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1. Laboratory and field studies to investigate the efficacy of a novel, orally administered combination product containing moxidectin, sarolaner and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs

Author:
Ulrich, Michael,   et al.   ; Kryda, Kristina; Six, Robert H.; Walsh, Kelly F.; Holzmer, Susan J.; Chapin, Sara; Mahabir, Sean P.; Myers, Melanie; Inskeep, Tammy; Rugg, Jady; Cundiff, Blair; Pullins, Aleah; McCall, John W.; McTier, Tom L.; Maeder, Steven J.;     Show all 15 Authors
Source:
Parasites & vectors 2019 v.12 no.1 pp. 445
ISSN:
1756-3305
Subject:
Dirofilaria immitis; adults; antigens; dirofilariasis; dog diseases; dogs; heartworms; ivermectin; larvae; moxidectin; necropsy; oral administration; pyrantel; valleys; veterinary clinics; United States
Abstract:
... BACKGROUND: Dirofilaria immitis is a filarial parasite of dogs that can cause serious or fatal cardiopulmonary disease. Three studies were conducted to evaluate the efficacy and safety of monthly treatment with moxidectin in a chewable tablet product in combination with sarolaner and pyrantel to prevent heartworm disease in dogs after experimental challenge and in a clinical field study in the USA ...
DOI:
10.1186/s13071-019-3702-6
PubMed:
31506094
PubMed Central:
PMC6737634