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You searched for: Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Subject brain Remove constraint Subject: brain
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1. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer’s Signaling in Human Nerve Cells

Author:
Zhibin Liang; Bei Zhang; Meng Xu; Christophe Morisseau; Sung Hee Hwang; Bruce D. Hammock; Qing X. Li
Source:
ACS Chemical Neuroscience 2019 v.10 no.9 pp. 4018-4030
ISSN:
1948-7193
Subject:
amyloid; brain; death; epoxide hydrolase; humans; inflammation; mitochondria; nerve tissue; neurites; neurodegenerative diseases; neurophysiology; neuroprotective effect; neurotoxicity; phosphotransferases (kinases); synergism; therapeutics; urea
Abstract:
... Alzheimer’s disease (AD) is the most common neurodegenerative disorder. Neuroinflammation is a prevalent pathogenic stress leading to neuronal death in AD. Targeting neuroinflammation to keep neurons alive is an attractive strategy for AD therapy. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) is a potent inhibitor of soluble epoxide hydrolase (sEH) and can enter into the brain ...
Handle:
10113/7338046
DOI:
10.1021/acschemneuro.9b00271
CHORUS:
10.1021/acschemneuro.9b00271

2. 110th Anniversary: Nanoparticle Mediated Drug Delivery for the Treatment of Alzheimer’s Disease: Crossing the Blood–Brain Barrier

Author:
Marissa E. Wechsler; Julia E. Vela Ramirez; Nicholas A. Peppas
Source:
Industrial & engineering chemistry process design and development 2019 v.58 no.33 pp. 15079-15087
ISSN:
1520-5045
Subject:
Alzheimer disease; amyloid; bioavailability; blood-brain barrier; brain; cognitive disorders; dendrimers; drugs; nanocarriers; nanoparticles; neurodegenerative diseases; neurons; neurotransmitters; pharmacodynamics; pharmacokinetics; process design; solubility; surveys
Abstract:
... Alzheimer’s disease is an irreversible neurodegenerative disorder affecting approximately 6 million Americans, 90% of which are over the age of 65. The hallmarks of the disease are represented by amyloid plaques and neurofibrillary tangles. While the neuronal characteristics of Alzheimer’s disease are well-known, current treatments only provide temporary relief of the disease symptoms. Many of the ...
DOI:
10.1021/acs.iecr.9b02196

3. 137Cs and 40K in gray seals Halichoerus grypus in the southern Baltic Sea

Author:
Michał Saniewski; Tamara Zalewska; Maria Suplińska; Lucyna Falkowska; Agnieszka Grajewska; Iga Nehring; Dominika Saniewska; Marta Staniszewska; Iwona Pawliczka
Source:
Environmental science and pollution research 2019 v.26 no.17 pp. 17418-17426
ISSN:
0944-1344
Subject:
Halichoerus grypus; adults; brain; cesium; fish; liver; lungs; muscles; placenta; potassium; pups; radionuclides; seals; staple foods; tissues; Baltic Sea
Abstract:
... This study presents levels of ¹³⁷Cs and ⁴⁰K concentrations in the placentas of seals gathered in the period 2007–2015. The mean activity of ¹³⁷Cs and ⁴⁰K was 5.49 Bq kg⁻¹w.w. and 136.6 Bq kg⁻¹ ww respectively. Statistically significant correlation was observed between the ¹³⁷Cs activities in placenta and in herring—the staple food for seals. The concentrations of ¹³⁷Cs and ⁴⁰K were also determined ...
DOI:
10.1007/s11356-019-05145-7
PubMed:
31020531
PubMed Central:
PMC6546647

4. 13C-lutein is differentially distributed in tissues of an adult female rhesus macaque following a single oral administration: a pilot study

Author:
Sookyoung Jeon; Qiyao Li; Stanislav S. Rubakhin; Jonathan V. Sweedler; Joshua W. Smith; Martha Neuringer; Matthew Kuchan; John W. Erdman
Source:
Nutrition research 2019 v.61 pp. 102-108
ISSN:
0271-5317
Subject:
Macaca mulatta; adrenal glands; adults; brain; females; high performance liquid chromatography; isotope labeling; liver; lutein; mass spectrometry; monkeys; oral administration; pharmacokinetics; retina; tissue distribution; tissues
Abstract:
... Despite the growing awareness regarding lutein's putative roles in eyes and brain, its pharmacokinetics and tissue distribution in primates have been poorly understood. We hypothesized that 13C-lutein will be differentially distributed into tissues of an adult rhesus macaque (Macaca mulatta) 3 days following a single oral dose. After a year of prefeeding a diet supplemented with unlabeled lutein ( ...
DOI:
10.1016/j.nutres.2018.10.007
PubMed:
30522845
PubMed Central:
PMC6348040

5. 17β-Hydroxysteroid dehydrogenases and neurosteroid metabolism in the central nervous system

Author:
Xue-Ying He; Carl Dobkin; Song-Yu Yang
Source:
Molecular and cellular endocrinology 2019 v.489 pp. 92-97
ISSN:
0303-7207
Subject:
Alzheimer disease; alcohol oxidoreductases; anesthetics; animal models; anticonvulsants; antidepressants; biochemical pathways; brain; cholesterol; chromosome mapping; cognition; endocrine glands; genes; genomics; homeostasis; memory; metabolism; mitochondria; mutation; neurogenesis; neurons; neuroprotective effect; pathogenesis; patients; prasterone; pregnenolone; receptors; tranquilizers
Abstract:
... 17β-Hydroxysteroid dehydrogenases are indispensable for downstream enzyme steps of the neurosteroidogenesis. Neurosteroids are synthesized de novo in neurons and glia from cholesterol transported into mitochondria, or by conversion from proneurosteroids, e. g. dehydroepiandrosterone (DHEA) and pregnenolone, through the same metabolic pathway as revealed in the de novo neurosteroidogenesis. Hormona ...
DOI:
10.1016/j.mce.2018.10.002

6. 1988–2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research

Author:
Maria Gallo; Sira Defaus; David Andreu
Source:
Archives of biochemistry and biophysics 2019 v.661 pp. 74-86
ISSN:
0003-9861
Subject:
G-protein coupled receptors; biomedical research; brain; cell membranes; drugs; nucleic acids; parasites; peptides; therapeutics; tissues
Abstract:
... In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell translocation properties, setting the ground for a new area of research that over the years has grown into considerable therapeutic potential. The vectors, named cell-penetrating peptides (CPPs), constitute a now large and diversified family, sharing the extraordinary ability to diffuse unaltered across cell m ...
DOI:
10.1016/j.abb.2018.11.010

7. 24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells

Author:
Luisa Cigliano; Maria Stefania Spagnuolo; Gaetana Napolitano; Lucia Iannotta; Gianluca Fasciolo; Daniela Barone; Paola Venditti
Source:
Molecular and cellular endocrinology 2019 pp. -
ISSN:
0303-7207
Subject:
biogenesis; brain; catalase; cell culture; cholesterol; dose response; excretion; glioblastoma; glutathione peroxidase; homeostasis; humans; hydrogen peroxide; metabolites; mitochondria; models; neuroglia; neurons; toxicity
Abstract:
... The cholesterol metabolite 24(S)-hydroxycholesterol (24S-OHC) allows cholesterol excretion from the brain and was suggested to be critically involved in physiological as well as neurodegenerative processes. It induces on human neuronal cell cultures a dose dependent toxicity associated with increased reactive oxygen species production. Since glial cells play a key role in assisting neuronal functi ...
DOI:
10.1016/j.mce.2019.02.013

8. 24S-hydroxycholesterol alters activity of large-conductance Ca2+-dependent K+ (slo1 BK) channel through intercalation into plasma membrane

Author:
Nobuyoshi Tajima; Liu Xiaoyan; Makoto Taniguchi; Nobuo Kato
Source:
Biochimica et biophysica acta 2019 v.1864 no.10 pp. 1525-1535
ISSN:
1388-1981
Subject:
25-hydroxycholesterol; brain; calcium; gamma-cyclodextrin; inhibitory concentration 50; ion channels; oxidation; plasma membrane; potassium
Abstract:
... Oxysterols, oxidization products of cholesterol, are regarded as bioactive lipids affecting various physiological functions. However, little is known of their effects on ion channels. Using inside-out patch clamp recording, we found that naturally occurring side-chain oxidized oxysterols, 20S‑hydroxycholesterol, 22R‑hydroxycholesterol, 24S‑hydroxycholestero, 25‑hydroxycholesterol, and 27‑hydroxych ...
DOI:
10.1016/j.bbalip.2019.05.010

9. 3,4-Dimethoxycinnamic Acid as a Novel Matrix for Enhanced In Situ Detection and Imaging of Low-Molecular-Weight Compounds in Biological Tissues by MALDI-MSI

Author:
Huixin He; Liang Qin; Yawen Zhang; Manman Han; Jinming Li; Yaqin Liu; Kaidi Qiu; Xiaoyan Dai; Yanyan Li; Maomao Zeng; Huihong Guo; Yijun Zhou; Xiaodong Wang
Source:
Analytical chemistry 2019 v.91 no.4 pp. 2634-2643
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; absorption; alkaloids; brain; desorption; flavonoids; graphene oxide; image analysis; ionization; lipids; liquid chromatography; liver; metabolites; nanosilver; oligopeptides; plant tissues; rats; seeds; tandem mass spectrometry
Abstract:
... Low-molecular-weight (low-MW) compounds have many essential functions in biological processes, and the molecular imaging of as many low-MW compounds as possible is critical for understanding complex biological processes. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is an emerging molecular-imaging technology that enables determination of the spatial distributio ...
DOI:
10.1021/acs.analchem.8b03522

10. 3-Aminophthalhydrazide (Luminol) As a Matrix for Dual-Polarity MALDI MS Imaging

Author:
Bin Li; Ruiyang Sun; Andrew Gordon; Junyue Ge; Ying Zhang; Ping Li; Hua Yang
Source:
Analytical chemistry 2019 v.91 no.13 pp. 8221-8228
ISSN:
1520-6882
Subject:
2,5-dihydroxybenzoic acid; absorption; biochemical pathways; biomarkers; brain; central nervous system diseases; desorption; fatty acids; image analysis; ionization; matrix-assisted laser desorption-ionization mass spectrometry; metabolites; mice; nucleotides; sodium; sphingolipids
Abstract:
... In many aspects of the matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) technique, the discovery of new MALDI matrixes has been a major task for the improvement of ionization efficiency, signal intensity, and molecular coverage. In this work, five analog compounds, including phthalhydrazide, 3-aminophthalhydrazide (3-APH or luminol) and its sodium salt, 4-aminophth ...
DOI:
10.1021/acs.analchem.9b00803

11. 3-D geometry and irregular connectivity dictate neuronal firing in frequency domain and synchronization

Author:
Tanchen Ren; Bianka Grosshäuser; Kaushik Sridhar; Thomas J.F. Nieland; Alessandro Tocchio; Ute Schepers; Utkan Demirci
Source:
Biomaterials 2019 v.197 pp. 171-181
ISSN:
0142-9612
Subject:
brain; calcium; cell growth; cell viability; crosslinking; fluorescence; gels; geometry; models; neurons
Abstract:
... The replication of the complex structure and three dimensional (3-D) interconnectivity of neurons in the brain is a great challenge. A few 3-D neuronal patterning approaches have been developed to mimic the cell distribution in the brain but none have demonstrated the relationship between 3-D neuron patterning and network connectivity. Here, we used photolithographic crosslinking to fabricate in v ...
DOI:
10.1016/j.biomaterials.2019.01.017

12. 3D Bioprinted Scaffolds Containing Viable Macrophages and Antibiotics Promote Clearance of Staphylococcus aureus Craniotomy-Associated Biofilm Infection

Author:
Amy Aldrich; Mitchell A. Kuss; Bin Duan; Tammy Kielian
Source:
ACS applied materials & interfaces 2019 v.11 no.13 pp. 12298-12307
ISSN:
1944-8252
Subject:
Staphylococcus aureus; animal models; antibacterial properties; biofilm; bioprinting; brain; chronic diseases; daptomycin; epilepsy; macrophages; mice; microbial load; neoplasms; rifampicin; skull; slurries; surgery
Abstract:
... Craniotomy involves the removal of a skull fragment to access the brain, such as during tumor or epilepsy surgery, which is immediately replaced intraoperatively. The infection incidence after craniotomy ranges from 0.8 to 3%, with approximately half caused by Staphylococcus aureus (S. aureus). To mitigate infectious complications following craniotomy, we engineered a three-dimensional (3D) biopri ...
DOI:
10.1021/acsami.9b00264
PubMed:
30855125
PubMed Central:
PMC7034353

13. 4,5‐dicaffeyolquinic acid improves high‐fat diet‐induced cognitive dysfunction through the regulation of insulin degrading enzyme

Author:
Jin Yong Kang; Seon Kyeong Park; Jong Min Kim; Su Bin Park; Seul Ki Yoo; Hye Ju Han; Dae Ok Kim; Ho Jin Heo
Source:
Journal of food biochemistry 2019 v.43 no.7 pp. e12855
ISSN:
0145-8884
Subject:
Alzheimer disease; Artemisia argyi; amyloid; apoptosis; bioactive compounds; brain; cognition; cognitive disorders; epidemiological studies; ethyl acetate; herbal medicines; high fat diet; insulin; mitochondria; neurotransmitters; noninsulin-dependent diabetes mellitus; oxidative stress; risk factors; tissue analysis; Asia
Abstract:
... This study was performed to investigate the effects of Artemisia argyi and 4,5‐dicaffeyolquinic acid (4,5‐diCQA) as a main compound of ethyl acetate fraction from Artemisia argyi (EFAA) on high‐fat diet (HFD)‐induced cognitive dysfunction. Both EFAA and 4,5‐diCQA were effective in improving cognitive function on HFD‐induced cognitive dysfunction. In brain tissue analysis, it was confirmed that EFA ...
DOI:
10.1111/jfbc.12855

14. 5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models

Author:
Donato Angelino; Diogo Carregosa; Cristina Domenech-Coca; Monia Savi; Inês Figueira; Nicoletta Brindani; Saebyeol Jang; Sukla Lakshman; Aleksey Molokin; Joseph F. Urban; Cindy D. Davis; Maria Alexandra Brito; Kwang Sik Kim; Furio Brighenti; Claudio Curti; Cinta Bladé; Josep M. del Bas; Donatella Stilli; Gloria I. Solano-Aguilar; Claudia Nunes dos Santos; Daniele del Rio; Pedro Mena
Source:
Nutrients 2019 v.11 no.11 pp. -
ISSN:
2072-6643
Subject:
acids; animal models; blood-brain barrier; brain; chronic diseases; endothelial cells; flavanols; foods; gastrointestinal system; grapes; in vitro studies; in vivo studies; intestinal microorganisms; isomers; lactones; metabolites; neuroprotective effect; permeability; phenolic compounds; rats; swine feeding
Abstract:
... Phenolic compounds have been recognized as promising compounds for the prevention of chronic diseases, including neurodegenerative ones. However, phenolics like flavan-3-ols (F3O) are poorly absorbed along the gastrointestinal tract and structurally rearranged by gut microbiota, yielding smaller and more polar metabolites like phenyl-γ-valerolactones, phenylvaleric acids and their conjugates ...
DOI:
10.3390/nu11112678
PubMed:
31694297
PubMed Central:
PMC6893823

15. The 5-HT1A receptor: Signaling to behavior

Author:
Paul R. Albert; Faranak Vahid-Ansari
Source:
Biochimie 2019 v.161 pp. 34-45
ISSN:
0300-9084
Subject:
adenylate cyclase; adults; antidepressants; brain; calcium channels; calcium-calmodulin-dependent protein kinase; cell lines; cell viability; inositols; mitogen-activated protein kinase; neurons; phosphatidylinositol 3-kinase; phospholipase C; potassium channels; protein kinase C; receptor protein-tyrosine kinase; receptors; serotonin; synaptogenesis
Abstract:
... The 5-HT1A receptor is highly expressed both in 5-HT neurons as a presynaptic inhibitory autoreceptor, and in many brain regions innervated by 5-HT as a post-synaptic heteroreceptor. This review examines the signaling of 5-HT1A receptors to regulate 5-HT activity and behavior. Initial findings in heterologous cell systems, neuronal cell lines, neurons, and in vivo show that the 5-HT1A receptor is ...
DOI:
10.1016/j.biochi.2018.10.015

16. Cyprinid herpesvirus 3 Evolves In Vitro through an Assemblage of Haplotypes that Alternatively Become Dominant or Under-Represented

Author:
Sandro Klafack; Anna-Sophie Fiston-Lavier; Sven M. Bergmann; Saliha Hammoumi; Lars Schröder; Walter Fuchs; Angela Lusiastuti; Pei-Yu Lee; Sarahi Vega Heredia; Master student consortium; Anne-Sophie Gosselin-Grenet; Jean-Christophe Avarre
Source:
Viruses 2019 v.11 no.8 pp. -
ISSN:
1999-4915
Subject:
Cyprinid herpesvirus 3; Cyprinus carpio; brain; cell culture; etiological agents; fish diseases; genomics; haplotypes; mutation; polymerase chain reaction; virulence; viruses
Abstract:
... Viruses are able to evolve in vitro by mutations after serial passages in cell cultures, which can lead to either a loss, or an increase, of virulence. Cyprinid herpesvirus 3 (CyHV-3), a 295-kb double-stranded DNA virus, is the etiological agent of the koi herpesvirus disease (KHVD). To assess the influence of serial passages, an isolate of CyHV-3 (KHV-T) was passaged 99 times onto common carp bra ...
DOI:
10.3390/v11080754
PubMed:
31443175
PubMed Central:
PMC6723609

17. Elaeagnus glabra f. oxyphylla Attenuates Scopolamine-Induced Learning and Memory Impairments in Mice by Improving Cholinergic Transmission via Activation of CREB/NGF Signaling

Author:
Eunjin Sohn; Hye-Sun Lim; Yu Jin Kim; Bu-Yeo Kim; Joo-Hwan Kim; Soo-Jin Jeong
Source:
Nutrients 2019 v.11 no.6 pp. -
ISSN:
2072-6643
Subject:
Elaeagnus; Western blotting; acetylcholine; acetylcholinesterase; animal models; apoptosis; brain; caspase-3; choline acetyltransferase; cognition; cyclic AMP; enzyme-linked immunosorbent assay; males; memory; memory disorders; mice; nerve growth factor; protein synthesis; proteins; scopolamine; staining; therapeutics; tissues
Abstract:
... We aimed to investigate the therapeutic effects of an Elaeagnus glabra f. oxyphylla (EGFO) ethanol extract in mice with scopolamine-induced memory dysfunction. Fifty male mice were randomly divided into a normal control group, a scopolamine-treated group, a scopolamine and EGFO extract-treated group, and a scopolamine and tacrine-treated group. EGFO (50 or 100 mg/kg/day) was received for 21 days. ...
DOI:
10.3390/nu11061205
PubMed:
31141948
PubMed Central:
PMC6627942

18. AAV2/DJ-mediated alpha-synuclein overexpression in the rat substantia nigra as early stage model of Parkinson’s disease

Author:
Friederike Freiin von Hövel; Regina Rumpel; Andreas Ratzka; Dietmar Schreiner; Claudia Grothe
Source:
Cell and tissue research 2019 v.378 no.1 pp. 1-14
ISSN:
0302-766X
Subject:
Parkinson disease; adults; animal models; brain; cytoplasmic inclusions; gene overexpression; green fluorescent protein; humans; mutants; neurons; rats; viral load
Abstract:
... Parkinson’s disease (PD) is pathologically characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and alpha-synucleinopathy. We mimic the disease pathology with overexpression of either the human α-syn wildtype (α-syn-WT) or E46K mutant form (α-syn-E46K) in DA neurons of the SNpc in adult rats using AAV2/DJ as a viral vector for the first ti ...
DOI:
10.1007/s00441-019-03013-x

19. ABCB1 (P-glycoprotein) contributes to the regulation of absorption and trans-intestinal efflux of vitamin D

Author:
M. Margier; X. Collet; C. Le May; C. Desmarchelier; F. André; C. Lebrun; C. Defoort; A. Bluteau; P. Borel; A. Lespine; E. Reboul
Source:
Nutrition clinique et métabolisme 2019 v.33 no.1 pp. 11-12
ISSN:
0985-0562
Subject:
25-hydroxycholecalciferol; Caenorhabditis elegans; P-glycoproteins; absorption; adults; brain; cholecalciferol; computer simulation; enterocytes; excretion; homeostasis; industrialization; liver; public health; t-test
Abstract:
... Introduction and purpose of the study: Vitamin D is an essential molecule for phosphocalcic homeostasis. It would also play a key role in the prevention of a number of immune and metabolic pathologies, as well as with respect to certain cancers. However, vitamin D deficiencies and sub-deficiencies remain a major public health problem in both developing and industrialized countries. Better understa ...
DOI:
10.1016/j.nupar.2019.01.235

20. ABCD: Alzheimer’s disease Biomarkers Comprehensive Database

Author:
Ashwani Kumar; Ankush Bansal; Tiratha Raj Singh
Source:
3 Biotech 2019 v.9 no.10 pp. 351
ISSN:
2190-572X
Subject:
Alzheimer disease; animal models; biomarkers; brain; databases; drug therapy; genetic markers; memory disorders; microRNA; mitochondrial genes; pathogenesis; patients; personality; regulatory sequences; single nucleotide polymorphism; transcription factors; user interface
Abstract:
... Alzheimer’s disease (AD) is an age-related, non-reversible, and progressive brain disorder. Memory loss, confusion, and personality changes are major symptoms noticed. AD ultimately leads to a severe loss of mental function. Due to lack of effective biomarkers, no effective medication was available for the complete treatment of AD. There is a need to provide all AD-related essential information to ...
DOI:
10.1007/s13205-019-1888-0
PubMed:
31501752
PubMed Central:
PMC6722159

21. AMGSEFLamide, a member of a broadly conserved peptide family, modulates multiple neural networks in Homarus americanus

Author:
Patsy S. Dickinson; Evyn S. Dickinson; Emily R. Oleisky; Cindy D. Rivera; Meredith E. Stanhope; Elizabeth A. Stemmier; J. J. Hull; Andrew E. Christie
Source:
Journal of experimental biology 2019 v.222 no.2 pp. 1-15
ISSN:
1477-9145
Subject:
Homarus americanus; amides; amino acid motifs; brain; cardiac output; complementary DNA; conserved sequences; eyes; ganglia; gene expression; genome; genomics; lobsters; neural pathways; neuropeptides; neurophysiology; neurotransmitters; protein isoforms; reverse transcriptase polymerase chain reaction; transcriptome; transcriptomics
Abstract:
... Recent genomic/transcriptomic studies have identified a novel peptide family whose members share the carboxyl terminal sequence –GSEFLamide. However, the presence/identity of the predicted isoforms of this peptide group have yet to be confirmed biochemically, and no physiological function has yet been ascribed to any member of this peptide family. To determine the extent to which GSEFLamides are c ...
Handle:
10113/6542289
DOI:
10.1242/jeb.194092
PubMed:
30464043
PubMed Central:
PMC6371962
CHORUS:
10.1242/jeb.194092
Chorus Open Access:
10.1242/jeb.194092

22. ATAT1 regulates forebrain development and stress-induced tubulin hyperacetylation

Author:
Lin Li; Sriram Jayabal; Mohammad Ghorbani; Lisa-Marie Legault; Serge McGraw; Alanna J. Watt; Xiang-Jiao Yang
Source:
Cellular and molecular life sciences 2019 v.76 no.18 pp. 3621-3640
ISSN:
1420-682X
Subject:
Tetrahymena; acetylation; acetyltransferases; brain; catalytic activity; cell proliferation; cultured cells; fibroblasts; flow cytometry; genes; glucose; heart; humans; hydrogen peroxide; lysine; mice; mutants; neurons; oviducts; oxidative stress; patients; skeletal muscle; spleen; stress response; thymus gland; tubulin
Abstract:
... α-Tubulin acetyltransferase 1 (ATAT1) catalyzes acetylation of α-tubulin at lysine 40 in various organisms ranging from Tetrahymena to humans. Despite the importance in mammals suggested by studies of cultured cells, the mouse Atat1 gene is non-essential for survival, raising an intriguing question about its real functions in vivo. To address this question, we systematically analyzed a mouse strai ...
DOI:
10.1007/s00018-019-03088-3

23. AZD3759 induces apoptosis in hepatoma cells by activating a p53-SMAD4 positive feedback loop

Author:
Danyang Chao; Lijun Pang; Ying Shi; Wenjing Wang; Kai Liu
Source:
Biochemical and biophysical research communications 2019 v.509 no.2 pp. 535-540
ISSN:
0006-291X
Subject:
apoptosis; brain; enzyme inhibitors; genes; hepatoma; human cell lines; lung neoplasms; metastasis; mothers against decapentaplegic homolog proteins; therapeutics; transcription (genetics); tyrosine; viability
Abstract:
... AZD3759 is a tyrosine kinase inhibitor and has an encouraging future in treating brain metastases of non-small cell lung cancer. Here, we determined that AZD3759 suppressed the viability of HepG2 cells, a hepatoma cell line, and induced their apoptosis, suggesting a new therapeutic potential of AZD3759 in hepatocellular carcinoma (HCC) treatment. Furthermore, we found that the activation of p53-SM ...
DOI:
10.1016/j.bbrc.2018.12.102

24. Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome

Author:
Maritza Omaña-Molina; Virginia Vanzzini-Zago; Dolores Hernández-Martínez; María Reyes-Batlle; Ismael Castelan-Ramírez; Perla Hernández-Olmos; Lizbeth Salazar-Villatoro; Arturo González-Robles; Elizabeth Ramírez-Flores; Christopher Servín-Flores; Víctor Flores-Alvarado; Marino Alcántara-Castro; Jacob Lorenzo-Morales
Source:
Experimental parasitology 2019 v.196 pp. 22-27
ISSN:
0014-4894
Subject:
Acanthamoeba; Leucoma; brain; chlorhexidine; cornea; dogs; drugs; epithelial cells; genotyping; inflammation; itraconazole; keratitis; kidneys; mice; netilmicin; pain; swimming; trophozoites; virulence; women; Mexico
Abstract:
... Acanthamoeba keratitis (AK) is a sight-threatening corneal infection. The early symptoms include redness, pain, photophobia and intense tearing. Chronic infection usually progresses to stromal inflammation, ring ulcers, corneal opacification and hypopyon. Here we document an AK case in a high myopic 38-year-old woman from Mexico City, with a history of wearing contact lenses while swimming. Cornea ...
DOI:
10.1016/j.exppara.2018.11.005

25. Accidental death in a jack-knife position

Author:
Francesco Simonit; Leonardo Ciccone; Lorenzo Desinan
Source:
Forensic science international 2019 v.1 pp. 100048
ISSN:
2665-9107
Subject:
asphyxia; brain; case studies; coronary disease; death; edema; forensic sciences; lungs; necropsy; women
Abstract:
... Postural (or “positional”) asphyxia occurs due to a person being in a prolonged abnormal body position that prevents adequate breathing. Its diagnosis is based on several criteria, in particular the exclusion of involvement of other people and other causes of death. This case report is about a 73-year-old woman whose body was found in a jack-knifed position by her son. She was on the floor, wedged ...
DOI:
10.1016/j.fsir.2019.100048

26. Acer okamotoanum and isoquercitrin improve cognitive function via attenuation of oxidative stress in high fat diet- and amyloid beta-induced mice

Author:
Ji Hyun Kim; Sanghyun Lee; Eun Ju Cho
Source:
Food & function 2019 v.10 no.10 pp. 6803-6814
ISSN:
2042-650X
Subject:
Acer; Alzheimer disease; active ingredients; amyloid; brain; cognition; cognitive disorders; ethyl acetate; high fat diet; isoquercitrin; lipid peroxidation; memory; mice; nitric oxide; obesity; oxidative stress; protective effect; reactive oxygen species; risk factors
Abstract:
... Obesity induced by high-fat diet (HFD) and accumulation of amyloid beta (Aβ) are known as a risk factor of Alzheimer's disease. We previously identified isoquercitrin (IQ) as an active compound of Acer okamotoanum. In the present study, we investigated the protective effects of the active ethyl acetate (EtOAc) fraction from A. okamotoanum and IQ on HFD and Aβ₂₅–₃₅-induced cognitive impairment mice ...
DOI:
10.1039/c9fo01694e

27. Acer okamotoanum protects SH-SY5Y neuronal cells against hydrogen peroxide-induced oxidative stress

Author:
Ji Hyun Kim; Sanghyun Lee; Eun Ju Cho
Source:
Food science and biotechnology 2019 v.28 no.1 pp. 191-200
ISSN:
1226-7708
Subject:
Acer; apoptosis; brain; caspase-3; caspase-9; cell viability; gene expression regulation; genes; hydrogen peroxide; inducible nitric oxide synthase; inflammation; lactate dehydrogenase; neurodegenerative diseases; neurons; neuroprotective effect; oxidative stress; prostaglandin synthase; proteins
Abstract:
... Oxidative stress by over-production of reactive oxygen species (ROS) in brain is widely known as a cause of neurodegenerative disease. We investigated protective effects of Acer okamotoanum against oxidative stress by hydrogen peroxide (H₂O₂) in SH-SY5Y neuronal cells. Acer okamotoanum reduced ROS production and lactate dehydrogenase release in H₂O₂-induced SH-SY5Y cells, resulting in elevation of ...
DOI:
10.1007/s10068-018-0381-6
PubMed:
30815310
PubMed Central:
PMC6365339

28. Acesulfame potassium: Its ecotoxicity measured through oxidative stress biomarkers in common carp (Cyprinus carpio)

Author:
Claudia Cruz-Rojas; Nely SanJuan-Reyes; María Paulina Aideé Gracia Fuentes-Benites; Octavio Dublan-García; Marcela Galar-Martínez; Hariz Islas-Flores; Leobardo Manuel Gómez-Oliván
Source:
Science of the total environment 2019 v.647 pp. 772-784
ISSN:
0048-9697
Subject:
Cyprinus carpio; acesulfame potassium; biomarkers; blood; brain; carp; catalase; ecotoxicology; enzyme activity; exposure duration; liver; muscles; oxidative stress; risk; superoxide dismutase; surface water
Abstract:
... Acesulfame potassium (ACS) is a widely-used sweetener worldwide. Its presence has been demonstrated in diverse bodies of water. However, the deleterious effects this causes in aquatic organisms has not yet been identified, which generates controversy concerning the risks that ACS represents after its disposal into the bodies of water. Thus, the objective of this work was to evaluate if the exposur ...
DOI:
10.1016/j.scitotenv.2018.08.034

29. Acetic Acid Increased the Inactivation of Multi-drug Resistant Non-typhoidal Salmonella by Large-Scaffold Antibiotic

Author:
Vinicius Silva Castro; Bruno Serpa Vieira; Adelino Cunha-Neto; Eduardo Eustáquio de Souza Figueiredo; Carlos Adam Conte-Junior
Source:
Indian journal of microbiology 2019 v.59 no.4 pp. 508-513
ISSN:
0046-8991
Subject:
Gram-negative bacteria; Salmonella; acetic acid; agar; analysis of variance; antibiotic resistance; brain; cell walls; heart; mechanism of action; multiple drug resistance; permeability; screening; vancomycin
Abstract:
... Salmonella is a gram-negative bacterium with intrinsic resistance to large-scaffold antibiotics due to the presence of an outer membrane. Based on the mode of action of the organic acids in outer membrane disintegration, and consequently, an enhancement in cell permeability, a combination of acetic acid and a large-scaffold antibiotic is it evaluated. Therefore, the aim of this study is to assess ...
DOI:
10.1007/s12088-019-00837-7
PubMed:
31762515
PubMed Central:
PMC6842369

30. Acetylcholinesterase inhibitor from Anthocleista vogelii leaf extracts

Author:
O.S. Ajayi; M.A. Aderogba; E.M. Obuotor; R.R.T. Majinda
Source:
Journal of ethnopharmacology 2019 v.231 pp. 503-506
ISSN:
0378-8741
Subject:
Alzheimer disease; Anthocleista; acetylcholinesterase; brain; butanol; enzyme inhibition; enzyme inhibitors; ethyl acetate; fractionation; hexane; inflammation; inhibitory concentration 50; leaf extracts; methanol; methylene chloride; nuclear magnetic resonance spectroscopy; oxidative stress; physostigmine; solvents; traditional medicine
Abstract:
... Anthocleista vogelii (Planch) is used in folk medicine in conditions related to inflammation and oxidative stress. This suggests that some of its constituents could possess ability to reduce oxidative damage to cells and ameliorate inflammatory conditions which are two prominent features in the brain of a person suffering from Alzheimer’s disease.The leaf extracts were investigated for their bioac ...
DOI:
10.1016/j.jep.2018.11.009

31. Achyranthes aspera Linn. alleviates cerebral ischemia-reperfusion-induced neurocognitive, biochemical, morphological and histological alterations in Wistar rats

Author:
Gollapalle Lakshminarayanashastry Viswanatha; Marikunte V. Venkataranganna; Nunna Bheema Lingeswara Prasad; Hanumanthappa Shylaja
Source:
Journal of ethnopharmacology 2019 v.228 pp. 58-69
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; Achyranthes aspera; aerial parts; antioxidants; apigenin; brain; brain damage; carboxymethylcellulose; catalase; cell lines; cognition; edema; enzyme activity; epilepsy; gallic acid; glucose; glutathione; histology; histopathology; infarction; ingredients; inhibitory concentration 50; interleukin-10; interleukin-6; ischemia; laboratory animals; leukocytes; lipid peroxidation; liquid chromatography; males; methanol; nitrites; oral administration; oxygen radical absorbance capacity; quercetin; rats; reference standards; roots; stroke; superoxide dismutase; tandem mass spectrometry; traditional medicine; tumor necrosis factor-alpha
Abstract:
... In the traditional system of Indian medicine, the whole plant and roots of Achyranthes aspera L have been extensively used to treat neurological conditions such as epilepsy and stroke by the various ethnic communities of India.The present study was aimed to evaluate the cerebroprotective potential of methanol extract of A. aspera aerial parts (MeAA).Initially the MeAA was evaluated for total pheno ...
DOI:
10.1016/j.jep.2018.09.018

32. Acid sensing ion channels in rat cerebral arteries: Probing the expression pattern and vasomotor activity

Author:
Oluwadamilola Akanji; Nina Weinzierl; Rudolf Schubert; Lothar Schilling
Source:
Life sciences 2019 v.227 pp. 193-200
ISSN:
0024-3205
Subject:
acidosis; arteries; brain; gene expression; ion channels; laboratory animals; messenger RNA; pH; polymerase chain reaction; rats
Abstract:
... The recent identification of acid sensing ion channels (ASICs) in vascular beds suggests their possible involvement in modulating vasomotor tone. Therefore, we investigated the gene expression profiles of ASIC subtypes in the middle cerebral artery (MCA) of Wistar rats and the functional implication of ASICs in acidosis-induced relaxation as well as maintenance of resting tension.Real time PCR was ...
DOI:
10.1016/j.lfs.2019.04.054

33. Activation of endoplasmic reticulum stress in rat brain following low-intensity microwave exposure

Author:
Ranjeet Kumar; Pravin S. Deshmukh; Sonal Sharma; BasuDev Banerjee
Source:
Environmental science and pollution research 2019 v.26 no.9 pp. 9314-9321
ISSN:
1614-7499
Subject:
brain; endoplasmic reticulum stress; gene expression; laboratory animals; males; messenger RNA; microwave radiation; quantitative polymerase chain reaction; rats; transcription factors; unfolded protein response
Abstract:
... The present study was designed to explore the effects of low-intensity microwave radiation on endoplasmic reticulum stress and unfolded protein response. Experiments were performed on male Wistar rats exposed to microwave radiation for 30 days at 900 MHz, 1800 MHz, and 2450 MHz frequencies on four groups of animal: sham-exposed group, 900 MHz exposed (SAR 5.84 × 10⁻⁴ W/kg), 1800 MHz exposed (SAR 5 ...
DOI:
10.1007/s11356-019-04377-x

34. Acute Kahweol Treatment Attenuates Traumatic Brain Injury Neuroinflammation and Functional Deficits

Author:
Hung-Fu Lee; Jhih Syuan Lin; Che-Feng Chang
Source:
Nutrients 2019 v.11 no.10 pp. -
ISSN:
2072-6643
Subject:
animal models; brain; brain damage; cognition; cytokines; diterpenoids; edema; long term effects; macrophage activation; mice; neuroglia; neurons; neutrophils; patients; protein synthesis; secretion; therapeutics
Abstract:
... Traumatic brain injury (TBI) affects millions worldwide with devastating long-term effects on health and cognition. Emerging data suggest that targeting the immune response may offer promising strategies to alleviate TBI outcomes; kahweol, an anti-inflammatory diterpene that remains in unfiltered coffee, has been shown to be beneficial in neuronal recovery. Here, we examined whether kahweol could ...
DOI:
10.3390/nu11102301
PubMed:
31569604
PubMed Central:
PMC6835740

35. Adapter Proteins for Opposing Motors Interact Simultaneously with Nuclear Pore Protein Nup358

Author:
Heying Cui; Crystal R. Noell; Rachael P. Behler; Jacqueline B. Zahn; Lynn R. Terry; Blaine B. Russ; Sozanne R. Solmaz
Source:
Biochemistry 2019 v.58 no.50 pp. 5085-5097
ISSN:
1520-4995
Subject:
binding sites; brain; chromosome segregation; dynein ATPase; insects; light; microtubules; mitotic spindle apparatus; motors; mutation; nuclear pore; oligomerization; protein subunits; proteins; vertebrates
Abstract:
... Nup358 is a protein subunit of the nuclear pore complex that recruits the opposing microtubule motors kinesin-1 and dynein [via the dynein adaptor Bicaudal D2 (BicD2)] to the nuclear envelope. This pathway is important for positioning of the nucleus during the early steps of mitotic spindle assembly and also essential for an important process in brain development. It is unknown whether dynein and ...
DOI:
10.1021/acs.biochem.9b00907

36. Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment – Transcriptome-wide microarray profiles of neuroglia cells

Author:
Ean-Jeong Seo; Sabine M. Klauck; Thomas Efferth; Alexander Panossian
Source:
Phytomedicine 2019 v.55 pp. 80-91
ISSN:
0944-7113
Subject:
Andrographis paniculata; Eleutherococcus; Rhodiola; Schisandra; andrographolide; axons; brain; cell death; clinical trials; cognition; cognitive disorders; cyclophosphamide; data collection; databases; death; drug therapy; epirubicin; fluorouracil; gene expression regulation; genes; humans; messenger RNA; microarray technology; neoplasms; nerve tissue; neurogenesis; neuroglia; neuroprotective effect; plant extracts; roots; sensory system; small fruits
Abstract:
... Cancer chemotherapy-induced cognitive impairments are presumably associated with undesirable effects of chemotherapy on physiological functions of brain cells. Adaptogens are natural compounds or plant extracts increasing an organism's adaptability and survival in stress. They exhibited neuroprotective effects and increased cognitive functions in clinical studies in human beings.We hypothesized th ...
DOI:
10.1016/j.phymed.2018.10.022

37. Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells

Author:
Ean-Jeong Seo; Sabine M. Klauck; Thomas Efferth; Alexander Panossian
Source:
Phytomedicine 2019 v.58 pp. 152743
ISSN:
0944-7113
Subject:
Rhodiola; andrographolide; brain; cell death; clinical trials; cognition; cognitive disorders; cyclophosphamide; cytotoxicity; death; drug therapy; epirubicin; fluorouracil; genes; herbs; neurogenesis; neuroglia; neurons; neuroprotective effect; plant extracts
Abstract:
... Cancer chemotherapy-induced cognitive impairments are apparently associated with harmful effects on physiological functions of brain cells. Adaptogens, are known to exhibit neuroprotective effects and to increase cognitive functions in clinical studies. In our previous study (Seo et al., 2018), we demonstrated that selected adaptogenic extracts significantly attenuate cytostatic-induced regulation ...
DOI:
10.1016/j.phymed.2018.11.004

38. Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma

Author:
William J. Griffiths; Peter J. Crick; Anna Meljon; Spyridon Theofilopoulos; Jonas Abdel-Khalik; Eylan Yutuc; Josie E. Parker; Diane E. Kelly; Steven L. Kelly; Ernest Arenas; Yuqin Wang
Source:
Biochimica et biophysica acta 2019 v.1864 no.2 pp. 191-211
ISSN:
1388-1981
Subject:
bile acids; biosynthesis; brain; cytochrome P-450; enzyme activity; enzymes; genes; humans; knockout mutants; ligands; liquid chromatography; liver; mass spectrometry; metabolites; mice; motor neurons; mutation; oxysterols; patients; phenotype; pregnanes; stereochemistry
Abstract:
... Cytochrome P450 (CYP) 27A1 is a key enzyme in both the acidic and neutral pathways of bile acid biosynthesis accepting cholesterol and ring-hydroxylated sterols as substrates introducing a (25R)26-hydroxy and ultimately a (25R)26-acid group to the sterol side-chain. In human, mutations in the CYP27A1 gene are the cause of the autosomal recessive disease cerebrotendinous xanthomatosis (CTX). Surpri ...
DOI:
10.1016/j.bbalip.2018.11.006
PubMed:
30471425
PubMed Central:
PMC6327153

39. Addressing the alterations in cerebral ischemia-reperfusion injury on the brain mitochondrial activity: A possible link to cognitive decline

Author:
Sriram Ravindran; Gino A. Kurian
Source:
Biochemical and biophysical research communications 2019 v.518 no.1 pp. 100-106
ISSN:
0006-291X
Subject:
animal models; antioxidant enzymes; brain; carotid arteries; catalase; cognition; cognitive disorders; cortex; energy metabolism; enzyme activity; histology; ischemia; mitochondria; research
Abstract:
... Studies suggest that different anatomical regions in a normal brain show distinct mitochondrial physiology. But the pathological role of mitochondria during ischemia-reperfusion injury (IRI) from these brain regions are yet to be addressed. The objective of this study is to identify mitochondrial perturbations from the brain regions of cortex and striatum, exposed to IRI and their correlation with ...
DOI:
10.1016/j.bbrc.2019.08.014

40. Adenosine stimulates neuromedin U mRNA expression in the rat pars tuberalis

Author:
Sayaka Aizawa; Tingting Gu; Arisa Kaminoda; Ryuya Fujioka; Fumiya Ojima; Ichiro Sakata; Takafumi Sakai; Maho Ogoshi; Sumio Takahashi; Sakae Takeuchi
Source:
Molecular and cellular endocrinology 2019 pp. 110518
ISSN:
0303-7207
Subject:
adenosine; agonists; brain; cyclic AMP; gene expression; melatonin; purinergic receptors; rats; signal transduction
Abstract:
... Neuromedin U (NMU) shows circadian expression in the rat pars tuberalis (PT), and is known to be suppressed by melatonin. Here we examined the involvement of adenosine in the regulation of Nmu expression. We found that the rat PT expressed adenosine receptor A2b and that an adenosine receptor agonist, NECA, stimulated Nmu expression in brain slice cultures. In vitro promoter assays revealed that N ...
DOI:
10.1016/j.mce.2019.110518

41. Advances in Microfluidic Blood–Brain Barrier (BBB) Models

Author:
Arianna Oddo; Bo Peng; Ziqiu Tong; Yingkai Wei; Wing Yin Tong; Helmut Thissen; Nicolas Hans Voelcker
Source:
Trends in biotechnology 2019 v.37 no.12 pp. 1295-1314
ISSN:
0167-7799
Subject:
blood-brain barrier; brain; drugs; microfluidic technology; models; neurodegenerative diseases; organ-on-a-chip; physiological response; screening; therapeutics
Abstract:
... Therapeutic options for neurological disorders currently remain limited. The intrinsic complexity of the brain architecture prevents potential therapeutics from reaching their cerebral target, thus limiting their efficacy. Recent advances in microfluidic technology and organ-on-chip systems have enabled the development of a new generation of in vitro platforms that can recapitulate complex in vivo ...
DOI:
10.1016/j.tibtech.2019.04.006

42. Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering

Author:
Sahba Mobini; Young Hye Song; Michaela W. McCrary; Christine E. Schmidt
Source:
Biomaterials 2019 v.198 pp. 146-166
ISSN:
0142-9612
Subject:
animal models; bioreactors; brain; cell culture; disease models; lab-on-a-chip technology; medicine; spinal cord; tissue engineering
Abstract:
... The technologies related to ex vivo models and lab-on-a-chip devices for studying the regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural tissue engineering and regenerative medicine research. The need for ex vivo systems, lab-on-a-chip technologies and disease models for neural tissue engineering applications are emerging to overcome the shortages and d ...
DOI:
10.1016/j.biomaterials.2018.05.012
PubMed:
29880219
PubMed Central:
PMC6957334

43. Advancing the Zebrafish embryo test for endocrine disruptor screening using micro‐injection: Ethinyl estradiol as a case study

Author:
Ellen D. G. Michiels; Lucia Vergauwen; Foon Yin Lai; Raewyn M. Town; Adrian Covaci; Alexander L. N. van Nuijs; Steven J. Van Cruchten; Dries Knapen
Source:
Environmental toxicology and chemistry 2019 v.38 no.3 pp. 533-547
ISSN:
0730-7268
Subject:
Danio rerio; abnormal development; absorbed dose; aromatase; biomarkers; brain; case studies; dose response; droplet size; embryo (animal); endocrine-disrupting chemicals; estradiol; estrogen receptors; exposure pathways; fish; guidelines; hydrophobicity; models; screening; solvents; toxicity testing; vitellogenin
Abstract:
... Fish (embryo) toxicity test guidelines are mostly based on aquatic exposures. However, in some cases, other exposure routes can be more practical and relevant. Micro‐injection into the yolk of fish embryos could offer a particular advantage for administering hydrophobic compounds, such as many endocrine disruptors. Single‐dose micro‐injection was compared with continuous aquatic exposure in terms ...
DOI:
10.1002/etc.4343

44. Adverse effects of maternal dioxin exposure on fetal brain development before birth assessed by neonatal electroencephalography (EEG) leading to poor neurodevelopment; a 2-year follow-up study

Author:
GiangThi Thuy Nghiem; Muneko Nishijo; Thao Ngoc Pham; Mika Ito; Tai The Pham; Anh Hai Tran; Hiroshi Nishimaru; Yoshikazu Nishino; Hisao Nishijo
Source:
Science of the total environment 2019 v.667 pp. 718-729
ISSN:
0048-9697
Subject:
adverse effects; body length; brain; breast milk; childhood; children; dioxins; electroencephalography; gestational age; head circumference; hospitals; language development; linear models; maternal exposure; mothers; neonates; neurodevelopment; neurons; regression analysis; sleep; United States; Vietnam
Abstract:
... We previously reported the adverse effects of perinatal dioxin exposure on child neurodevelopment around a former US military airbase in Vietnam. In the present study, we investigated the effects of maternal dioxin exposure on fetal brain development, which may predict neurodevelopmental outcomes in early childhood. A total of 55 newborns with mothers from dioxin-contaminated areas were recruited ...
DOI:
10.1016/j.scitotenv.2019.02.395

45. Aeromonas hydrophila infection in silver catfish causes hyperlocomotion related to stress

Author:
Guerino Bandeira Junior; Carine de Freitas Souza; Sharine Nunes Descovi; Alfredo Antoniazzi; Juliana Felipetto Cargnelutti; Bernardo Baldisserotto
Source:
Microbial pathogenesis 2019 v.132 pp. 261-265
ISSN:
0882-4010
Subject:
Aeromonas hydrophila; Rhamdia quelen; bacterial infections; behavior change; brain; cortisol; fish; fish diseases; gene expression; heat shock proteins; mortality; probability; septicemia
Abstract:
... Aeromonosis is a fish disease that leads to haemorrhagic septicaemia and high mortality. The detection of early behavioural changes associated to this disease could be helpful in anticipating the initiation of treatment, increasing the probability of success. The influence of this disease on the hypothalamic-pituitary-interrenal (HPI) axis and on the brain expression of heat shock proteins (HSP) i ...
DOI:
10.1016/j.micpath.2019.05.017

46. Aeromonas salmonicida infects Atlantic salmon (Salmo salar) erythrocytes

Author:
Katherinne Valderrama; Manuel Soto‐Dávila; Cristopher Segovia; Ignacio Vásquez; My Dang; Javier Santander
Source:
Journal of fish diseases 2019 v.42 no.11 pp. 1601-1608
ISSN:
0140-7775
Subject:
Aeromonas salmonicida subsp. salmonicida; Salmo salar; bacteremia; brain; erythrocytes; etiological agents; freshwater fish; furunculosis; gills; hemolysis; kidneys; leukocytes; liver; microbial load; smolts; spleen
Abstract:
... Aeromonas salmonicida subsp. salmonicida (hereafter A. salmonicida) is the aetiological agent of furunculosis in marine and freshwater fish. Once A. salmonicida invade the fish host through skin, gut or gills, it spreads and colonizes the head kidney, liver, spleen and brain. A. salmonicida infects leucocytes and exhibits an extracellular phase in the blood of the host; however, it is unknown whet ...
DOI:
10.1111/jfd.13077

47. Aerosol infection of Balb/c mice with eastern equine encephalitis virus; susceptibility and lethality

Author:
Amanda L. Phelps; Lyn M. O’Brien; Lin S. Eastaugh; Carwyn Davies; Mark S. Lever; Jane Ennis; Larry Zeitlin; Alejandro Nunez; David O. Ulaeto
Source:
Virology journal 2019 v.16 no.1 pp. 2
ISSN:
1743-422X
Subject:
Culicidae; Eastern equine encephalitis virus; aerosols; birds; blood; blood-brain barrier; brain; death; disease susceptibility; dose response; epizootic diseases; histopathology; horses; human diseases; humans; lethal dose 50; lungs; meningoencephalitis; mice; models; mortality; pathogenesis; signs and symptoms (animals and humans); spleen; viral load; virology; viruses; United States
Abstract:
... BACKGROUND: Eastern equine encephalitis virus is an alphavirus that naturally cycles between mosquitoes and birds or rodents in Eastern States of the US. Equine infection occurs by being bitten by cross-feeding mosquitoes, with a case fatality rate of up to 75% in humans during epizootic outbreaks. There are no licensed medical countermeasures, and with an anticipated increase in mortality when ex ...
DOI:
10.1186/s12985-018-1103-7
PubMed:
30611287
PubMed Central:
PMC6321726

48. Agathisflavone isolated from Schinus polygamus (Cav.) Cabrera leaves prevents scopolamine-induced memory impairment and brain oxidative stress in zebrafish (Danio rerio)

Author:
Gabriela Dumitru; Heba A.S. El-Nashar; Nada M. Mostafa; Omayma A. Eldahshan; Razvan Stefan Boiangiu; Elena Todirascu-Ciornea; Lucian Hritcu; Abdel Nasser B. Singab
Source:
Phytomedicine 2019 v.58 pp. 152889
ISSN:
0944-7113
Subject:
Danio rerio; Schinus polygama; acetylcholinesterase; amnesia; anti-inflammatory activity; antioxidant activity; antioxidants; anxiety; brain; cognition; electrospray ionization mass spectrometry; flavonoids; leaves; models; neoplasms; oxidative stress; scopolamine
Abstract:
... Agathisflavone, a biflavonoid isolated from Schinus polygamus (Cav.) Cabrera leaves been reported to promote various biological activities such as anti-inflammatory properties, promoting cognition and preventing cancer, antioxidant and antiapoptotic activities.Here, we tested the hypothesis whether anxiety, amnesia, and brain oxidative stress induced by scopolamine could be counteracted in zebrafi ...
DOI:
10.1016/j.phymed.2019.152889

49. Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice

Author:
Maa O. Quartey; Jennifer N.K. Nyarko; Paul R. Pennington; Ryan M. Heistad; Bradley M. Chaharyn; Zelan Wei; Dennis Bainbridge; Glen B. Baker; Darrell D. Mousseau
Source:
Biochemical and biophysical research communications 2019 pp. -
ISSN:
0006-291X
Subject:
Alzheimer disease; age; amyloid; animal models; brain; cognition; cognitive disorders; dopamine; females; glycosylation; males; memory; mice; neurotoxicity; norepinephrine; peptides; phenotype; precipitin tests; proteinases; serotonin; tail suspension test
Abstract:
... Biological sex exerts distinct influences on brain levels of the β-amyloid (Aβ) peptide in both clinical depression and Alzheimer disease (AD), yet studies in animal models focus primarily on males. We examined behavioral ‘despair’/depression (using the tail-suspension test) and memory (using the novel object recognition task) in J20 (hAPPSwe/Ind) mice. Three month-old male (but not female) J20 mi ...
DOI:
10.1016/j.bbrc.2019.02.083

50. The Ageing Gut–Brain study: Exploring the role of the gut microbiota in dementia

Author:
A. M. Johnstone; A. I. C. Donaldson; K. P. Scott; P. K. Myint
Source:
Nutrition bulletin 2019 v.44 no.2 pp. 145-153
ISSN:
1471-9827
Subject:
Alzheimer disease; brain; diet; intestinal microorganisms; metabolites; nutrients; nutritional intervention; patients
Abstract:
... Up to 90% of people with dementia will experience behavioural and psychological symptoms of dementia (BPSD) as part of their illness, and nearly two‐thirds of those living with dementia in care homes will experience BPSD. BPSD describe the disturbed perceptions, thought content, moods or behaviours that frequently occur in patients with dementia. There is increasing evidence that the gut microbiot ...
DOI:
10.1111/nbu.12378