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You searched for: Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Subject term animal models Remove constraint Subject term: animal models
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1. (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation

Author:
Yihang Zhao; Qianxu Wang; Mengzhen Jia; Shangchen Fu; Junru Pan; Chuanqi Chu; Xiaoning Liu; Xuebo Liu; Zhigang Liu
Source:
Journal of nutritional biochemistry 2019 v.64 pp. 61-71
ISSN:
0955-2863
Subject:
animal models; antidepressants; anxiety; blood serum; cognition; cognitive disorders; cortex; food composition; forced swimming test; hippocampus; inducible nitric oxide synthase; interleukin-1beta; lignans; memory disorders; mice; neuroglia; neurons; neurotrophins; serotonin; synapse; tail suspension test; therapeutics; tumor necrosis factor-alpha; ultrastructure
Abstract:
... Depression is a mood disorder that is related to neuroinflammation and cognition loss. This study is aimed to determine the potential antidepressant effects of (+)-sesamin, a lignan component of sesame, in a mild stress-induced depression mouse model. CD-1 mice were treated with chronic unpredictable mild stress (CUMS) process and orally administrated with sesamin (50 mg/kg/d) for 6 weeks. Behavio ...
DOI:
10.1016/j.jnutbio.2018.10.006

2. (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice

Author:
Yunxia Dong; Henglei Lu; Qiang Li; Xinming Qi; Yuanchao Li; Zean Zhang; Jing Chen; Jin Ren
Source:
Life sciences 2019 v.232 pp. 116644
ISSN:
0024-3205
Subject:
acyl-CoA dehydrogenase; acyl-CoA oxidase; alanine transaminase; animal models; aspartate transaminase; beta oxidation; blood serum; carnitine palmitoyltransferase; diet; fatty acids; fatty liver; gene expression; hepatoprotective effect; histology; lipid peroxidation; liver; mice; neoplasms; peroxisome proliferator-activated receptor alpha; rheumatoid arthritis; stearoyl-CoA desaturase
Abstract:
... (5R)-5-hydroxytriptolide (LLDT-8) is a triptolide analog with excellent capability against cancers, cerebral ischemic injury and rheumatoid arthritis. Here, we discovered its hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease (NAFLD) by ameliorating liver lipid accumulation.Male C57BL/6J mice were fed with a high-fat/high-fructose (HFHFr) diet for 29 weeks to induce the ...
DOI:
10.1016/j.lfs.2019.116644

3. (−)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury

Author:
L.T. Melo; V. Panchalingam; P. Cherkas; A.R. Campos; L. Avivi-Arber; B.J. Sessle
Source:
Life sciences 2019 v.227 pp. 122-128
ISSN:
0024-3205
Subject:
adults; analysis of variance; animal models; hypersensitivity; males; nerve tissue; neurons; nociception; pain; rats; therapeutics
Abstract:
... Neuropathic orofacial pain conditions represent a challenge to diagnose and treat. Natural substances are promising therapeutic options for the control of pain.This study aimed to examine whether (−)-α-bisabolol (BISA), a natural terpene, can attenuate nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain.Infraorbital nerve transection (IONX) or sham oper ...
DOI:
10.1016/j.lfs.2019.04.032

4. 1,3‐1‐6 ß‐glucans enhance tissue regeneration in zebrafish (Danio rerio): Potential advantages for aquaculture applications

Author:
Baldassare Fronte; Cheol‐Hee Kim; Marco Bagliacca; Lucia Casini; Mahanama De Zoysa
Source:
Aquaculture research 2019 v.50 no.11 pp. 3163-3170
ISSN:
1355-557X
Subject:
Danio rerio; amputation; animal models; aquaculture; beta-glucans; diet; fish; gills; macrophages; oral administration; secondary infection; stocking rate; tissue repair; tissues
Abstract:
... High aquacultural rearing density and handling of fish may frequently result in skin or gills wounds, thereby facilitating the onset of secondary infections. The capacity of the zebrafish to regenerate tissues, as well as fins and other organs, makes it an ideal animal model for studying the mechanisms of tissue regeneration. Since macrophages are involved in tissue regeneration, a diet including ...
DOI:
10.1111/are.14270

5. 119 Combined exposure to phthalates and 4-vinylcyclohexene diepoxide accelerate the loss of ovarian follicles, leading to premature ovarian failure in rat model

Author:
D. N. Tran; J.-H. Lee; Y.-M. Yoo; E.-M. Jung; C. Ahn; S. Y. Park; B. Lee; B.-H. Jeon; E.-B. Jeung
Source:
Reproduction, fertility, and development 2019 v.31 no.1 pp. 185
ISSN:
1031-3613
Subject:
adverse effects; amenorrhea; animal models; autoimmunity; blood serum; corn oil; dibutyl phthalate; females; follicle-stimulating hormone; follicular development; laboratory animals; messenger RNA; oral administration; ovarian follicles; rats; steroidogenesis; synergism; toxic substances; women
Abstract:
... Premature ovarian failure (POF) is observed in women under 40 years with primary or secondary amenorrhea. The causes for POF are idiopathic, genetic, iatrogenic incidence, autoimmunity, and adverse effects from toxic chemical exposures. Several classes of chemicals have been shown to alter follicle development and reduce fertility, leading to POF in mammals. We investigated the synergistic effects ...
DOI:
10.1071/RDv31n1Ab119

6. 17β-Hydroxysteroid dehydrogenases and neurosteroid metabolism in the central nervous system

Author:
Xue-Ying He; Carl Dobkin; Song-Yu Yang
Source:
Molecular and cellular endocrinology 2019 v.489 pp. 92-97
ISSN:
0303-7207
Subject:
Alzheimer disease; alcohol oxidoreductases; anesthetics; animal models; anticonvulsants; antidepressants; biochemical pathways; brain; cholesterol; chromosome mapping; cognition; endocrine glands; genes; genomics; homeostasis; memory; metabolism; mitochondria; mutation; neurogenesis; neurons; neuroprotective effect; pathogenesis; patients; prasterone; pregnenolone; receptors; tranquilizers
Abstract:
... 17β-Hydroxysteroid dehydrogenases are indispensable for downstream enzyme steps of the neurosteroidogenesis. Neurosteroids are synthesized de novo in neurons and glia from cholesterol transported into mitochondria, or by conversion from proneurosteroids, e. g. dehydroepiandrosterone (DHEA) and pregnenolone, through the same metabolic pathway as revealed in the de novo neurosteroidogenesis. Hormona ...
DOI:
10.1016/j.mce.2018.10.002

7. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis

Author:
Yun Yu; Xiu-Yuan Lang; Xi-Xi Li; Run-Ze Gu; Qing-Shan Liu; Rongfeng Lan; Xiao-Yan Qin
Source:
Food & function 2019 v.10 no.9 pp. 6009-6019
ISSN:
2042-650X
Subject:
Alzheimer disease; Parkinson disease; Reynoutria multiflora; animal behavior; animal models; apoptosis; atrophy; cell lines; cell viability; dopamine; immunohistochemistry; in vitro studies; ingredients; mice; neurites; neuroprotective effect; neurotoxicity; neurotrophins; signal transduction; tail suspension test
Abstract:
... The major bioactive ingredient THSG of Polygonum multiflorum is well established for its anti-oxidation, anti-aging and anti-inflammation properties. Increasing evidence supports the capacity of THSG to ameliorate the biochemistry of neurotrophins and their downstream signaling axis in mouse models to attenuate neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this study, ...
DOI:
10.1039/c9fo01309a

8. 2-Amino-4-(1-piperidine) pyridine exhibits inhibitory effect on colon cancer through suppression of FOXA2 expression

Author:
Jieshu Wang; Bo Li; Kun Zhao; Xinyou Su
Source:
3 Biotech 2019 v.9 no.11 pp. 384
ISSN:
2190-572X
Subject:
animal models; apoptosis; cadherins; cell proliferation; colorectal neoplasms; human cell lines; mice; neoplasm cells; pyridines; viability; vimentin
Abstract:
... The present study was aimed to investigate the effect of 2-amino-4-(1-piperidine) pyridine on migration and invasion of colon cancer cells. Treatment of colon cancer cells with 2-amino-4-(1-piperidine) pyridine reduced viability in concentration-based manner. The migration potential of HCT116 and HT29 cells was also suppressed on treatment with 2-amino-4-(1-piperidine) pyridine. In HCT116 and HT29 ...
DOI:
10.1007/s13205-019-1915-1
PubMed:
31656722
PubMed Central:
PMC6778160

9. 3,3′-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal Caenorhabditis elegans

Author:
Joo Yeon Kim; Tram Anh Ngoc Le; So Young Lee; Dae-Geun Song; Sung-Chul Hong; Kwang Hyun Cha; Jae Wook Lee; Cheol-Ho Pan; Kyungsu Kang
Source:
Journal of agricultural and food chemistry 2019 v.67 no.33 pp. 9277-9285
ISSN:
1520-5118
Subject:
Brassicaceae; Caenorhabditis elegans; Pseudomonas aeruginosa; animal models; dietary supplements; electrical resistance; gastrointestinal diseases; human cell lines; humans; interleukin-1beta; intestines; longevity; metabolites; occludins; permeability; tight junctions; vegetables
Abstract:
... 3,3′-Diindolylmethane (DIM), a digestive metabolite originating from cruciferous vegetables, has dietary potential for the treatment of various human intestinal diseases. Although intestinal permeability dysfunction is closely related to the initiation and progression of human intestinal inflammatory diseases (IBDs), the effect of DIM on intestinal permeability is unclear. We evaluated the effect ...
DOI:
10.1021/acs.jafc.9b03039

10. 3,3′-Diindolylmethane nanoencapsulation improves its antinociceptive action: Physicochemical and behavioral studies

Author:
Juliane Mattiazzi; Marcel Henrique Marcondes Sari; Taíne de Bastos Brum; Paulo César Oliveira Araújo; Jéssica Mendes Nadal; Paulo Vítor Farago; Cristina Wayne Nogueira; Letícia Cruz
Source:
Colloids and surfaces 2019 v.181 pp. 295-304
ISSN:
0927-7765
Subject:
Primula; X-ray diffraction; adjuvants; adults; analgesic effect; animal models; differential scanning calorimetry; dose response; encapsulation; hot plate test; inflammation; infrared spectroscopy; males; mice; nanocapsules; nociception; oils; pain; scanning electron microscopy; therapeutics; thermal stability; thermogravimetry
Abstract:
... This study aimed to characterize the physicochemical properties of 3,3′-diindolylmethane (DIM)-loaded nanocapsules (NCs) as well as the antinociceptive effect using distinct animal models (hot plate test, formalin-induced nociception and complete Freud’s adjuvant induced paw inflammation). The DIM-loaded NCs (composed by primula oil and ethylcellulose) were characterized using differential scannin ...
DOI:
10.1016/j.colsurfb.2019.05.063

11. 3-Methyl-3-buten-1-ol (isoprenol) confers longevity and stress tolerance in Caenorhabditis elegans

Author:
Swapnil Pandey; Suresh Chandra Phulara; Anubhuti Jha; Puneet Singh Chauhan; Pratima Gupta; Virendra Shukla
Source:
International journal of food sciences and nutrition 2019 v.70 no.5 pp. 595-602
ISSN:
1465-3478
Subject:
Caenorhabditis elegans; animal models; computer simulation; dietary supplements; lead; longevity; reactive oxygen species; stress tolerance; superoxide dismutase
Abstract:
... The present investigation demonstrates the longevity-promoting effects of 3-methyl-3-buten-1-ol (isoprenol) in the animal model Caenorhabditis elegans that might be served as a lead nutraceutical in geriatric research. Our results showed that 0.5 mM isoprenol extended the mean lifespan of worms by 25% in comparison to control worms. Isoprenol also significantly enhanced survival of the worms under ...
DOI:
10.1080/09637486.2018.1554031

12. 3D Bioprinted Scaffolds Containing Viable Macrophages and Antibiotics Promote Clearance of Staphylococcus aureus Craniotomy-Associated Biofilm Infection

Author:
Amy Aldrich; Mitchell A. Kuss; Bin Duan; Tammy Kielian
Source:
ACS applied materials & interfaces 2019 v.11 no.13 pp. 12298-12307
ISSN:
1944-8252
Subject:
Staphylococcus aureus; animal models; antibacterial properties; biofilm; bioprinting; brain; chronic diseases; daptomycin; epilepsy; macrophages; mice; microbial load; neoplasms; rifampicin; skull; slurries; surgery
Abstract:
... Craniotomy involves the removal of a skull fragment to access the brain, such as during tumor or epilepsy surgery, which is immediately replaced intraoperatively. The infection incidence after craniotomy ranges from 0.8 to 3%, with approximately half caused by Staphylococcus aureus (S. aureus). To mitigate infectious complications following craniotomy, we engineered a three-dimensional (3D) biopri ...
DOI:
10.1021/acsami.9b00264
PubMed:
30855125
PubMed Central:
PMC7034353

13. 3D biomaterial matrix to support long term, full thickness, immuno-competent human skin equivalents with nervous system components

Author:
Sarah E. Lightfoot Vidal; Kasey A. Tamamoto; Hanh Nguyen; Rosalyn D. Abbott; Dana M. Cairns; David L. Kaplan
Source:
Biomaterials 2019 v.198 pp. 194-203
ISSN:
0142-9612
Subject:
animal models; animal use replacement; artificial skin; biocompatible materials; bioengineering; collagen; crosslinking; cytokines; drugs; inflammation; mechanics; nerve tissue; neurons; proteomics; secretion; silk; skin diseases
Abstract:
... Current commercially available human skin equivalents (HSEs) are used for relatively short term studies (∼1 week) due in part to the time-dependent contraction of the collagen gel-based matrix and the limited cell types and skin tissue components utilized. In contrast, here we describe a new matrix consisting of a silk-collagen composite system that provides long term, stable cultivation with redu ...
DOI:
10.1016/j.biomaterials.2018.04.044
PubMed:
29709325
PubMed Central:
PMC6200656

14. 3‐Bromopyruvate as a potent anticancer therapy in honor and memory of the late Professor André Goffeau

Author:
Young H. Ko; Katarzyna Niedźwiecka; Margarida Casal; Peter L. Pedersen; Stanisław Ułaszewski
Source:
Yeast 2019 v.36 no.4 pp. 211-221
ISSN:
0749-503X
Subject:
Cryptococcus neoformans; adenosine triphosphate; adverse effects; algae; animal models; antimicrobial properties; antineoplastic activity; apoptosis; bromination; cancer therapy; cell movement; fungi; glucose; glycolysis; hexokinase; lactic acid; mitochondria; neoplasm cells; neoplasms; oxygen; patients; pumps; pyruvic acid; transporters
Abstract:
... 3‐Bromopyruvate (3BP) is a small, highly reactive molecule formed by bromination of pyruvate. In the year 2000, the antitumor properties of 3BP were discovered. Studies using animal models proved its high efficacy for anticancer therapy with no apparent side effects. This was also found to be the case in a limited number of cancer patients treated with 3BP. Due to the “Warburg effect,” most tumor ...
DOI:
10.1002/yea.3367

15. 41 Cases of Treatment of Cranial Cruciate Ligament Rupture with Porous TTA: Three Years of Follow Up

Author:
Rodrigo Trisciuzzi; Laura Fracassi; Hernando Afonso Martin; Donato Monopoli Forleo; Daniel Amat; Leonor Santos-Ruiz; Elena De Palma; Alberto Maria Crovace
Source:
Veterinary sciences 2019 v.6 no.1 pp. -
ISSN:
2306-7381
Subject:
aluminum; animal models; breeds; clinical examination; cranial cruciate ligament; dog diseases; dogs; gait; manufacturing; melting; neutralization; osteoarthritis; osteotomy; patients; production technology; questionnaires; radiography; sedation; tibia; titanium; vanadium
Abstract:
... Tibial Tuberosity Advancement (TTA) is a surgical technique based on a linear osteotomy that determines a cranial advancement of the tibial tuberosity in patients suffering from cranial cruciate ligament rupture (CCL). The aim is to neutralize the cranial tibial thrust (CTT) and to reach a 90° angle between the patellar tendon and the tibial plateau with a physiological knee extension of 135&d ...
DOI:
10.3390/vetsci6010018
PubMed:
30791613
PubMed Central:
PMC6466427

16. 47 Effect of a long-term, high-fat diet on metabolic health and oocyte quality of an outbred (Swiss) versus inbred (C57BL/6N) mouse strain

Author:
A. Smits; W. F. A. Marei; O. Mohey-Elsaeed; I. Pintelon; K. Moerloose; D. Ginneberge; J. L. M. R. Leroy
Source:
Reproduction, fertility, and development 2019 v.31 no.1 pp. 149
ISSN:
1031-3613
Subject:
animal models; blood serum; body weight changes; cholesterol; droplets; free fatty acids; high fat diet; human chorionic gonadotropin; humans; laboratory animals; membrane potential; metabolic diseases; mice; mitochondria; mitochondrial membrane; obesity; oocytes; oxidative stress; pregnant mare serum gonadotropin; t-test; translation (genetics); transmission electron microscopy; triacylglycerols; ultrastructure
Abstract:
... Maternal metabolic disorders like obesity and diabetes type II are known to affect reproductive physiology, ultimately leading to poor fertility. The oocyte and embryo are extremely vulnerable during the periconceptional period to metabolic stressors, leading to disappointing fertility results. Most mouse model research regarding obesity and Western type diets has been performed on the inbred C57B ...
DOI:
10.1071/RDv31n1Ab47

17. 5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models

Author:
Donato Angelino; Diogo Carregosa; Cristina Domenech-Coca; Monia Savi; Inês Figueira; Nicoletta Brindani; Saebyeol Jang; Sukla Lakshman; Aleksey Molokin; Joseph F. Urban; Cindy D. Davis; Maria Alexandra Brito; Kwang Sik Kim; Furio Brighenti; Claudio Curti; Cinta Bladé; Josep M. del Bas; Donatella Stilli; Gloria I. Solano-Aguilar; Claudia Nunes dos Santos; Daniele del Rio; Pedro Mena
Source:
Nutrients 2019 v.11 no.11 pp. -
ISSN:
2072-6643
Subject:
acids; animal models; blood-brain barrier; brain; chronic diseases; endothelial cells; flavanols; foods; gastrointestinal system; grapes; in vitro studies; in vivo studies; intestinal microorganisms; isomers; lactones; metabolites; neuroprotective effect; permeability; phenolic compounds; rats; swine feeding
Abstract:
... Phenolic compounds have been recognized as promising compounds for the prevention of chronic diseases, including neurodegenerative ones. However, phenolics like flavan-3-ols (F3O) are poorly absorbed along the gastrointestinal tract and structurally rearranged by gut microbiota, yielding smaller and more polar metabolites like phenyl-γ-valerolactones, phenylvaleric acids and their conjugates ...
DOI:
10.3390/nu11112678
PubMed:
31694297
PubMed Central:
PMC6893823

18. 5-Azacytidine and trichostatin A enhance the osteogenic differentiation of bone marrow mesenchymal stem cells isolated from steroid-induced avascular necrosis of the femoral head in rabbit

Author:
Peng Zhang; Fulin Tao; Qinghu Li; Shuai Wu; Baisheng Fu; Ping Liu
Source:
Journal of biosciences 2019 v.44 no.4 pp. 87
ISSN:
0250-5991
Subject:
alkaline phosphatase; animal models; apoptosis; beta catenin; bone formation; bone marrow; caspase-3; caspase-9; cell proliferation; femur; gene expression; gene expression regulation; interphase; mesenchymal stromal cells; messenger RNA; necrosis; osteocalcin; rabbits; signal transduction; transcription factors
Abstract:
... Bone marrow mesenchymal stem cells (BMSCs) play an important role in the process of bone repair. The present study investigated the effect of 5-azacytidine (AZA) and trichostatin A (TSA) on BMSC behaviors in vitro. The role of WNT family member 5A (WNT5A)/WNT family member 5A (WNT7A)/β-catenin signaling was also investigated. BMSCs were isolated from a steroid-induced avascular necrosis of the fem ...
DOI:
10.1007/s12038-019-9901-7

19. 52 Decellularization of goat uterus as a promising 3-dimensional homing matrix of biological scaffold: A pilot study

Author:
M. Ghiringhelli; N. Verdile; T. A. L. Brevini; F. Gandolfi
Source:
Reproduction, fertility, and development 2019 v.31 no.1 pp. 151-152
ISSN:
1031-3613
Subject:
DNA; analysis of variance; animal models; bioengineering; collagen; deoxycholic acid; dimethyl sulfoxide; extracellular matrix; female fertility; fluorescent antibody technique; goats; human population; medicine; opacity; patients; quantitative polymerase chain reaction; slaughter; uterus; veterinary medicine
Abstract:
... Female infertility or absence of a functional uterus has a prevalence of 3 to 5% in the general human population. Nowadays most patients diagnosed with absolute uterine factor infertility remain untreatable. Moreover, the world population is aging rapidly, and as people live longer, uterus frailty increases the risk of developing age-related diseases. Whole-organ decellularization and recellulariz ...
DOI:
10.1071/RDv31n1Ab52

20. 55 Peri-conceptional undernourishment perturbs offspring sperm methylome

Author:
P. Toschi; E. Capra; D. Anzalone; F. Turri; F. Pizzi; B. Lazzari; A. Stella; P. Ajmone-Marsan; P. Loi
Source:
Reproduction, fertility, and development 2019 v.31 no.1 pp. 153
ISSN:
1031-3613
Subject:
DNA methylation; adults; animal models; biotin; bisulfites; blastocyst; body weight; chondroitin sulfate; chromatin; conception; diet; embryogenesis; epigenetics; flow cytometry; folic acid; gene ontology; genotype; glucagon; inheritance (genetics); ion transport; lambs; malnutrition; maternal exposure; maternal nutrition; metabolism; mothers; nutrient availability; phenotype; potassium; progeny; rams; semen; sequence analysis; sperm motility; spermatozoa
Abstract:
... Whereas an organism’s genotype is relatively static throughout life, the epigenome is highly dynamic and can adapt, or be altered, in response to the external environment such as diet. Intrauterine exposure to nutrient availability can alter the establishment of epigenetic marks, not only in the exposed individuals, but also in their offspring. Inheritance of such an environmentally acquired pheno ...
DOI:
10.1071/RDv31n1Ab55