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1. Changes of porcine gut microbiota in response to dietary chlorogenic acid supplementation

Author:
Chen, Jiali,   et al.   ; Yu, Bing; Chen, Daiwen; Zheng, Ping; Luo, Yuheng; Huang, Zhiqing; Luo, Junqiu; Mao, Xiangbing; Yu, Jie; He, Jun;     Show all 10 Authors
Source:
Applied microbiology and biotechnology 2019 v.103 no.19 pp. 8157-8168
ISSN:
0175-7598
Subject:
Anaerovibrio; Lactobacillus; Prevotella; acetates; animal models; antimicrobial properties; bacteria; bacterial communities; butyrates; cecum; chlorogenic acid; diamine oxidase; diet; digesta; human nutrition; ileum; intestinal microorganisms; jejunum; major histocompatibility complex; mucosa; polyphenols; propionic acid; ribosomal RNA; species diversity; swine
Abstract:
... Chlorogenic acids (CGA), the most abundant natural polyphenol present in human diet and plants, have attracted considerable research interest because of their broad bioactivities including the antimicrobial activity. However, little is known about their influences on intestinal bacterial communities. Here, we described a response in intestinal microbiome to CGA using a porcine model. Twenty-four w ...
DOI:
10.1007/s00253-019-10025-8

2. Determination of five nucleosides by LC‐MS/MS and the application of the method to quantify N6‐methyladenosine level in liver messenger ribonucleic acid of an acetaminophen‐induced hepatotoxicity mouse model

Author:
Zhang, Jiali,   et al.   ; Liu, Ruijuan; Zhao, Fang; Wei, Jingyao; Yu, Pei; Zhang, Ji; Wang, Yueqin; Li, Zeyun; Zhang, Xiaojian; Tian, Xin;     Show all 10 Authors
Source:
Journal of separation science 2019 v.42 no.16 pp. 2668-2678
ISSN:
1615-9306
Subject:
RNA; adenosine; animal models; cytidine; electrospray ionization mass spectrometry; epigenetics; formic acid; guanosine; hepatotoxicity; liver; methanol; methylation; mice; spectrometers; tandem mass spectrometry; ultra-performance liquid chromatography; uridine
Abstract:
... Ribonucleic acid N⁶‐methyladenosine methylation plays an important role in a variety of biological processes and diseases. Acetaminophen‐induced hepatotoxicity is one of the major challenges faced by clinicians. To date, the link between N⁶‐methyladenosine and acetaminophen‐induced hepatotoxicity has not been studied. In this study, a simple ultra high performance liquid chromatography with tandem ...
DOI:
10.1002/jssc.201900041

3. Monascus yellow, red and orange pigments from red yeast rice ameliorate lipid metabolic disorders and gut microbiota dysbiosis in Wistar rats fed on a high-fat diet

Author:
Hong, Jiali,   et al.   ; ZhouThese authors contributed equally to this study., Wenbin; Guo, Rui; Guo, Weiling; Li, Lu; Ni, Li; Sun, Jinyuan; Liu, Bin; Rao, Pingfan; Lv, Xucong;     Show all 10 Authors
Source:
Food & function 2019 v.10 no.2 pp. 1073-1084
ISSN:
2042-650X
Subject:
Clostridium; Monascus; Ruminococcus albus; animal models; bile acids; blood lipids; blood serum; cholesterol; cholesterol metabolism; dysbiosis; excretion; functional foods; gene expression; genes; high fat diet; homeostasis; hyperlipidemia; ingredients; intestinal microorganisms; laboratory animals; messenger RNA; oral administration; phylotype; pigments; rats; red yeast rice; triacylglycerols
Abstract:
... This study aimed to compare the hypolipidaemic activities of different Monascus pigments (yellow, red and orange pigments) and elucidate their possible regulatory mechanisms on lipid and cholesterol metabolism in rats fed on a high-fat diet (HFD). Results showed that oral administrations of Monascus yellow, red and orange pigments can markedly alleviate the disturbance of lipid metabolism through ...
DOI:
10.1039/c8fo02192a

4. Huachansu suppresses TRPV1 up-regulation and spinal astrocyte activation to prevent oxaliplatin-induced peripheral neuropathic pain in rats

Author:
Wang, Jiali,   et al.   ; Hao, Yue; Luo, Xinxin; Ba, Xiyuan; Zhou, Shiyang; Yang, Shimin; Fang, Changji; Jiang, Changyu; Sun, Wuping;     Show all 9 Authors
Source:
Gene 2019 v.680 pp. 43-50
ISSN:
0378-1119
Subject:
adverse effects; analgesic effect; animal models; astrocytes; drug therapy; hypersensitivity; pain; protective effect; rats; toads; transient receptor potential vanilloid channels; China
Abstract:
... Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a major dose- and therapy-limiting side effect that is particularly difficult to treat. Huachansu, an aqueous extract from toad skin, is a widely used anti-cancer natural product in China. Clinical findings have established the safety and effectiveness of Huachansu in combination with chemotherapy to promote the therapeutic efficacy while ...
DOI:
10.1016/j.gene.2018.09.035