U.S. flag

An official website of the United States government

PubAg

Main content area

You searched for: Publication Year 2019 Remove constraint Publication Year: 2019 Subject antineoplastic agents Remove constraint Subject: antineoplastic agents Subject antioxidant activity Remove constraint Subject: antioxidant activity Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
Start Over

Search

18  Search Results

1 - 18 of 18
Number of results to display per page

Search Results

1. Allium vegetables for possible future of cancer treatment

Author:
Asemani, Yahya; Zamani, Nasrindokht; Bayat, Maryam; Amirghofran, Zahra
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
ISSN:
0951-418X
Subject:
Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
Abstract:
... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
DOI:
10.1002/ptr.6490

2. Inhibition of human breast cancer cells (MCF-7 cell line) growth via cell proliferation, migration, and angiogenesis by auraptene of Ferula szowitsiana root extract

Author:
Charmforoshan, Ensiyeh; Karimi, Ehsan; Oskoueian, Ehsan; Es-Haghi, Ali; Iranshahi, Mehrdad
Source:
Journal of food measurement & characterization 2019 v.13 no.4 pp. 2644-2653
ISSN:
2193-4126
Subject:
2,2-diphenyl-1-picrylhydrazyl; Ferula; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; breast neoplasms; caspase-3; caspase-8; cell proliferation; chemoprevention; coumarins; cytotoxicity; drug therapy; enriched foods; food industry; free radicals; functional foods; gene expression regulation; genes; human cell lines; inhibitory concentration 50; neoplasm cells; root extracts; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2; Central Asia; Iran
Abstract:
... The different species of the Ferula (Apiaceae) genus are endemic in central Asia and are used as a medicinal food in Iran. The Ferula szowitsiana has been reported with anti-inflammatory, anti-hypertensive, anti-helicobacter, antileishmanial and cancer chemopreventive activities. Auraptene is one of the main coumarins from Ferula szowitsiana root. Despite the interesting biological properties of F ...
DOI:
10.1007/s11694-019-00185-6

3. Thidiazuron-induced efficient biosynthesis of phenolic compounds in callus culture of Ipomoea turbinata Lagasca and Segura

Author:
Ahmad, Waqar; Zahir, Adnan; Nadeem, Muhammad; Zia, Muhammad; Hano, Christophe; Abbasi, Bilal Haider
Source:
In vitro cellular & developmental biology 2019 v.55 no.6 pp. 710-719
ISSN:
1054-5476
Subject:
Ipomoea alba; antineoplastic agents; antioxidant activity; biomass production; biosynthesis; callus culture; chlorogenic acid; explants; flowering; high performance liquid chromatography; kaempferol; leaves; metabolites; phenolic acids; quercetin; thidiazuron
Abstract:
... Ipomoea turbinata Lagasca and Segura (Purple Moonflower) belongs to the largest flowering genus Ipomoea in the Convolvulaceae family. Ipomoea turbinata has not been previously explored for its in vitro potential. This is the first study focused on thidiazuron-induced callus culture for efficient biosynthesis of commercially important phenolic compounds in this plant species. Among the two plant gr ...
DOI:
10.1007/s11627-019-10027-1

4. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Author:
Sezer, Ebru Demirel; Oktay, Latife Merve; Karadadaş, Elif; Memmedov, Hikmet; Selvi Gunel, Nur; Sözmen, Eser
Source:
Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
ISSN:
1557-7600
Subject:
2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
Abstract:
... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
DOI:
10.1089/jmf.2019.0098

5. Production and characterization of exopolysaccharides from Chlorella zofingiensis and Chlorella vulgaris with anti-colorectal cancer activity

Author:
Zhang, Jianzhi; Liu, Lu; Chen, Feng
Source:
International journal of biological macromolecules 2019 v.134 pp. 976-983
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Chlorella vulgaris; antineoplastic activity; antineoplastic agents; antioxidant activity; cell viability; colorectal neoplasms; exopolysaccharides; human cell lines; humans; hydroxyl radicals; microalgae; molecular weight; neoplasm cells; sugars
Abstract:
... The production, physicochemical characteristics, antioxidant and antitumor activities of partial purified exopolysaccharides from Chlorella zofingiensis, Chlorella vulgaris were investigated. The final exopolysaccharides productions were 208.4, 364.3 mg/L and the average molecular weights were 2.66×104, 1.88×104 Da, respectively. Monosaccharide analysis indicating that these exopolysaccharides con ...
DOI:
10.1016/j.ijbiomac.2019.05.117

6. Changes Over the Fermentation Period in Phenolic Compounds and Antioxidant and Anticancer Activities of Blueberries Fermented by Lactobacillus plantarum

Author:
Ryu, Ji‐Yeon; Kang, Hye Rim; Cho, Somi Kim
Source:
Journal of food science 2019 v.84 no.8 pp. 2347-2356
ISSN:
0022-1147
Subject:
2,2-diphenyl-1-picrylhydrazyl; Lactobacillus plantarum; additives; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; catechol; chlorogenic acid; epigallocatechin; ethanol; fermentation; free radicals; gallic acid; high performance liquid chromatography; human cell lines; lactic acid bacteria; malvidin; metabolites; phenol; polyphenols; protocatechuic acid; syringic acid; uterine cervical neoplasms
Abstract:
... This study determined the effects of blueberry fermentation by Lactobacillus plantarum on antioxidant and anticancer activities. The fermented blueberries extracted with 80% ethanol (FBE) showed increased superoxide dismutase‐like activity, increased scavenging of DPPH and alkyl radicals, and increased antiproliferative activity against human cervical carcinoma HeLa cells by inducing apoptosis. Se ...
DOI:
10.1111/1750-3841.14731

7. Monochromatic lights-induced trends in antioxidant and antidiabetic polyphenol accumulation in in vitro callus cultures of Lepidium sativum L.

Author:
Ullah, Muhammad Asad; Tungmunnithum, Duangjai; Garros, Laurine; Hano, Christophe; Abbasi, Bilal Haider
Source:
Journal of photochemistry and photobiology 2019 v.196 pp. 111505
ISSN:
1011-1344
Subject:
Lepidium sativum; active ingredients; antineoplastic agents; antioxidant activity; antioxidants; bioactive compounds; biomass production; biosynthesis; blue light; caffeic acid; callus; callus culture; chlorogenic acid; enzyme activity; ferulic acid; green light; herbaceous plants; kaempferol; metabolites; p-coumaric acid; peroxidase; polyphenols; protocatechuic acid; quercetin; sinapic acid; superoxide dismutase; vanillic acid; white light
Abstract:
... Lepidium sativum L. is an important edible, herbaceous plant with huge medicinal value as cardio-protective, hepatoprotective and antitumor agent. This study was designed and performed to investigate biosynthesis of plant's active ingredients in callus cultures of L. sativum in response to the exposure of multi spectral lights. Optimum biomass accumulation (15.36 g/L DW), total phenolic and flavon ...
DOI:
10.1016/j.jphotobiol.2019.05.002

8. Daphne striata Tratt. and D. mezereum L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties

Author:
Tundis, Rosa; Loizzo, Monica R.; Bonesi, Marco; Peruzzi, Lorenzo; Efferth, Thomas
Source:
Natural product research 2019 v.33 no.12 pp. 1809-1812
ISSN:
1478-6427
Subject:
2,2-diphenyl-1-picrylhydrazyl; Daphne mezereum; aerial parts; antineoplastic agents; antioxidant activity; beta-carotene; bleaching; gas chromatography-mass spectrometry; hexane; humans; inhibitory concentration 50; maceration; methanol; methylene chloride; neoplasm cells; neoplasms; phytochemicals; statistics
Abstract:
... In this study, we investigated for the first time the anti-proliferative and antioxidant properties of D. mezereum and D. striata. The aerial parts were extracted by maceration with n-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxida ...
DOI:
10.1080/14786419.2018.1437432

9. Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition

Author:
Ibrahim, Abeer Y.; El-Newary, Samah A.; Ibrahim, Gamil E.
Source:
Annals of agricultural science 2019 v.64 no.1 pp. 29-37
ISSN:
0570-1783
Subject:
Cordia dichotoma; alkaloids; alpha-phellandrene; alpha-terpineol; antineoplastic activity; antineoplastic agents; antioxidant activity; ascites; body weight; bornyl acetate; butyrates; carcinoma; catechin; chemical composition; cytotoxicity; dose response; fructose; fruit pulp; fruits; gallic acid; gas chromatography-mass spectrometry; glucose; hematologic tests; high performance liquid chromatography; ions; lethal dose 50; longevity; metals; mice; phenols; quercetin; sucrose; superoxide anion; tannins; volatile compounds
Abstract:
... The aim of the present research was to investigate the chemical composition, antioxidant and anti-tumor effects of Cordia dichotoma fruit pulp extract “CDFP-extract”. Day after intraperitoneal inoculation of Ehrlich ascites carcinoma (EAC) cells in mice, CDFP-extract was administered orally at 500 mg/kg body weight (equal to 0.10 of determined LD50) for ten consecutive days. CDFP-extract contains ...
DOI:
10.1016/j.aoas.2019.05.008

10. Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability

Author:
Saratale, Rijuta Ganesh; Saratale, Ganesh Dattatraya; Ghodake, Gajanan; Cho, Si-Kyung; Kadam, Avinash; Kumar, Gopalakrishnan; Jeon, Byong-Hun; Pant, Deepak; Bhatnagar, Amit; Shin, Han Seung
Source:
International journal of biological macromolecules 2019 v.128 pp. 391-400
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Escherichia coli; Staphylococcus aureus; animal pathogens; antimicrobial properties; antineoplastic agents; antioxidant activity; biopolymers; cell lines; crystal structure; dose response; free radical scavengers; hydrogen peroxide; lethal dose 50; lignin; minimum inhibitory concentration; nanosilver; neoplasm cells; ovarian neoplasms; pharmaceutical industry; stabilizers; sustainable technology; toxicity testing; wheat straw
Abstract:
... Lignin, is the most abundant, renewable and degradable biopolymer available in the nature. The present study exploited purified lignin from wheat straw as reducing, capping and stabilizing agent for the green synthesis of silver nanoparticles (Li-AgNPs) under optimized conditions. The analytical studies revealed synthesized Li-AgNPs having a face centered cubic crystalline structure, size ranging ...
DOI:
10.1016/j.ijbiomac.2019.01.120

11. Synthetic phenolic antioxidant propyl gallate induces male infertility through disruption of calcium homeostasis and mitochondrial function

Author:
Ham, Jiyeon; Lim, Whasun; Park, Sunwoo; Bae, Hyocheol; You, Seungkwon; Song, Gwonhwa
Source:
Environmental pollution 2019 v.248 pp. 845-856
ISSN:
0269-7491
Subject:
Sertoli cells; acidification; antineoplastic agents; antioxidant activity; antioxidants; calcium; endoplasmic reticulum stress; enzymes; foods; gene expression; genes; homeostasis; hormone receptors; in situ hybridization; male sterility; messenger RNA; mice; mitochondria; propyl gallate; quantitative polymerase chain reaction; steroidogenesis; toxicity
Abstract:
... Propyl gallate (propyl 3,4,5-trihydroxybenzoate, PG) is a phenolic antioxidant that has been used for oil-containing foods to prevent acidification. Owing to its antioxidant properties, PG has been applied to various fields and active research is currently underway to prove PG as an anticancer agent. However, there are still concerns about PG as a possible reproductive toxicant. Therefore, we dete ...
DOI:
10.1016/j.envpol.2019.02.087

12. Bioactive compounds from by-products of rice cultivation and rice processing: Extraction and application in the food and pharmaceutical industries

Author:
Peanparkdee, Methavee; Iwamoto, Satoshi
Source:
Trends in food science & technology 2019 v.86 pp. 109-117
ISSN:
0924-2244
Subject:
anti-inflammatory agents; antineoplastic agents; antioxidant activity; bioactive compounds; bran; byproduct utilization; byproducts; essential amino acids; farm income; flavonoids; food colorants; food enrichment; food industry; food preservatives; foods; hulls; human health; milling; oryzanol; pharmaceutical industry; phenolic compounds; pollution; pollution control; rice; solvents; storage quality; straw; vitamin E
Abstract:
... Rice by-products, including straw, husk and bran, are generated through rice cultivation and rice milling processes and have been considered as rich sources of bioactive compounds, such as essential amino acids, phenolics, flavonoids, vitamin E and γ-oryzanol. These compounds are generating interest due to their potential beneficial effects on human health, in addition to their antioxidant capabil ...
DOI:
10.1016/j.tifs.2019.02.041

13. Roylea cinerea (D.Don) Baillon: Ethnomedicinal uses, phytochemistry and pharmacology: A review

Author:
Pundir, Swati; Mahindroo, Neeraj
Source:
Journal of ethnopharmacology 2019 v.232 pp. 193-200
ISSN:
0378-8741
Subject:
Roylea; adenosine triphosphate; aerial parts; antimalarials; antineoplastic agents; antioxidant activity; antipyretics; cell lines; diabetes; flavonoids; fractionation; glycemic effect; heat shock proteins; hepatoprotective effect; inflammation; jaundice; labdane; liver; lymphocytic leukemia; malaria; medicinal plants; neoplasm cells; phenols; plant extracts; saponins; shrubs; skin diseases; steroids; surveys; tannins; taxon descriptions; traditional medicine; Himalayan region; India; Nepal
Abstract:
... Roylea cinerea (D.Don) Baillon family Lamiaceae is a shrub of the monotypic genus. Aerial parts of the plant are used traditionally in Indian sub-Himalayas and Nepal for the treatment of jaundice, skin diseases, malaria, diabetes, febrifuge and contusions.This article reviews botanical description, phytochemistry, ethnomedicinal uses and pharmacological activities of R. cinerea to evaluate if the ...
DOI:
10.1016/j.jep.2018.12.042

14. Extracts of Hypsizygus tessellatus (white var.) caps inhibited MCF-7 and MDA-MB-231 cell lines proliferation

Author:
Ukaegbu, C. I.; Shah, S. R.; Hamid, H. A.; Normaiza, Z.; Alara, O. R.
Source:
Journal of food measurement & characterization 2019 v.13 no.1 pp. 368-382
ISSN:
2193-4126
Subject:
2,2-diphenyl-1-picrylhydrazyl; Hypsizygus; acetone; adverse effects; antineoplastic activity; antineoplastic agents; antioxidant activity; breast neoplasms; breasts; cell lines; chemical constituents of plants; drug therapy; ethyl acetate; free radical scavengers; hydrogen peroxide; inhibitory concentration 50; liquid chromatography; mass spectrometry; neoplasm cells
Abstract:
... Cancer management is associated with serious side-effects due to the harmful nature of radiation and chemotherapy on the body cells. These side-effects have necessitated the need for diversifying the alternative or complementary sources of cancer therapy. Natural products have been on the front line as alternative sources of anticancer agents and have attracted much attention in recent times. In t ...
DOI:
10.1007/s11694-018-9952-8

15. Optimization of polysaccharide extraction process from grifola frondosa and its antioxidant and anti-tumor research

Author:
Chen, Xiaoyu; Ji, Haiyu; Xu, Xiaomeng; Liu, Anjun
Source:
Journal of food measurement & characterization 2019 v.13 no.1 pp. 144-153
ISSN:
2193-4126
Subject:
2,2-diphenyl-1-picrylhydrazyl; Grifola frondosa; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; human cell lines; microwave treatment; polysaccharides; raw materials; temperature; ultrasonics
Abstract:
... In order to get high yield polysaccharide from grifola frondosa, single factor experiment and an orthogonal experiment were applied to optimize the best extraction conditions. Extraction time, extraction temperature, ratio of raw material to water and auxiliary factors (microwave assisted, ultrasound assisted) were the main factors to influence the yield and purity of the extracted crude polysacch ...
DOI:
10.1007/s11694-018-9927-9

16. Phytochemical profiling, antioxidant and anticancer activities of Gastrocotyle hispida growing in Saudi Arabia

Author:
Shahat, Abdelaaty A.; Hidayathulla, Syed; Khan, Azmat A.; Alanazi, Amer M.; Al Meanazel, Osaid T.; Alqahtani, Ali S.; Alsaid, Mansour S.; Hussein, Ahmed A.
Source:
Acta tropica 2019 v.191 pp. 243-247
ISSN:
0001-706X
Subject:
2,2-diphenyl-1-picrylhydrazyl; Boraginaceae; aerial parts; antineoplastic activity; antineoplastic agents; antioxidant activity; beta-sitosterol; breast neoplasms; breasts; cell lines; chromatography; dose response; free radical scavengers; gallic acid; in vitro studies; inhibitory concentration 50; kidneys; leaves; liver; methanol; models; neoplasm cells; polyphenols; quercetin; rheumatoid arthritis; rosmarinic acid; tea; Saudi Arabia
Abstract:
... The present study aimed at isolation the phytocompounds from the aerial parts of Gastrocotyle hispida and to evaluate its antioxidant and anticancer potential using in vitro assay. Gastrocotyle hispida is belonging to the family Boraginaceae used as a refreshing drink like tea. The decoction of the leaves is diuretic and is used in the treatment of rheumatism. Phytochemical study of a methanol ext ...
DOI:
10.1016/j.actatropica.2019.01.013

17. The chemical composition and events related to the cytotoxic effects of propolis on osteosarcoma cells: A comparative assessment of Colombian samples

Author:
Mora, Dolly Patricia Pardo; Santiago, Karina Basso; Conti, Bruno José; de Oliveira Cardoso, Eliza; Conte, Fernanda Lopes; Oliveira, Lucas Pires Garcia; de Assis Golim, Marjorie; Uribe, Jaime Fabian Cruz; Gutiérrez, Rafael María; Buitrago, Mauricio Rey; Popova, Milena; Trusheva, Boryana; Bankova, Vassya; García, Orlando Torres; Sforcin, José Maurício
Source:
Phytotherapy research 2019 v.33 no.3 pp. 591-601
ISSN:
0951-418X
Subject:
2,2-diphenyl-1-picrylhydrazyl; antineoplastic agents; antioxidant activity; apoptosis; benzophenones; cell viability; chemical composition; cytotoxicity; diterpenoids; fatty acids; flavonoids; flow cytometry; free radical scavengers; gas chromatography-mass spectrometry; inhibitory concentration 50; membrane permeability; metastasis; mitochondrial membrane; osteosarcoma; principal component analysis; propolis; reactive oxygen species; rhodamines; triterpenoids
Abstract:
... Osteosarcoma (OSA) is a type of bone cancer showing an aggressive biological behavior with metastatic progression. Because propolis potential for the development of new antitumoral drugs has been indicated, we evaluated the chemical composition of Colombian propolis samples and the mechanisms involved in their cytotoxic effects on OSA cells. The chemical composition was analyzed by GC–MS and the D ...
DOI:
10.1002/ptr.6246

18. Are polyphenol antioxidants at the root of medicinal plant anti-cancer success?

Author:
Oyenihi, A.B.; Smith, C.
Source:
Journal of ethnopharmacology 2019 v.229 pp. 54-72
ISSN:
0378-8741
Subject:
active ingredients; adverse effects; antineoplastic agents; antioxidant activity; antioxidants; chronic diseases; mechanism of action; medicinal plants; neoplasms; pharmaceutical industry; plant products; polyphenols; therapeutics; toxicity; traditional medicine
Abstract:
... Given the severe side effects associated with most of the conventional cancer medications, as well as the expanding body of evidence indicating secondary toxicity of these drugs, individuals with cancer are increasingly turning to natural alternatives. Similarly, the pharmaceutical industry is in search of natural products to treat cancer. An understanding of the specific active components in plan ...
DOI:
10.1016/j.jep.2018.09.037