Publication year rev: 7981-2019 / Subject term: antineoplastic activity and cell lines

1. (−)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

Author:: Abu Bakar Siddique; Hassan Y. Ebrahim; Mohamed R. Akl; Nehad M. Ayoub; Amira A. Goda; Mohamed M. Mohyeldin; Suresh K. Nagumalli; Wael M. Hananeh; Yong-Yu Liu; Sharon A. Meyer; Khalid A. El Sayed
Source:: Nutrients 2019 v.11 no.2 pp. -
ISSN:: 2072-6643
Subject:: Western blotting; antibodies; antineoplastic activity; breast neoplasms; breasts; cell lines; enzyme inhibitors; epidermal growth factor receptors; epithelium; erbB-2 receptor; extra-virgin olive oil; mice; models; neoplasm cells; non-specific protein-tyrosine kinase; non-specific serine/threonine protein kinase; therapeutics; tyrosine
Abstract:: ... Dysregulation of epidermal growth factor receptor (EGFR)/human epidermal growth factor-2 (HER2) family is a hallmark of aggressive breast cancer. Small-molecule tyrosine kinase inhibitors are among the most effective cancer targeted treatments. (−)-Oleocanthal (OC) is a naturally occurring phenolic secoiridoid lead from extra-virgin olive oil with documented anti-cancer activities via target ...
DOI:: 10.3390/nu11020412
PubMed:: 30781364
PubMed Central:: PMC6412724
: https://doi.org/10.3390/nu11020412

2. Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

Author:: Fenglin Sun; Duo Li; Cong Wang; Caixia Peng; Hong Zheng; Xiaofeng Wang
Source:: Phytotherapy research 2019 v.33 no.5 pp. 1551-1561
ISSN:: 0951-418X
Subject:: antineoplastic activity; apoptosis; calcium; calcium signaling; caspase-3; caspase-9; cell lines; cell viability; cytochrome c; electron microscopy; flavones; flow cytometry; mitochondria; neoplasm cells; small interfering RNA; squamous cell carcinoma
Abstract:: ... Aacacetin, a plant flavone has shown antitumor efficacy recently. However, its associated mechanisms are poorly known. We hypothesized that the muscarinic M3 receptor (M₃R), which is highly expressed in some cancer tissue, is related to the antitumor effect of acacetin in head and neck squamous cell carcinoma (HNSCC) cells. Our results showed that 12.5‐ to 200‐μM acacetin inhibited cell viability ...
DOI:: 10.1002/ptr.6343
: https://doi.org/10.1002/ptr.6343

3. Actinidia arguta (Hardy Kiwi) Root Extract Exerts Anti-cancer Effects via Mcl-1-Mediated Apoptosis in Cholangiocarcinoma

Author:: Xiangxuan Zhao; Feng Wen; Wei Wang; Zaiming Lu; Qiyong Guo
Source:: Nutrition and cancer 2019 v.71 no.2 pp. 246-256
ISSN:: 1532-7914
Subject:: Actinidia arguta; NAD ADP-ribosyltransferase; Western blotting; antineoplastic activity; apoptosis; caspase-3; caspase-8; cell lines; cell viability; ethanol; growth retardation; liver; mice; neoplasms; patients; tissues
Abstract:: ... Cholangiocarcinoma (CCA) is a highly aggressive and chemoresistant liver malignancy. Thus, identification of strategies to overcome insensitivity to apoptosis and growth inhibition is a growing focus of research in this malignancy. This study evaluated the potential anti-cancer effects of an ethanol extract from the Actinidia arguta (Hardy Kiwi) root (RAE) on CCA. Our data demonstrated that RAE de ...
DOI:: 10.1080/01635581.2018.1557218
: https://doi.org/10.1080/01635581.2018.1557218

4. Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

Author:: Martina Daga; Stefania Pizzimenti; Chiara Dianzani; Marie Angele Cucci; Roberta Cavalli; Margherita Grattarola; Benedetta Ferrara; Valentina Scariot; Francesco Trotta; Giuseppina Barrera
Source:: Phytomedicine 2019 v.56 pp. 156-164
ISSN:: 0944-7113
Subject:: Ailanthus altissima; Western blotting; active ingredients; antibodies; antineoplastic activity; apoptosis; bladder; cell growth; cell lines; cell movement; cisplatin; cortex; essential genes; flow cytometry; gene expression; humans; interphase; neoplasm cells; protein synthesis; staining; therapeutics; tissue repair; toxicity; urinary bladder neoplasms
Abstract:: ... Ailanthone (Aila) is a natural active compound isolated from the Ailanthus altissima, which has been shown to possess an “in vitro” growth-inhibitory effect against several cancer cell lines. Advanced bladder cancer is a common disease characterized by a frequent onset of resistance to cisplatin-based therapy. The cisplatin (CDDP) resistance is accompanied by an increase in Nrf2 protein expression ...
DOI:: 10.1016/j.phymed.2018.10.034
: https://doi.org/10.1016/j.phymed.2018.10.034

5. Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae

Author:: Kevin A. Martínez; Chiara Lauritano; Dana Druka; Giovanna Romano; Teresa Grohmann; Marcel Jaspars; Jesús Martín; Caridad Díaz; Bastien Cautain; Mercedes de la Cruz; Adrianna Ianora; Fernando Reyes
Source:: Marine drugs 2019 v.17 no.7 pp. -
ISSN:: 1660-3397
Subject:: Amphidinium; Aspergillus fumigatus; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Klebsiella pneumoniae; Mycobacterium tuberculosis; adenocarcinoma; antifungal properties; antineoplastic activity; bioactive compounds; biodiversity; breast neoplasms; breasts; cell lines; cytotoxicity; fractionation; fungi; habitats; hepatoma; humans; lungs; mass spectrometry; melanoma; methicillin-resistant Staphylococcus aureus; neoplasm cells; nuclear magnetic resonance spectroscopy; pancreas; physicochemical properties; skin (animal)
Abstract:: ... Due to the unique biodiversity and the physical-chemical properties of their environment, marine microorganisms have evolved defense and signaling compounds that often have no equivalent in terrestrial habitats. The aim of this study was to screen extracts of the dinoflagellate Amphidinium carterae for possible bioactivities (i.e., anticancer, anti-inflammatory, anti-diabetes, antibacterial and an ...
DOI:: 10.3390/md17070385
PubMed:: 31252576
PubMed Central:: PMC6669446
: https://doi.org/10.3390/md17070385

6. Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran

Author:: Maryam Akhbari; Reza Kord; Saeedeh Jafari Nodooshan; Sepideh Hamedi
Source:: Natural product research 2019 v.33 no.11 pp. 1629-1632
ISSN:: 1478-6427
Subject:: Artemia; Escherichia coli; Foeniculum vulgare; Pseudomonas aeruginosa; Shigella dysenteriae; antibacterial properties; antineoplastic activity; antineoplastic agents; breast neoplasms; carcinoma; cell lines; death; essential oils; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; lethal concentration 50; limonene; methyl chavicol; seed oils; seeds; toxicity; Iran
Abstract:: ... In this study, biological properties of the essential oil isolated from seeds of Foeniculum vulgare (F. vulgare) were evaluated. GC-MS analysis revealed Trans-Anethole (80.63%), L-Fenchone (11.57%), Estragole (3.67%) and Limonene (2.68%) were the major compounds of the essential oil. Antibacterial activity of the essential oil against nine Gram-positive and Gram-negative strains was studied using ...
DOI:: 10.1080/14786419.2017.1423310
: https://doi.org/10.1080/14786419.2017.1423310

7. Anchusa azurea Mill. (Boraginaceae) aerial parts methanol extract interfering with cytoskeleton organization induces programmed cancer cells death

Author:: Jessica CeramellaThese authors have contributed equally to the manuscript.; Monica Rosa Loizzo; Domenico Iacopetta; Marco Bonesi; Vincenzo Sicari; Teresa Maria Pellicanò; Carmela Saturnino; Aurélie Malzert-Fréon; Rosa TundisJoint senior authors.; Maria Stefania Sinicropi
Source:: Food & function 2019 v.10 no.7 pp. 4280-4290
ISSN:: 2042-650X
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Anchusa azurea; aerial parts; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; caffeic acid; caspase-3; catechin; cell death; cell lines; chemical composition; chlorogenic acid; cytoskeleton; death; high performance liquid chromatography; inhibitory concentration 50; menadione; methanol; mice; neoplasm cells; neoplasms; oxidative stress; toxicity
Abstract:: ... The present study aimed to determine the chemical composition, antioxidant effects and antitumor properties of a methanol extract of Anchusa azurea Mill. (Boraginaceae) aerial parts against four tumour cell lines (MCF-7, MDA-MB-231, RKO, and R₂C). The antioxidant effects were assessed by using β-carotene bleaching, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl ...
DOI:: 10.1039/c9fo00582j
: https://doi.org/10.1039/c9fo00582j

8. The Anti-Cancer Effect of Mangifera indica L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells

Author:: Marianna Lauricella; Valentina Lo Galbo; Cesare Cernigliaro; Antonella Maggio; Antonio Palumbo Piccionello; Giuseppe Calvaruso; Daniela Carlisi; Sonia Emanuele; Michela Giuliano; Antonella D’Anneo
Source:: Antioxidants 2019 v.8 no.10 pp. -
ISSN:: 2076-3921
Subject:: DNA damage; Mangifera indica; antineoplastic activity; apoptosis; cell lines; cell viability; colorectal neoplasms; fibroblasts; fruit pulp; gene expression regulation; high performance liquid chromatography; histones; humans; mango peels; mangoes; mass spectrometry; mitogen-activated protein kinase; models; mutagens; neoplasm cells; phenolic compounds; phosphorylation; reactive oxygen species; signal transduction; superoxide dismutase
Abstract:: ... Ethanolic extracts from Mangifera indica L. have been proved to possess anti-tumor properties in many cancer systems. However, although most effects have been demonstrated with fruit pulp extract, the underlying molecular mechanisms of mango peel are still unclear. This study was designed to explore the effects of mango peel extract (MPE) on colon cancer cell lines. MPE affected cell viability and ...
DOI:: 10.3390/antiox8100422
PubMed:: 31546694
PubMed Central:: PMC6826946
: https://doi.org/10.3390/antiox8100422

9. Anti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein

Author:: Byung Chull An; Sunwoong Hong; Ho Jin Park; Bong-Kyu Kim; Jun Young Ahn; Yongku Ryu; Jae Hyung An; Myung Jun Chung
Source:: Genes 2019 v.10 no.8 pp. -
ISSN:: 2073-4425
Subject:: antineoplastic activity; cell cycle checkpoints; cell lines; colorectal neoplasms; cytosol; endocytosis; gene therapy; in vitro studies; neoplasm cells; signal transduction; toxicity
Abstract:: ... Recently, we reported a novel therapeutic probiotic-derived protein, p8, which has anti-colorectal cancer (anti-CRC) properties. In vitro experiments using a CRC cell line (DLD-1), anti-proliferation activity (about 20%) did not improve after increasing the dose of recombinant-p8 (r-p8) to >10 μM. Here, we show that this was due to the low penetrative efficiency of r-p8 exogenous treatment. Fur ...
DOI:: 10.3390/genes10080624
PubMed:: 31430963
PubMed Central:: PMC6723380
: https://doi.org/10.3390/genes10080624

10. Anti-cancer activities of cytokinin ribosides

Author:: Jiří Voller; Tibor Béres; Marek Zatloukal; Petr Džubák; Marián Hajdúch; Karel Doležal; Thomas Schmülling; Strnad Miroslav
Source:: Phytochemistry reviews 2019 v.18 no.4 pp. 1101-1113
ISSN:: 1568-7767
Subject:: antineoplastic activity; antineoplastic agents; apoptosis; cell lines; cytokinins; genes; growth and development; immune response; in vivo studies; mutants; neoplasms; patients; plant development; plant growth; plant hormones; stem cells
Abstract:: ... Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived ...
DOI:: 10.1007/s11101-019-09620-4
: https://doi.org/10.1007/s11101-019-09620-4

11. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines

Author:: Silpa Narayanan; Pranav Gupta; Urooj Nazim; Mohsin Ali; Nishant Karadkhelkar; Mansoor Ahmad; Zhe-Sheng Chen
Source:: international journal of biochemistry & cell biology 2019 v.110 pp. 21-28
ISSN:: 1357-2725
Subject:: DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; biphenyl; cell lines; colorectal neoplasms; hydrazine; hydrazones; indans; inhibitory concentration 50; mitosis; neoplasm cells; patients; polymerization; toxicity; tubulin; United States
Abstract:: ... Colorectal cancer is the third leading cause of cancer related deaths in the United States. Currently, Irinotecan, a topoisomerase I inhibitor, is an approved anti-cancer drug for the treatment of patients with advanced or recurrent colorectal cancer. Considering low response rate and events of high toxicity caused by irinotecan, we evaluated a series of thirteen thiazolyl hydrazone derivatives of ...
DOI:: 10.1016/j.biocel.2019.02.004
: https://doi.org/10.1016/j.biocel.2019.02.004

12. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

Author:: Haroon Khan; Marcella Reale; Hammad Ullah; Antoni Sureda; Silvia Tejada; Ying Wang; Zhang-Jin Zhang; Jianbo Xiao
Source:: Biotechnology advances 2019 pp. -
ISSN:: 0734-9750
Subject:: antineoplastic activity; cell lines; chemoprevention; dietary nutrient sources; mechanism of action; monitoring; neoplasm cells; neoplasms; polyphenols; signal transduction; tumor suppressor genes
Abstract:: ... The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to ...
DOI:: 10.1016/j.biotechadv.2019.04.007
: https://doi.org/10.1016/j.biotechadv.2019.04.007

13. Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cells

Author:: Jiryeon Jang; Jeeyun Lee; Jun Ho Jang; Chul Won Jung; Silvia Park
Source:: Molecular biology reports 2019 v.46 no.6 pp. 5859-5866
ISSN:: 0301-4851
Subject:: Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; cell proliferation; cell viability; cholesterol; cytotoxicity; flow cytometry; humans; molecular biology; mutants; myeloid leukemia; simvastatin; therapeutics
Abstract:: ... The statins are a group of therapeutic drugs widely used for lowering plasma cholesterol level, while it has also been reported to induce cell death in human acute myeloid leukemia (AML) cells. To determine antitumor activity triggered by simvastatin, four AML cell lines—U937, KG1, THP1 (NRASᴳ¹²ᴰ mutant) and HL60 (NRASQ⁶¹ᴸ mutant)—were cultured with simvastatin and cell viability was assessed usin ...
DOI:: 10.1007/s11033-019-05019-8
: https://doi.org/10.1007/s11033-019-05019-8

14. Anti-tumor activity and the mechanism of a green tea (Camellia sinensis) polysaccharide on prostate cancer

Author:: Ke Yang; Zhi-Yong Gao; Tie-Qiu Li; Wei Song; Wei Xiao; Jue Zheng; Hao Chen; Gui-Heng Chen; Hao-Yu Zou
Source:: International journal of biological macromolecules 2019 v.122 pp. 95-103
ISSN:: 0141-8130
Subject:: Camellia sinensis; antineoplastic activity; apoptosis; cell lines; gene overexpression; glucose; green tea; growth retardation; humans; mice; molecular weight; patients; polysaccharides; prostatic neoplasms; protein synthesis; therapeutics; transfection
Abstract:: ... In this study, a homogeneous polysaccharide (GTP), with a molecular weight of 7.0 × 104 Da, was isolated from Green tea, which was only composed of glucose. The antitumor effects of GTP on prostate cancer (PC) cell line along with the possible mechanism was examined. First, we investigate the potential role of microRNA-93 (miR-93) in PC progression. Our results showed that miR-93 was significantly ...
DOI:: 10.1016/j.ijbiomac.2018.10.101
: https://doi.org/10.1016/j.ijbiomac.2018.10.101

15. Anti-tumor effect and mechanistic study of elemene on pancreatic carcinoma

Author:: Jin Long; Zhe Liu; Lian Hui
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 133
ISSN:: 1472-6882
Subject:: Western blotting; Zingiberaceae; alternative medicine; antineoplastic activity; body weight; carcinoma; cell lines; dose response; flow cytometry; histopathology; immunohistochemistry; inflammation; interphase; mice; neoplasm cells; pancreatic neoplasms; protein synthesis; staining; tissues
Abstract:: ... BACKGROUND: Elemene is an effective anticancer component extracted from Zingiberaceae plants. This work was aimed to evaluate the anti-tumor effect and mechanism actions of elemene on pancreatic carcinoma in vitro and in vivo. METHODS: The anti-proliferation experiment was measured by Methylthiazolyldiphenyl-tetrazolium bromide (MTT) method in the time of 24, 48 and 72 h in three different dosages ...
DOI:: 10.1186/s12906-019-2544-2
PubMed:: 31215421
PubMed Central:: PMC6582541
: https://doi.org/10.1186/s12906-019-2544-2

16. Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines

Author:: Annick D. van den Brand; Judith Villevoye; Sandra M. Nijmeijer; Martin van den Berg; Majorie B.M. van Duursen
Source:: Toxicology 2019 v.422 pp. 35-43
ISSN:: 0300-483X
Subject:: antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; cell cycle checkpoints; cell lines; cell viability; cytochrome P-450; epithelial cells; gene expression; humans; hydroxylation; interleukin-8; mammary glands; median effective concentration; models; neoplasm cells; polyphenols; pterostilbene; reporter genes; resveratrol
Abstract:: ... Resveratrol is a plant-derived polyphenol that is known for its anti-inflammatory and anti-tumorigenic properties in in vitro and in vivo models. Recent studies show that some resveratrol analogues might be more potent anti-tumor agents, which may partly be attributed to their ability to activate the aryl hydrocarbon receptor (AHR). Here, the anti-tumorigenic properties of resveratrol and structur ...
DOI:: 10.1016/j.tox.2019.04.009
: https://doi.org/10.1016/j.tox.2019.04.009

17. Anti-tumour activity of low molecular weight heparin doxorubicin nanoparticles for histone H1 high-expressive prostate cancer PC-3M cells

Author:: Shuang Zhang; Zhan-Tao Li; Man Liu; Jing-Ru Wang; Mei-Qi Xu; Zhuo-Yue Li; Xiao-Chuan Duan; Yan-Li Hao; Xiu-Chai Zheng; Hui Li; Zhen-Han Feng; Xuan Zhang
Source:: Journal of controlled release 2019 v.295 pp. 102-117
ISSN:: 0168-3659
Subject:: anticoagulant activity; antineoplastic activity; apoptosis; blood; cell lines; cell membranes; chromatin; doxorubicin; drug delivery systems; drug therapy; heparin; histones; humans; ligands; lysosomes; models; nanoparticles; neoplasm cells; prostatic neoplasms; rats
Abstract:: ... Nucleus-targeting drug delivery systems (NTDDs) deliver chemotherapeutic agents to nuclei in order to improve the efficacy of anti-tumour therapy. Histone H1 (H1) plays a key role in establishing and maintaining higher order chromatin structures and could bind to cell membranes. In the present study, we selected H1 as a target to prepare a novel H1-mediated NTDD. Low molecular weight heparin (LMHP ...
DOI:: 10.1016/j.jconrel.2018.12.034
: https://doi.org/10.1016/j.jconrel.2018.12.034

18. Anticancer activity of plant leaves extract collected from a tribal region of India

Author:: Gourav Kumar; Rashmi Gupta; Shruti Sharan; Partha Roy; Dev Mani Pandey
Source:: 3 Biotech 2019 v.9 no.11 pp. 399
ISSN:: 2190-572X
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Calotropis procera; Euphorbia neriifolia; Millettia pinnata; Moringa oleifera; Salmonella Typhi; anti-infective agents; antineoplastic activity; antioxidants; beta-sitosterol; cell lines; chloroform; cytotoxicity; epithelium; ethyl acetate; leaf extracts; leaves; lung neoplasms; lungs; medicinal plants; methanol; neoplasm cells; solvents; stigmasterol; India
Abstract:: ... The goal of this research was to explore the preliminary anticancer properties of five plants namely Calotropis procera, Moringa oleifera, Millettia pinnata, Basela alba and Euphorbia neriifolia available in Jharkhand which is used for the medicinal purpose by local tribes. In the present study, plant leaves from five species were collected, dried and extracted with solvents of increasing polarity ...
DOI:: 10.1007/s13205-019-1927-x
PubMed:: 31656737
PubMed Central:: PMC6790204
: https://doi.org/10.1007/s13205-019-1927-x

19. Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116 cell line- in vitro study

Author:: Shahnaz Majeed; Mohammed Danish; Muhammad Hisyamuddin Bin Ismail; Mohmmed Tahir Ansari; Mohamad Nasir Mohamad Ibrahim
Source:: Sustainable chemistry and pharmacy 2019 v.14 pp. 100179
ISSN:: 2352-5541
Subject:: Artocarpus heterophyllus; Fourier transform infrared spectroscopy; acridine orange; amides; amines; antineoplastic activity; apoptosis; cell lines; chromatin; color; colorectal neoplasms; energy; energy-dispersive X-ray analysis; ethidium; humans; in vitro studies; inhibitory concentration 50; leaf extracts; leaves; nanoparticles; neoplasm cells; nitrates; particle size; spectral analysis; staining; transmission electron microscopy; ultraviolet-visible spectroscopy; zinc; zinc oxide
Abstract:: ... Aim of this study was to synthesize the safe and stable zinc oxide nanoparticles (ZnONPs) from the leaves of Artocarpus heterophyllus. The alter in the color of the leaf extract dark brown upon addition of zinc nitrate Zn(NO₃) confirms the formation of Zinc Oxide nanoparticles (ZnONPs). UV-VIS spectrophotometric analysis showed lambda max at 235 nm while Fourier transform infra-red (FTIR) spectros ...
DOI:: 10.1016/j.scp.2019.100179
: https://doi.org/10.1016/j.scp.2019.100179

20. Anticancer, antimicrobial, antioxidant, and catalytic activities of green-synthesized silver and gold nanoparticles using Bauhinia purpurea leaf extract

Author:: Remya Vijayan; Siby Joseph; Beena Mathew
Source:: Bioprocess and biosystems engineering 2019 v.42 no.2 pp. 305-319
ISSN:: 1615-7591
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Bauhinia purpurea; Fourier transform infrared spectroscopy; X-ray diffraction; agar; antineoplastic activity; antioxidant activity; antioxidants; catalysts; catalytic activity; cell lines; dose response; dyes; energy-dispersive X-ray analysis; gold; inhibitory concentration 50; leaf extracts; lung neoplasms; medicinal plants; nanogold; nanoparticles; nanosilver; neoplasm cells; silver; stabilizers; surface plasmon resonance; transmission electron microscopy
Abstract:: ... The synthesis of metal nanoparticles by green methods attained enormous attention in recent years due to its easiness, non-toxicity, and eco-friendly nature. In the present study, noble metal nanoparticles such as silver and gold were prepared using an aqueous leaf extract of a medicinal plant, Bauhinia purpurea. The leaf extract performed as both reducing and stabilizing agents for the developmen ...
DOI:: 10.1007/s00449-018-2035-8
: https://doi.org/10.1007/s00449-018-2035-8

21. Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea

Author:: Chan-Su Rha; Hyun Woo Jeong; Saitbyul Park; Siyoung Lee; Young Sung Jung; Dae-Ok Kim
Source:: Antioxidants 2019 v.8 no.8 pp. -
ISSN:: 2076-3921
Subject:: adenoma; antineoplastic activity; antioxidant activity; apigenin; breast neoplasms; cell lines; colon; dose response; endo-1,4-beta-glucanase; flavanols; gene expression; genes; glycosides; green tea; kaempferol; macrophages; mass spectrometry; messenger RNA; mice; models; myricetin; neoplasm cells; oxidative stress; paclitaxel; quercetin; tannase; viability
Abstract:: ... (1) Background: Extensive research has focused on flavan-3-ols, but information about the bioactivities of green tea flavonols is limited. (2) Methods: In this study, we investigated the antioxidative, anti-inflammatory, and anticancer effects of flavonol glycosides and aglycones from green tea using in vitro cell models. The fractions rich in flavonol glycoside (FLG) and flavonol aglycone (FLA) w ...
DOI:: 10.3390/antiox8080278
PubMed:: 31387266
PubMed Central:: PMC6719943
: https://doi.org/10.3390/antiox8080278

22. Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells

Author:: Luana Paula Pelinson; Charles Elias Assmann; Taís Vidal Palma; Ivana Beatrice Mânica da Cruz; Micheli Mainardi Pillat; Aline Mânica; Naiara Stefanello; Grazielle Castagna Cezimbra Weis; Audrei de Oliveira Alves; Cinthia Melazzo de Andrade; Henning Ulrich; Vera Maria Melchiors Morsch; Maria Rosa Chitolina Schetinger; Margarete Dulce Bagatini
Source:: Molecular biology reports 2019 v.46 no.2 pp. 2085-2092
ISSN:: 0301-4851
Subject:: acid treatment; antibiotics; antineoplastic activity; apoptosis; caffeic acid; caspases; cell cycle; cell lines; cell viability; culture media; drug therapy; drugs; fetal bovine serum; humans; melanoma; mortality; neoplasm cells; patients
Abstract:: ... Cutaneous melanoma (CM) is an extremely aggressive cancer presenting low survival and high mortality. The vast majority of patients affected by this disease does not respond or show resistance to the chemotherapeutic drugs, which makes the treatment ineffective. In this sense, the necessity for the development of new agents to assist in CM therapy is extremely important. One of the sources of grea ...
DOI:: 10.1007/s11033-019-04658-1
: https://doi.org/10.1007/s11033-019-04658-1

23. Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple-Negative Breast Cancer Cells

Author:: Donghwa Kim; Cai Yi Wang; Ruoci Hu; Ji Yun Lee; Thi-Thu-Trang Luu; Hee-Juhn Park; Sang Kook Lee
Source:: Journal of natural products 2019 v.82 no.11 pp. 3140-3149
ISSN:: 1520-6025
Subject:: Persicaria; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell lines; cyclin-dependent kinase; mice; molecular models; neoplasm cells; proteins; quercitrin; signal transduction; sucrose; toxicity
Abstract:: ... A flavonoid glycoside, quercitrin (1), and two phenylpropanoyl sucrose derivatives, vanicoside B (2) and lapathoside C (3), were isolated for the first time from the herb Persicaria dissitiflora. Vanicoside B (2) exhibited antiproliferative activity against a panel of cancer cell lines in triple-negative breast cancer (TNBC) MDA-MB-231 cells. The underlying mechanisms of the antitumor activity of ...
DOI:: 10.1021/acs.jnatprod.9b00720
: https://doi.org/10.1021/acs.jnatprod.9b00720

24. Antitumor activity of alantolactone in lung cancer cell lines NCI‐H1299 and Anip973

Author:: Jianli Liu; Zhijun Yang; Yuchi Kong; Yin He; Yongliang Xu; Xiangyu Cao
Source:: Journal of food biochemistry 2019 v.43 no.9 pp. e12972
ISSN:: 0145-8884
Subject:: Inula helenium; antineoplastic activity; apoptosis; carcinogenesis; cell lines; cell viability; chemoprevention; death; drug therapy; lung neoplasms; medicine; mitogen-activated protein kinase; neoplasm cells; sesquiterpenoid lactones; transcription factor NF-kappa B
Abstract:: ... Alantolactone is a sesquiterpene lactone extracted from Inula helenium L. plants possessing many biological activities, including anti‐inflammatory, antiproliferation, and antimicrobial. The inhibitory effects and the underlying mechanisms of alantolactone on lung cancer cells NCI‐H1299 and Anip973 were investigated in this study. The results showed that alantolactone could decrease cell viability ...
DOI:: 10.1111/jfbc.12972
: https://doi.org/10.1111/jfbc.12972

25. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients

Author:: Sophia J. Lang; Michael Schmiech; Susanne Hafner; Christian Paetz; Carmen Steinborn; Roman Huber; Menna El Gaafary; Katharina Werner; Christoph Q. Schmidt; Tatiana Syrovets; Thomas Simmet
Source:: Phytomedicine 2019 v.62 pp. 152962
ISSN:: 0944-7113
Subject:: Artemisia annua; acetonitrile; active ingredients; antineoplastic activity; apoptosis; artemisinin; breast neoplasms; breasts; carbon; caspase-3; cell cycle; cell lines; cell proliferation; cell viability; chicks; chorioallantoic membrane; detection limit; epithelial cells; flow cytometry; high performance liquid chromatography; humans; lung neoplasms; lymphocytes; maceration; mammary glands; membrane potential; metastasis; mitochondrial membrane; models; neoplasm cells; nuclear magnetic resonance spectroscopy; pancreas; stable isotopes; tandem mass spectrometry
Abstract:: ... Artemisia annua L. has gained increasing attention for its anticancer activity. However, beside artemisinin, less is known about the possible bioactive ingredients of Artemisia annua and respective herbal preparations. We hypothesized that, in addition to artemisinin, Artemisia annua preparations might contain multiple ingredients with potential anticancer activity.MDA-MB-231 triple negative human ...
DOI:: 10.1016/j.phymed.2019.152962
: https://doi.org/10.1016/j.phymed.2019.152962

26. Antitumor activity of methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide against leukemia cell lines via mitotic arrest and apoptotic pathways

Author:: Laura Sartori Assunção; Iara Fabrícia Kretzer; Jelver Alexander Sierra Restrepo; Leônidas João de Mello Junior; Adny Henrique Silva; Eliana de Medeiros Oliveira; Misael Ferreira; Marcus Mandolesi Sá; Tânia Beatriz Creczynski-Pasa
Source:: Biochimica et biophysica acta 2019 v.1863 no.9 pp. 1332-1342
ISSN:: 0304-4165
Subject:: DNA damage; antineoplastic activity; apoptosis; autophagy; caspase-8; cell lines; cytotoxicity; endoplasmic reticulum; homeostasis; mechanism of action; membrane permeability; mitochondrial membrane; mitosis; neoplasm cells; pro-apoptotic proteins; salts
Abstract:: ... In a previous study, we described a series of 28 aryl- and alkyl-substituted isothiouronium salts with antitumor activity and selectivity toward a leukemia cell line. Among the synthesized compounds, methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide (IS-MF08) showed conspicuous activity. In the present study, we investigated the mechanism of action of IS-MF08. Our results showed that it ...
DOI:: 10.1016/j.bbagen.2019.05.018
: https://doi.org/10.1016/j.bbagen.2019.05.018

27. Antitumor effect of depsidones from lichens on tumor cell lines and experimental murine melanoma

Author:: Caroline Almeida Farias Alexandrino; Neli Kika Honda; Maria de Fatima Cepa Matos; Luciane Candeloro Portugal; Pedro Rafael Berquó de Souza; Renata Trentin Perdomo; Rita de Cássia Avellaneda Guimarães; Monica Cristina Toffoli Kadri; Magalli Costa Barbosa Lima Silva; Danielle Bogo
Source:: Revista Brasileira de Farmacognosia 2019 v.29 no.4 pp. 449-456
ISSN:: 0102-695X
Subject:: acids; antineoplastic activity; caspase-3; cell lines; flow cytometry; growth retardation; lichens; melanoma; mice; models; neoplasm cells
Abstract:: ... Lichens have exhibited numerous biological activities, including growth inhibition of tumor cells. This study evaluated the antiproliferative activity of hypostictic and salazinic acids against tumor cell lines (B16-F10, PC-03, MCF7, HT-29, HEP-G2, K562 and 786-0) by the SRB assay in vitro and antitumor activity in experimental murine melanoma in vivo. Activation of caspase-3 was quantified by flo ...
DOI:: 10.1016/j.bjp.2019.04.005
: https://doi.org/10.1016/j.bjp.2019.04.005

28. Antitumor effects of SB injection in canine osteosarcoma and melanoma cell lines

Author:: Kyeong Kweon; Jin-Ok Ahn; Woo-Jin Song; Qiang Li; Bo-Yeon Lee; Hyung-Kyu Chae; Hwa-Young Youn
Source:: In vitro cellular & developmental biology 2019 v.55 no.1 pp. 7-16
ISSN:: 1071-2690
Subject:: Anemone cernua; Glycyrrhiza glabra; Panax ginseng; antineoplastic activity; apoptosis; cell cycle; cell lines; cell proliferation; dogs; dose response; drug therapy; drugs; flow cytometry; in vitro studies; melanoma; mononuclear leukocytes; osteosarcoma; roots; veterinary medicine; viability; animal use replacement
Abstract:: ... The present study was designed to evaluate the effect of SB injection, which is composed of extracts from the roots of Pulsatilla koreana, Panax ginseng, and Glycyrrhiza glabra, on the viability of canine osteosarcoma and melanoma cells and nonneoplastic canine cells. Cells were treated with SB injection, conventional chemotherapeutic drugs, or a combination of both at various concentrations. Cell ...
DOI:: 10.1007/s11626-018-0294-y
: https://doi.org/10.1007/s11626-018-0294-y

29. Antitumour activity of Helix hemocyanin against bladder carcinoma permanent cell lines

Author:: Aleksandar Dolashki; Pavlina Dolashka; Arnulf Stenzl; Stefan Stevanovic; Wilhelm K. Aicher; Lyudmila Velkova; Radostina Velikova; Wolfgang Voelter
Source:: Biotechnology, biotechnological equipment 2019 v.33 no.1 pp. 20-32
ISSN:: 1314-3530
Subject:: Rapana venosa; antineoplastic activity; apoptosis; biotechnology; bladder; carcinoma; cell growth; cell lines; doxorubicin; equipment; glycoproteins; glycosylation; hemocyanin; hexoses; humans; methylation; neoplasm cells; oligosaccharides; therapeutics; two-dimensional gel electrophoresis; urinary bladder neoplasms
Abstract:: ... Hemocyanins are oxygen-transporting glycoproteins in molluscs and arthropods. In this study, we assayed the biomacromolecules from the molluscs Helix lucorum (HlH), Rapana venosa (RvH) and Megatura crenulata (KLH) including their functional units (FUs), for therapy of bladder cancer permanent cells. In vitro studies antitumour activities of these proteins were performed with bladder cancer permane ...
DOI:: 10.1080/13102818.2018.1507755
: https://doi.org/10.1080/13102818.2018.1507755

30. Anti‐tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells

Author:: Masaya Igase; Kazuha Shousu; Noriyuki Fujiki; Masashi Sakurai; Makoto Bonkobara; Chung C. Hwang; Matt Coffey; Shunsuke Noguchi; Yuki Nemoto; Takuya Mizuno
Source:: Veterinary and comparative oncology 2019 v.17 no.2 pp. 184-193
ISSN:: 1476-5810
Subject:: Reoviridae; antineoplastic activity; apoptosis; cell lines; clinical trials; dogs; interferons; mice; neoplasm cells; prognosis; sarcoma; severe combined immunodeficiency; therapeutics
Abstract:: ... Canine histiocytic sarcoma is an aggressive, fatal neoplastic disease with a poor prognosis. Lomustine is generally accepted as the first‐line systemic therapy, although this compound does not provide complete regression. Therefore, research into a novel approach against canine histiocytic sarcoma is needed. However, anti‐tumour effects of oncolytic therapy using reovirus against histiocytic sarco ...
DOI:: 10.1111/vco.12468
: https://doi.org/10.1111/vco.12468

31. Apoptosis and G2/M cell cycle arrest induced by a timosaponin A3 from Anemarrhena asphodeloides Bunge on AsPC-1 pancreatic cancer cells

Author:: Yumi Kim; Kang-Hoon Kim; In-Seung Lee; Ji Young Park; Yun-Cheol Na; Won-Seok Chung; Hyeung-Jin Jang
Source:: Phytomedicine 2019 v.56 pp. 48-56
ISSN:: 0944-7113
Subject:: Anemarrhena asphodeloides; active ingredients; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell growth; cell lines; cell proliferation; chemical constituents of plants; cyclins; cytotoxicity; drug therapy; ethyl acetate; genes; humans; immunoblotting; liquid chromatography; mass spectrometry; mechanism of action; metastasis; mitogen-activated protein kinase; neoplasm cells; pancreatic neoplasms; protein content; reverse transcription; saponins; solvents; viability
Abstract:: ... Timosaponin A3 (TA3), one of the active components of spirostanol saponin isolated from A. asphodeloides, is widely used as an anticancer agent in a variety of cancer cell lines. However, the research on the anticancer efficacy is very limited in human pancreatic cancer models.In this study, we investigated the molecular targets in the active components of A. asphodeloides, which showed anti-cance ...
DOI:: 10.1016/j.phymed.2018.08.006
: https://doi.org/10.1016/j.phymed.2018.08.006

32. Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway

Author:: Hua Luo; Erwei Hao; Dechao Tan; Wei Wei; Jinling Xie; Xiaohui Feng; Zhengcai Du; Chunying Huang; Gang Bai; Yuanyuan Hou; Chuanjing Cheng; Xiangxi Yi; Yitao Wang; Xiaotao Hou; Jiagang Deng
Source:: Food and chemical toxicology 2019 pp. -
ISSN:: 0278-6915
Subject:: Aegiceras corniculatum; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; butanol; cell cycle checkpoints; cell lines; cell proliferation; colorectal neoplasms; dose response; flow cytometry; human diseases; leaf extracts; leaves; mechanism of action; mice; mitochondria; neoplasm cells; patients; proteins; signal transduction; viability
Abstract:: ... Aegiceras corniculatum (L.) Blanco is known to exhibit anticancer effects against different types of cancer; however, to the best of our knowledge, the anticancer activity and underlying mechanisms of action of A. corniculatum leaf extract on colorectal cancer have not been elucidated. In the present study, colony-forming assay, western blot analysis, flow cytometry, and a xenograft model were use ...
DOI:: 10.1016/j.fct.2019.110861
: https://doi.org/10.1016/j.fct.2019.110861

33. Asparanin A from Asparagus officinalis L. Induces G0/G1 Cell Cycle Arrest and Apoptosis in Human Endometrial Carcinoma Ishikawa Cells via Mitochondrial and PI3K/AKT Signaling Pathways

Author:: Fan Zhang; Yuan-Yuan Zhang; Ya-Sai Sun; Run-Hui Ma; Kiran Thakur; Jian-Guo Zhang; Zhao-Jun Wei
Source:: Journal of agricultural and food chemistry 2019 v.68 no.1 pp. 213-224
ISSN:: 1520-5118
Subject:: Asparagus officinalis; antineoplastic activity; apoptosis; carcinoma; caspases; cell cycle checkpoints; cell lines; cell proliferation; clinical trials; cytochrome c; endometrium; enzyme inhibition; functional foods; human diseases; ingredients; interphase; mitochondria; phosphatidylinositol 3-kinase; signal transduction; steroid saponins; uterine neoplasms
Abstract:: ... Asparanin A (AA), a steroidal saponin from Asparagus officinalis L., has anticancer activity: however, its detailed molecular mechanisms in endometrial cancer (EC) have not been studied so far. We evaluated the anticancer activity and underlying mechanism of AA on EC cell line Ishikawa in vitro and in vivo. AA inhibited the Ishikawa cell proliferation and caused cell morphology alteration and cell ...
DOI:: 10.1021/acs.jafc.9b07103
: https://doi.org/10.1021/acs.jafc.9b07103

34. Assessment of the cytotoxicity, antioxidant activity and chemical composition of extracts from the cyanobacterium Fischerella major Gomont

Author:: Tsvetelina Batsalova; Diyana Basheva; Krum Bardarov; Ventzislav Bardarov; Balik Dzhambazov; Ivanka Teneva
Source:: Chemosphere 2019 v.218 pp. 93-103
ISSN:: 0045-6535
Subject:: Fischerella; active ingredients; antibiotics; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; cell culture; cell lines; cytotoxicity; environmental assessment; environmental impact; exposure duration; hormones; human health; immunosuppressive agents; in vitro studies; insecticides; microcystins; photosynthesis; repellents; risk assessment; saxitoxins; vitamins
Abstract:: ... Cyanoprokaryotes (Cyanobacteria/Cyanophyta) are ancient photosynthetic prokaryotic organisms with cosmopolitan distribution. They are producers of a number of biologically active substances with antitumor and antifungal activity, vitamins, antibiotics, algaecides, insecticides, repellents, hormones, immunosuppressants and toxins. So far, the cyanobacterium Fischerella major Gomont has not been stu ...
DOI:: 10.1016/j.chemosphere.2018.11.097
: https://doi.org/10.1016/j.chemosphere.2018.11.097

35. Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell

Author:: Mingjiang Yao; Xiaodi Fan; Bo Yuan; Norio Takagi; Sai Liu; Xiao Han; Junguo Ren; Jianxun Liu
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 216
ISSN:: 1472-6882
Subject:: Western blotting; alternative medicine; antineoplastic activity; berberine; breast neoplasms; caspase-1; cell lines; cell proliferation; cytotoxicity; dose response; females; gene expression regulation; genes; humans; inflammasomes; interleukin-18; interleukin-1alpha; interleukin-1beta; interleukin-6; lactate dehydrogenase; messenger RNA; metastasis; necrosis; purinergic receptors; quantitative polymerase chain reaction; secretion; tissue repair; tumor necrosis factor-alpha; viability
Abstract:: ... BACKGROUND: Breast cancer is still the most common malignant tumor that threatens the female’s life in the world, especially triple-negative breast cancer (TNBC), one of the most difficult subtypes. Lack of targeted therapies brings about urgent demand for novel treatments. In this study we aim to investigate the anti-tumor activity of Berberine (BBR), a Chinese plant-derived alkaloid, against the ...
DOI:: 10.1186/s12906-019-2615-4
PubMed:: 31412862
PubMed Central:: PMC6694465
: https://doi.org/10.1186/s12906-019-2615-4

36. Bioactivities and molecular networking-based elucidation of metabolites of potent actinobacterial strains isolated from the Unkeshwar geothermal springs in India

Author:: Gajanan T. Mehetre; Vinodh J. S.; Bhushan B. Burkul; D. Desai; Santhakumari B; Mahesh S. Dharne; Syed G. Dastager
Source:: RSC advances 2019 v.9 no.17 pp. 9850-9859
ISSN:: 2046-2069
Subject:: Acinetobacter junii; Actinomadura; Cellulomonas; Cellulosimicrobium; Dietzia; Glycomyces; Janibacter; Klebsiella pneumoniae; Marmoricola; Micromonospora; Pseudomonas aeruginosa; Salmonella Abony; Shigella flexneri; Staphylococcus epidermidis; Streptomyces; antimicrobial properties; antineoplastic activity; biosynthesis; breast neoplasms; cell lines; drugs; fungi; hot springs; multigene family; neoplasm cells; polyketides; ribosomal RNA; screening; secondary metabolites; sequence analysis; tripeptides; India
Abstract:: ... The bioactive potential of Actinobacteria endemic to hot springs has rarely been investigated. This study highlights the cultivable diversity and bioactivities of Actinobacteria associated with the Unkeshwar hot springs, India. Potent strains were evaluated for their biosynthetic potentials and metabolite analysis was performed using effective dereplication molecular networking tools. A total of 8 ...
DOI:: 10.1039/c8ra09449g
: https://doi.org/10.1039/c8ra09449g

37. Biological Activities of Artemisinins Beyond Anti-Malarial: a Review

Author:: Saeed-ur-Rahman; Muhammad Khalid; Sadaf-Ilyas Kayani; Farooq Jan; Ayaz Ullah; Kexuan Tang
Source:: Tropical plant biology 2019 v.12 no.4 pp. 231-243
ISSN:: 1935-9756
Subject:: Artemisia annua; animal models; antineoplastic activity; artemisinin; bioactive compounds; cell lines; drug development; drugs; intravenous injection; malaria; multiple drug resistance; risk
Abstract:: ... Artemisinins, as a class of bioactive molecules, are mainly derived from the extracts of Artemisia annua L. and are the mainstay for malaria treatment, including severe malaria, uncomplicated malaria and multi-drug resistant malaria. They are well-known for their good tolerability, safety and rapid onset of action. Their efficacy is not only limited to malaria but also extends to a variety of huma ...
DOI:: 10.1007/s12042-019-09228-0
: https://doi.org/10.1007/s12042-019-09228-0

38. Biological effects of whole Z.Officinale extract on chronic myeloid leukemia cell line K562

Author:: Pinar Mega Tiber; Sevgi Kocyigit Sevinc; Olca Kilinc; Oya Orun
Source:: Gene 2019 v.692 pp. 217-222
ISSN:: 0378-1119
Subject:: Zingiber officinale; antineoplastic activity; apoptosis; cell lines; cell viability; cytotoxicity; ginger; membrane potential; mitochondrial membrane; mononuclear leukocytes; myeloid leukemia; neoplasm cells; patients; pro-apoptotic proteins; proteins; rhizomes; therapeutics
Abstract:: ... The anticancer activity of Zingiber officinalis (ginger) is an area of active research. However, data is quite limited regarding its action and mechanism, especially in hematologic cancer types. Here, antiproliferative and apoptotic effects of whole extract of the rhizome of Zingiber officinalis (ZOWE), was investigated in K562 cell line derived from a chronic myeloid leukemia (CML) patient. Vario ...
DOI:: 10.1016/j.gene.2019.01.015
: https://doi.org/10.1016/j.gene.2019.01.015

39. Blackberry Extract Inhibits Telomerase Activity in Human Colorectal Cancer Cells

Author:: Mohsen Tatar; Zohreh Bagheri; Masoumeh Varedi; Fakhraddin Naghibalhossaini
Source:: Nutrition and cancer 2019 v.71 no.3 pp. 461-471
ISSN:: 1532-7914
Subject:: antineoplastic activity; blackberries; cell free system; cell lines; colorectal neoplasms; dose response; enzyme activity; enzyme inhibition; fruit juices; gene expression; inhibitory concentration 50; messenger RNA; methylation; mononuclear leukocytes; neoplasm cells; telomerase
Abstract:: ... Several mechanisms have been proposed to explain berries’ anticancer effects. However, no previously published studies have investigated berries’ anti-telomerase activity. In this study, the anti-telomerase activity of blackberry crude extract was analyzed in six human colorectal cancer (CRC) cell lines by TRAP assay. The peripheral blood mononuclear cells (PBMCs) from a healthy donor were used as ...
DOI:: 10.1080/01635581.2018.1506491
: https://doi.org/10.1080/01635581.2018.1506491

40. Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells

Author:: Zhitao Gao; Chuan Tong; Yao Wang; Deyun Chen; Zhiqiang Wu; Weidong Han
Source:: Journal of genetics and genomics 2019 v.46 no.8 pp. 367-377
ISSN:: 1673-8527
Subject:: T-lymphocytes; animal disease models; antibodies; antigens; antineoplastic activity; apoptosis; cell lines; clinical trials; cytotoxicity; disease control; disease progression; glycoproteins; humans; immunotherapy; interferon-gamma; interleukin-2; manufacturing; neoplasm cells; neoplasms; tumor necrosis factor-alpha
Abstract:: ... Chimeric antigen receptor T-cell (CAR T) therapy is a kind of effective cancer immunotherapy. However, designing CARs remains a challenge because many targetable antigens are shared by T cells and tumor cells. This shared expression of antigens can cause CAR T cell fratricide. CD38-targeting approaches (e.g., daratumumab) have been used in clinical therapy and have shown promising results. CD38 is ...
DOI:: 10.1016/j.jgg.2019.06.007
: https://doi.org/10.1016/j.jgg.2019.06.007

41. Brazilian red propolis extracts: study of chemical composition by ESI-MS/MS (ESI+) and cytotoxic profiles against colon cancer cell lines

Author:: Denis Amilton dos Santos; Fernanda Mosena Munari; Caroline Olivieri da Silva Frozza; Sidnei Moura; Thiago Barcellos; João Antonio Pêgas Henriques; Mariana Roesch-Ely
Source:: Biotechnology Research and Innovation 2019 v.3 no.1 pp. 120-130
ISSN:: 2452-0721
Subject:: active ingredients; antineoplastic activity; cell lines; chromatography; colorectal neoplasms; cytotoxicity; formononetin; fractionation; honey bees; inhibitory concentration 50; neoplasm cells; propolis; staining; tandem mass spectrometry; viability assays
Abstract:: ... Red propolis is a natural resin mixture produced by honeybees and presents a source of active compounds with a variety of biological activities. In this study, we describe the chemical characterization and potential antitumor activity of total extract of Brazilian red propolis and its fractions. Fractions were obtained through column chromatography revealing 14 different compounds in all samples, ...
DOI:: 10.1016/j.biori.2019.02.001
: https://doi.org/10.1016/j.biori.2019.02.001

42. C-prenylated flavonoids with potential cytotoxic activity against solid tumor cell lines

Author:: Lenka Molčanová; Dominika Janošíková; Stefano Dall´Acqua; Karel Šmejkal
Source:: Phytochemistry reviews 2019 v.18 no.4 pp. 1051-1100
ISSN:: 1568-7767
Subject:: antineoplastic activity; antineoplastic agents; bioassays; cell culture; cell lines; chemoprevention; cytotoxicity; drug therapy; flavanones; flavonols; in vitro studies; isoflavonoids; neoplasm cells; neoplasms; oxygen; secondary metabolites
Abstract:: ... Natural products of plant origin or their semisynthetic derivatives acting as chemopreventive or chemotherapeutic agents for various types of cancer are under study as potential new anticancer drugs. Within the huge class of plant phenolic secondary metabolites, the subclass of prenylated flavonoids is quite rich in structural variety and pharmacological activity. One of their most prominent chara ...
DOI:: 10.1007/s11101-019-09641-z
: https://doi.org/10.1007/s11101-019-09641-z

43. Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and reactive oxygen species generation in A549 and NCI-H1299 non-small cell lung cancer cells

Author:: Jiyon Lee; Hui-Ju Jang; Hyunwoo Chun; Thu-Huyen Pham; Yesol Bak; Jong-Woon Shin; Hang Jin; Yong-In Kim; Hyung Won Ryu; Sei Ryang Oh; Do-Young Yoon
Source:: BMC complementary and alternative medicine 2019 v.19 no.1 pp. 134
ISSN:: 1472-6882
Subject:: Calotropis gigantea; Western blotting; alternative medicine; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; ethanol; fever; flowers; humans; indigestion; isothiocyanates; leprosy; lung neoplasms; neoplasm cells; propidium; quantitative polymerase chain reaction; reactive oxygen species; reverse transcriptase polymerase chain reaction; rheumatoid arthritis; signal transduction; staining
Abstract:: ... BACKGROUND: Calotropis gigantea (CG) is a tall and waxy flower that is used as a traditional remedy for fever, indigestion, rheumatism, leprosy, and leukoderma. However, the precise mechanisms of its anticancer effects have not yet been examined in human non-small cell lung cancer (NSCLC) cells. In this study, we investigated whether CG extract exerted an apoptotic effect in A549 and NCI-H1299 NSC ...
DOI:: 10.1186/s12906-019-2561-1
PubMed:: 31215445
PubMed Central:: PMC6582476
: https://doi.org/10.1186/s12906-019-2561-1

44. Carboplatin prodrug conjugated Fe₃O₄ nanoparticles for magnetically targeted drug delivery in ovarian cancer cells

Author:: Haiqin SongThe two authors contributed equally to this work.; Feifei Quan; Zhiqiang Yu; Minhua Zheng; Yan Ma; Haihua Xiao; Fang Ding
Source:: Journal of materials chemistry B 2019 v.7 no.3 pp. 433-442
ISSN:: 2050-7518
Subject:: adverse effects; animal ovaries; antineoplastic activity; cell lines; chemistry; cisplatin; cytotoxicity; drug resistance; endocytosis; in vivo studies; iron oxides; magnetic fields; nanocarriers; nanoparticles; neoplasm cells; ovarian neoplasms; platinum; toxicity testing; zeta potential
Abstract:: ... Platinum (Pt)-based drugs including cisplatin, carboplatin and oxaliplatin have been widely used as first-line anticancer regimens due to their excellent anticancer efficacy. However, the clinical application of these drugs is greatly limited due to their side effects and drug resistance. In this study, an antitumor drug delivery system based on carboplatin prodrug loading Fe₃O₄ nanoparticles (NPs ...
DOI:: 10.1039/c8tb02574f
: https://doi.org/10.1039/c8tb02574f

45. Carvacrol/β-cyclodextrin inclusion complex inhibits cell proliferation and migration of prostate cancer cells

Author:: Gabriela G.G. Trindade; Greeshma Thrivikraman; Paula P. Menezes; Cristiane M. França; Bruno S. Lima; Yasmim M.B.G. Carvalho; Eloísa P.B.S.S. Souza; Marcelo C. Duarte; Saravanan Shanmugam; Lucindo J. Quintans-Júnior; Daniel P. Bezerra; Luiz E. Bertassoni; Adriano A.S. Araújo
Source:: Food and chemical toxicology 2019 v.125 pp. 198-209
ISSN:: 0278-6915
Subject:: Fourier transform infrared spectroscopy; X-ray diffraction; antineoplastic activity; beta-cyclodextrin; bioavailability; carvacrol; cell culture; cell growth; cell lines; cell proliferation; cytotoxicity; dose response; freeze drying; high performance liquid chromatography; monoterpenoids; neoplasm cells; nuclear magnetic resonance spectroscopy; prostatic neoplasms; scanning electron microscopy; solubility; thermal analysis; thyme oil; toxicology
Abstract:: ... Carvacrol, a phenolic monoterpene derived from thyme oil has gained wide interest recently because of its anticancer activities. To improve the solubility of carvacrol, the formation of inclusion complexes with β-cyclodextrin was performed by ultrasound and freeze-drying methods and characterized using thermal analysis, FTIR, XRD, SEM, NMR and HPLC analysis. From these results, carvacrol was succe ...
DOI:: 10.1016/j.fct.2019.01.003
: https://doi.org/10.1016/j.fct.2019.01.003

46. Characterization and screening of anti-tumor activity of fucoidan from acid-processed hijiki (Hizikia fusiforme)

Author:: Yu-Lin Dai; Yun-Fei Jiang; Hyo Geun Lee; You-Jin Jeon; Min-Cheol Kang
Source:: International journal of biological macromolecules 2019 v.139 pp. 170-180
ISSN:: 0141-8130
Subject:: B-cell lymphoma; Fourier transform infrared spectroscopy; antineoplastic activity; apoptosis; caspase-3; cell growth; cell lines; citric acid; fucoidan; fucose; heavy metals; high performance liquid chromatography; membrane potential; mitochondrial membrane; neoplasm cells; reactive oxygen species; screening; staining; sulfates; South Korea
Abstract:: ... The aim of this study was to investigate the antiproliferative effects of fucoidan from three regional hijiki (Hizikia fusiforme) samples (Zhejiang-China, Jeju-Korea [JH], and Wando-Korea) in East Asia. Hijiki was processed using 1% citric acid to decrease heavy metal content. The JH sample was separated using diethylaminoethyl-cellulose-ion exchange chromatography to obtain four active fractions ...
DOI:: 10.1016/j.ijbiomac.2019.07.119
: https://doi.org/10.1016/j.ijbiomac.2019.07.119

47. Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry)

Author:: Sen Guo; Li Liu; Shanshan Zhang; Chuang Yang; Wenping Yue; Haoan Zhao; Chi-Tang Ho; Junfeng Du; Hai Zhang; Naisheng Bai
Source:: Food & function 2019 v.10 no.10 pp. 6915-6926
ISSN:: 2042-650X
Subject:: Morus australis; acetylcholinesterase; alpha-glucosidase; antineoplastic activity; apoptosis; cell lines; chromatography; cytotoxicity; enzyme inhibition; mitochondria; mulberries; phosphatidylinositol 3-kinase; polyphenols; roots; spectral analysis; China
Abstract:: ... Morus species, commonly known as mulberry, is widely distributed in China. The mulberry tree is a high-value plant in agriculture. Morus australis is one of the major Morus species growing in Northern China. However, the biological properties of the main constituents of M. australis roots were not well studied. In the present study, through extensive chromatographic and spectral analysis, 12 pheno ...
DOI:: 10.1039/c9fo01457h
: https://doi.org/10.1039/c9fo01457h

48. Chemical secondary metabolite profiling of Bauhinia longifolia ethanolic leaves extracts

Author:: Amanda J. Aquino; Thayana da C. Alves; Regina V. Oliveira; Antonio G. Ferreira; Quezia B. Cass
Source:: Industrial crops and products 2019 v.132 pp. 59-68
ISSN:: 0926-6690
Subject:: Bauhinia; antineoplastic activity; cell lines; chemical analysis; databases; flavonoids; glycosides; indigenous species; leaf extracts; leaves; liquid chromatography; medicine; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; phenolic acids; proanthocyanidins; quality control; secondary metabolites; solid phase extraction; spectrometers; tea; Brazil
Abstract:: ... The genus Bauhinia belongs to the family Fabaceae and comprises about 18,000 known species in the world. In Brazil, approximately more than 60 native species of Bauhinia are found. Bauhinia leaves tea infusion or other preparations have been widely used in the Brazilian popular medicine for treatment of several illnesses. Therefore, this work aims to a better understanding of Bauhinia longifolia t ...
DOI:: 10.1016/j.indcrop.2019.01.040
: https://doi.org/10.1016/j.indcrop.2019.01.040

49. Chitooligosaccharides display anti-tumor effects against human cervical cancer cells via the apoptotic and autophagic pathways

Author:: Mengyao Zhao; Liming Gu; Yun Li; Shumin Chen; Jiangshan You; Liqiang Fan; Yudong Wang; Liming Zhao
Source:: Carbohydrate polymers 2019 pp. -
ISSN:: 0144-8617
Subject:: antineoplastic activity; apoptosis; bioavailability; cell lines; chitooligosaccharides; females; humans; mitochondria; molecular weight; neoplasm cells; oxidative stress; polymerization; uterine cervical neoplasms; water solubility
Abstract:: ... Gynecological cancers are the most commonly diagnosed forms of cancer among the female population. Chitooligosaccharides (COS)—hydrolysis products from chitosan—display high bioavailability, high water solubility, and low molecular weight properties. Here, we investigated the influence of COS on 11 gynecological tumor cell types, and subsequently elucidated molecular mechanisms through which the o ...
DOI:: 10.1016/j.carbpol.2019.115171
: https://doi.org/10.1016/j.carbpol.2019.115171

50. Clinically relevant concentration of sevoflurane suppresses cervical cancer growth and migration through targeting multiple oncogenic pathways

Author:: Jie Ding; Lixin Zhang; Si Zeng; Tao Feng
Source:: Biochemical and biophysical research communications 2019 v.514 no.4 pp. 1179-1184
ISSN:: 0006-291X
Subject:: antineoplastic activity; cell lines; enzyme activity; genetic background; guanosinetriphosphatase; metastasis; neoplasm cells; sevoflurane; signal transduction; uterine cervical neoplasms
Abstract:: ... The biological effects of sevoflurane, a volatile anesthetics, on cancer cells seem to be contradictory and are not fully understood. While some studies demonstrate that sevoflurane promotes tumor growth, other studies report that sevoflurane displays anti-cancer activities. In this work, we systematically investigated the effects of sevoflurane at clinically relevant dose on the multiple biologic ...
DOI:: 10.1016/j.bbrc.2019.05.082
: https://doi.org/10.1016/j.bbrc.2019.05.082

51. Co-encapsulation of thymoquinone with docetaxel enhances the encapsulation efficiency into PEGylated liposomes and the chemosensitivity of MCF7 breast cancer cells to docetaxel

Author:: Fadwa Odeh; Randa Naffa; Hanan Azzam; Ismail S. Mahmoud; Walhan Alshaer; Abeer Al Bawab; Said Ismail
Source:: Heliyon 2019 v.5 no.11 pp. e02919
ISSN:: 2405-8440
Subject:: Nigella sativa; antineoplastic activity; breast neoplasms; cell lines; cell viability; cytotoxicity; drug therapy; encapsulation; neoplasm cells; synergism; thymoquinone; viability assays
Abstract:: ... Combinatorial therapeutic strategies to eradicate tumors can be superior to a single therapeutic modality. Docetaxel (DT) has been approved for the treatment of local or metastasized breast cancer alone or in combination with other chemotherapeutic agents. Thymoquinone (TQ) originated from the seeds of Nigella Sativa plant has been reported to possess in vitro and in vivo antitumor activity agains ...
DOI:: 10.1016/j.heliyon.2019.e02919
PubMed:: 31844767
PubMed Central:: PMC6895652
: https://doi.org/10.1016/j.heliyon.2019.e02919

52. Comparative assessment of Prunus spinosa L. flower extract in non-neoplastic hepatocytes and hepatoblastoma cells

Author:: T. Murati; M. Miletić; A. Štefanko; I. Landeka Jurčević; I. Elez Garofulić; V. Dragović-Uzelac; I. Kmetič
Source:: South African journal of botany 2019 v.123 pp. 36-42
ISSN:: 0254-6299
Subject:: Prunus spinosa; antineoplastic activity; apoptosis; bioactive compounds; cell lines; cytotoxicity; flower extracts; flowers; hepatocytes; hepatoma; necrosis; neoplasm cells; viability
Abstract:: ... Prunus spinosa L. (blackthorn) flower was most recently pointed out as a valuable source of bioactive compounds that have potent anticancer properties. To test for antineoplastic activity, hepatocarcinoma cells (Hepa 1–6) and corresponding non-neoplastic hepatocytes (AML 12) were subjected to Prunus spinosa L. blossom ethanolic extract (5–200 μg mL−1). Antiproliferative activity was determined by ...
DOI:: 10.1016/j.sajb.2019.02.006
: https://doi.org/10.1016/j.sajb.2019.02.006

53. Could volatile compounds from leaves and fruits of Pistacia lentiscus constitute a novel source of anticancer, antioxidant, antiparasitic and antibacterial drugs?

Author:: Abdelhakim Bouyahya; Inès Christelle Chadon Assemian; Houda Mouzount; Ilhame Bourais; Abdeslam Et-Touys; Hajiba Fellah; Abdelaziz Benjouad; Nadia Dakka; Youssef Bakri
Source:: Industrial crops and products 2019 v.128 pp. 62-69
ISSN:: 0926-6690
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Leishmania infantum; Leishmania major; Leishmania tropica; Pistacia lentiscus; Proteus mirabilis; Pseudomonas aeruginosa; adenocarcinoma; alpha-pinene; alternative medicine; antibacterial properties; antibiotics; antineoplastic activity; antioxidant activity; antioxidants; antiparasitic agents; antiparasitic properties; bioactive compounds; cell lines; cytotoxicity; essential oils; fruits; gas chromatography-mass spectrometry; inhibitory concentration 50; leaves; limonene; membrane permeability; myrcene; volatile compounds
Abstract:: ... Essential oils possess remarkable biological properties, which constitute an important source for the development of bioactive compounds used in alternative medicine. This work aimed to determine the volatile compounds Pistacia lentiscus L. essential oils extracted from leaves and fruits and to evaluate their anticancer, antioxidant, antibacterial and antiparasitic activities. The gas chromatograp ...
DOI:: 10.1016/j.indcrop.2018.11.001
: https://doi.org/10.1016/j.indcrop.2018.11.001

54. Crude extract of Origanum vulgare L. induced cell death and suppressed MAPK and PI3/Akt signaling pathways in SW13 and H295R cell lines

Author:: Beatrice Rubin; Jacopo Manso; Halenya Monticelli; Loris Bertazza; Marco Redaelli; Francesca Sensi; Maira Zorzan; Carla Scaroni; Caterina Mian; Maurizio Iacobone; Decio Armanini; Cristina Bertolini; Susi Barollo; Marco Boscaro; Raffaele Pezzani
Source:: Natural product research 2019 v.33 no.11 pp. 1646-1649
ISSN:: 1478-6427
Subject:: Artemia; Origanum vulgare; antineoplastic activity; cell cycle; cell death; cell lines; cell viability; death; menstruation; mitogen-activated protein kinase; models; neoplasm cells; oregano; respiratory tract diseases; rheumatoid arthritis; signal transduction; toxicity
Abstract:: ... Oregano (Origanum vulgare L.) is a common aromatic plant used in Mediterranean and Asian Regions for treating respiratory diseases, painful menstruation, rheumatoid arthritis, etc. Recently its role as an anticancer plant has been suggested, although oregano has been never evaluated into adrenocortical tumour cell models. This study analysed for the first time the anticancer effects of a crude ext ...
DOI:: 10.1080/14786419.2018.1425846
: https://doi.org/10.1080/14786419.2018.1425846

55. Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells

Author:: Nishtha S Srivastava; Rai Ajit K Srivastava
Source:: Phytomedicine 2019 v.52 pp. 117-128
ISSN:: 0944-7113
Subject:: anti-inflammatory activity; antineoplastic activity; antineoplastic agents; apoptosis; berberine; beta catenin; caspases; cell lines; cell proliferation; curcumin; cyclins; epigallocatechin; inhibitory concentration 50; mechanism of action; melanoma; mitogen-activated protein kinase; neoplasm cells; phosphatidylinositol 3-kinase; quercetin; signal transduction; synergism; therapeutics; transcription factor NF-kappa B
Abstract:: ... Traditional therapy using natural products, especially flavonoids and alkaloids have been in practice for a long time. Among flavonoids, curcumin, quercetin, berberine, and epigallocatechin have been studied in greater detail in terms of their anticancer and anti-inflammatory activities. Although many studies focused on the PI3K, MAP kinase and NF-κB pathways, a thorough investigation of modulatio ...
DOI:: 10.1016/j.phymed.2018.09.224
: https://doi.org/10.1016/j.phymed.2018.09.224

56. Curcumin potentiates the antitumor activity of Paclitaxel in rat glioma C6 cells

Author:: Deborah Fratantonio; Maria Sofia Molonia; Romina Bashllari; Claudia Muscarà; Guido Ferlazzo; Gregorio Costa; Antonella Saija; Francesco Cimino; Antonio Speciale
Source:: Phytomedicine 2019 v.55 pp. 23-30
ISSN:: 0944-7113
Subject:: adverse effects; antineoplastic activity; apoptosis; brain; brain neoplasms; caspase-3; cell cycle checkpoints; cell lines; curcumin; cytotoxicity; drug resistance; drug therapy; drugs; microtubules; paclitaxel; phosphorylation; pro-apoptotic proteins; rats; stabilizers; transcription factor NF-kappa B
Abstract:: ... Glioma is the most common primary cancer in central nervous system, especially in brain. Paclitaxel (PTX) is a microtubule stabilizing agent with anticancer potential, but its clinical application to brain tumours is limited by drug resistance, side effects, and lower brain penetration.Herein we explored the in vitro effects, in glioma C6 cells, of the combination of PTX with curcumin, a natural c ...
DOI:: 10.1016/j.phymed.2018.08.009
: https://doi.org/10.1016/j.phymed.2018.08.009

57. Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma

Author:: Federico Cocozza; Florencia Menay; Rodrigo Tsacalian; Analía Elisei; Pura Sampedro; Ivana Soria; Claudia Waldner; María José Gravisaco; Claudia Mongini
Source:: Vaccine 2019 v.37 no.12 pp. 1565-1576
ISSN:: 0264-410X
Subject:: T-cell lymphoma; acidosis; antigens; antineoplastic activity; cancer vaccines; cell lines; cell-mediated immunity; cyclophosphamide; cytotoxicity; exosomes; hypoxia; immune response; immunization; immunogenicity; interferon-gamma; mice; neoplasm cells; proteins; secretion
Abstract:: ... Exosomes are 60–150 nm small extracellular vesicles (EVs) released by most cells. Tumor-cell-derived exosomes, used as a vaccine, elicit a specific cytotoxic response against tumor cells, usually with a greater immunogenicity than tumor-cell lysates. However, the number of exosomes isolated from culture cells is limited. In recent studies, it was observed that cells respond to different stressor s ...
DOI:: 10.1016/j.vaccine.2019.02.004
: https://doi.org/10.1016/j.vaccine.2019.02.004

58. Cytotoxic and Antiproliferative Effects of Preussin, a Hydroxypyrrolidine Derivative from the Marine Sponge-Associated Fungus Aspergillus candidus KUFA 0062, in a Panel of Breast Cancer Cell Lines and Using 2D and 3D Cultures

Author:: Fernanda Malhão; Alice A. Ramos; Suradet Buttachon; Tida Dethoup; Anake Kijjoa; Eduardo Rocha
Source:: Marine drugs 2019 v.17 no.8 pp. -
ISSN:: 1660-3397
Subject:: Aspergillus candidus; antineoplastic activity; breast neoplasms; caspase-3; cell death; cell lines; cell structures; cell viability; cytotoxicity; electron microscopy; fungi; histology; immunocytochemistry; lactate dehydrogenase; models; neoplasm cells
Abstract:: ... Preussin, a hydroxyl pyrrolidine derivative isolated from the marine sponge-associated fungus Aspergillus candidus KUFA 0062, displayed anticancer effects in some cancer cell lines, including MCF7. Preussin was investigated for its cytotoxic and antiproliferative effects in breast cancer cell lines (MCF7, SKBR3, and MDA-MB-231), representatives of major breast cancers subtypes, and in a non-tumor ...
DOI:: 10.3390/md17080448
PubMed:: 31366127
PubMed Central:: PMC6722565
: https://doi.org/10.3390/md17080448

59. Cytotoxic and antimicrobial indole alkaloids from an endophytic fungus Chaetomium sp. SYP-F7950 of Panax notoginseng

Author:: Fei Peng; Shao-Yang Hou; Tian-Yuan Zhang; Ying-Ying Wu; Meng-Yue Zhang; Xi-Meng Yan; Ming-Yu Xia; Yi-Xuan Zhang
Source:: RSC advances 2019 v.9 no.49 pp. 28754-28763
ISSN:: 2046-2069
Subject:: Bacillus subtilis; Candida albicans; Chaetomium; Enterococcus faecium; Panax notoginseng; Staphylococcus aureus; active sites; antibacterial properties; antifungal properties; antineoplastic activity; cell lines; circular dichroism spectroscopy; computer simulation; cytotoxicity; drug therapy; endophytes; fermented foods; fungi; indole alkaloids; inhibitory concentration 50; minimum inhibitory concentration; neoplasm cells; nuclear magnetic resonance spectroscopy; paclitaxel; phenotype; spectral analysis
Abstract:: ... Two new compounds chetoseminudin F (1) and G (2) together with eleven known compounds were isolated from the solid fermentation products of the endophytic fungus Chaetomium sp. SYP-F7950. The structures of the isolated compounds were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HRFABMS experiments. The absolute configurations of chetoseminudin F (1) and G (2) were d ...
DOI:: 10.1039/c9ra04747f
: https://doi.org/10.1039/c9ra04747f

60. Cytotoxic and cell cycle arrest induction of pentacyclic triterpenoides separated from Lantana camara leaves against MCF-7 cell line in vitro

Author:: Zahraa R. Shamsee; Ali Z. Al-Saffar; Ahmed F. Al-Shanon; Jameel R. Al-Obaidi
Source:: Molecular biology reports 2019 v.46 no.1 pp. 381-390
ISSN:: 0301-4851
Subject:: Lantana camara; active ingredients; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; caspase-9; cell cycle checkpoints; cell lines; cell viability; cytotoxicity; dose response; inhibitory concentration 50; interphase; leaves; liquid chromatography; medicinal plants; tandem mass spectrometry; triterpenoids
Abstract:: ... Lantana camara is an important medicinal plant that contains many active compounds, including pentacyclic triterpenoids, with numerous biological activities. The present study was conducted to evaluate the anti-oxidant, anti-tumour, and cell cycle arrest properties of chemical compounds extracted from L. camara leaves. Four compounds were identified after subjecting the plant methanolic extract to ...
DOI:: 10.1007/s11033-018-4482-3
: https://doi.org/10.1007/s11033-018-4482-3

61. Cytotoxic effect induced apoptosis in lung cancer cell line on Ageratina adenophora leaf extract

Author:: Suganya Mani; Karthik Natesan; Kavitha Shivaji; Mythili Gnanamangai Balasubramanian; Ponmurugan Ponnusamy
Source:: Biocatalysis and agricultural biotechnology 2019 v.22 pp. 101381
ISSN:: 1878-8181
Subject:: Ageratina adenophora; antineoplastic activity; apoptosis; cell lines; cytotoxicity; drug therapy; drugs; inhibitory concentration 50; leaf extracts; lung neoplasms; neoplasm cells; propidium; staining
Abstract:: ... Ageratina, adenophora, (A. adenophora) is a conventional prescription plant utilized for various purposes in around the world. However, its biological impacts and their potential components have not been adequately examined. The present investigation assessed the anticancerous properties of A. adenophora leaf extract. The methanolic extract inspired the most pronounced cytotoxic effect in lung can ...
DOI:: 10.1016/j.bcab.2019.101381
: https://doi.org/10.1016/j.bcab.2019.101381

62. DNA Binding and Molecular Dynamic Studies of Polycyclic Tetramate Macrolactams (PTM) with Potential Anticancer Activity Isolated from a Sponge-Associated Streptomyces zhaozhouensis subsp. mycale subsp. nov.

Author:: M. Dhaneesha; O. Hasin; K. C. Sivakumar; R. Ravinesh; C. Benjamin Naman; S. Carmeli; T. P. Sajeevan
Source:: Marine biotechnology 2019 v.21 no.1 pp. 124-137
ISSN:: 1436-2228
Subject:: Mycale; Streptomyces; anticarcinogenic activity; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; coasts; computer simulation; culture media; cytotoxicity; ethyl acetate; flow cytometry; fractionation; interphase; lung neoplasms; mechanism of action; neoplasm cells; new subspecies; phylogeny; ribosomal DNA; ribosomal RNA; sequence homology; India; Indian Ocean
Abstract:: ... A sponge-associated actinomycete (strain MCCB267) was isolated from a marine sponge Mycale sp. collected in the Indian Ocean off the Southeast coast of India. Phylogenetic studies of this strain using 16S rRNA gene sequencing showed high sequence similarity to Streptomyces zhaozhouensis. However, strain MCCB267 showed distinct physiological and biochemical characteristic features and was thus desi ...
DOI:: 10.1007/s10126-018-9866-9
: https://doi.org/10.1007/s10126-018-9866-9

63. Design and synthesis of a phenyl C-glycoside derivative of Spliceostatin A and its biological evaluation toward prostate cancer treatment

Author:: Yusuke Yoshikawa; Airi Ishibashi; Kenichi Murai; Yasufumi Kaneda; Keisuke Nimura; Mitsuhiro Arisawa
Source:: Tetrahedron letters 2019 v.60 no.51 pp. 151313
ISSN:: 0040-4039
Subject:: antineoplastic activity; biological assessment; cell lines; cell proliferation; chemical reactions; chemical structure; glycosides; neoplasm cells; organic compounds; prostatic neoplasms; sugars
Abstract:: ... We designed and synthesized a novel phenyl C-glycoside analogue of Spliceostatin A, which is potent splicing inhibitor and has anti-cancer activities. We successfully synthesized its right phenyl C-glycoside sugar fragment in shorter steps compared to previous synthetic methods for Spliceostatin A and revealed an appropriate fragment combination with a Julia-coupling reaction. Regarding biological ...
DOI:: 10.1016/j.tetlet.2019.151313
: https://doi.org/10.1016/j.tetlet.2019.151313

64. Dried leaf Artemisia annua efficacy against non-small cell lung cancer

Author:: Dina J. Rassias; Pamela J. Weathers
Source:: Phytomedicine 2019 v.52 pp. 247-253
ISSN:: 0944-7113
Subject:: Artemisia annua; DNA damage; animal models; antineoplastic activity; apoptosis; artemisinin; cell lines; cell movement; cell viability; cytotoxicity; drugs; fibroblasts; growth retardation; histones; humans; leaves; lung neoplasms; malaria; mice; mitosis; patients; phosphorylation; prognosis; therapeutics
Abstract:: ... Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer with poor prognosis. Artemisinin (AN), produced naturally in Artemisia annua L., has anti-cancer activity. Artemisinin delivered as dried leaf Artemisia (DLA) showed efficacy against malaria in rodents and humans.DLA is posited as being at least as efficacious as artesunate (AS) in its ability to induce cytotoxicity in NSCLC cell ...
DOI:: 10.1016/j.phymed.2018.09.167
: https://doi.org/10.1016/j.phymed.2018.09.167

65. Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells

Author:: Samiya Rehman; Ken Keefover-Ring; Ihsan ul Haq; Erum Dilshad; Mohammad Imran Khan; Nosheen Akhtar; Bushra Mirza
Source:: Applied biochemistry and biotechnology 2019 v.188 no.2 pp. 460-480
ISSN:: 0273-2289
Subject:: Withania coagulans; antineoplastic activity; apoptosis; atmospheric precipitation; cell lines; cell proliferation; cell viability; climatic factors; fruits; germplasm; humans; leaf extracts; leaves; men; neoplasm cells; prostatic neoplasms; roots; stems; tissues; Pakistan
Abstract:: ... Prostate cancer is one of the major causes of cancer-related deaths in men and there is a growing interest in identifying natural compounds for its management. We analyzed bioactive withanolides in Withania coagulans from 11 different sites in Pakistan and evaluated the antiprostate cancer activities of leaf extracts from two sites with the greatest amounts. Total withanolide concentration differe ...
DOI:: 10.1007/s12010-018-02933-8
: https://doi.org/10.1007/s12010-018-02933-8

66. Effect of germination on anticancer activity of Trigonella foenum seeds extract

Author:: Al-Shimaa M. Abas; Deyala M. Naguib
Source:: Biocatalysis and agricultural biotechnology 2019 v.18 pp. 101067
ISSN:: 1878-8181
Subject:: DNA fragmentation; Trigonella; alkaloids; antineoplastic activity; antioxidants; apoptosis; caspase-3; cell lines; cell viability; fenugreek; flavonoids; germination; humans; neoplasms; phenolic compounds; phytic acid; seed extracts; seeds; steroids
Abstract:: ... Trigonella foenum has a role in cancer treatment. This study tries to evaluate the effect of germination on the anticancer activity of fenugreek seeds. We prepared a dry and germinated aqueous extract from fenugreek seeds. We investigated the growth inhibitory effect of both extracts on MCF7 human breast and Pancreatic (AsPC-1) cells. Fenugreek extracts induced significant effect on cell viability ...
DOI:: 10.1016/j.bcab.2019.101067
: https://doi.org/10.1016/j.bcab.2019.101067

67. Effect of selected nonsteroidal anti-inflammatory drugs on the viability of canine osteosarcoma cells of the D-17 line: in vitro studies

Author:: Dominik Poradowski; Bożena Obmińska-Mrukowicz
Source:: Journal of Veterinary Research 2019 v.63 no.3 pp. 399-403
ISSN:: 2450-8608
Subject:: antineoplastic activity; blood serum; cell lines; cytotoxicity; dogs; flunixin; in vitro studies; ketoprofen; median effective concentration; osteosarcoma; pain; toxicity testing; veterinary medicine; viability
Abstract:: ... Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in veterinary medicine. They are used in pain control and in anti-inflammatory and antipyretic therapies. Some NSAIDs, e.g piroxicam, also have a documented anticancer effect. The objective of this study was to evaluate which of the commonly used NSAIDs (etodolac, flunixin, tolfenamic acid, carprofen, and ketoprofen) are cytotoxic to t ...
DOI:: 10.2478/jvetres-2019-0051
: https://doi.org/10.2478/jvetres-2019-0051

68. Enantioselective Synthesis, DFT Calculations, and Preliminary Antineoplastic Activity of Dibenzo 1-Azaspiro[4.5]decanes on Drug-Resistant Leukemias

Author:: Joseane A. Mendes; Pedro Merino; Tatiana Soler; Eduardo J. Salustiano; Paulo R. R. Costa; Miguel Yus; Francisco Foubelo; Camilla D. Buarque
Source:: Journal of organic chemistry 2019 v.84 no.4 pp. 2219-2233
ISSN:: 1520-6904
Subject:: antineoplastic activity; catalytic activity; cell lines; chemical reactions; chemical structure; enantioselective synthesis; ethyl ether; imines; ketones; multiple drug resistance; myeloid leukemia; neoplasm cells; organic chemistry; palladium; solvents; stereochemistry; toluene; topology; viability
Abstract:: ... The addition of 2-bromobenzylmagnesium bromide to chiral N-tert-butanesulfinyl imines derived from tetralone-type ketones proceeds with high levels of diastereocontrol. The resulting sulfinamide derivatives were transformed into dibenzoazaspiro compounds after a palladium-catalyzed intramolecular N-arylation. DFT calculations have been performed to rationalize the stereochemical course of the reac ...
DOI:: 10.1021/acs.joc.8b03203
: https://doi.org/10.1021/acs.joc.8b03203

69. Encapsulated human mesenchymal stem cells (eMSCs) as a novel anti-cancer agent targeting breast cancer stem cells: Development of 3D primed therapeutic MSCs

Author:: Saurabh Mandal; Frank Arfuso; Gautam Sethi; Arun Dharmarajan; Sudha Warrier
Source:: international journal of biochemistry & cell biology 2019 v.110 pp. 59-69
ISSN:: 1357-2725
Subject:: Western blotting; angiogenesis; antagonists; antineoplastic activity; antineoplastic agents; biocompatible materials; breast neoplasms; breasts; cadherins; caspases; cell lines; cell viability; encapsulation; epithelium; gene expression; gene expression regulation; genes; humans; immunomodulation; interferon-gamma; interleukin-10; mesenchymal stromal cells; microbeads; mortality; neoplasm cells; nitric oxide; reactive oxygen species; secretion; signal transduction; sodium alginate; stem cells; therapeutics; transforming growth factor beta; transporters; tumor necrosis factor-alpha; vascular endothelial growth factors; women
Abstract:: ... Breast cancer is a leading cause of mortality in women across the globe. The major reason for its recurrence and high mortality is due to the presence of a drug refractory and self-renewing population of cells, the cancer stem cells (CSCs). Mesenchymal stem cells (MSCs) have recently emerged as a promising cell-based therapeutic agent for the treatment of different cancer types. However, the anti- ...
DOI:: 10.1016/j.biocel.2019.02.001
: https://doi.org/10.1016/j.biocel.2019.02.001

70. Encapsulation of Doxorubicin in Furcellaran/Chitosan Nanocapsules by Layer-by-Layer Technique for Selectively Controlled Drug Delivery

Author:: Vedran Milosavljevic; Ewelina Jamroz; Milica Gagic; Yazan Haddad; Hana Michalkova; Radka Balkova; Barbora Tesarova; Amitava Moulick; Zbynek Heger; Lukas Richtera; Pavel Kopel; Vojtech Adam
Source:: Biomacromolecules 2019 v.21 no.2 pp. 418-434
ISSN:: 1526-4602
Subject:: DNA damage; DNA fragmentation; adverse effects; antineoplastic activity; apoptosis; cell lines; chitosan; doxorubicin; drug delivery systems; electrostatic interactions; encapsulation; endocytosis; erythrocyte membrane; nanocapsules; necrosis; pH; peptides; toxicity testing
Abstract:: ... Minimization of drug side effects is a hallmark of advanced targeted therapy. Herein we describe the synthesis of polysaccharide-based nanocapsules prepared from furcellaran and chitosan via layer-by-layer deposition using electrostatic interaction. Using doxorubicin as a model drug, prepared nanocapsules showed excellent drug loading properties and release influence by pH and stability. Targeted ...
DOI:: 10.1021/acs.biomac.9b01175
: https://doi.org/10.1021/acs.biomac.9b01175

71. Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties

Author:: Mandisa Mangisa; Vuyelwa J. Tembu; Gerda Fouche; Rudzani Nthambeleni; Xolani Peter; Moses K. Langat
Source:: Natural product research 2019 v.33 no.22 pp. 3240-3247
ISSN:: 1478-6427
Subject:: Euphorbiaceae; antineoplastic activity; bark extracts; breasts; cell lines; circular dichroism spectroscopy; cytotoxicity; diterpenoids; fractionation; melanoma; neoplasm cells; spectral analysis
Abstract:: ... The stem bark extract of Suregada zanzibariensis afforded a previously undescribed ent-abietane diterpenoid trivially named mangiolide (1) and a known jolkinolide B (2) via anticancer bioassay-guided fractionation. The CH₂Cl₂:MeOH extract of S. zanzibariensis was initially analysed for its anticancer properties against three cancer cell lines, renal (TK10), melanoma (UACC62), and breast (MCF7) and ...
DOI:: 10.1080/14786419.2018.1470628
: https://doi.org/10.1080/14786419.2018.1470628

72. Ethanolic extract of Cordyceps cicadae exerts antitumor effect on human gastric cancer SGC-7901 cells by inducing apoptosis, cell cycle arrest and endoplasmic reticulum stress

Author:: Hongqing Xie; Xiaotong Li; Yajie Chen; Mingzi Lang; Zhangfei Shen; Liangen Shi
Source:: Journal of ethnopharmacology 2019 v.231 pp. 230-240
ISSN:: 0378-8741
Subject:: Cordyceps; Oriental traditional medicine; Western blotting; adenine; adenosine; antineoplastic activity; antineoplastic agents; apoptosis; calcium; caspase-12; caspase-3; caspase-6; caspase-8; caspase-9; cell cycle checkpoints; cell lines; cyclin-dependent kinase; cyclins; cytochrome c; cytosol; dose response; endoplasmic reticulum; endoplasmic reticulum stress; flow cytometry; fluorescent dyes; high performance liquid chromatography; humans; interphase; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; staining; stomach neoplasms; therapeutics; toxicity; toxicity testing; uridine
Abstract:: ... Cordyceps cicadae (Miq.) Massee is a traditional Chinese medicine that has been used for approximately 1600 years in China. C. cicadae, a member of the Cordyceps genus, exerts a therapeutic effect on many diseases, such as cancer.This study aimed to evaluate the antineoplasmic activity of C. cicadae and to identify its molecular mechanism of cell death.The toxicity of the ethanolic extract of C. c ...
DOI:: 10.1016/j.jep.2018.11.028
: https://doi.org/10.1016/j.jep.2018.11.028

73. Euphorbia heterophylla (L.) mediated fabrication of ZnO NPs: Characterization and evaluation of antibacterial and anticancer properties

Author:: K. Lingaraju; H. Raja Naika; H. Nagabhushana; G. Nagaraju
Source:: Biocatalysis and agricultural biotechnology 2019 v.18 pp. 100894
ISSN:: 1878-8181
Subject:: Escherichia coli; Euphorbia heterophylla; Fourier transform infrared spectroscopy; Gram-negative bacteria; Klebsiella aerogenes; Pseudomonas; Raman spectroscopy; Staphylococcus aureus; X-ray diffraction; antineoplastic activity; cell lines; cytotoxicity; energy; energy-dispersive X-ray analysis; fuels; green chemistry; hepatoma; leaf extracts; lungs; moieties; reducing agents; reflectance spectroscopy; scanning electron microscopy; transmission electron microscopy; zinc oxide
Abstract:: ... Euphorbia heterophylla leaves extract mediated synthesis of multifunctional Zinc oxide nanoparticles (ZnO NPs) by green chemistry approaches. The prepared product was well characterized using various analytical tools namely X-ray diffraction (XRD), Ultra Violet-Diffused reflectance spectroscopy (UV-DRS), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, Scanning electron microsc ...
DOI:: 10.1016/j.bcab.2018.10.011
: https://doi.org/10.1016/j.bcab.2018.10.011

74. Evaluation of 5-fluorouracil-treated lung cancer cells by atomic force microscopy

Author:: Xiaolin Jiang; Ke Ma; Cuihua Hu; Mingyan Gao; Jiashuo Zhang; Ying Wang; Yujuan Chen; Zhengxun Song; Zuobin Wang
Source:: Analytical methods 2019 v.11 no.39 pp. 4977-4982
ISSN:: 1759-9679
Subject:: Cercopithecus aethiops; adhesion; adverse effects; analytical methods; anticarcinogenic agents; antineoplastic activity; atomic force microscopy; cell lines; drug toxicity; fluorouracil; kidneys; lung neoplasms; modulus of elasticity; neoplasm cells
Abstract:: ... Atomic force microscopy (AFM) can be used to obtain the physical information of single live cancer cells; however, the physical changes in live cells with time based on AFM remain to be studied, which play a key role in the evaluation of the efficacy and side effects of drugs. Herein, the treatment of the A549 cell line with the anticarcinogen 5-fluorouracil has been discussed based on the AFM ana ...
DOI:: 10.1039/c9ay01485c
: https://doi.org/10.1039/c9ay01485c

75. Evaluation of polyamines as marker of melanoma cell proliferation and differentiation by an improved high-performance liquid chromatographic method

Author:: Bruno Provenzano; Alessandro Lentini; Roberta Tatti; Angelo De Martino; Ilaria Borromeo; Carlo Mischiati; Giordana Feriotto; Cinzia Forni; Claudio Tabolacci; Simone Beninati
Source:: Amino acids 2019 v.51 no.10-12 pp. 1623-1631
ISSN:: 0939-4451
Subject:: antineoplastic activity; body fluids; cadaverine; cell differentiation; cell lines; cell proliferation; detection limit; enzyme activity; fluorescence; high performance liquid chromatography; melanin; melanoma; metastasis; mice; neoplasm cells; new drugs; packaging materials; protein-glutamine gamma-glutamyltransferase; putrescine; spermidine; spermine; theophylline; therapeutics
Abstract:: ... The differentiation therapy is focused on the identification of new agents able to impair the proliferative and metastatic potential of cancer cells through the induction of differentiation. Although several markers of cell differentiation on tumor cells have been identified, their causal relationship with neoplastic competence has not been characterized in sufficient detail to propose their use a ...
DOI:: 10.1007/s00726-019-02799-y
: https://doi.org/10.1007/s00726-019-02799-y

76. Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans

Author:: Juana Maria Lugo; Carolina Tafalla; Ayme Oliva; Tirso Pons; Brizaida Oliva; Carolina Aquilino; Reynold Morales; Mario Pablo Estrada
Source:: Fish & shellfish immunology 2019 v.86 pp. 559-570
ISSN:: 1050-4648
Subject:: Clarias gariepinus; Gram-positive bacteria; animal pathogenic bacteria; antimicrobial properties; antineoplastic activity; aquaculture; bacterial infections; catfish; cell lines; cytotoxicity; dose response; erythrocytes; fungi; genes; glucagon; humans; immune response; immune system; lung neoplasms; medicine; neoplasm cells; polypeptides; prediction; secretin; shellfish; therapeutics
Abstract:: ... Pituitary adenylate cyclase-activating polypeptide (PACAP) is a regulatory neuropeptide that belongs to the secretin/glucagon superfamily, of which some members have shown antimicrobial activities. Contrasting to mammals, published studies on the action of PACAP in non-mammalian vertebrate immune system remain scarce. Some of our recent studies added this peptide to the growing list of mediators t ...
DOI:: 10.1016/j.fsi.2018.11.056
: https://doi.org/10.1016/j.fsi.2018.11.056

77. Exploitation of apple pomace towards extraction of triterpenic acids, antioxidant potential, cytotoxic effects, and inhibition of clinically important enzymes

Author:: Shivraj Hariram Nile; Arti Nile; Junqiu Liu; Doo Hwan Kim; Guoyin Kai
Source:: Food and chemical toxicology 2019 v.131 pp. 110563
ISSN:: 0278-6915
Subject:: allopurinol; antineoplastic activity; antioxidant activity; antioxidants; apple pomace; betulinic acid; cell lines; chloroform; cytotoxicity; ethanol; ethyl acetate; functional foods; hexane; inhibitory concentration 50; kojic acid; methanol; neoplasm cells; neoplasms; tandem mass spectrometry; thiourea; urease; ursolic acid; xanthine oxidase
Abstract:: ... Apple pomace (AP) utilised for analysis of triterpenic acids (TTAs) using HPLC-MS/MS. The methanol, ethanol and ethyl acetate extracts showed high phenolic content with significant antioxidant activity compared to chloroform and n-hexane. AP TTAs; ursolic acid, betulinic acid and maslinic acid showed potent antioxidant and enzyme inhibitory effects. The IC50 values were 13.2–30.8 μg/mL (tyrosinase ...
DOI:: 10.1016/j.fct.2019.110563
: https://doi.org/10.1016/j.fct.2019.110563

78. Exploring the Chemical Composition and Anticancer Potential of Oil from Squid (Loligo duvauceli) Liver Waste from Fish Processing Industry

Author:: Meivelu Moovendhan; P. Seedevi; S. Vairamani; A. Shanmugam
Source:: Waste and biomass valorization 2019 v.10 no.10 pp. 2967-2973
ISSN:: 1877-2641
Subject:: Loligo; antineoplastic activity; carbohydrates; cell lines; cholesterol; cod liver oil; cytotoxicity; essential amino acids; fat soluble vitamins; fatty acids; fish processing; humans; industry; lipid composition; liver; lung neoplasms; minerals; neoplasm cells; nutrition; protein content; squid; wastes; water content
Abstract:: ... The present study was aimed to evaluate the nutritional fact and anticancer effect of liver oil extracted from the squid Loligo duvauceli. The ash and moisture content was noted as 3.21 and 2.13% whereas the total protein, lipid and carbohydrate, recorded 23.44, 21.23 and 2.13% respectively. The water and fat soluble vitamins and minerals were found in good level. The lipid profile was noted simil ...
DOI:: 10.1007/s12649-018-0304-z
: https://doi.org/10.1007/s12649-018-0304-z

79. Exploring the anticancer properties of essential oils from family Lamiaceae

Author:: Ludmilla Santos Silva de Mesquita; Tássio Rômulo Silva Araújo Luz; José Wilson Carvalho de Mesquita; Denise Fernandes Coutinho; Flavia Maria Mendonça do Amaral; Maria Nilce de Sousa Ribeiro; Sonia Malik
Source:: Food reviews international 2019 v.35 no.2 pp. 105-131
ISSN:: 1525-6103
Subject:: DNA repair; Lamiaceae; antineoplastic activity; antineoplastic agents; apoptosis; camphor; cell cycle checkpoints; cell lines; cineole; essential oils; geraniol; menthol; metastasis; neoplasms; plant growth substances; surveys; therapeutics; thymol
Abstract:: ... Lamiaceae is among the largest families of flowering plants with about 250 genera and over 7,000 species distributed around the world. It is considered as the important source of essential oils, for example, menthol, geraniol, eucalyptol, camphor and thymol. Therefore, it is imperative to study these economically important compounds under in vitro conditions for their sustainable and enhanced prod ...
DOI:: 10.1080/87559129.2018.1467443
: https://doi.org/10.1080/87559129.2018.1467443

80. Extracts of Hypsizygus tessellatus (white var.) caps inhibited MCF-7 and MDA-MB-231 cell lines proliferation

Author:: C. I. Ukaegbu; S. R. Shah; H. A. Hamid; Z. Normaiza; O. R. Alara
Source:: Journal of food measurement & characterization 2019 v.13 no.1 pp. 368-382
ISSN:: 2193-4126
Subject:: 2,2-diphenyl-1-picrylhydrazyl; Hypsizygus; acetone; adverse effects; antineoplastic activity; antineoplastic agents; antioxidant activity; breast neoplasms; breasts; cell lines; chemical constituents of plants; drug therapy; ethyl acetate; free radical scavengers; hydrogen peroxide; inhibitory concentration 50; liquid chromatography; mass spectrometry; neoplasm cells
Abstract:: ... Cancer management is associated with serious side-effects due to the harmful nature of radiation and chemotherapy on the body cells. These side-effects have necessitated the need for diversifying the alternative or complementary sources of cancer therapy. Natural products have been on the front line as alternative sources of anticancer agents and have attracted much attention in recent times. In t ...
DOI:: 10.1007/s11694-018-9952-8
: https://doi.org/10.1007/s11694-018-9952-8

81. Fabrication of Stable and Self-Assembling Rapeseed Protein Nanogel for Hydrophobic Curcumin Delivery

Author:: Zhigao Wang; Rui Xue Zhang; Cheng Zhang; Caixia Dai; Xingrong Ju; Rong He
Source:: Journal of agricultural and food chemistry 2019 v.67 no.3 pp. 887-894
ISSN:: 1520-5118
Subject:: acylation; antineoplastic activity; biopolymers; cell lines; crosslinking; curcumin; disulfide bonds; drug delivery systems; encapsulation; freeze drying; functional foods; heat; heat treatment; hydrophilicity; hydrophobicity; ionic strength; moieties; nanoparticles; neoplasm cells; neoplasms; pH; protein denaturation; protein isolates; rapeseed protein; temperature
Abstract:: ... Food-dervied biopolymer nanogels have recently received considerable attention as favorable carrier systems for nutraceuticals and drugs. In the present study, new biocompatible and self-assembled acylated rapeseed protein isolate (ARPI)-based nanogels were fabricated for potential hydrophobic drug delivery by chemical acylation and heat-induced protein denaturation. The effects of the ARPI concen ...
DOI:: 10.1021/acs.jafc.8b05572
: https://doi.org/10.1021/acs.jafc.8b05572

82. Fabrication of chitosan-bis (4-formyl-2 methoxy phenyl carbonate) Schiff base nanoparticles and evaluation of their antioxidant and anticancer properties

Author:: P. Thyriyalakshmi; K. V. Radha
Source:: Molecular biology reports 2019 v.46 no.4 pp. 4333-4347
ISSN:: 0301-4851
Subject:: X-ray diffraction; antineoplastic activity; antioxidants; carbon; carbonates; cell lines; chitosan; crosslinking; cytotoxicity; dose response; drugs; hydrolysis; moieties; nanoparticles; neoplasms; nuclear magnetic resonance spectroscopy; schiff bases; stable isotopes; therapeutics; thermal stability; thermogravimetry; transmission electron microscopy; vanillin
Abstract:: ... The present study details on the mechanism of synthesis of bis (4-formyl-2 methoxy phenyl carbonate), using two green reagents dimethyl carbonate and vanillin for application as therapeutic agent. The synthesized FMPC was identified from the ¹³C nuclear magnetic resonance spectra. The novel modified Schiff base nanoparticles resulted from the crosslinking of FMPC with chitosan were confirmed by cr ...
DOI:: 10.1007/s11033-019-04887-4
: https://doi.org/10.1007/s11033-019-04887-4

83. First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2′,4′-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy

Author:: Saskia Mayer; Marie Prechtl; Pia Liebfried; Ron-Patrick Cadeddu; Fabian Stuhldreier; Matthias Kohl; Folker Wenzel; Björn Stork; Sebastian Wesselborg; Peter Proksch; Ulrich Germing; Rainer Haas; Paul Jäger
Source:: Marine drugs 2019 v.17 no.9 pp. -
ISSN:: 1660-3397
Subject:: antineoplastic activity; antineoplastic agents; apoptosis; cancer therapy; cell lines; cytotoxicity; hematopoietic stem cells; humans; inhibitory concentration 50; mononuclear leukocytes; myeloid leukemia; niches; screening; viability
Abstract:: ... There is a variety of antineoplastic drugs that are based on natural compounds from ecological niches with high evolutionary pressure. We used two cell lines (Jurkat J16 and Ramos) in a screening to assess 300 different naturally occurring compounds with regard to their antineoplastic activity. The results of the compounds 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol (P01F03), 4,5,6-trib ...
DOI:: 10.3390/md17090521
PubMed:: 31491907
PubMed Central:: PMC6780284
: https://doi.org/10.3390/md17090521

84. Fluvastatin-mediated down-regulation of SATB1 affects aggressive phenotypes of human non-small-cell lung cancer cell line H292

Author:: Hong-Yu Xu; Jian-Xin Xue; Hui Gao; Fei-Fei Na; Hua Li; Tao Zhang; You Lu
Source:: Life sciences 2019 v.222 pp. 212-220
ISSN:: 0024-3205
Subject:: Western blotting; antineoplastic activity; apoptosis; binding proteins; cell lines; dose response; gene expression regulation; genome; humans; lung neoplasms; mechanics; metastasis; neoplasm cells; phenotype; reverse transcriptase polymerase chain reaction; therapeutics; transcription (genetics); transfection; viability assays
Abstract:: ... Fluvastatin reduces tumor proliferation and increased apoptotic activity in various cancers. Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer that reprogrammes the gene transcription profiles of tumors to promote growth and metastasis. The antitumor effect and molecular mechanisms of fluvastatin on lung cancer is poorly understood. This study aimed to investigate the antitu ...
DOI:: 10.1016/j.lfs.2018.12.022
: https://doi.org/10.1016/j.lfs.2018.12.022

85. Formulation and evaluation of cyclodextrin complexes for improved anticancer activity of repurposed drug: Niclosamide

Author:: Anurag Lodagekar; Roshan M. Borkar; Sowjanya Thatikonda; Rahul B. Chavan; V.G.M. Naidu; Nalini R. Shastri; R. Srinivas; Naveen Chella
Source:: Carbohydrate polymers 2019 v.212 pp. 252-259
ISSN:: 0144-8617
Subject:: Fourier transform infrared spectroscopy; antineoplastic activity; bioavailability; biopharmaceuticals; bricks; cell lines; cyclodextrins; cytotoxicity; freeze drying; geometry; males; mice; molecular models; neoplasm cells; niclosamide; pharmacokinetics; solubility
Abstract:: ... Niclosamide, previously used as an anthelmintic drug is currently being repurposed for its anticancer activity. Niclosamide is a brick like biopharmaceutical classification system (BCS) class II drug with poor aqueous solubility and dissolution consequently leading to low bioavailability. By considering the physicochemical properties and geometry of niclosamide, inclusion complex with cyclodextrin ...
DOI:: 10.1016/j.carbpol.2019.02.041
: https://doi.org/10.1016/j.carbpol.2019.02.041

86. Fucosterol exerts antiproliferative effects on human lung cancer cells by inducing apoptosis, cell cycle arrest and targeting of Raf/MEK/ERK signalling pathway

Author:: Zhangfan Mao; Xiaoling Shen; Ping Dong; Gaoli Liu; Shize Pan; Xiangran Sun; Haifeng Hu; Li Pan; Jie Huang
Source:: Phytomedicine 2019 v.61 pp. 152809
ISSN:: 0944-7113
Subject:: 4',6-diamidino-2-phenylindole; Western blotting; algae; antineoplastic activity; antineoplastic agents; apoptosis; caspase-3; cell cycle checkpoints; cell lines; cell movement; cell viability; cyclins; humans; in vivo studies; inhibitory concentration 50; lung neoplasms; lungs; mice; mitogen-activated protein kinase; neoplasm cells; phytosterols; protein synthesis; signal transduction; staining
Abstract:: ... Phytochemicals have attained tremendous attention as the chemo-preventive and chemotheruptic agents. Fucosterol is a phytosterol that in prevalently found in marine algae and many other plant species. Previous studies have indicated the potential of fucosterol as an anticancer agent. However, the information on the anticancer activity of fucosterol against lung cancer as well as several other type ...
DOI:: 10.1016/j.phymed.2018.12.032
: https://doi.org/10.1016/j.phymed.2018.12.032

87. Functional characterization of a potent anti-tumor polysaccharide in a mouse model of gastric cancer

Author:: Guangyu Li; Yiran Zhang; Enjun Xie; Xiang Yang; Hao Wang; Xijuan Wang; Wenwen Li; Zijun Song; Qingdian Mu; Weihua Zhan; Qian Wu; Juqing Huang; Yufeng Chen; Ying Zhang; Fudi Wang; Junxia Min
Source:: Life sciences 2019 v.219 pp. 11-19
ISSN:: 0024-3205
Subject:: agar; animal models; antineoplastic activity; apoptosis; bamboos; beta-galactosidase; biocompatibility; cell cycle; cell lines; cytokines; flow cytometry; humans; immunohistochemistry; immunostimulants; liver; lung neoplasms; macrophages; mice; neoplasm cells; screening; staining; stomach neoplasms; toxicity; viability assays
Abstract:: ... Natural polysaccharides are emerging as a new class of immunomodulatory agents due to their potent immunostimulatory effects and suitable biocompatibility. The aim of this study was to identify potent and selective anticancer activity of a bioactive polysaccharide.In vitro, viability assay was performed to screen 16 of bioactive polysaccharides in a panel of normal and cancer cell lines. Foci form ...
DOI:: 10.1016/j.lfs.2019.01.003
: https://doi.org/10.1016/j.lfs.2019.01.003

88. Fungal-mediated synthesis of pharmaceutically active silver nanoparticles and anticancer property against A549 cells through apoptosis

Author:: Tahira Akther; Vabeiryureilai Mathipi; Nachimuthu Senthil Kumar; MubarakAli Davoodbasha; Hemalatha Srinivasan
Source:: Environmental science and pollution research international 2019 v.26 no.13 pp. 13649-13657
ISSN:: 0944-1344
Subject:: Botryosphaeria rhodina; Catharanthus roseus; DNA fragmentation; antineoplastic activity; apoptosis; cell lines; cytotoxicity; endophytes; energy-dispersive X-ray analysis; fungi; inhibitory concentration 50; internal transcribed spacers; lungs; medicinal plants; metal ions; nanoparticles; nanosilver; neoplasm cells; neoplasms; scanning electron microscopy; secondary metabolites; spectrophotometers; transmission electron microscopy
Abstract:: ... Generally, fungi have the ability to secrete large amounts of secondary metabolites which have the ability to reduce metal ions to metallic nanoparticles. In this report, silver nanoparticles (AgNPs) were synthesized by using an endophytic fungus isolated from the medicinal plant, Catharanthus roseus (Linn.). The endophytic fungus was identified as Botryosphaeria rhodina based on the ITS sequencin ...
DOI:: 10.1007/s11356-019-04718-w
: https://doi.org/10.1007/s11356-019-04718-w

89. Gemcitabine anticancer activity enhancement by water soluble celecoxib/sulfobutyl ether-β-cyclodextrin inclusion complex

Author:: Antonio Rescifina; Emanuela Surdo; Venera Cardile; Rosanna Avola; Adriana Carol Eleonora Graziano; Rosanna Stancanelli; Silvana Tommasini; Venerando Pistarà; Cinzia Anna Ventura
Source:: Carbohydrate polymers 2019 v.206 pp. 792-800
ISSN:: 0144-8617
Subject:: antineoplastic activity; aromatic compounds; cell lines; cell viability; cytotoxicity; drugs; hydrogen bonding; lungs; nuclear magnetic resonance spectroscopy; therapeutics; water solubility
Abstract:: ... We investigated the complexation of celecoxib (CCB) into sulfobuthyl-ether-β-cyclodextrin (SBE-β-CD) for the realization of an inhalable dry-powder formulation containing gemcitabine (GEM) for lung anticancer therapy. Complexation increased the water solubility of CCB (0.003 mg/mL and 0.834 mg/mL for CCB free and complexed, respectively) and produced a quantitative dissolution of the drug within 1 ...
DOI:: 10.1016/j.carbpol.2018.11.060
: https://doi.org/10.1016/j.carbpol.2018.11.060

90. Green approach for the biosynthesis of silver nanoparticles and its antibacterial and antitumor effect against osteoblast MG-63 and breast MCF-7 cancer cell lines

Author:: Shahnaz Majeed; Nur Fadlin Binti Bakhtiar; Mohammed Danish; M.N. Mohamad Ibrahim; Rokiah Hashim
Source:: Sustainable chemistry and pharmacy 2019 v.12 pp. 100138
ISSN:: 2352-5541
Subject:: Artocarpus integer; Bacillus cereus; Escherichia coli; Fourier transform infrared spectroscopy; Salmonella; Staphylococcus aureus; absorption; alkenes; amides; amines; antibacterial properties; antineoplastic activity; biosynthesis; breasts; cell lines; ciprofloxacin; color; fibroblasts; green chemistry; inhibitory concentration 50; leaf extracts; nanoparticles; nanosilver; neoplasm cells; neoplasms; osteoblasts; particle size; protein degradation; silver nitrate; thermogravimetry; transmission electron microscopy
Abstract:: ... The proposed study aimed to biosynthesize the silver nanoparticles (AgNPs) using aqueous leaf extract of Artocarpus integer (Family-Moraceae) The aqueous extract of A. integer was challenged with silver nitrate solution to produce silver nanoparticles. The color change of the solution confirms the formation of nanoparticles. Characterization of the nanoparticles was performed through UV–Vis spectr ...
DOI:: 10.1016/j.scp.2019.100138
: https://doi.org/10.1016/j.scp.2019.100138

91. Green approach synthesis of Pd@TiO2 nanoparticles: characterization, visible light active picric acid degradation and anticancer activity

Author:: D. Hariharan; P. Thangamuniyandi; P. Selvakumar; U. Devan; A. Pugazhendhi; R. Vasantharaja; L.C. Nehru
Source:: Process biochemistry 2019 pp. -
ISSN:: 1359-5113
Subject:: X-ray diffraction; X-ray photoelectron spectroscopy; absorption; antineoplastic activity; cell death; cell lines; electron transfer; energy; light; nanoparticles; optical properties; palladium; photocatalysis; photolysis; titanium dioxide; transmission electron microscopy
Abstract:: ... Titanium dioxide (TiO2) and palladium (Pd) doped TiO2 (Pd@TiO2) nanoparticles have been synthesized using green approach technique. X-ray diffraction analysis reveals the formation of anatase phases for both pure TiO2 and Pd@TiO2. The optical properties confirm that the synthesized Pd@TiO2 eventually absorbs visible light. High resolution transmission electron microscopy analysis shows that the ti ...
DOI:: 10.1016/j.procbio.2019.09.024
: https://doi.org/10.1016/j.procbio.2019.09.024

92. Green synthesis of silver nanoparticles at low temperature in a fast pace with unique DPPH radical scavenging and selective cytotoxicity against MCF-7 and BT-20 tumor cell lines

Author:: Sadegh Khorrami; Atefeh Zarepour; Ali Zarrabi
Source:: Biotechnology reports 2019 v.24 pp. e00393
ISSN:: 2215-017X
Subject:: 2,2-diphenyl-1-picrylhydrazyl; ambient temperature; antineoplastic activity; antioxidant activity; biosynthesis; breast neoplasms; cell death; cell lines; cultivars; cytotoxicity; free radicals; median effective concentration; nanoparticles; nanosilver; neoplasm cells; pomegranates
Abstract:: ... "Black Peel Pomegranate" is a rare pomegranate cultivar that its specific features are still uncovered particularly in the bio-nano researches. The present study was organized to evaluate this pomegranate's potential in the biosynthesis of silver nanoparticles as well as bio-medical activities. According to the results, the pomegranate peel extract incredibly inhibited 100 % of DPPH free radicals ...
DOI:: 10.1016/j.btre.2019.e00393
PubMed:: 31763203
PubMed Central:: PMC6864360
: https://doi.org/10.1016/j.btre.2019.e00393

93. Green synthesis of zinc oxide nanoparticles and evaluation of anti-angiogenesis, anti-inflammatory and cytotoxicity properties

Author:: Ghasem Rahimi Kalateh Shah Mohammad; Masoud Homayouni Tabrizi; Touran Ardalan; Soheyla Yadamani; Elham Safavi
Source:: Journal of biosciences 2019 v.44 no.2 pp. 30
ISSN:: 0250-5991
Subject:: Fourier transform infrared spectroscopy; X-ray diffraction; angiogenesis; anti-inflammatory activity; antineoplastic activity; blood vessels; breast neoplasms; carrageenan; cell lines; chorioallantoic membrane; cytotoxicity; edema; genes; inflammation; interleukin-10; mice; nanoparticles; neoplasm cells; scanning electron microscopy; transmission electron microscopy; vascular endothelial growth factors; zinc oxide
Abstract:: ... In this study, zinc oxide nanoparticles (ZnO-NPs) were synthesized using the extract of Hyssops officinalis L. via green method and confirmed by transmission electron microscopy, field emission scanning electron microscopy, X-ray powder diffraction and Fourier transforms infrared spectroscopy techniques. In the in vivo section, the anti-angiogenesis and anti-inflammatory properties of the NPs were ...
DOI:: 10.1007/s12038-019-9845-y
: https://doi.org/10.1007/s12038-019-9845-y

94. High-yield expression in Escherichia coli, biophysical characterization, and biological evaluation of plant toxin gelonin

Author:: Guo-Bin Ding; Gengfeng Wu; Binchun Li; Peng Yang; Zhuoyu Li
Source:: 3 Biotech 2019 v.9 no.1 pp. 19
ISSN:: 2190-572X
Subject:: Escherichia coli; antineoplastic activity; cell lines; circular dichroism spectroscopy; colorectal neoplasms; cytotoxicity; neoplasm cells; protein subunits; protein synthesis; ribosomal proteins; toxins
Abstract:: ... Gelonin is a plant toxin that exerts potent cytotoxic activity by inactivation of the 60S ribosomal subunit. The high-level expression of soluble gelonin still remains a great challenge and there was no detailed biophysical analysis of gelonin from Escherichia coli (E. coli) yet. In this study, the soluble and high-yield expression of recombinant gelonin (rGel) was achieved in E. coli BL21 (DE3) f ...
DOI:: 10.1007/s13205-018-1559-6
PubMed:: 30622857
PubMed Central:: PMC6314936
: https://doi.org/10.1007/s13205-018-1559-6

95. Histopathological and genetic changes proved the anti-cancer potential of free and nano-capsulated sinapic acid

Author:: Doaa A. Badr; Mohamed E. Amer; Wagih M. Abd-Elhay; Mohamed S. M. Nasr; Tamer M. M. Abuamara; Harbi Ali; Aly F. Mohamed; Maha A. Youssef; Nasser S. Awwad; Yi-Hsu Ju; Ahmed E. Fazary
Source:: Applied biological chemistry 2019 v.62 no.1 pp. 59
ISSN:: 2468-0842
Subject:: adverse effects; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; colon; drug therapy; drugs; emulsifiers; encapsulation; fibroblasts; gene expression regulation; genes; histopathology; inhibitory concentration 50; lungs; mitosis; neoplasm cells; neoplasms; radiotherapy; sinapic acid; surgery; toxicity
Abstract:: ... Cancer is known to be a fierce disease that causes a large percentage of the deaths worldwide. The common cancer treatments; chemotherapy, radiotherapy and surgery are known for their severe side effects; therefore scientists are working on finding solutions to reduce these drawbacks. One of these treatment systems is the sustained released drugs formulations, these systems depend on the encapsula ...
DOI:: 10.1186/s13765-019-0462-0
: https://doi.org/10.1186/s13765-019-0462-0

96. Identification and characterization of oligomeric proanthocyanidins with significant anti-cancer activity in adzuki beans (Vigna angularis)

Author:: Sei-ichi Kawahara; Chisato Ishihara; Kiriko Matsumoto; Shogo Senga; Koichiro Kawaguchi; Ayaka Yamamoto; Jutalak Suwannachot; Yasunori Hamauzu; Hidefumi Makabe; Hiroshi Fujii
Source:: Heliyon 2019 v.5 no.10 pp. e02610
ISSN:: 2405-8440
Subject:: Vigna angularis; amberlite; antineoplastic activity; catechin; cell growth; cell lines; chromatography; electrospray ionization mass spectrometry; fatty acid-binding proteins; genes; humans; metastasis; neoplasm cells; proanthocyanidins; prostatic neoplasms
Abstract:: ... The aim of the present study was to characterize and evaluate the anti-cancer activity of proanthocyanidin-enriched fractions from adzuki beans. For this purpose, we concentrated proanthocyanidins from adzuki beans (Vigna angularis) into five fractions using Amberlite XAD-1180N, Toyopearl HW40F, and Sepacore C-18 reverse-phase flash column chromatography. Proanthocyanidin-enriched fractions were c ...
DOI:: 10.1016/j.heliyon.2019.e02610
PubMed:: 31687492
PubMed Central:: PMC6820087
: https://doi.org/10.1016/j.heliyon.2019.e02610

97. Identification of novel inhibitors of signal transducer and activator of transcription 3 over signal transducer and activator of transcription 1 for the treatment of breast cancer by in-silico and in-vitro approach

Author:: Stella Sravanthi V.; Bhagath Kumar Palaka; Gnana vel; Rengarajan Venkatesan; Dinakara Rao Ampasala; Latha Periyasamy
Source:: Process biochemistry 2019 v.82 pp. 153-166
ISSN:: 1359-5113
Subject:: antineoplastic activity; binding capacity; breast neoplasms; cell lines; computer software; density functional theory; in vitro studies; ligands; neoplasm cells; protein structure; screening; signal transduction; transactivators
Abstract:: ... In the present study, we have modelled signal transducer and activator of transcription (STAT) 3 and STAT1 proteins using SWISS-MODEL server and refined by molecular dynamic simulations using GROMACS 5.1.2 software for 30 ns. Later, refined protein structures were docked against 29,388 ligands by employing virtual screening workflow and selected 6 novel inhibitors with a better binding affinity to ...
DOI:: 10.1016/j.procbio.2019.04.018
: https://doi.org/10.1016/j.procbio.2019.04.018

98. Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum

Author:: Roberto T. Abdala Díaz; V. Casas Arrojo; M. A. Arrojo Agudo; C. Cárdenas; S. Dobretsov; F. L. Figueroa
Source:: Marine biotechnology 2019 v.21 no.4 pp. 577-587
ISSN:: 1436-2228
Subject:: Gelidium; Laminaria; Porphyra; adenocarcinoma; antineoplastic activity; antioxidant activity; antioxidants; breast neoplasms; breasts; cell lines; coasts; colorectal neoplasms; humans; immunomodulators; inhibitory concentration 50; leukemia; macroalgae; macrophage activation; melanoma; metabolites; mice; nonfood industry; pharmaceutical industry; polysaccharides; Spain
Abstract:: ... Seaweeds of the genera Laminaria, Gelidium, and Porphyra have been used in both food and non-food industries due to their unique properties and characteristic biological activity. This study assesses the antioxidant activity and immunomodulatory properties of the acidic polysaccharides extracted from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum collected in the Atlantic coast o ...
DOI:: 10.1007/s10126-019-09905-x
: https://doi.org/10.1007/s10126-019-09905-x

99. Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model

Author:: Eulalio Gracia; Andrea Mancini; Alessandro Colapietro; Cristina Mateo; Ignacio Gracia; Claudio Festuccia; Manuel Carmona
Source:: Nutrients 2019 v.11 no.10 pp. -
ISSN:: 2072-6643
Subject:: Curcuma longa; Fourier transform infrared spectroscopy; animal disease models; antineoplastic activity; bioactive compounds; biodegradability; cell lines; curcumin; intestinal absorption; medicinal plants; men; metabolism; metastasis; neoplasm progression; patients; plant extracts; prostatic neoplasms; screening; subcutaneous injection; survival rate
Abstract:: ... Prostate cancer (PCa) is one of the most common cancers in older men and is associated with high mortality. Despite advances in screening for early detection of PCa, a large proportion of patients continue to be diagnosed with metastatic disease, with ~20% of men showing a high tumor grade and stage. Medicinal plant extracts have a great potential to prevent/treat PCa, as well as to reduce its inc ...
DOI:: 10.3390/nu11102312
PubMed:: 31569529
PubMed Central:: PMC6835253
: https://doi.org/10.3390/nu11102312

100. In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)

Author:: Ana Carolina B. da C. Rodrigues; Felipe P. de Oliveira; Rosane B. Dias; Caroline B.S. Sales; Clarissa A.G. Rocha; Milena B.P. Soares; Emmanoel V. Costa; Felipe M.A. da Silva; Waldireny C. Rocha; Hector H.F. Koolen; Daniel P. Bezerra
Source:: Journal of ethnopharmacology 2019 v.231 pp. 516-524
ISSN:: 0378-8741
Subject:: Salacia; analgesic effect; analgesics; anti-inflammatory activity; antineoplastic activity; antiviral properties; bark; cell lines; cytotoxicity; dengue; diabetes; ethyl acetate; herbal medicines; humans; inflammation; influenza; leukemia; medicinal plants; mice; models; neoplasm cells; pain; rheumatoid arthritis; severe combined immunodeficiency; traditional medicine; triterpenoids; Amazonia
Abstract:: ... Salacia impressifolia (Miers) A. C. Smith (family Celastraceae) is a traditional medicinal plant found in the Amazon Rainforest known as “miraruíra”, "cipó-miraruíra" or “panu” and is traditionally used to treat dengue, flu, inflammation, pain, diabetes, male impotency, renal affections, rheumatism and cancer. Aim of the study: The aim of this study was to investigate in vitro and in vivo anti-leu ...
DOI:: 10.1016/j.jep.2018.11.008
: https://doi.org/10.1016/j.jep.2018.11.008

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1. (−)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo

2. Acacetin‐induced cell apoptosis in head and neck squamous cell carcinoma cells: Evidence for the role of muscarinic M3 receptor

3. Actinidia arguta (Hardy Kiwi) Root Extract Exerts Anti-cancer Effects via Mcl-1-Mediated Apoptosis in Cholangiocarcinoma

4. Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.

5. Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae

6. Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran

7. Anchusa azurea Mill. (Boraginaceae) aerial parts methanol extract interfering with cytoskeleton organization induces programmed cancer cells death

8. The Anti-Cancer Effect of Mangifera indica L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells

9. Anti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein

10. Anti-cancer activities of cytokinin ribosides

11. Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines

12. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

13. Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cells

14. Anti-tumor activity and the mechanism of a green tea (Camellia sinensis) polysaccharide on prostate cancer

15. Anti-tumor effect and mechanistic study of elemene on pancreatic carcinoma

16. Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines

17. Anti-tumour activity of low molecular weight heparin doxorubicin nanoparticles for histone H1 high-expressive prostate cancer PC-3M cells

18. Anticancer activity of plant leaves extract collected from a tribal region of India

19. Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116 cell line- in vitro study

20. Anticancer, antimicrobial, antioxidant, and catalytic activities of green-synthesized silver and gold nanoparticles using Bauhinia purpurea leaf extract

21. Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea

22. Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells

23. Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple-Negative Breast Cancer Cells

24. Antitumor activity of alantolactone in lung cancer cell lines NCI‐H1299 and Anip973

25. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients

26. Antitumor activity of methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide against leukemia cell lines via mitotic arrest and apoptotic pathways

27. Antitumor effect of depsidones from lichens on tumor cell lines and experimental murine melanoma

28. Antitumor effects of SB injection in canine osteosarcoma and melanoma cell lines

29. Antitumour activity of Helix hemocyanin against bladder carcinoma permanent cell lines

30. Anti‐tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells

31. Apoptosis and G2/M cell cycle arrest induced by a timosaponin A3 from Anemarrhena asphodeloides Bunge on AsPC-1 pancreatic cancer cells

32. Apoptosis effect of Aegiceras corniculatum on human colorectal cancer via activation of FoxO signaling pathway

33. Asparanin A from Asparagus officinalis L. Induces G0/G1 Cell Cycle Arrest and Apoptosis in Human Endometrial Carcinoma Ishikawa Cells via Mitochondrial and PI3K/AKT Signaling Pathways

34. Assessment of the cytotoxicity, antioxidant activity and chemical composition of extracts from the cyanobacterium Fischerella major Gomont

35. Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell

36. Bioactivities and molecular networking-based elucidation of metabolites of potent actinobacterial strains isolated from the Unkeshwar geothermal springs in India

37. Biological Activities of Artemisinins Beyond Anti-Malarial: a Review

38. Biological effects of whole Z.Officinale extract on chronic myeloid leukemia cell line K562

39. Blackberry Extract Inhibits Telomerase Activity in Human Colorectal Cancer Cells

40. Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells

41. Brazilian red propolis extracts: study of chemical composition by ESI-MS/MS (ESI+) and cytotoxic profiles against colon cancer cell lines

42. C-prenylated flavonoids with potential cytotoxic activity against solid tumor cell lines

43. Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and reactive oxygen species generation in A549 and NCI-H1299 non-small cell lung cancer cells

44. Carboplatin prodrug conjugated Fe₃O₄ nanoparticles for magnetically targeted drug delivery in ovarian cancer cells

45. Carvacrol/β-cyclodextrin inclusion complex inhibits cell proliferation and migration of prostate cancer cells

46. Characterization and screening of anti-tumor activity of fucoidan from acid-processed hijiki (Hizikia fusiforme)

47. Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry)

48. Chemical secondary metabolite profiling of Bauhinia longifolia ethanolic leaves extracts

49. Chitooligosaccharides display anti-tumor effects against human cervical cancer cells via the apoptotic and autophagic pathways

50. Clinically relevant concentration of sevoflurane suppresses cervical cancer growth and migration through targeting multiple oncogenic pathways

51. Co-encapsulation of thymoquinone with docetaxel enhances the encapsulation efficiency into PEGylated liposomes and the chemosensitivity of MCF7 breast cancer cells to docetaxel

52. Comparative assessment of Prunus spinosa L. flower extract in non-neoplastic hepatocytes and hepatoblastoma cells

53. Could volatile compounds from leaves and fruits of Pistacia lentiscus constitute a novel source of anticancer, antioxidant, antiparasitic and antibacterial drugs?

54. Crude extract of Origanum vulgare L. induced cell death and suppressed MAPK and PI3/Akt signaling pathways in SW13 and H295R cell lines

55. Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells

56. Curcumin potentiates the antitumor activity of Paclitaxel in rat glioma C6 cells

57. Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma

58. Cytotoxic and Antiproliferative Effects of Preussin, a Hydroxypyrrolidine Derivative from the Marine Sponge-Associated Fungus Aspergillus candidus KUFA 0062, in a Panel of Breast Cancer Cell Lines and Using 2D and 3D Cultures

59. Cytotoxic and antimicrobial indole alkaloids from an endophytic fungus Chaetomium sp. SYP-F7950 of Panax notoginseng

60. Cytotoxic and cell cycle arrest induction of pentacyclic triterpenoides separated from Lantana camara leaves against MCF-7 cell line in vitro

61. Cytotoxic effect induced apoptosis in lung cancer cell line on Ageratina adenophora leaf extract

62. DNA Binding and Molecular Dynamic Studies of Polycyclic Tetramate Macrolactams (PTM) with Potential Anticancer Activity Isolated from a Sponge-Associated Streptomyces zhaozhouensis subsp. mycale subsp. nov.

63. Design and synthesis of a phenyl C-glycoside derivative of Spliceostatin A and its biological evaluation toward prostate cancer treatment

64. Dried leaf Artemisia annua efficacy against non-small cell lung cancer

65. Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells

66. Effect of germination on anticancer activity of Trigonella foenum seeds extract

67. Effect of selected nonsteroidal anti-inflammatory drugs on the viability of canine osteosarcoma cells of the D-17 line: in vitro studies

68. Enantioselective Synthesis, DFT Calculations, and Preliminary Antineoplastic Activity of Dibenzo 1-Azaspiro[4.5]decanes on Drug-Resistant Leukemias

69. Encapsulated human mesenchymal stem cells (eMSCs) as a novel anti-cancer agent targeting breast cancer stem cells: Development of 3D primed therapeutic MSCs

70. Encapsulation of Doxorubicin in Furcellaran/Chitosan Nanocapsules by Layer-by-Layer Technique for Selectively Controlled Drug Delivery

19. Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116 cell line- in vitro study