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You searched for: Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Subject term animal models Remove constraint Subject term: animal models Subject term cerebrospinal fluid Remove constraint Subject term: cerebrospinal fluid
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1. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002

2. Effects of L-theanine on Anxiety-like Behavior, Cerebrospinal Fluid Amino Acid Profile, and Hippocampal Activity in Wistar Kyoto Rats (P14-022-19)

Author:
Shintaro Ogawa; Miho Ota; Jun Ogura; Koichi Kato; Hiroshi Kunugi
Source:
Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:
2475-2991
Subject:
amino acid composition; animal models; anxiety; cerebellum; cerebrospinal fluid; elevated plus-maze test; glutamic acid; high performance liquid chromatography; hippocampus; laboratory animals; life insurance; mental depression; methionine; positron-emission tomography; rats; tranquilizers; Japan
Abstract:
... L-theanine (N-ethyl-L-glutamine), an amino acid is well known as a relaxing agent. In the present study, we examined the effects of repeated L-theanine administration on behavior, hippocampal activity in Wistar Kyoto (WKY) rats, levels of amino acids in the cerebrospinal fluid (CSF), and studied an animal model of anxiety and depressive disorders. Behavioral tests were performed after 7–10 days of ...
DOI:
10.1093/cdn/nzz052.P14-022-19

3. Melatonin protective effect against amyloid β-induced neurotoxicity mediated by mitochondrial biogenesis; involvement of hippocampal Sirtuin-1 signaling pathway

Author:
Mitra Ansari Dezfouli; Maryam Zahmatkesh; Maryam Farahmandfar; Fariba Khodagholi
Source:
Physiology & behavior 2019 v.204 pp. 65-75
ISSN:
0031-9384
Subject:
Alzheimer disease; amyloid; animal models; antioxidant activity; antioxidants; anxiety; biogenesis; cerebrospinal fluid; clinical trials; cognition; cognitive disorders; hippocampus; melatonin; memory; mitochondria; mitochondrial DNA; neuroprotective effect; neurotoxicity; patients; rats; signal transduction; therapeutics; transcription factors
Abstract:
... Melatonin has a potential therapeutic value in Alzheimer's disease (AD), a disease that is associated with a dramatic decline in memory and cognitive abilities. The aggregation of the amyloid β (Aβ) peptide, a hallmark of AD, deactivates mitochondrial biogenesis and antioxidant defenses. Melatonin as an endogenous antioxidant, decreases in plasma and cerebrospinal fluid of AD patients. Even though ...
DOI:
10.1016/j.physbeh.2019.02.016