essential and toxic trace metals including Na, K, Ca, Mg, Fe, Zn, Cu, Mn, Cr, Co, Sr, Li, Ni, Pb, and Cd in commercially available citrus fruits from Pakistan. The samples were digested in HNO₃ and HCLO₄ mixt ...
- DOI:
- 10.1007/s10661-019-7829-x
- https://doi.org/10.1007/s10661-019-7829-x
- Author:
- Preuttiporn Supaphon; Sita Preedanon
- Source:
- Annals of microbiology 2019 v.69 no.13 pp. 1397-1406
- ISSN:
- 1590-4261
- Subject:
- Gram-positive bacteria; Helianthus annuus; Nigrospora; Talaromyces; alpha-glucosidase; antibiotic resistance; antifungal properties; antioxidant activity; cell structures; culture media; cytotoxicity; endophytes; enzyme inhibition; ethyl acetate; fungal biomass; gas chromatography-mass spectrometry; hexane; human cell lines; human diseases; inhibitory concentration 50; internal transcribed spacers; leaves; medicinal plants; methicillin; methicillin-resistant Staphylococcus aureus; minimum inhibitory concentration; neoplasm cells; neoplasms; ribosomal DNA; scanning electron microscopy; secondary metabolites; solvents; yeasts
- Abstract:
- ... PURPOSE: This study aimed to evaluate alpha-glucosidase inhibition and antimicrobial activity as well as cytotoxic activity of extracts from the endophytic fungus, Nigrospora sp., isolated from leaves of Helianthus annuus, which is widely cultivated for food and used as a medicinal plant. METHODS: The fungus (TSU-CS003) was identified based on internal transcribed spacer ribosomal DNA sequences an ...
- DOI:
- 10.1007/s13213-019-01523-1
- https://doi.org/10.1007/s13213-019-01523-1
- Author:
- Eman Zahran; Hebatallah Ahmed Mahgoub; Fatma Abdelhamid; Jean-Rémy Sadeyen; Engy Risha
- Source:
- Aquaculture 2019 v.512 pp. 734319
- ISSN:
- 0044-8486
- Subject:
- Enterococcus faecalis; Oreochromis niloticus; antioxidant activity; antioxidant enzymes; bacterial infections; blood serum; fish; fish diseases; gene expression; glutathione; heart; histopathology; immune response; innate immunity; interleukin-8; liver; lysozyme; malondialdehyde; messenger RNA; mortality; necrosis; neoplasms; oxidants; pathogenesis; pathogens; respiratory burst; septicemia; superoxide dismutase; transcription (genetics); transmission electron microscopes; transmission electron microscopy; tumor necrosis factor-alpha
- Abstract:
- ... Enterococcus faecalis, an opportunistic fish pathogen, has been recognized as a causative agent of hemorrhagic septicaemic disease in fish with high mortalities. Knowledge about host immune response following E. faecalis infection in fish is still limited. To address this issue, Nile tilapia (Oreochromis niloticus), were infected intraperitoneally with 0.2 mL of E. faecalis suspension containing 3 ...
- DOI:
- 10.1016/j.aquaculture.2019.734319
- https://doi.org/10.1016/j.aquaculture.2019.734319
- Author:
- Shivraj Hariram Nile; Arti Nile; Junqiu Liu; Doo Hwan Kim; Guoyin Kai
- Source:
- Food and chemical toxicology 2019 v.131 pp. 110563
- ISSN:
- 0278-6915
- Subject:
- allopurinol; antineoplastic activity; antioxidant activity; antioxidants; apple pomace; betulinic acid; cell lines; chloroform; cytotoxicity; ethanol; ethyl acetate; functional foods; hexane; inhibitory concentration 50; kojic acid; methanol; neoplasm cells; neoplasms; tandem mass spectrometry; thiourea; urease; ursolic acid; xanthine oxidase
- Abstract:
- ... Apple pomace (AP) utilised for analysis of triterpenic acids (TTAs) using HPLC-MS/MS. The methanol, ethanol and ethyl acetate extracts showed high phenolic content with significant antioxidant activity compared to chloroform and n-hexane. AP TTAs; ursolic acid, betulinic acid and maslinic acid showed potent antioxidant and enzyme inhibitory effects. The IC50 values were 13.2–30.8 μg/mL (tyrosinase ...
- DOI:
- 10.1016/j.fct.2019.110563
- https://doi.org/10.1016/j.fct.2019.110563
- Author:
- Maheshkumar Prakash Patil; Min-jae Kang; Irvine Niyonizigiye; Alka Singh; Jong-Oh Kim; Yong Bae Seo; Gun-Do Kim
- Source:
- Colloids and surfaces 2019 v.183 pp. 110455
- ISSN:
- 0927-7765
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Fourier transform infrared spectroscopy; antioxidant activity; aquatic bacteria; biocompatible materials; cell lines; color; green chemistry; growth retardation; humans; light scattering; moieties; nanogold; nanoparticles; neoplasm cells; neoplasms; particle size; transmission electron microscopy
- Abstract:
- ... Green chemistry is beneficial for the production of eco-friendly and stable nanoparticles using biological agents. The present study was performed to explore the potential of the marine bacterium Paracoccus haeundaensis BC74171ᵀ for the extracellular synthesis of gold nanoparticles (AuNPs). Cell-free supernatant-mediated AuNPs were characterized by different techniques and analyzed for their antio ...
- DOI:
- 10.1016/j.colsurfb.2019.110455
- https://doi.org/10.1016/j.colsurfb.2019.110455
- Author:
- St Lopresti; B. Popovic; M. Kulkarni; C. Skillen; B.N. Brown
- Source:
- Biomaterials 2019 pp. 119376
- ISSN:
- 0142-9612
- Subject:
- antioxidant activity; antioxidants; atherosclerosis; biochemical compounds; extracellular matrix; ischemia; macrophages; muscles; neoplasms; nitrogen; oxidative stress; oxygen; phenotype; stroke
- Abstract:
- ... Oxidative stress leads to the progression of many diseases including chronic wounds, atherosclerosis, stroke and cancer. The modification of biomolecules with reactive nitrogen or oxygen species has been shown to trigger oxidative stress pathways that are beneficial for healing. Extracellular matrix scaffolds have been used successfully in reconstructive applications due to the beneficial host res ...
- DOI:
- 10.1016/j.biomaterials.2019.119376
- https://doi.org/10.1016/j.biomaterials.2019.119376
- Author:
- Azahara Rodríguez-Luna; Javier Ávila-Román; Helena Oliveira; Virginia Motilva; Elena Talero
- Source:
- Marine drugs 2019 v.17 no.8 pp. -
- ISSN:
- 1660-3397
- Subject:
- anti-inflammatory activity; antioxidant activity; antioxidant genes; apoptosis; carotenoids; caspase-1; cell viability; inflammasomes; inflammation; interleukins; keratinocytes; marine environment; neoplasms; oxidative stress; polyphenols; risk factors; rosmarinic acid; signal transduction; ultraviolet radiation
- Abstract:
- ... Excessive exposure to ultraviolet (UV) radiation is the main risk factor to develop skin pathologies or cancer because it encourages oxidative condition and skin inflammation. In this sense, strategies for its prevention are currently being evaluated. Natural products such as carotenoids or polyphenols, which are abundant in the marine environment, have been used in the prevention of oxidative str ...
- DOI:
- 10.3390/md17080451
- PubMed:
- 31374828
- PubMed Central:
- PMC6722862
- https://doi.org/10.3390/md17080451
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