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You searched for: Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Subject term antineoplastic activity Remove constraint Subject term: antineoplastic activity Subject term cell lines Remove constraint Subject term: cell lines Subject term cytotoxicity Remove constraint Subject term: cytotoxicity Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. A green chemistry to produce iron oxide – Chitosan nanocomposite (CS-IONC) for the upgraded bio-restorative and pharmacotherapeutic activities - Supra molecular nanoformulation against drug-resistant pathogens and malignant growth

Author:
Arul Maximus Rabel; S. Karthick Raja Namasivayam; M. Prasanna; R.S. Arvind Bharani
Source:
International journal of biological macromolecules 2019 v.138 pp. 1109-1129
ISSN:
0141-8130
Subject:
Escherichia coli; Fourier transform infrared spectroscopy; Staphylococcus aureus; X-ray diffraction; absorbance; antibacterial properties; antineoplastic activity; apoptosis; biocompatibility; biofilm; cell lines; cell structures; chitosan; cytotoxicity; drug resistance; drug therapy; enzymes; ethanol; green chemistry; humans; iron oxides; medicine; minimum inhibitory concentration; nanocomposites; nanoparticles; pathogens; proteins; scanning electron microscopy; solubilization; tumor necrosis factor-alpha
Abstract:
... The logical research on fundamentally adjusted iron oxide nanoparticles has turned out to expanded in biomedicine because of the improved activity and best biocompatibility. In this present work upgraded bio-restorative and pharmacotherapeutic property of chitosan‑iron oxide nanocomposite, which was set up by eco-friendly in situ substance technique. Characterisation of the synthesised nanocomposi ...
DOI:
10.1016/j.ijbiomac.2019.07.158

2. A novel antibody-drug conjugate, HcHAb18-DM1, has potent anti-tumor activity against human non-small cell lung cancer

Author:
Muren Huhe; Jiaxin Lou; Yumeng Zhu; Yu Zhao; Ying Shi; Bo Wang; Xiuxuan Sun; Xiaoqin Zhang; Yang Zhang; Zhi-Nan Chen
Source:
Biochemical and biophysical research communications 2019 v.513 no.4 pp. 1083-1091
ISSN:
0006-291X
Subject:
antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; drugs; epidermal growth factor receptors; humans; immunoglobulins; in vitro studies; lung neoplasms; mice; microtubules; mitotic spindle apparatus; monoclonal antibodies; patients; therapeutics; transmembrane proteins
Abstract:
... Cluster of differentiation 147 (CD147), a transmembrane protein of the immunoglobulin superfamily, is a potential target of treatment against human non-small cell lung cancer (NSCLC). Although there have been exciting advances in epidermal growth factor receptor (EGFR)-targeted therapy for NSCLC in recent years, additional novel targeted agents are needed to improve the efficiency and to offer mor ...
DOI:
10.1016/j.bbrc.2019.04.046

3. A stereo-selective growth inhibition profile of ginsenoside Rh2 on human colon cancer cells

Author:
Yunju Jeong; Seockmo Ku; Hyun Ju You; Geun Eog Ji
Source:
CyTA: journal of food 2019 v.17 no.1 pp. 488-493
ISSN:
1947-6345
Subject:
antineoplastic activity; cell lines; cell viability; colorectal neoplasms; cytotoxicity; dose response; ginsenosides; growth retardation; human diseases; neoplasm cells
Abstract:
... We compared the stereo-selective growth inhibition effects of purified enantiomeric pairs of ginsenoside Rh2 (20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2) on human colon cancer cells in vitro with non-invasive real-time cellular analysis. When 50 μM, respectively, of 20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2 were administered to the colon cancer cell line HT-29, only the S-type ginsenosi ...
DOI:
10.1080/19476337.2019.1607562

4. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications

Author:
Heerasing Takooree; Muhammad Z. Aumeeruddy; Kannan R.R. Rengasamy; Katharigatta N. Venugopala; Rajesh Jeewon; Gokhan Zengin; Mohamad F. Mahomoodally
Source:
Critical reviews in food science and nutrition 2019 v.59 no.sup1 pp. S210
ISSN:
1549-7852
Subject:
2,2-diphenyl-1-picrylhydrazyl; Piper nigrum; analgesics; anticonvulsants; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidant enzymes; apoptosis; autophagy; bacterial motility; bioactive compounds; biofilm; black pepper; breasts; cell lines; chemical constituents of plants; cholesterol; clinical trials; colon; cytotoxicity; databases; dietary supplements; digestive system diseases; flavor; fruits; high density lipoprotein; hydrogen peroxide; in vivo studies; ingredients; livestock; low density lipoprotein; molybdenum; neuroprotective effect; nitric oxide; nitrogen; oxygen; pathogens; pharmacokinetics; seeds; signal transduction; superoxide anion; systematic review; taste; transporters; triacylglycerols; veterinary medicine; India
Abstract:
... Considered as the “King of spices”, black pepper (Piper nigrum L.) is a widely used spice which adds flavor of its own to dishes, and also enhances the taste of other ingredients. Piper nigrum has also been extensively explored for its biological properties and its bioactive phyto-compounds. There is, however, no updated compilation of these available data to provide a complete profile of the medi ...
DOI:
10.1080/10408398.2019.1565489

5. Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cells

Author:
Jiryeon Jang; Jeeyun Lee; Jun Ho Jang; Chul Won Jung; Silvia Park
Source:
Molecular biology reports 2019 v.46 no.6 pp. 5859-5866
ISSN:
0301-4851
Subject:
Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; cell proliferation; cell viability; cholesterol; cytotoxicity; flow cytometry; humans; molecular biology; mutants; myeloid leukemia; simvastatin; therapeutics
Abstract:
... The statins are a group of therapeutic drugs widely used for lowering plasma cholesterol level, while it has also been reported to induce cell death in human acute myeloid leukemia (AML) cells. To determine antitumor activity triggered by simvastatin, four AML cell lines—U937, KG1, THP1 (NRASᴳ¹²ᴰ mutant) and HL60 (NRASQ⁶¹ᴸ mutant)—were cultured with simvastatin and cell viability was assessed usin ...
DOI:
10.1007/s11033-019-05019-8

6. Antitumor activity of methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide against leukemia cell lines via mitotic arrest and apoptotic pathways

Author:
Laura Sartori Assunção; Iara Fabrícia Kretzer; Jelver Alexander Sierra Restrepo; Leônidas João de Mello Junior; Adny Henrique Silva; Eliana de Medeiros Oliveira; Misael Ferreira; Marcus Mandolesi Sá; Tânia Beatriz Creczynski-Pasa
Source:
Biochimica et biophysica acta 2019 v.1863 no.9 pp. 1332-1342
ISSN:
0304-4165
Subject:
DNA damage; antineoplastic activity; apoptosis; autophagy; caspase-8; cell lines; cytotoxicity; endoplasmic reticulum; homeostasis; mechanism of action; membrane permeability; mitochondrial membrane; mitosis; neoplasm cells; pro-apoptotic proteins; salts
Abstract:
... In a previous study, we described a series of 28 aryl- and alkyl-substituted isothiouronium salts with antitumor activity and selectivity toward a leukemia cell line. Among the synthesized compounds, methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide (IS-MF08) showed conspicuous activity. In the present study, we investigated the mechanism of action of IS-MF08. Our results showed that it ...
DOI:
10.1016/j.bbagen.2019.05.018

7. Apoptosis and G2/M cell cycle arrest induced by a timosaponin A3 from Anemarrhena asphodeloides Bunge on AsPC-1 pancreatic cancer cells

Author:
Yumi Kim; Kang-Hoon Kim; In-Seung Lee; Ji Young Park; Yun-Cheol Na; Won-Seok Chung; Hyeung-Jin Jang
Source:
Phytomedicine 2019 v.56 pp. 48-56
ISSN:
0944-7113
Subject:
Anemarrhena asphodeloides; active ingredients; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell growth; cell lines; cell proliferation; chemical constituents of plants; cyclins; cytotoxicity; drug therapy; ethyl acetate; genes; humans; immunoblotting; liquid chromatography; mass spectrometry; mechanism of action; metastasis; mitogen-activated protein kinase; neoplasm cells; pancreatic neoplasms; protein content; reverse transcription; saponins; solvents; viability
Abstract:
... Timosaponin A3 (TA3), one of the active components of spirostanol saponin isolated from A. asphodeloides, is widely used as an anticancer agent in a variety of cancer cell lines. However, the research on the anticancer efficacy is very limited in human pancreatic cancer models.In this study, we investigated the molecular targets in the active components of A. asphodeloides, which showed anti-cance ...
DOI:
10.1016/j.phymed.2018.08.006

8. Assessment of the cytotoxicity, antioxidant activity and chemical composition of extracts from the cyanobacterium Fischerella major Gomont

Author:
Tsvetelina Batsalova; Diyana Basheva; Krum Bardarov; Ventzislav Bardarov; Balik Dzhambazov; Ivanka Teneva
Source:
Chemosphere 2019 v.218 pp. 93-103
ISSN:
0045-6535
Subject:
Fischerella; active ingredients; antibiotics; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; cell culture; cell lines; cytotoxicity; environmental assessment; environmental impact; exposure duration; hormones; human health; immunosuppressive agents; in vitro studies; insecticides; microcystins; photosynthesis; repellents; risk assessment; saxitoxins; vitamins
Abstract:
... Cyanoprokaryotes (Cyanobacteria/Cyanophyta) are ancient photosynthetic prokaryotic organisms with cosmopolitan distribution. They are producers of a number of biologically active substances with antitumor and antifungal activity, vitamins, antibiotics, algaecides, insecticides, repellents, hormones, immunosuppressants and toxins. So far, the cyanobacterium Fischerella major Gomont has not been stu ...
DOI:
10.1016/j.chemosphere.2018.11.097

9. Biological effects of whole Z.Officinale extract on chronic myeloid leukemia cell line K562

Author:
Pinar Mega Tiber; Sevgi Kocyigit Sevinc; Olca Kilinc; Oya Orun
Source:
Gene 2019 v.692 pp. 217-222
ISSN:
0378-1119
Subject:
Zingiber officinale; antineoplastic activity; apoptosis; cell lines; cell viability; cytotoxicity; ginger; membrane potential; mitochondrial membrane; mononuclear leukocytes; myeloid leukemia; neoplasm cells; patients; pro-apoptotic proteins; proteins; rhizomes; therapeutics
Abstract:
... The anticancer activity of Zingiber officinalis (ginger) is an area of active research. However, data is quite limited regarding its action and mechanism, especially in hematologic cancer types. Here, antiproliferative and apoptotic effects of whole extract of the rhizome of Zingiber officinalis (ZOWE), was investigated in K562 cell line derived from a chronic myeloid leukemia (CML) patient. Vario ...
DOI:
10.1016/j.gene.2019.01.015

10. Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells

Author:
Zhitao Gao; Chuan Tong; Yao Wang; Deyun Chen; Zhiqiang Wu; Weidong Han
Source:
Journal of genetics and genomics 2019 v.46 no.8 pp. 367-377
ISSN:
1673-8527
Subject:
T-lymphocytes; animal disease models; antibodies; antigens; antineoplastic activity; apoptosis; cell lines; clinical trials; cytotoxicity; disease control; disease progression; glycoproteins; humans; immunotherapy; interferon-gamma; interleukin-2; manufacturing; neoplasm cells; neoplasms; tumor necrosis factor-alpha
Abstract:
... Chimeric antigen receptor T-cell (CAR T) therapy is a kind of effective cancer immunotherapy. However, designing CARs remains a challenge because many targetable antigens are shared by T cells and tumor cells. This shared expression of antigens can cause CAR T cell fratricide. CD38-targeting approaches (e.g., daratumumab) have been used in clinical therapy and have shown promising results. CD38 is ...
DOI:
10.1016/j.jgg.2019.06.007

11. Brazilian red propolis extracts: study of chemical composition by ESI-MS/MS (ESI+) and cytotoxic profiles against colon cancer cell lines

Author:
Denis Amilton dos Santos; Fernanda Mosena Munari; Caroline Olivieri da Silva Frozza; Sidnei Moura; Thiago Barcellos; João Antonio Pêgas Henriques; Mariana Roesch-Ely
Source:
Biotechnology Research and Innovation 2019 v.3 no.1 pp. 120-130
ISSN:
2452-0721
Subject:
active ingredients; antineoplastic activity; cell lines; chromatography; colorectal neoplasms; cytotoxicity; formononetin; fractionation; honey bees; inhibitory concentration 50; neoplasm cells; propolis; staining; tandem mass spectrometry; viability assays
Abstract:
... Red propolis is a natural resin mixture produced by honeybees and presents a source of active compounds with a variety of biological activities. In this study, we describe the chemical characterization and potential antitumor activity of total extract of Brazilian red propolis and its fractions. Fractions were obtained through column chromatography revealing 14 different compounds in all samples, ...
DOI:
10.1016/j.biori.2019.02.001

12. C-prenylated flavonoids with potential cytotoxic activity against solid tumor cell lines

Author:
Lenka Molčanová; Dominika Janošíková; Stefano Dall´Acqua; Karel Šmejkal
Source:
Phytochemistry reviews 2019 v.18 no.4 pp. 1051-1100
ISSN:
1568-7767
Subject:
antineoplastic activity; antineoplastic agents; bioassays; cell culture; cell lines; chemoprevention; cytotoxicity; drug therapy; flavanones; flavonols; in vitro studies; isoflavonoids; neoplasm cells; neoplasms; oxygen; secondary metabolites
Abstract:
... Natural products of plant origin or their semisynthetic derivatives acting as chemopreventive or chemotherapeutic agents for various types of cancer are under study as potential new anticancer drugs. Within the huge class of plant phenolic secondary metabolites, the subclass of prenylated flavonoids is quite rich in structural variety and pharmacological activity. One of their most prominent chara ...
DOI:
10.1007/s11101-019-09641-z

13. Carboplatin prodrug conjugated Fe₃O₄ nanoparticles for magnetically targeted drug delivery in ovarian cancer cells

Author:
Haiqin SongThe two authors contributed equally to this work.; Feifei Quan; Zhiqiang Yu; Minhua Zheng; Yan Ma; Haihua Xiao; Fang Ding
Source:
Journal of materials chemistry B 2019 v.7 no.3 pp. 433-442
ISSN:
2050-7518
Subject:
adverse effects; animal ovaries; antineoplastic activity; cell lines; chemistry; cisplatin; cytotoxicity; drug resistance; endocytosis; in vivo studies; iron oxides; magnetic fields; nanocarriers; nanoparticles; neoplasm cells; ovarian neoplasms; platinum; toxicity testing; zeta potential
Abstract:
... Platinum (Pt)-based drugs including cisplatin, carboplatin and oxaliplatin have been widely used as first-line anticancer regimens due to their excellent anticancer efficacy. However, the clinical application of these drugs is greatly limited due to their side effects and drug resistance. In this study, an antitumor drug delivery system based on carboplatin prodrug loading Fe₃O₄ nanoparticles (NPs ...
DOI:
10.1039/c8tb02574f

14. Carvacrol/β-cyclodextrin inclusion complex inhibits cell proliferation and migration of prostate cancer cells

Author:
Gabriela G.G. Trindade; Greeshma Thrivikraman; Paula P. Menezes; Cristiane M. França; Bruno S. Lima; Yasmim M.B.G. Carvalho; Eloísa P.B.S.S. Souza; Marcelo C. Duarte; Saravanan Shanmugam; Lucindo J. Quintans-Júnior; Daniel P. Bezerra; Luiz E. Bertassoni; Adriano A.S. Araújo
Source:
Food and chemical toxicology 2019 v.125 pp. 198-209
ISSN:
0278-6915
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; antineoplastic activity; beta-cyclodextrin; bioavailability; carvacrol; cell culture; cell growth; cell lines; cell proliferation; cytotoxicity; dose response; freeze drying; high performance liquid chromatography; monoterpenoids; neoplasm cells; nuclear magnetic resonance spectroscopy; prostatic neoplasms; scanning electron microscopy; solubility; thermal analysis; thyme oil; toxicology
Abstract:
... Carvacrol, a phenolic monoterpene derived from thyme oil has gained wide interest recently because of its anticancer activities. To improve the solubility of carvacrol, the formation of inclusion complexes with β-cyclodextrin was performed by ultrasound and freeze-drying methods and characterized using thermal analysis, FTIR, XRD, SEM, NMR and HPLC analysis. From these results, carvacrol was succe ...
DOI:
10.1016/j.fct.2019.01.003

15. Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry)

Author:
Sen Guo; Li Liu; Shanshan Zhang; Chuang Yang; Wenping Yue; Haoan Zhao; Chi-Tang Ho; Junfeng Du; Hai Zhang; Naisheng Bai
Source:
Food & function 2019 v.10 no.10 pp. 6915-6926
ISSN:
2042-650X
Subject:
Morus australis; acetylcholinesterase; alpha-glucosidase; antineoplastic activity; apoptosis; cell lines; chromatography; cytotoxicity; enzyme inhibition; mitochondria; mulberries; phosphatidylinositol 3-kinase; polyphenols; roots; spectral analysis; China
Abstract:
... Morus species, commonly known as mulberry, is widely distributed in China. The mulberry tree is a high-value plant in agriculture. Morus australis is one of the major Morus species growing in Northern China. However, the biological properties of the main constituents of M. australis roots were not well studied. In the present study, through extensive chromatographic and spectral analysis, 12 pheno ...
DOI:
10.1039/c9fo01457h

16. Comparative assessment of Prunus spinosa L. flower extract in non-neoplastic hepatocytes and hepatoblastoma cells

Author:
T. Murati; M. Miletić; A. Štefanko; I. Landeka Jurčević; I. Elez Garofulić; V. Dragović-Uzelac; I. Kmetič
Source:
South African journal of botany 2019 v.123 pp. 36-42
ISSN:
0254-6299
Subject:
Prunus spinosa; antineoplastic activity; apoptosis; bioactive compounds; cell lines; cytotoxicity; flower extracts; flowers; hepatocytes; hepatoma; necrosis; neoplasm cells; viability
Abstract:
... Prunus spinosa L. (blackthorn) flower was most recently pointed out as a valuable source of bioactive compounds that have potent anticancer properties. To test for antineoplastic activity, hepatocarcinoma cells (Hepa 1–6) and corresponding non-neoplastic hepatocytes (AML 12) were subjected to Prunus spinosa L. blossom ethanolic extract (5–200 μg mL−1). Antiproliferative activity was determined by ...
DOI:
10.1016/j.sajb.2019.02.006

17. Could volatile compounds from leaves and fruits of Pistacia lentiscus constitute a novel source of anticancer, antioxidant, antiparasitic and antibacterial drugs?

Author:
Abdelhakim Bouyahya; Inès Christelle Chadon Assemian; Houda Mouzount; Ilhame Bourais; Abdeslam Et-Touys; Hajiba Fellah; Abdelaziz Benjouad; Nadia Dakka; Youssef Bakri
Source:
Industrial crops and products 2019 v.128 pp. 62-69
ISSN:
0926-6690
Subject:
2,2-diphenyl-1-picrylhydrazyl; Leishmania infantum; Leishmania major; Leishmania tropica; Pistacia lentiscus; Proteus mirabilis; Pseudomonas aeruginosa; adenocarcinoma; alpha-pinene; alternative medicine; antibacterial properties; antibiotics; antineoplastic activity; antioxidant activity; antioxidants; antiparasitic agents; antiparasitic properties; bioactive compounds; cell lines; cytotoxicity; essential oils; fruits; gas chromatography-mass spectrometry; inhibitory concentration 50; leaves; limonene; membrane permeability; myrcene; volatile compounds
Abstract:
... Essential oils possess remarkable biological properties, which constitute an important source for the development of bioactive compounds used in alternative medicine. This work aimed to determine the volatile compounds Pistacia lentiscus L. essential oils extracted from leaves and fruits and to evaluate their anticancer, antioxidant, antibacterial and antiparasitic activities. The gas chromatograp ...
DOI:
10.1016/j.indcrop.2018.11.001

18. Curcumin potentiates the antitumor activity of Paclitaxel in rat glioma C6 cells

Author:
Deborah Fratantonio; Maria Sofia Molonia; Romina Bashllari; Claudia Muscarà; Guido Ferlazzo; Gregorio Costa; Antonella Saija; Francesco Cimino; Antonio Speciale
Source:
Phytomedicine 2019 v.55 pp. 23-30
ISSN:
0944-7113
Subject:
adverse effects; antineoplastic activity; apoptosis; brain; brain neoplasms; caspase-3; cell cycle checkpoints; cell lines; curcumin; cytotoxicity; drug resistance; drug therapy; drugs; microtubules; paclitaxel; phosphorylation; pro-apoptotic proteins; rats; stabilizers; transcription factor NF-kappa B
Abstract:
... Glioma is the most common primary cancer in central nervous system, especially in brain. Paclitaxel (PTX) is a microtubule stabilizing agent with anticancer potential, but its clinical application to brain tumours is limited by drug resistance, side effects, and lower brain penetration.Herein we explored the in vitro effects, in glioma C6 cells, of the combination of PTX with curcumin, a natural c ...
DOI:
10.1016/j.phymed.2018.08.009

19. Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma

Author:
Federico Cocozza; Florencia Menay; Rodrigo Tsacalian; Analía Elisei; Pura Sampedro; Ivana Soria; Claudia Waldner; María José Gravisaco; Claudia Mongini
Source:
Vaccine 2019 v.37 no.12 pp. 1565-1576
ISSN:
0264-410X
Subject:
T-cell lymphoma; acidosis; antigens; antineoplastic activity; cancer vaccines; cell lines; cell-mediated immunity; cyclophosphamide; cytotoxicity; exosomes; hypoxia; immune response; immunization; immunogenicity; interferon-gamma; mice; neoplasm cells; proteins; secretion
Abstract:
... Exosomes are 60–150 nm small extracellular vesicles (EVs) released by most cells. Tumor-cell-derived exosomes, used as a vaccine, elicit a specific cytotoxic response against tumor cells, usually with a greater immunogenicity than tumor-cell lysates. However, the number of exosomes isolated from culture cells is limited. In recent studies, it was observed that cells respond to different stressor s ...
DOI:
10.1016/j.vaccine.2019.02.004

20. Cytotoxic and antimicrobial indole alkaloids from an endophytic fungus Chaetomium sp. SYP-F7950 of Panax notoginseng

Author:
Fei Peng; Shao-Yang Hou; Tian-Yuan Zhang; Ying-Ying Wu; Meng-Yue Zhang; Xi-Meng Yan; Ming-Yu Xia; Yi-Xuan Zhang
Source:
RSC advances 2019 v.9 no.49 pp. 28754-28763
ISSN:
2046-2069
Subject:
Bacillus subtilis; Candida albicans; Chaetomium; Enterococcus faecium; Panax notoginseng; Staphylococcus aureus; active sites; antibacterial properties; antifungal properties; antineoplastic activity; cell lines; circular dichroism spectroscopy; computer simulation; cytotoxicity; drug therapy; endophytes; fermented foods; fungi; indole alkaloids; inhibitory concentration 50; minimum inhibitory concentration; neoplasm cells; nuclear magnetic resonance spectroscopy; paclitaxel; phenotype; spectral analysis
Abstract:
... Two new compounds chetoseminudin F (1) and G (2) together with eleven known compounds were isolated from the solid fermentation products of the endophytic fungus Chaetomium sp. SYP-F7950. The structures of the isolated compounds were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HRFABMS experiments. The absolute configurations of chetoseminudin F (1) and G (2) were d ...
DOI:
10.1039/c9ra04747f

21. Cytotoxic and cell cycle arrest induction of pentacyclic triterpenoides separated from Lantana camara leaves against MCF-7 cell line in vitro

Author:
Zahraa R. Shamsee; Ali Z. Al-Saffar; Ahmed F. Al-Shanon; Jameel R. Al-Obaidi
Source:
Molecular biology reports 2019 v.46 no.1 pp. 381-390
ISSN:
0301-4851
Subject:
Lantana camara; active ingredients; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; caspase-9; cell cycle checkpoints; cell lines; cell viability; cytotoxicity; dose response; inhibitory concentration 50; interphase; leaves; liquid chromatography; medicinal plants; tandem mass spectrometry; triterpenoids
Abstract:
... Lantana camara is an important medicinal plant that contains many active compounds, including pentacyclic triterpenoids, with numerous biological activities. The present study was conducted to evaluate the anti-oxidant, anti-tumour, and cell cycle arrest properties of chemical compounds extracted from L. camara leaves. Four compounds were identified after subjecting the plant methanolic extract to ...
DOI:
10.1007/s11033-018-4482-3

22. Cytotoxic effect induced apoptosis in lung cancer cell line on Ageratina adenophora leaf extract

Author:
Suganya Mani; Karthik Natesan; Kavitha Shivaji; Mythili Gnanamangai Balasubramanian; Ponmurugan Ponnusamy
Source:
Biocatalysis and agricultural biotechnology 2019 v.22 pp. 101381
ISSN:
1878-8181
Subject:
Ageratina adenophora; antineoplastic activity; apoptosis; cell lines; cytotoxicity; drug therapy; drugs; inhibitory concentration 50; leaf extracts; lung neoplasms; neoplasm cells; propidium; staining
Abstract:
... Ageratina, adenophora, (A. adenophora) is a conventional prescription plant utilized for various purposes in around the world. However, its biological impacts and their potential components have not been adequately examined. The present investigation assessed the anticancerous properties of A. adenophora leaf extract. The methanolic extract inspired the most pronounced cytotoxic effect in lung can ...
DOI:
10.1016/j.bcab.2019.101381

23. DNA Binding and Molecular Dynamic Studies of Polycyclic Tetramate Macrolactams (PTM) with Potential Anticancer Activity Isolated from a Sponge-Associated Streptomyces zhaozhouensis subsp. mycale subsp. nov.

Author:
M. Dhaneesha; O. Hasin; K. C. Sivakumar; R. Ravinesh; C. Benjamin Naman; S. Carmeli; T. P. Sajeevan
Source:
Marine biotechnology 2019 v.21 no.1 pp. 124-137
ISSN:
1436-2228
Subject:
Mycale; Streptomyces; anticarcinogenic activity; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; coasts; computer simulation; culture media; cytotoxicity; ethyl acetate; flow cytometry; fractionation; interphase; lung neoplasms; mechanism of action; neoplasm cells; new subspecies; phylogeny; ribosomal DNA; ribosomal RNA; sequence homology; India; Indian Ocean
Abstract:
... A sponge-associated actinomycete (strain MCCB267) was isolated from a marine sponge Mycale sp. collected in the Indian Ocean off the Southeast coast of India. Phylogenetic studies of this strain using 16S rRNA gene sequencing showed high sequence similarity to Streptomyces zhaozhouensis. However, strain MCCB267 showed distinct physiological and biochemical characteristic features and was thus desi ...
DOI:
10.1007/s10126-018-9866-9

24. Dried leaf Artemisia annua efficacy against non-small cell lung cancer

Author:
Dina J. Rassias; Pamela J. Weathers
Source:
Phytomedicine 2019 v.52 pp. 247-253
ISSN:
0944-7113
Subject:
Artemisia annua; DNA damage; animal models; antineoplastic activity; apoptosis; artemisinin; cell lines; cell movement; cell viability; cytotoxicity; drugs; fibroblasts; growth retardation; histones; humans; leaves; lung neoplasms; malaria; mice; mitosis; patients; phosphorylation; prognosis; therapeutics
Abstract:
... Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer with poor prognosis. Artemisinin (AN), produced naturally in Artemisia annua L., has anti-cancer activity. Artemisinin delivered as dried leaf Artemisia (DLA) showed efficacy against malaria in rodents and humans.DLA is posited as being at least as efficacious as artesunate (AS) in its ability to induce cytotoxicity in NSCLC cell ...
DOI:
10.1016/j.phymed.2018.09.167

25. Effect of selected nonsteroidal anti-inflammatory drugs on the viability of canine osteosarcoma cells of the D-17 line: in vitro studies

Author:
Dominik Poradowski; Bożena Obmińska-Mrukowicz
Source:
Journal of Veterinary Research 2019 v.63 no.3 pp. 399-403
ISSN:
2450-8608
Subject:
antineoplastic activity; blood serum; cell lines; cytotoxicity; dogs; flunixin; in vitro studies; ketoprofen; median effective concentration; osteosarcoma; pain; toxicity testing; veterinary medicine; viability
Abstract:
... Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in veterinary medicine. They are used in pain control and in anti-inflammatory and antipyretic therapies. Some NSAIDs, e.g piroxicam, also have a documented anticancer effect. The objective of this study was to evaluate which of the commonly used NSAIDs (etodolac, flunixin, tolfenamic acid, carprofen, and ketoprofen) are cytotoxic to t ...
DOI:
10.2478/jvetres-2019-0051

26. Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties

Author:
Mandisa Mangisa; Vuyelwa J. Tembu; Gerda Fouche; Rudzani Nthambeleni; Xolani Peter; Moses K. Langat
Source:
Natural product research 2019 v.33 no.22 pp. 3240-3247
ISSN:
1478-6427
Subject:
Euphorbiaceae; antineoplastic activity; bark extracts; breasts; cell lines; circular dichroism spectroscopy; cytotoxicity; diterpenoids; fractionation; melanoma; neoplasm cells; spectral analysis
Abstract:
... The stem bark extract of Suregada zanzibariensis afforded a previously undescribed ent-abietane diterpenoid trivially named mangiolide (1) and a known jolkinolide B (2) via anticancer bioassay-guided fractionation. The CH₂Cl₂:MeOH extract of S. zanzibariensis was initially analysed for its anticancer properties against three cancer cell lines, renal (TK10), melanoma (UACC62), and breast (MCF7) and ...
DOI:
10.1080/14786419.2018.1470628

27. Euphorbia heterophylla (L.) mediated fabrication of ZnO NPs: Characterization and evaluation of antibacterial and anticancer properties

Author:
K. Lingaraju; H. Raja Naika; H. Nagabhushana; G. Nagaraju
Source:
Biocatalysis and agricultural biotechnology 2019 v.18 pp. 100894
ISSN:
1878-8181
Subject:
Escherichia coli; Euphorbia heterophylla; Fourier transform infrared spectroscopy; Gram-negative bacteria; Klebsiella aerogenes; Pseudomonas; Raman spectroscopy; Staphylococcus aureus; X-ray diffraction; antineoplastic activity; cell lines; cytotoxicity; energy; energy-dispersive X-ray analysis; fuels; green chemistry; hepatoma; leaf extracts; lungs; moieties; reducing agents; reflectance spectroscopy; scanning electron microscopy; transmission electron microscopy; zinc oxide
Abstract:
... Euphorbia heterophylla leaves extract mediated synthesis of multifunctional Zinc oxide nanoparticles (ZnO NPs) by green chemistry approaches. The prepared product was well characterized using various analytical tools namely X-ray diffraction (XRD), Ultra Violet-Diffused reflectance spectroscopy (UV-DRS), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, Scanning electron microsc ...
DOI:
10.1016/j.bcab.2018.10.011

28. Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans

Author:
Juana Maria Lugo; Carolina Tafalla; Ayme Oliva; Tirso Pons; Brizaida Oliva; Carolina Aquilino; Reynold Morales; Mario Pablo Estrada
Source:
Fish & shellfish immunology 2019 v.86 pp. 559-570
ISSN:
1050-4648
Subject:
Clarias gariepinus; Gram-positive bacteria; animal pathogenic bacteria; antimicrobial properties; antineoplastic activity; aquaculture; bacterial infections; catfish; cell lines; cytotoxicity; dose response; erythrocytes; fungi; genes; glucagon; humans; immune response; immune system; lung neoplasms; medicine; neoplasm cells; polypeptides; prediction; secretin; shellfish; therapeutics
Abstract:
... Pituitary adenylate cyclase-activating polypeptide (PACAP) is a regulatory neuropeptide that belongs to the secretin/glucagon superfamily, of which some members have shown antimicrobial activities. Contrasting to mammals, published studies on the action of PACAP in non-mammalian vertebrate immune system remain scarce. Some of our recent studies added this peptide to the growing list of mediators t ...
DOI:
10.1016/j.fsi.2018.11.056

29. Exploitation of apple pomace towards extraction of triterpenic acids, antioxidant potential, cytotoxic effects, and inhibition of clinically important enzymes

Author:
Shivraj Hariram Nile; Arti Nile; Junqiu Liu; Doo Hwan Kim; Guoyin Kai
Source:
Food and chemical toxicology 2019 v.131 pp. 110563
ISSN:
0278-6915
Subject:
allopurinol; antineoplastic activity; antioxidant activity; antioxidants; apple pomace; betulinic acid; cell lines; chloroform; cytotoxicity; ethanol; ethyl acetate; functional foods; hexane; inhibitory concentration 50; kojic acid; methanol; neoplasm cells; neoplasms; tandem mass spectrometry; thiourea; urease; ursolic acid; xanthine oxidase
Abstract:
... Apple pomace (AP) utilised for analysis of triterpenic acids (TTAs) using HPLC-MS/MS. The methanol, ethanol and ethyl acetate extracts showed high phenolic content with significant antioxidant activity compared to chloroform and n-hexane. AP TTAs; ursolic acid, betulinic acid and maslinic acid showed potent antioxidant and enzyme inhibitory effects. The IC50 values were 13.2–30.8 μg/mL (tyrosinase ...
DOI:
10.1016/j.fct.2019.110563

30. Exploring the Chemical Composition and Anticancer Potential of Oil from Squid (Loligo duvauceli) Liver Waste from Fish Processing Industry

Author:
Meivelu Moovendhan; P. Seedevi; S. Vairamani; A. Shanmugam
Source:
Waste and biomass valorization 2019 v.10 no.10 pp. 2967-2973
ISSN:
1877-2641
Subject:
Loligo; antineoplastic activity; carbohydrates; cell lines; cholesterol; cod liver oil; cytotoxicity; essential amino acids; fat soluble vitamins; fatty acids; fish processing; humans; industry; lipid composition; liver; lung neoplasms; minerals; neoplasm cells; nutrition; protein content; squid; wastes; water content
Abstract:
... The present study was aimed to evaluate the nutritional fact and anticancer effect of liver oil extracted from the squid Loligo duvauceli. The ash and moisture content was noted as 3.21 and 2.13% whereas the total protein, lipid and carbohydrate, recorded 23.44, 21.23 and 2.13% respectively. The water and fat soluble vitamins and minerals were found in good level. The lipid profile was noted simil ...
DOI:
10.1007/s12649-018-0304-z

31. Fabrication of chitosan-bis (4-formyl-2 methoxy phenyl carbonate) Schiff base nanoparticles and evaluation of their antioxidant and anticancer properties

Author:
P. Thyriyalakshmi; K. V. Radha
Source:
Molecular biology reports 2019 v.46 no.4 pp. 4333-4347
ISSN:
0301-4851
Subject:
X-ray diffraction; antineoplastic activity; antioxidants; carbon; carbonates; cell lines; chitosan; crosslinking; cytotoxicity; dose response; drugs; hydrolysis; moieties; nanoparticles; neoplasms; nuclear magnetic resonance spectroscopy; schiff bases; stable isotopes; therapeutics; thermal stability; thermogravimetry; transmission electron microscopy; vanillin
Abstract:
... The present study details on the mechanism of synthesis of bis (4-formyl-2 methoxy phenyl carbonate), using two green reagents dimethyl carbonate and vanillin for application as therapeutic agent. The synthesized FMPC was identified from the ¹³C nuclear magnetic resonance spectra. The novel modified Schiff base nanoparticles resulted from the crosslinking of FMPC with chitosan were confirmed by cr ...
DOI:
10.1007/s11033-019-04887-4

32. Formulation and evaluation of cyclodextrin complexes for improved anticancer activity of repurposed drug: Niclosamide

Author:
Anurag Lodagekar; Roshan M. Borkar; Sowjanya Thatikonda; Rahul B. Chavan; V.G.M. Naidu; Nalini R. Shastri; R. Srinivas; Naveen Chella
Source:
Carbohydrate polymers 2019 v.212 pp. 252-259
ISSN:
0144-8617
Subject:
Fourier transform infrared spectroscopy; antineoplastic activity; bioavailability; biopharmaceuticals; bricks; cell lines; cyclodextrins; cytotoxicity; freeze drying; geometry; males; mice; molecular models; neoplasm cells; niclosamide; pharmacokinetics; solubility
Abstract:
... Niclosamide, previously used as an anthelmintic drug is currently being repurposed for its anticancer activity. Niclosamide is a brick like biopharmaceutical classification system (BCS) class II drug with poor aqueous solubility and dissolution consequently leading to low bioavailability. By considering the physicochemical properties and geometry of niclosamide, inclusion complex with cyclodextrin ...
DOI:
10.1016/j.carbpol.2019.02.041

33. Fungal-mediated synthesis of pharmaceutically active silver nanoparticles and anticancer property against A549 cells through apoptosis

Author:
Tahira Akther; Vabeiryureilai Mathipi; Nachimuthu Senthil Kumar; MubarakAli Davoodbasha; Hemalatha Srinivasan
Source:
Environmental science and pollution research international 2019 v.26 no.13 pp. 13649-13657
ISSN:
0944-1344
Subject:
Botryosphaeria rhodina; Catharanthus roseus; DNA fragmentation; antineoplastic activity; apoptosis; cell lines; cytotoxicity; endophytes; energy-dispersive X-ray analysis; fungi; inhibitory concentration 50; internal transcribed spacers; lungs; medicinal plants; metal ions; nanoparticles; nanosilver; neoplasm cells; neoplasms; scanning electron microscopy; secondary metabolites; spectrophotometers; transmission electron microscopy
Abstract:
... Generally, fungi have the ability to secrete large amounts of secondary metabolites which have the ability to reduce metal ions to metallic nanoparticles. In this report, silver nanoparticles (AgNPs) were synthesized by using an endophytic fungus isolated from the medicinal plant, Catharanthus roseus (Linn.). The endophytic fungus was identified as Botryosphaeria rhodina based on the ITS sequencin ...
DOI:
10.1007/s11356-019-04718-w

34. Gemcitabine anticancer activity enhancement by water soluble celecoxib/sulfobutyl ether-β-cyclodextrin inclusion complex

Author:
Antonio Rescifina; Emanuela Surdo; Venera Cardile; Rosanna Avola; Adriana Carol Eleonora Graziano; Rosanna Stancanelli; Silvana Tommasini; Venerando Pistarà; Cinzia Anna Ventura
Source:
Carbohydrate polymers 2019 v.206 pp. 792-800
ISSN:
0144-8617
Subject:
antineoplastic activity; aromatic compounds; cell lines; cell viability; cytotoxicity; drugs; hydrogen bonding; lungs; nuclear magnetic resonance spectroscopy; therapeutics; water solubility
Abstract:
... We investigated the complexation of celecoxib (CCB) into sulfobuthyl-ether-β-cyclodextrin (SBE-β-CD) for the realization of an inhalable dry-powder formulation containing gemcitabine (GEM) for lung anticancer therapy. Complexation increased the water solubility of CCB (0.003 mg/mL and 0.834 mg/mL for CCB free and complexed, respectively) and produced a quantitative dissolution of the drug within 1 ...
DOI:
10.1016/j.carbpol.2018.11.060

35. Green synthesis of zinc oxide nanoparticles and evaluation of anti-angiogenesis, anti-inflammatory and cytotoxicity properties

Author:
Ghasem Rahimi Kalateh Shah Mohammad; Masoud Homayouni Tabrizi; Touran Ardalan; Soheyla Yadamani; Elham Safavi
Source:
Journal of biosciences 2019 v.44 no.2 pp. 30
ISSN:
0250-5991
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; angiogenesis; anti-inflammatory activity; antineoplastic activity; blood vessels; breast neoplasms; carrageenan; cell lines; chorioallantoic membrane; cytotoxicity; edema; genes; inflammation; interleukin-10; mice; nanoparticles; neoplasm cells; scanning electron microscopy; transmission electron microscopy; vascular endothelial growth factors; zinc oxide
Abstract:
... In this study, zinc oxide nanoparticles (ZnO-NPs) were synthesized using the extract of Hyssops officinalis L. via green method and confirmed by transmission electron microscopy, field emission scanning electron microscopy, X-ray powder diffraction and Fourier transforms infrared spectroscopy techniques. In the in vivo section, the anti-angiogenesis and anti-inflammatory properties of the NPs were ...
DOI:
10.1007/s12038-019-9845-y

36. In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)

Author:
Ana Carolina B. da C. Rodrigues; Felipe P. de Oliveira; Rosane B. Dias; Caroline B.S. Sales; Clarissa A.G. Rocha; Milena B.P. Soares; Emmanoel V. Costa; Felipe M.A. da Silva; Waldireny C. Rocha; Hector H.F. Koolen; Daniel P. Bezerra
Source:
Journal of ethnopharmacology 2019 v.231 pp. 516-524
ISSN:
0378-8741
Subject:
Salacia; analgesic effect; analgesics; anti-inflammatory activity; antineoplastic activity; antiviral properties; bark; cell lines; cytotoxicity; dengue; diabetes; ethyl acetate; herbal medicines; humans; inflammation; influenza; leukemia; medicinal plants; mice; models; neoplasm cells; pain; rheumatoid arthritis; severe combined immunodeficiency; traditional medicine; triterpenoids; Amazonia
Abstract:
... Salacia impressifolia (Miers) A. C. Smith (family Celastraceae) is a traditional medicinal plant found in the Amazon Rainforest known as “miraruíra”, "cipó-miraruíra" or “panu” and is traditionally used to treat dengue, flu, inflammation, pain, diabetes, male impotency, renal affections, rheumatism and cancer. Aim of the study: The aim of this study was to investigate in vitro and in vivo anti-leu ...
DOI:
10.1016/j.jep.2018.11.008

37. In vitro and in vivo evaluation of a novel mitomycin nanomicelle delivery system

Author:
Hongmei Yang; Miao Wang; Yihe Huang; Qiaoyu Qiao; Chunjie Zhao; Min Zhao
Source:
RSC advances 2019 v.9 no.26 pp. 14708-14717
ISSN:
2046-2069
Subject:
Streptomyces caespitosus; adverse effects; antibiotics; antineoplastic activity; blood circulation; cell lines; cytotoxicity; dialysis; drug therapy; hydrophobicity; ibuprofen; in vivo studies; micelles; mitomycin; nanocarriers; neoplasm cells; neoplasms; particle size; pharmacokinetics; tissue distribution; tissues
Abstract:
... Mitomycin C (MMC), naturally synthesized by Streptomyces caespitosus, is a potent antineoplastic antibiotic for the treatment of various solid tumors. However, the defects of conventional MMC injections have greatly limited its clinical application due to its toxic side effects and non-specific interactions. To solve this problem, the PEG₂ₖ-Fmoc-Ibuprofen (PEG-FIbu) micellar nanocarrier was synthe ...
DOI:
10.1039/c9ra02660f

38. Induction of apoptosis by chalepin through phosphatidylserine externalisations and DNA fragmentation in breast cancer cells (MCF7)

Author:
Musa Isah Fakai; Sri Nurestri Abd Malek; Saiful Anuar Karsani
Source:
Life sciences 2019 v.220 pp. 186-193
ISSN:
0024-3205
Subject:
DNA fragmentation; Ruta; antineoplastic activity; antineoplastic agents; apoptosis; breast neoplasms; caspase-3; caspase-8; cell lines; chromatin; cytotoxicity; flow cytometry; fluorescence microscopes; neoplasm cells; phosphatidylserines; screening; staining
Abstract:
... Chalepin, a naturally occurring compound isolated from Ruta angustifolia have been shown to exert a promising anticancer activity through various mechanisms. Hence, the need to investigate the apoptotic inducing ability of chalepin in MCF7 cells by various detection assays.Cytotoxicity screening of chalepin against MCF7 cells was conducted using SRB assay. Apoptosis induction was examined by estab ...
DOI:
10.1016/j.lfs.2019.01.029

39. Investigation into perturbed nucleoside metabolism and cell cycle for elucidating the cytotoxicity effect of resveratrol on human lung adenocarcinoma epithelial cells

Author:
Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
Source:
Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
ISSN:
1875-5364
Subject:
DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
Abstract:
... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
DOI:
10.1016/S1875-5364(19)30063-9

40. Liquisolid system of paclitaxel using modified polysaccharides: In vitro cytotoxicity, apoptosis study, cell cycle analysis, in vitro mitochondrial membrane potential assessment, and pharmacokinetics

Author:
Vijay Sharma; Kamla Pathak
Source:
International journal of biological macromolecules 2019 v.137 pp. 20-31
ISSN:
0141-8130
Subject:
absorption; antineoplastic activity; apoptosis; bioavailability; biodegradability; cell cycle; cell lines; coatings; cytotoxicity; drying; fluorouracil; guar gum; humans; inhibitory concentration 50; liquids; locust bean gum; mannitol; membrane potential; mitochondrial membrane; neoplasms; oral administration; paclitaxel; particle size distribution; permeability; pharmacokinetics; seeds; solvents; tamarinds
Abstract:
... The research was aimed to develop a liquisolid formulation of paclitaxel using novel, highly porous liquisolid carriers (modified polysaccharides) to enhance bioavailability of orally administered paclitaxel. Modified polysaccharides namely co-grinded treated guar gum (C-TGG), co-grinded treated tamarind kernel powder (C-TTKP) and co-grinded treated locust bean gum (C-TLBG) were developed by seque ...
DOI:
10.1016/j.ijbiomac.2019.06.188

41. Mechanisms of action of cytotoxic phenolic compounds from Glycyrrhiza iconica roots

Author:
Dicle Çevik; Yüksel Kan; Hasan Kırmızıbekmez
Source:
Phytomedicine 2019 v.58 pp. 152872
ISSN:
0944-7113
Subject:
Glycyrrhiza; Western blotting; active ingredients; anticarcinogenic activity; antineoplastic activity; antineoplastic agents; apoptosis; breast neoplasms; caspases; cell cycle; cell lines; chemical structure; chloroform; chromatography; colorectal neoplasms; cytotoxicity; ethyl acetate; flow cytometry; fractionation; hepatoma; indigenous species; inhibitory concentration 50; licorice; mechanism of action; methanol; neoplasm cells; nuclear magnetic resonance spectroscopy; phenolic compounds; roots; secondary metabolites; staining
Abstract:
... Glycyrrhiza (licorice) species are rich in bioactive secondary metabolites and their roots are used traditionally for the treatment of several diseases. In recent years, secondary metabolites of licorice are gaining popularity, especially due to their significant cytotoxic and antitumor effects. However, Glycyrrhiza iconica, an endemic species to Turkey, was not investigated in terms of its antica ...
DOI:
10.1016/j.phymed.2019.152872

42. Mechanistic and therapeutic study of novel anti-tumor function of natural compound imperialine for treating non-small cell lung cancer

Author:
Qing Lin; Mengke Qu; Hirak K. Patra; Shanshan He; Luyao Wang; Xun Hu; Linyu Xiao; Yu Fu; Tao Gong; Qin He; Ling Zhang; Xun Sun; Zhirong Zhang
Source:
Journal of ethnopharmacology 2019 pp. -
ISSN:
0378-8741
Subject:
Fritillaria cirrhosa; Oriental traditional medicine; Western blotting; active ingredients; adverse effects; animal models; antineoplastic activity; antineoplastic agents; blood cell counts; cancer therapy; case studies; cell lines; cytotoxicity; drug delivery systems; enzyme-linked immunosorbent assay; films (materials); herbal medicines; histopathology; immunohistochemistry; in vivo studies; inflammation; lung neoplasms; mice; transcription factor NF-kappa B
Abstract:
... Bulbus Fritillaria cirrhosa D. Don (BFC) is a Chinese traditional herbal medicine that has long been used as an indispensable component in herbal prescriptions for bronchopulmonary diseases due to its well-established strong anti-inflammation and pulmonary harmonizing effects. Interestingly, there are few case reports in traditional Chinese medicine available where they found it to contribute in a ...
DOI:
10.1016/j.jep.2019.112283

43. Metabolic profiling and investigations on crude extract of Olea europaea L. leaves as a potential therapeutic agent against skin cancer

Author:
Debabrata Majumder; Mousumi Debnath; K.V. Libin Kumar; Priyatosh Nath; Rahul Debnath; Chaitali Sarkar; G.B.K.S. Prasad; Yogesh Kumar Verma; Debasish Maiti
Source:
Journal of functional foods 2019 pp. -
ISSN:
1756-4646
Subject:
2,2-diphenyl-1-picrylhydrazyl; Olea europaea; antineoplastic activity; antioxidant activity; apigenin; apoptosis; bioactive compounds; cell lines; cytotoxicity; leaf extracts; liquid chromatography; luteolin; melanoma; metabolites; metabolomics; metastasis; mice; mitogen-activated protein kinase; myeloma; oleuropein; olives; skin neoplasms; tandem mass spectrometry; therapeutics
Abstract:
... Olive (OleaeuropaeaL.) leaf extract (OLE) have shown therapeutic activity against different types of cancer. However, it is less known that olive leaf extract has anti myeloma activity. The in vitro cytotoxic activity of OLE was evaluated against mouse metastatic melanoma B16F10 cell lines. The extracts were analyzed for their antioxidant activity by DPPH radical scavenging activity and the presen ...
DOI:
10.1016/j.jff.2019.05.005

44. Multifunctional CuO nanoparticles with cytotoxic effects on KYSE30 esophageal cancer cells, antimicrobial and heavy metal sensing activities

Author:
Zahra Nakhaeepour; Mansour Mashreghi; Maryam M. Matin; Ali NakhaeiPour; Mohammad Reza Housaindokht
Source:
Life sciences 2019 v.234 pp. 116758
ISSN:
0024-3205
Subject:
Fourier transform infrared spectroscopy; Vibrio; X-ray diffraction; agar; antibacterial properties; antineoplastic activity; bacterial growth; cadmium; cell lines; cell viability; copper sulfate; crystallites; cupric oxide; cytotoxicity; esophageal neoplasms; fibroblasts; fluorescence; fluorescent lighting; heavy metals; humans; inhibitory concentration 50; ions; lead; mercury; minimum inhibitory concentration; mutants; nanoparticles; neoplasm cells; nitrates; transmission electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... In this work, fluorescent copper oxide nanoparticles (CuO NPs) were green synthesized using viable cells, cell lysate supernatant (CLS) and protein extracts of luminescent Vibrio sp. VLC. Biogenic CuO NPs were then characterized by XRD, FTIR, UV/Vis spectroscopy, TEM, DLS, and PL spectroscopy. Results showed that CLS method was more efficient for CuO NPs production, therefore CuO NPs synthesized b ...
DOI:
10.1016/j.lfs.2019.116758

45. Novel camphor-based pyrimidine derivatives induced cancer cell death through a ROS-mediated mitochondrial apoptosis pathway

Author:
Yan Zhang; Yunyun Wang; Yuxun Zhao; Wen Gu; Yongqiang Zhu; Shifa Wang
Source:
RSC advances 2019 v.9 no.51 pp. 29711-29720
ISSN:
2046-2069
Subject:
X-ray diffraction; antineoplastic activity; apoptosis; caspase-3; cell lines; cytochrome c; cytotoxicity; dose response; etoposide; humans; inhibitory concentration 50; interphase; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; neoplasms; pro-apoptotic proteins
Abstract:
... A series of novel camphor-based pyrimidine derivatives (3a–3x) have been synthesized; their structures were determined by using conventional methods and compound 3f was further confirmed through single crystal XRD analysis. The cytotoxic activity of the target compounds against a panel of human normal (GES-1) and cancer cell lines (MDA-MB-231, RPMI-8226, A549) was evaluated by MTS assay. Here we f ...
DOI:
10.1039/c9ra05900h

46. Novel design of NIR-triggered plasmonic nanodots capped mesoporous silica nanoparticles loaded with natural capsaicin to inhibition of metastasis of human papillary thyroid carcinoma B-CPAP cells in thyroid cancer chemo-photothermal therapy

Author:
Tianyu Yu; Lingling Tong; Yu Ao; Genmao Zhang; Yunpeng Liu; Hejia Zhang
Source:
Journal of photochemistry and photobiology 2019 v.197 pp. 111534
ISSN:
1011-1344
Subject:
Fourier transform infrared spectroscopy; X-ray photoelectron spectroscopy; anisotropy; antineoplastic activity; apoptosis; capsaicin; carcinoma; cell lines; chemical bonding; cytotoxicity; gold; humans; light scattering; medicine; metastasis; nanogold; nanoparticles; neoplasm cells; photochemotherapy; photothermotherapy; porous media; scanning electron microscopy; silica; spectral analysis; tetrazolium; thyroid neoplasms; transmission electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... In the search for developing a biomedicine based nanomaterial for therapeutic applications, here we described a new benign development of Photo-triggered Gold nanodots capped mesoporous silica nanoparticles Au@MSNs loaded with capsaicin (Cap) for photothermal therapy of cancer cells. Electron microscopic techniques (SEM and TEM) studies depict the anisotropic shape of Cap-Au@MSNs with mean size ≈1 ...
DOI:
10.1016/j.jphotobiol.2019.111534

47. Poly (ethyl 2-cyanoacrylate) nanoparticles (PECA-NPs) as possible agents in tumor treatment

Author:
Antonella Obinu; Giovanna Rassu; Paola Corona; Marcello Maestri; Federica Riva; Dalila Miele; Paolo Giunchedi; Elisabetta Gavini
Source:
Colloids and surfaces 2019 v.177 pp. 520-528
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; adverse effects; antineoplastic activity; antineoplastic agents; cell lines; cytotoxicity; emulsions; epithelium; hepatoma; humans; kidneys; models; nanoparticles; neoplasm cells; nuclear magnetic resonance spectroscopy; particle size; polymerization; toxicity testing; transmission electron microscopy; zeta potential
Abstract:
... Tumor eradication has many challenges due to the difficulty of selectively delivering anticancer drugs to malignant cells avoiding contact with healthy tissues/organs. The improvement of antitumor efficacy and the reduction of systemic side effects can be achieved using drug loaded nanoparticles. In this study, poly (ethyl 2-cyanoacrylate) nanoparticles (PECA-NPs) were prepared using an emulsion p ...
DOI:
10.1016/j.colsurfb.2019.02.036

48. Reactive oxygen species mediate the chemopreventive effects of syringin in breast cancer cells

Author:
Chien-Hsing Lee; Chiung-Wei Huang; Po-Chih Chang; Jun-Ping Shiau; In-Pin Lin; Mei-Ying Lin; Chih-Cheng Lai; Chung-Yi Chen
Source:
Phytomedicine 2019 v.61 pp. 152844
ISSN:
0944-7113
Subject:
Eleutherococcus senticosus; NAD ADP-ribosyltransferase; antineoplastic activity; apoptosis; body weight changes; breast neoplasms; cell cycle checkpoints; cell lines; chemoprevention; cytotoxicity; enzyme inhibitors; flow cytometry; glycosides; metastasis; models; neoplasm cells; oxidative stress; proteins; reactive oxygen species; therapeutics
Abstract:
... Syringin (Syr), a phenylpropanoid glycoside extracted from Eleutherococcus senticosus, possesses various biological properties, including anticancer activities. However, the cytotoxicity effects of Syr on breast cancer have not yet been elucidated.In this study, we evaluated the anticancer potential of Syr on breast carcinoma and the mechanism involved.Non-tumorigenic (M10), tumorigenic (MCF7) and ...
DOI:
10.1016/j.phymed.2019.152844

49. Screening for selective anticancer activity of plants from Grazalema Natural Park, Spain

Author:
José Manuel Calderón-Montaño; Sara María Martínez-Sánchez; Estefanía Burgos-Morón; Emilio Guillén-Mancina; Julio José Jiménez-Alonso; Felipe García; Abelardo Aparicio; Miguel López-Lázaro
Source:
Natural product research 2019 v.33 no.23 pp. 3454-3458
ISSN:
1478-6427
Subject:
Daphne laureola; antineoplastic activity; cell lines; cisplatin; cytotoxicity; diterpenoids; indigenous species; inhibitory concentration 50; leaves; lung neoplasms; lungs; neoplasm cells; ortho esters; screening; species diversity; tissues; Spain
Abstract:
... Since plants are an important source of anticancer drugs, we have carried out a random screening for selective anticancer activity of 57 extracts from 45 plants collected in Grazalema Natural Park, an area in the South of Spain of high plant diversity and endemism. Using lung cancer cells (A549) and lung non-malignant cells (MRC-5), we found that several extracts were more cytotoxic and selective ...
DOI:
10.1080/14786419.2018.1480620

50. Seasonal Variation of Phyto-Constituents of Tea Leaves Affects Antiproliferative Potential

Author:
Sayantan Maitra; Arnab De; Bhaskar Das; Sudipendra Nath Roy; Ranadhir Chakraborty; Amalesh Samanta; Subhrajit Bhattacharya
Source:
Journal of the American College of Nutrition 2019 v.38 no.5 pp. 415-423
ISSN:
1541-1087
Subject:
Camellia sinensis; adults; albino; alternative medicine; antineoplastic activity; antioxidants; ascites; autumn; beverages; carcinoma; cell lines; chemical constituents of plants; cytotoxicity; dose response; females; gas chromatography-mass spectrometry; laboratory animals; leaves; mice; seasonal variation; tea; toxicity testing; wet season
Abstract:
... Objective: Tea (Camellia sinensis Linn.; family: Theaceae) is popular as a stimulant beverage across the globe and is also utilized as a functional antioxidant in alternative medicine. This study has evaluated the impact of seasonal variation on phyto-constituents of tea. Method: The antiproliferative potential of methanolic extracts of tea leaves collected in the rainy season (MECR) was compared ...
DOI:
10.1080/07315724.2018.1538829

51. Secretory Expression of a Chimeric Peptide in Lactococcus lactis: Assessment of its Cytotoxic Activity and a Deep View on Its Interaction with Cell-Surface Glycosaminoglycans by Molecular Modeling

Author:
Abbas Tanhaeian; Mahmoud Reza Jaafari; Farajollah Shahriari Ahmadi; Roghayyeh Vakili‐Ghartavol; Mohammad Hadi Sekhavati
Source:
Probiotics and antimicrobial proteins 2019 v.11 no.3 pp. 1034-1041
ISSN:
1867-1306
Subject:
Lactococcus lactis; adverse effects; agarose; amino acid composition; amino acids; antimicrobial peptides; antineoplastic activity; antineoplastic agents; breast neoplasms; camels; cell lines; chondroitin sulfate; colorectal neoplasms; computer simulation; culture media; cytotoxicity; death; heparan sulfate; hepatoma; hydrogen bonding; lactoferrin; mechanism of action; molecular models; neoplasm cells; recombinant peptides; screening; therapeutics
Abstract:
... Nowadays, cancer remains a major cause of death affecting millions of people. Currently, the antimicrobial peptides (AMPs) as potent anticancer therapeutic agents offer specificity and low levels of side effects in cancer therapy. In the present study, a cationic chimeric peptide (cLFchimera), derived from camel lactoferrin, was expressed as a secretory peptide using P170 expression system in L. l ...
DOI:
10.1007/s12602-018-9496-6

52. Self-Assembled and Self-Monitored Sorafenib/Indocyanine Green Nanodrug with Synergistic Antitumor Activity Mediated by Hyperthermia and Reactive Oxygen Species-Induced Apoptosis

Author:
Haiqiu Wu; Cun Wang; Jiaxin Sun; Luyan Sun; Jiaxun Wan; Siying Wang; Dishui Gu; Chengtao Yu; Chen Yang; Jia He; Zihao Zhang; Yuanyuan Lv; Hui Wang; Ming Yao; Wenxin Qin; Changchun Wang; Haojie Jin
Source:
ACS applied materials & interfaces 2019 v.11 no.47 pp. 43996-44006
ISSN:
1944-8252
Subject:
adverse effects; antineoplastic activity; apoptosis; blood; cell lines; cytotoxicity; fever; half life; hepatoma; image analysis; in vitro studies; irradiation; models; morbidity; mortality; nanoparticles; near-infrared spectroscopy; oxygen; patients; permeability; reactive oxygen species; regrowth; therapeutics; China
Abstract:
... Liver cancer is a leading cause of cancer morbidity and mortality worldwide, especially in China. Sorafenib (SRF) is currently the most commonly used systemic agent against advanced hepatocellular carcinoma (HCC), which is the most common type of liver cancer. However, HCC patients have only limited benefit and suffer a serious side effect from SRF. Therefore, new approaches are urgently needed to ...
DOI:
10.1021/acsami.9b18086

53. Small molecule inhibitor of c-Myc 10058-F4 inhibits proliferation and induces apoptosis in acute leukemia cells, irrespective of PTEN status

Author:
Davood Bashash; Mohamad Sayyadi; Ava Safaroghli-Azar; Negar Sheikh-Zeineddini; Niknam Riyahi; Majid Momeny
Source:
international journal of biochemistry & cell biology 2019 v.108 pp. 7-16
ISSN:
1357-2725
Subject:
antineoplastic activity; apoptosis; arsenic oxide; cell lines; cytotoxicity; lymphocytic leukemia; neoplasm cells; phosphatidylinositol 3-kinase; vincristine
Abstract:
... Based on the frequent over-expression of c-Myc in hematologic malignancies and its crucial role in the regulation of diverse oncogenic pathways involved in leukomogenesis, intense interest has recently focused on this factor as an appealing therapeutically target in leukemia. In the present study, we aimed to investigate the anti-leukemic property of small molecule inhibitor of c-Myc 10058-F4 in t ...
DOI:
10.1016/j.biocel.2019.01.005

54. Solvent-driven structural topology involving energetically significant intra- and intermolecular chelate ring contacts and anticancer activities of Cu(ii) phenanthroline complexes involving benzoates: experimental and theoretical studies

Author:
Manjit K. Bhattacharyya; Utpal Saha; Debajit Dutta; Amal Das; Akalesh K. Verma; Antonio Frontera
Source:
RSC advances 2019 v.9 no.29 pp. 16339-16356
ISSN:
2046-2069
Subject:
Rhizobium leguminosarum; X-ray diffraction; active sites; antibacterial properties; antineoplastic activity; apoptosis; benzoates; cell lines; cell viability; chromatin; cytotoxicity; divalent metals; methanol; neoplasm cells; neoplasms; nitrates; nitrogen; oxygen; solvents; spectroscopy; thermogravimetry; topology
Abstract:
... Two new coordination solids [Cu₂(μ²-Bz)₄(CH₃OH)₂][Cu₂(η²-Bz)₂(phen)₂(H₂O)₂]·(NO₃)₂ (1) and [Cu(phen)(H₂O)(Bz)(η²-Bz)] (2) (phen = 1,10-phenanthroline; Bz = benzoate) have been synthesized and characterized using elemental analysis, TGA, spectroscopic (IR, UV-vis-NIR and ESR) and single crystal X-ray diffraction techniques. Change of the solvent from methanol to DMF results in changes in the archit ...
DOI:
10.1039/c9ra01181a

55. Spruce and beech bark aqueous extracts: source of polyphenols, tannins and antioxidants correlated to in vitro antitumor potential on two different cell lines

Author:
Sanda-Liliana Coșarcă; Elena-Alina Moacă; Corneliu Tanase; Daniela Lucia Muntean; Ioana Zinuca Pavel; Cristina Adriana Dehelean
Source:
Wood science and technology 2019 v.53 no.2 pp. 313-333
ISSN:
0043-7719
Subject:
2,2-diphenyl-1-picrylhydrazyl; Fagus sylvatica; Picea abies; antineoplastic activity; antioxidant activity; antioxidants; bark; cell lines; cell proliferation; cytotoxicity; dose response; humans; keratinocytes; lung neoplasms; melanoma; metastasis; neoplasm cells; plant extracts; polyphenols; tannins; ultrasonic treatment
Abstract:
... The purpose of the present study was to determine the antioxidant capacity, the total phenol content, tannins, the cytotoxic and antiproliferative activity of some aqueous extracts obtained from spruce bark (Picea abies L.) and beech bark (Fagus sylvatica L.). In this regard, two types of extracts were obtained from both species using different methods of extraction: classical water bath extractio ...
DOI:
10.1007/s00226-018-1071-5

56. Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potential antiproliferative agents for castration-resistant prostate cancer

Author:
Huiqing Chen; Yajing Xing; Jia Xie; Jiuqing Xie; Dong Xing; Jie Tang; Fan Yang; Zhengfang Yi; Wen-Wei Qiu
Source:
RSC advances 2019 v.9 no.58 pp. 33794-33799
ISSN:
2046-2069
Subject:
antineoplastic activity; apoptosis; biological assessment; cell cycle; cell lines; cisplatin; cytotoxicity; fibroblasts; humans; neoplasm cells; prostatic neoplasms; tissue repair
Abstract:
... A series of novel 3-nitro-4-chromanones were synthesized and their in vitro cytotoxicity was evaluated on castration-resistant prostate cancer cell (CRPC) lines using the sulforhodamine B (SRB) assay. The amide derivatives showed more potent antitumor activity than their corresponding ester derivatives. Most of the tested compounds showed less toxicity towards human fibroblasts (HAF) compared with ...
DOI:
10.1039/c9ra06420f

57. Synthesis and biological evaluation of C-13, C-14 modified taxane analogues from 1-deoxybaccatin VI

Author:
Ping Tang; Hai-Xia Lin; Tian-Hai Yuan; Yong-Mei Cui
Source:
Natural product research 2019 v.33 no.24 pp. 3478-3484
ISSN:
1478-6427
Subject:
antineoplastic activity; biological assessment; cell lines; cytotoxicity; taxanes
Abstract:
... Four C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group on C-14 could improve the cytotoxic activities. ...
DOI:
10.1080/14786419.2018.1484459

58. Synthesis of novel 10,11-methylenedioxy-camptothecin glycoside derivatives and investigation of their anti-tumor effects in vivo

Author:
Guanzhao Wu; Xiaoyuan Mai; Feng Liu; Mingming Lin; Xueyang Dong; Qingliang Xu; Cui Hao; Lijuan Zhang; Rilei Yu; Tao Jiang
Source:
RSC advances 2019 v.9 no.20 pp. 11142-11150
ISSN:
2046-2069
Subject:
Western blotting; animal models; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; cytotoxicity; esters; glycosides; humans; inhibitory concentration 50; ligands; mice; neoplasm cells; pro-apoptotic proteins; prostatic neoplasms
Abstract:
... 10,11-Methylenedioxy-camptothecin (FL118) is a novel camptothecin analogue that possesses exceptional antitumor efficacy in human tumor xenograft models. The aim of the current study was to develop novel 20-substituted FL118 derivatives coupled with glycosyl-succinic acid esters with improved antitumor efficacy. These FL118 glycoside derivatives were designed, synthesized and their cytotoxicity ev ...
DOI:
10.1039/c9ra00315k

59. Synthesis of polyunsaturated fatty boronic esters and their in vitro inhibition to HCT116 cell lines

Author:
Yongkai Yuan; Peng Chen; Shuaizhong Zhang; Xiang Lan; Zhuzhu Liu; Dongfeng Wang; Ying Xu; Xun Sun
Source:
Tetrahedron 2019 pp. -
ISSN:
0040-4020
Subject:
antineoplastic activity; bioactive compounds; cell lines; chemical bonding; chemical reactions; chemical structure; cytotoxicity; esters; polyunsaturated fatty acids
Abstract:
... Five polyunsaturated fatty boronic esters (PUFB) were synthesized using a photoinduced decarboxylative borylation reaction from corresponding polyunsaturated fatty acids (PUFA) and in vitro anti-proliferation activity of these molecules on HCT116 cell lines was tested. The yield of the photoinduced decarboxylative borylation reaction was negatively correlated with the number of double bonds in PUF ...
DOI:
10.1016/j.tet.2019.130578

60. Tannic acid-stabilized gold nano-particles are superior to native tannic acid in inducing ROS-dependent mitochondrial apoptosis in colorectal carcinoma cells via the p53/AKT axis

Author:
Sayoni Nag; Krishnendu Manna; Krishna Das Saha
Source:
RSC advances 2019 v.9 no.14 pp. 8025-8038
ISSN:
2046-2069
Subject:
DNA damage; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; colorectal neoplasms; cytochrome c; cytotoxicity; death; gold; inhibitory concentration 50; membrane potential; mitochondria; mitochondrial membrane; nanogold; nanoparticles; neoplasm cells; tannins
Abstract:
... Gold nanoparticle formulated tannic acid (AuNP-TA) was synthesized, and its anticancer activity was compared to that of free tannic acid (TA). The half maximal inhibitory concentration (IC₅₀) was reduced by half when cell lines were treated with AuNP-TA as compared to IC₅₀ values upon free TA treatment. Both showed better cytotoxic activity in HCT116 cell line as compared to MCF7 and HepG2. AuNP-T ...
DOI:
10.1039/c9ra00808j

61. Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

Author:
Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
Source:
Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
ISSN:
1875-5364
Subject:
Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
Abstract:
... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
DOI:
10.1016/S1875-5364(19)30005-6

62. Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production

Author:
Adrianna Sławińska-Brych; Barbara Zdzisińska; Arkadiusz Czerwonka; Magdalena Mizerska-Kowalska; Magdalena Dmoszyńska-Graniczka; Andrzej Stepulak; Mariusz Gagoś
Source:
Biochimica et biophysica acta 2019 pp. -
ISSN:
0304-4165
Subject:
acetylcysteine; antineoplastic activity; apoptosis; caspase-3; cell cycle; cell lines; cell proliferation; cyclins; cytotoxicity; enzyme inhibitors; enzyme-linked immunosorbent assay; flow cytometry; fluorescence; immunoblotting; mitochondria; mitogen-activated protein kinase; myeloma; protein synthesis; signal transduction; staining; therapeutics; vascular endothelial growth factors; viability
Abstract:
... Xanthohumol (XN, a hop-derived prenylflavonoid) was found to exert anticancer effects on various cancer types. However, the mechanisms by which XN affects the survival of multiple myeloma cells (MM) are little known. Therefore, our study was undertaken to address this issue.Anti-proliferative activity of XN towards two phenotypically distinct MM cell lines U266 and RPMI8226 was evaluated with the ...
DOI:
10.1016/j.bbagen.2019.08.001