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- Park, Sunghoon, et al. Show all 9 Authors
- Metabolic engineering 2019 v.53 pp. 48-58
- Escherichia coli; carbon; genes; glycerol; glycerol kinase; metabolism; mutants; mutation; sequence analysis; toxicity; yeast extract
- ... 3-Hydroxypropionic acid (3-HP) is an important platform chemical, but its toxic effect at high concentrations (> 200 mM) is a serious challenge for commercial production. In this study, a highly 3-HP-tolerant strain of Escherichia coli W (tolerance concentration: 400 mM in M9 minimal medium and 800 mM when yeast extract was added) was developed by adaptive laboratory evolution (ALE) with glycerol ...