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- Author:
- Abu Bakar Siddique; Hassan Y. Ebrahim; Mohamed R. Akl; Nehad M. Ayoub; Amira A. Goda; Mohamed M. Mohyeldin; Suresh K. Nagumalli; Wael M. Hananeh; Yong-Yu Liu; Sharon A. Meyer; Khalid A. El Sayed
- Source:
- Nutrients 2019 v.11 no.2 pp. -
- ISSN:
- 2072-6643
- Subject:
- Western blotting; antibodies; antineoplastic activity; breast neoplasms; breasts; cell lines; enzyme inhibitors; epidermal growth factor receptors; epithelium; erbB-2 receptor; extra-virgin olive oil; mice; models; neoplasm cells; non-specific protein-tyrosine kinase; non-specific serine/threonine protein kinase; therapeutics; tyrosine
- Abstract:
- ... Dysregulation of epidermal growth factor receptor (EGFR)/human epidermal growth factor-2 (HER2) family is a hallmark of aggressive breast cancer. Small-molecule tyrosine kinase inhibitors are among the most effective cancer targeted treatments. (−)-Oleocanthal (OC) is a naturally occurring phenolic secoiridoid lead from extra-virgin olive oil with documented anti-cancer activities via target ...
- DOI:
- 10.3390/nu11020412
- PubMed:
- 30781364
- PubMed Central:
- PMC6412724
- https://doi.org/10.3390/nu11020412
- Author:
- Arul Maximus Rabel; S. Karthick Raja Namasivayam; M. Prasanna; R.S. Arvind Bharani
- Source:
- International journal of biological macromolecules 2019 v.138 pp. 1109-1129
- ISSN:
- 0141-8130
- Subject:
- Escherichia coli; Fourier transform infrared spectroscopy; Staphylococcus aureus; X-ray diffraction; absorbance; antibacterial properties; antineoplastic activity; apoptosis; biocompatibility; biofilm; cell lines; cell structures; chitosan; cytotoxicity; drug resistance; drug therapy; enzymes; ethanol; green chemistry; humans; iron oxides; medicine; minimum inhibitory concentration; nanocomposites; nanoparticles; pathogens; proteins; scanning electron microscopy; solubilization; tumor necrosis factor-alpha
- Abstract:
- ... The logical research on fundamentally adjusted iron oxide nanoparticles has turned out to expanded in biomedicine because of the improved activity and best biocompatibility. In this present work upgraded bio-restorative and pharmacotherapeutic property of chitosan‑iron oxide nanocomposite, which was set up by eco-friendly in situ substance technique. Characterisation of the synthesised nanocomposi ...
- DOI:
- 10.1016/j.ijbiomac.2019.07.158
- https://doi.org/10.1016/j.ijbiomac.2019.07.158
- Author:
- Chaopan Zheng; Ling Han; Shihai Wu
- Source:
- Molecular biology reports 2019 v.46 no.4 pp. 3857-3864
- ISSN:
- 0301-4851
- Subject:
- Glycyrrhiza glabra; Oriental traditional medicine; alanine; antineoplastic activity; apoptosis; aspartic acid; biomarkers; biosynthesis; carcinoma; cell lines; cysteine; drugs; gas chromatography-mass spectrometry; glutamic acid; glutamine; glutathione; lipid metabolism; metabolites; metabolome; metabolomics; methionine; neoplasm cells; patients; serine; stearic acid; therapeutics; threonine
- Abstract:
- ... Although a majority of nasopharyngeal carcinoma (NPC) are undifferentiated and strongly radiosensitive, many NPC patients still have troubles in recurrence. Traditional Chinese medicine (TCM) is considered as potential therapeutic drugs in NPC. However, the effect of Glycyrrhiza glabra on NPC is limited. The present study shows the decreased proliferation and high apoptosis in G. glabra root extra ...
- DOI:
- 10.1007/s11033-019-04828-1
- https://doi.org/10.1007/s11033-019-04828-1
- Author:
- Muren Huhe; Jiaxin Lou; Yumeng Zhu; Yu Zhao; Ying Shi; Bo Wang; Xiuxuan Sun; Xiaoqin Zhang; Yang Zhang; Zhi-Nan Chen
- Source:
- Biochemical and biophysical research communications 2019 v.513 no.4 pp. 1083-1091
- ISSN:
- 0006-291X
- Subject:
- antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; drugs; epidermal growth factor receptors; humans; immunoglobulins; in vitro studies; lung neoplasms; mice; microtubules; mitotic spindle apparatus; monoclonal antibodies; patients; therapeutics; transmembrane proteins
- Abstract:
- ... Cluster of differentiation 147 (CD147), a transmembrane protein of the immunoglobulin superfamily, is a potential target of treatment against human non-small cell lung cancer (NSCLC). Although there have been exciting advances in epidermal growth factor receptor (EGFR)-targeted therapy for NSCLC in recent years, additional novel targeted agents are needed to improve the efficiency and to offer mor ...
- DOI:
- 10.1016/j.bbrc.2019.04.046
- https://doi.org/10.1016/j.bbrc.2019.04.046
- Author:
- Snehal Suryavanshi; Amit Choudhari; Prerna Raina; Ruchika Kaul-Ghanekar
- Source:
- Journal of ethnopharmacology 2019 v.242 pp. 112022
- ISSN:
- 0378-8741
- Subject:
- Cedrus deodara; Cissampelos; Cyperus rotundus; Hemidesmus indicus; Holarrhena pubescens; Marsdenia tenacissima; Picrorhiza kurrooa; Swertia chirayita; Tinospora cordifolia; Zingiber officinale; antineoplastic activity; breast milk; breast neoplasms; cell cycle checkpoints; cell growth; cell lines; cell movement; chromatin; clinical trials; dyes; gene expression; hypoxia-inducible factor 1; ingredients; interphase; lactating women; mechanism of action; medicinal plants; milk quality; neoplasm cells; propidium; staining; toxicity testing; traditional medicine; vascular endothelial growth factors; viability; India
- Abstract:
- ... HC9, a polyherbal formulation, is based upon a traditional Ayurvedic formulation, Stanya Shodhana Kashaya (SSK, having 10 plant materials), formulated on Stanyashodhana gana, explained by Charaka in Charakasaṃhita Sutrasthana IV and mentioned in other texts as well. Stanyasodhana is the Sanskrit name for a group of medicinal plants, classified for “improving the quality of milk”. SSK is used by Ay ...
- DOI:
- 10.1016/j.jep.2019.112022
- https://doi.org/10.1016/j.jep.2019.112022
- Author:
- Shufeng Yan; Qingqing Huang; Xiaorong Song; Zhuo Chen; Mingdong Huang; Juncheng Zhang
- Source:
- RSC advances 2019 v.9 no.42 pp. 24560-24567
- ISSN:
- 2046-2069
- Subject:
- animal models; antineoplastic activity; apoptosis; breast neoplasms; cell lines; electrical charges; hepatoma; in vivo studies; mice; neoplasm cells; photochemotherapy; photosensitizing agents; reactive oxygen species
- Abstract:
- ... In recent years, photodynamic therapy (PDT) studies have gained considerable attention as a non-invasive method used to fight cancer. In this study, a series of structurally similar photosensitizers (PSs) with incremental positive electric charges (ZnPc-4, 8 and 12) was investigated via in vitro and in vivo experiments. Photodynamic antitumor studies of these PSs, including phototoxicities, cellul ...
- DOI:
- 10.1039/c9ra03486b
- https://doi.org/10.1039/c9ra03486b
- Author:
- Yunju Jeong; Seockmo Ku; Hyun Ju You; Geun Eog Ji
- Source:
- CyTA: journal of food 2019 v.17 no.1 pp. 488-493
- ISSN:
- 1947-6345
- Subject:
- antineoplastic activity; cell lines; cell viability; colorectal neoplasms; cytotoxicity; dose response; ginsenosides; growth retardation; human diseases; neoplasm cells
- Abstract:
- ... We compared the stereo-selective growth inhibition effects of purified enantiomeric pairs of ginsenoside Rh2 (20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2) on human colon cancer cells in vitro with non-invasive real-time cellular analysis. When 50 μM, respectively, of 20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2 were administered to the colon cancer cell line HT-29, only the S-type ginsenosi ...
- DOI:
- 10.1080/19476337.2019.1607562
- https://doi.org/10.1080/19476337.2019.1607562
- Author:
- Heerasing Takooree; Muhammad Z. Aumeeruddy; Kannan R.R. Rengasamy; Katharigatta N. Venugopala; Rajesh Jeewon; Gokhan Zengin; Mohamad F. Mahomoodally
- Source:
- Critical reviews in food science and nutrition 2019 v.59 no.sup1 pp. S210
- ISSN:
- 1549-7852
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Piper nigrum; analgesics; anticonvulsants; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidant enzymes; apoptosis; autophagy; bacterial motility; bioactive compounds; biofilm; black pepper; breasts; cell lines; chemical constituents of plants; cholesterol; clinical trials; colon; cytotoxicity; databases; dietary supplements; digestive system diseases; flavor; fruits; high density lipoprotein; hydrogen peroxide; in vivo studies; ingredients; livestock; low density lipoprotein; molybdenum; neuroprotective effect; nitric oxide; nitrogen; oxygen; pathogens; pharmacokinetics; seeds; signal transduction; superoxide anion; systematic review; taste; transporters; triacylglycerols; veterinary medicine; India
- Abstract:
- ... Considered as the “King of spices”, black pepper (Piper nigrum L.) is a widely used spice which adds flavor of its own to dishes, and also enhances the taste of other ingredients. Piper nigrum has also been extensively explored for its biological properties and its bioactive phyto-compounds. There is, however, no updated compilation of these available data to provide a complete profile of the medi ...
- DOI:
- 10.1080/10408398.2019.1565489
- https://doi.org/10.1080/10408398.2019.1565489
- Author:
- Fan Su; Qiaoling Song; Chuanliang Zhang; Xiaohan Xu; Mengyuan Li; Dan Yao; Lijuan Wu; Xianjun Qu; Huashi Guan; Guangli Yu; Jinbo Yang; Chenyang Zhao
- Source:
- Carbohydrate polymers 2019 v.222 pp. 114993
- ISSN:
- 0144-8617
- Subject:
- Durvillaea; algae; antibodies; antineoplastic activity; beta-glucans; cell lines; chemokines; inflammation; macrophages; models; neoplasm progression; neoplasms; phagocytosis; secretion; Antarctica
- Abstract:
- ... β-glucans trigger the proinflammatory responses of innate immune cells to enhance the host defense. A variety of β-glucans were identified as strong immune stimulator and exerted antitumor activities. Our previous work indicates that a β-1,3/1,6-glucan (BG136) derived from marina alga Durvillaea antarctica promotes the proinflammatory responses in macrophage cell line RAW264.7. In the present stud ...
- DOI:
- 10.1016/j.carbpol.2019.114993
- https://doi.org/10.1016/j.carbpol.2019.114993
- Author:
- Fenglin Sun; Duo Li; Cong Wang; Caixia Peng; Hong Zheng; Xiaofeng Wang
- Source:
- Phytotherapy research 2019 v.33 no.5 pp. 1551-1561
- ISSN:
- 0951-418X
- Subject:
- antineoplastic activity; apoptosis; calcium; calcium signaling; caspase-3; caspase-9; cell lines; cell viability; cytochrome c; electron microscopy; flavones; flow cytometry; mitochondria; neoplasm cells; small interfering RNA; squamous cell carcinoma
- Abstract:
- ... Aacacetin, a plant flavone has shown antitumor efficacy recently. However, its associated mechanisms are poorly known. We hypothesized that the muscarinic M3 receptor (M₃R), which is highly expressed in some cancer tissue, is related to the antitumor effect of acacetin in head and neck squamous cell carcinoma (HNSCC) cells. Our results showed that 12.5‐ to 200‐μM acacetin inhibited cell viability ...
- DOI:
- 10.1002/ptr.6343
- https://doi.org/10.1002/ptr.6343
- Author:
- Xiangxuan Zhao; Feng Wen; Wei Wang; Zaiming Lu; Qiyong Guo
- Source:
- Nutrition and cancer 2019 v.71 no.2 pp. 246-256
- ISSN:
- 1532-7914
- Subject:
- Actinidia arguta; NAD ADP-ribosyltransferase; Western blotting; antineoplastic activity; apoptosis; caspase-3; caspase-8; cell lines; cell viability; ethanol; growth retardation; liver; mice; neoplasms; patients; tissues
- Abstract:
- ... Cholangiocarcinoma (CCA) is a highly aggressive and chemoresistant liver malignancy. Thus, identification of strategies to overcome insensitivity to apoptosis and growth inhibition is a growing focus of research in this malignancy. This study evaluated the potential anti-cancer effects of an ethanol extract from the Actinidia arguta (Hardy Kiwi) root (RAE) on CCA. Our data demonstrated that RAE de ...
- DOI:
- 10.1080/01635581.2018.1557218
- https://doi.org/10.1080/01635581.2018.1557218
- Author:
- Martina Daga; Stefania Pizzimenti; Chiara Dianzani; Marie Angele Cucci; Roberta Cavalli; Margherita Grattarola; Benedetta Ferrara; Valentina Scariot; Francesco Trotta; Giuseppina Barrera
- Source:
- Phytomedicine 2019 v.56 pp. 156-164
- ISSN:
- 0944-7113
- Subject:
- Ailanthus altissima; Western blotting; active ingredients; antibodies; antineoplastic activity; apoptosis; bladder; cell growth; cell lines; cell movement; cisplatin; cortex; essential genes; flow cytometry; gene expression; humans; interphase; neoplasm cells; protein synthesis; staining; therapeutics; tissue repair; toxicity; urinary bladder neoplasms
- Abstract:
- ... Ailanthone (Aila) is a natural active compound isolated from the Ailanthus altissima, which has been shown to possess an “in vitro” growth-inhibitory effect against several cancer cell lines. Advanced bladder cancer is a common disease characterized by a frequent onset of resistance to cisplatin-based therapy. The cisplatin (CDDP) resistance is accompanied by an increase in Nrf2 protein expression ...
- DOI:
- 10.1016/j.phymed.2018.10.034
- https://doi.org/10.1016/j.phymed.2018.10.034
- Author:
- Kevin A. Martínez; Chiara Lauritano; Dana Druka; Giovanna Romano; Teresa Grohmann; Marcel Jaspars; Jesús Martín; Caridad Díaz; Bastien Cautain; Mercedes de la Cruz; Adrianna Ianora; Fernando Reyes
- Source:
- Marine drugs 2019 v.17 no.7 pp. -
- ISSN:
- 1660-3397
- Subject:
- Amphidinium; Aspergillus fumigatus; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Klebsiella pneumoniae; Mycobacterium tuberculosis; adenocarcinoma; antifungal properties; antineoplastic activity; bioactive compounds; biodiversity; breast neoplasms; breasts; cell lines; cytotoxicity; fractionation; fungi; habitats; hepatoma; humans; lungs; mass spectrometry; melanoma; methicillin-resistant Staphylococcus aureus; neoplasm cells; nuclear magnetic resonance spectroscopy; pancreas; physicochemical properties; skin (animal)
- Abstract:
- ... Due to the unique biodiversity and the physical-chemical properties of their environment, marine microorganisms have evolved defense and signaling compounds that often have no equivalent in terrestrial habitats. The aim of this study was to screen extracts of the dinoflagellate Amphidinium carterae for possible bioactivities (i.e., anticancer, anti-inflammatory, anti-diabetes, antibacterial and an ...
- DOI:
- 10.3390/md17070385
- PubMed:
- 31252576
- PubMed Central:
- PMC6669446
- https://doi.org/10.3390/md17070385
- Author:
- Alfonso Varela-López; Maurizio Battino; María D. Navarro-Hortal; Francesca Giampieri; Tamara Y. Forbes-Hernández; José M. Romero-Márquez; Ricardo Collado; José L. Quiles
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- antineoplastic activity; antioxidant activity; ascorbic acids; autophagy; bioactive compounds; bone marrow; brain; calcium; cardiotoxicity; cell lines; clinical trials; dietary minerals; doxorubicin; drug therapy; homeostasis; kidneys; liver; mechanism of action; neoplasm cells; neoplasms; nutrients; omega-3 fatty acids; protective effect; selenium; testes; toxicity; vitamin A; vitamin E
- Abstract:
- ... Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical use is limited by toxicity. Different strategies have been proposed to attenuate toxicity, including combined therapy with bioactive compounds. This review update mechanisms of action and toxicity of doxorubicin and the role of nutrients like vitamins (A, C, E), minerals (selenium) and n-3 polyunsaturated f ...
- DOI:
- 10.1016/j.fct.2019.110834
- https://doi.org/10.1016/j.fct.2019.110834
- Author:
- Maryam Akhbari; Reza Kord; Saeedeh Jafari Nodooshan; Sepideh Hamedi
- Source:
- Natural product research 2019 v.33 no.11 pp. 1629-1632
- ISSN:
- 1478-6427
- Subject:
- Artemia; Escherichia coli; Foeniculum vulgare; Pseudomonas aeruginosa; Shigella dysenteriae; antibacterial properties; antineoplastic activity; antineoplastic agents; breast neoplasms; carcinoma; cell lines; death; essential oils; gas chromatography-mass spectrometry; humans; inhibitory concentration 50; lethal concentration 50; limonene; methyl chavicol; seed oils; seeds; toxicity; Iran
- Abstract:
- ... In this study, biological properties of the essential oil isolated from seeds of Foeniculum vulgare (F. vulgare) were evaluated. GC-MS analysis revealed Trans-Anethole (80.63%), L-Fenchone (11.57%), Estragole (3.67%) and Limonene (2.68%) were the major compounds of the essential oil. Antibacterial activity of the essential oil against nine Gram-positive and Gram-negative strains was studied using ...
- DOI:
- 10.1080/14786419.2017.1423310
- https://doi.org/10.1080/14786419.2017.1423310
- Author:
- Jessica CeramellaThese authors have contributed equally to the manuscript.; Monica Rosa Loizzo; Domenico Iacopetta; Marco Bonesi; Vincenzo Sicari; Teresa Maria Pellicanò; Carmela Saturnino; Aurélie Malzert-Fréon; Rosa TundisJoint senior authors.; Maria Stefania Sinicropi
- Source:
- Food & function 2019 v.10 no.7 pp. 4280-4290
- ISSN:
- 2042-650X
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Anchusa azurea; aerial parts; antineoplastic activity; antioxidant activity; beta-carotene; bleaching; caffeic acid; caspase-3; catechin; cell death; cell lines; chemical composition; chlorogenic acid; cytoskeleton; death; high performance liquid chromatography; inhibitory concentration 50; menadione; methanol; mice; neoplasm cells; neoplasms; oxidative stress; toxicity
- Abstract:
- ... The present study aimed to determine the chemical composition, antioxidant effects and antitumor properties of a methanol extract of Anchusa azurea Mill. (Boraginaceae) aerial parts against four tumour cell lines (MCF-7, MDA-MB-231, RKO, and R₂C). The antioxidant effects were assessed by using β-carotene bleaching, 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picryl ...
- DOI:
- 10.1039/c9fo00582j
- https://doi.org/10.1039/c9fo00582j
- Author:
- Byung Chull An; Sunwoong Hong; Ho Jin Park; Bong-Kyu Kim; Jun Young Ahn; Yongku Ryu; Jae Hyung An; Myung Jun Chung
- Source:
- Genes 2019 v.10 no.8 pp. -
- ISSN:
- 2073-4425
- Subject:
- antineoplastic activity; cell cycle checkpoints; cell lines; colorectal neoplasms; cytosol; endocytosis; gene therapy; in vitro studies; neoplasm cells; signal transduction; toxicity
- Abstract:
- ... Recently, we reported a novel therapeutic probiotic-derived protein, p8, which has anti-colorectal cancer (anti-CRC) properties. In vitro experiments using a CRC cell line (DLD-1), anti-proliferation activity (about 20%) did not improve after increasing the dose of recombinant-p8 (r-p8) to >10 μM. Here, we show that this was due to the low penetrative efficiency of r-p8 exogenous treatment. Fur ...
- DOI:
- 10.3390/genes10080624
- PubMed:
- 31430963
- PubMed Central:
- PMC6723380
- https://doi.org/10.3390/genes10080624
- Author:
- Jiří Voller; Tibor Béres; Marek Zatloukal; Petr Džubák; Marián Hajdúch; Karel Doležal; Thomas Schmülling; Strnad Miroslav
- Source:
- Phytochemistry reviews 2019 v.18 no.4 pp. 1101-1113
- ISSN:
- 1568-7767
- Subject:
- antineoplastic activity; antineoplastic agents; apoptosis; cell lines; cytokinins; genes; growth and development; immune response; in vivo studies; mutants; neoplasms; patients; plant development; plant growth; plant hormones; stem cells
- Abstract:
- ... Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived ...
- DOI:
- 10.1007/s11101-019-09620-4
- https://doi.org/10.1007/s11101-019-09620-4
- Author:
- Silpa Narayanan; Pranav Gupta; Urooj Nazim; Mohsin Ali; Nishant Karadkhelkar; Mansoor Ahmad; Zhe-Sheng Chen
- Source:
- international journal of biochemistry & cell biology 2019 v.110 pp. 21-28
- ISSN:
- 1357-2725
- Subject:
- DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; biphenyl; cell lines; colorectal neoplasms; hydrazine; hydrazones; indans; inhibitory concentration 50; mitosis; neoplasm cells; patients; polymerization; toxicity; tubulin; United States
- Abstract:
- ... Colorectal cancer is the third leading cause of cancer related deaths in the United States. Currently, Irinotecan, a topoisomerase I inhibitor, is an approved anti-cancer drug for the treatment of patients with advanced or recurrent colorectal cancer. Considering low response rate and events of high toxicity caused by irinotecan, we evaluated a series of thirteen thiazolyl hydrazone derivatives of ...
- DOI:
- 10.1016/j.biocel.2019.02.004
- https://doi.org/10.1016/j.biocel.2019.02.004
- Author:
- Haroon Khan; Marcella Reale; Hammad Ullah; Antoni Sureda; Silvia Tejada; Ying Wang; Zhang-Jin Zhang; Jianbo Xiao
- Source:
- Biotechnology advances 2019 pp. -
- ISSN:
- 0734-9750
- Subject:
- antineoplastic activity; cell lines; chemoprevention; dietary nutrient sources; mechanism of action; monitoring; neoplasm cells; neoplasms; polyphenols; signal transduction; tumor suppressor genes
- Abstract:
- ... The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to ...
- DOI:
- 10.1016/j.biotechadv.2019.04.007
- https://doi.org/10.1016/j.biotechadv.2019.04.007
- Author:
- Jiryeon Jang; Jeeyun Lee; Jun Ho Jang; Chul Won Jung; Silvia Park
- Source:
- Molecular biology reports 2019 v.46 no.6 pp. 5859-5866
- ISSN:
- 0301-4851
- Subject:
- Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; cell proliferation; cell viability; cholesterol; cytotoxicity; flow cytometry; humans; molecular biology; mutants; myeloid leukemia; simvastatin; therapeutics
- Abstract:
- ... The statins are a group of therapeutic drugs widely used for lowering plasma cholesterol level, while it has also been reported to induce cell death in human acute myeloid leukemia (AML) cells. To determine antitumor activity triggered by simvastatin, four AML cell lines—U937, KG1, THP1 (NRASᴳ¹²ᴰ mutant) and HL60 (NRASQ⁶¹ᴸ mutant)—were cultured with simvastatin and cell viability was assessed usin ...
- DOI:
- 10.1007/s11033-019-05019-8
- https://doi.org/10.1007/s11033-019-05019-8
- Author:
- Ke Yang; Zhi-Yong Gao; Tie-Qiu Li; Wei Song; Wei Xiao; Jue Zheng; Hao Chen; Gui-Heng Chen; Hao-Yu Zou
- Source:
- International journal of biological macromolecules 2019 v.122 pp. 95-103
- ISSN:
- 0141-8130
- Subject:
- Camellia sinensis; antineoplastic activity; apoptosis; cell lines; gene overexpression; glucose; green tea; growth retardation; humans; mice; molecular weight; patients; polysaccharides; prostatic neoplasms; protein synthesis; therapeutics; transfection
- Abstract:
- ... In this study, a homogeneous polysaccharide (GTP), with a molecular weight of 7.0 × 104 Da, was isolated from Green tea, which was only composed of glucose. The antitumor effects of GTP on prostate cancer (PC) cell line along with the possible mechanism was examined. First, we investigate the potential role of microRNA-93 (miR-93) in PC progression. Our results showed that miR-93 was significantly ...
- DOI:
- 10.1016/j.ijbiomac.2018.10.101
- https://doi.org/10.1016/j.ijbiomac.2018.10.101
- Author:
- Jin Long; Zhe Liu; Lian Hui
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 133
- ISSN:
- 1472-6882
- Subject:
- Western blotting; Zingiberaceae; alternative medicine; antineoplastic activity; body weight; carcinoma; cell lines; dose response; flow cytometry; histopathology; immunohistochemistry; inflammation; interphase; mice; neoplasm cells; pancreatic neoplasms; protein synthesis; staining; tissues
- Abstract:
- ... BACKGROUND: Elemene is an effective anticancer component extracted from Zingiberaceae plants. This work was aimed to evaluate the anti-tumor effect and mechanism actions of elemene on pancreatic carcinoma in vitro and in vivo. METHODS: The anti-proliferation experiment was measured by Methylthiazolyldiphenyl-tetrazolium bromide (MTT) method in the time of 24, 48 and 72 h in three different dosages ...
- DOI:
- 10.1186/s12906-019-2544-2
- PubMed:
- 31215421
- PubMed Central:
- PMC6582541
- https://doi.org/10.1186/s12906-019-2544-2
- Author:
- Annick D. van den Brand; Judith Villevoye; Sandra M. Nijmeijer; Martin van den Berg; Majorie B.M. van Duursen
- Source:
- Toxicology 2019 v.422 pp. 35-43
- ISSN:
- 0300-483X
- Subject:
- antineoplastic activity; antineoplastic agents; breast neoplasms; breasts; cell cycle checkpoints; cell lines; cell viability; cytochrome P-450; epithelial cells; gene expression; humans; hydroxylation; interleukin-8; mammary glands; median effective concentration; models; neoplasm cells; polyphenols; pterostilbene; reporter genes; resveratrol
- Abstract:
- ... Resveratrol is a plant-derived polyphenol that is known for its anti-inflammatory and anti-tumorigenic properties in in vitro and in vivo models. Recent studies show that some resveratrol analogues might be more potent anti-tumor agents, which may partly be attributed to their ability to activate the aryl hydrocarbon receptor (AHR). Here, the anti-tumorigenic properties of resveratrol and structur ...
- DOI:
- 10.1016/j.tox.2019.04.009
- https://doi.org/10.1016/j.tox.2019.04.009
- Author:
- Shuang Zhang; Zhan-Tao Li; Man Liu; Jing-Ru Wang; Mei-Qi Xu; Zhuo-Yue Li; Xiao-Chuan Duan; Yan-Li Hao; Xiu-Chai Zheng; Hui Li; Zhen-Han Feng; Xuan Zhang
- Source:
- Journal of controlled release 2019 v.295 pp. 102-117
- ISSN:
- 0168-3659
- Subject:
- anticoagulant activity; antineoplastic activity; apoptosis; blood; cell lines; cell membranes; chromatin; doxorubicin; drug delivery systems; drug therapy; heparin; histones; humans; ligands; lysosomes; models; nanoparticles; neoplasm cells; prostatic neoplasms; rats
- Abstract:
- ... Nucleus-targeting drug delivery systems (NTDDs) deliver chemotherapeutic agents to nuclei in order to improve the efficacy of anti-tumour therapy. Histone H1 (H1) plays a key role in establishing and maintaining higher order chromatin structures and could bind to cell membranes. In the present study, we selected H1 as a target to prepare a novel H1-mediated NTDD. Low molecular weight heparin (LMHP ...
- DOI:
- 10.1016/j.jconrel.2018.12.034
- https://doi.org/10.1016/j.jconrel.2018.12.034
- Author:
- Gourav Kumar; Rashmi Gupta; Shruti Sharan; Partha Roy; Dev Mani Pandey
- Source:
- 3 Biotech 2019 v.9 no.11 pp. 399
- ISSN:
- 2190-572X
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Calotropis procera; Euphorbia neriifolia; Millettia pinnata; Moringa oleifera; Salmonella Typhi; anti-infective agents; antineoplastic activity; antioxidants; beta-sitosterol; cell lines; chloroform; cytotoxicity; epithelium; ethyl acetate; leaf extracts; leaves; lung neoplasms; lungs; medicinal plants; methanol; neoplasm cells; solvents; stigmasterol; India
- Abstract:
- ... The goal of this research was to explore the preliminary anticancer properties of five plants namely Calotropis procera, Moringa oleifera, Millettia pinnata, Basela alba and Euphorbia neriifolia available in Jharkhand which is used for the medicinal purpose by local tribes. In the present study, plant leaves from five species were collected, dried and extracted with solvents of increasing polarity ...
- DOI:
- 10.1007/s13205-019-1927-x
- PubMed:
- 31656737
- PubMed Central:
- PMC6790204
- https://doi.org/10.1007/s13205-019-1927-x
- Author:
- Shahnaz Majeed; Mohammed Danish; Muhammad Hisyamuddin Bin Ismail; Mohmmed Tahir Ansari; Mohamad Nasir Mohamad Ibrahim
- Source:
- Sustainable chemistry and pharmacy 2019 v.14 pp. 100179
- ISSN:
- 2352-5541
- Subject:
- Artocarpus heterophyllus; Fourier transform infrared spectroscopy; acridine orange; amides; amines; antineoplastic activity; apoptosis; cell lines; chromatin; color; colorectal neoplasms; energy; energy-dispersive X-ray analysis; ethidium; humans; in vitro studies; inhibitory concentration 50; leaf extracts; leaves; nanoparticles; neoplasm cells; nitrates; particle size; spectral analysis; staining; transmission electron microscopy; ultraviolet-visible spectroscopy; zinc; zinc oxide
- Abstract:
- ... Aim of this study was to synthesize the safe and stable zinc oxide nanoparticles (ZnONPs) from the leaves of Artocarpus heterophyllus. The alter in the color of the leaf extract dark brown upon addition of zinc nitrate Zn(NO₃) confirms the formation of Zinc Oxide nanoparticles (ZnONPs). UV-VIS spectrophotometric analysis showed lambda max at 235 nm while Fourier transform infra-red (FTIR) spectros ...
- DOI:
- 10.1016/j.scp.2019.100179
- https://doi.org/10.1016/j.scp.2019.100179
- Author:
- Remya Vijayan; Siby Joseph; Beena Mathew
- Source:
- Bioprocess and biosystems engineering 2019 v.42 no.2 pp. 305-319
- ISSN:
- 1615-7591
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Bauhinia purpurea; Fourier transform infrared spectroscopy; X-ray diffraction; agar; antineoplastic activity; antioxidant activity; antioxidants; catalysts; catalytic activity; cell lines; dose response; dyes; energy-dispersive X-ray analysis; gold; inhibitory concentration 50; leaf extracts; lung neoplasms; medicinal plants; nanogold; nanoparticles; nanosilver; neoplasm cells; silver; stabilizers; surface plasmon resonance; transmission electron microscopy
- Abstract:
- ... The synthesis of metal nanoparticles by green methods attained enormous attention in recent years due to its easiness, non-toxicity, and eco-friendly nature. In the present study, noble metal nanoparticles such as silver and gold were prepared using an aqueous leaf extract of a medicinal plant, Bauhinia purpurea. The leaf extract performed as both reducing and stabilizing agents for the developmen ...
- DOI:
- 10.1007/s00449-018-2035-8
- https://doi.org/10.1007/s00449-018-2035-8
- Author:
- Chan-Su Rha; Hyun Woo Jeong; Saitbyul Park; Siyoung Lee; Young Sung Jung; Dae-Ok Kim
- Source:
- Antioxidants 2019 v.8 no.8 pp. -
- ISSN:
- 2076-3921
- Subject:
- adenoma; antineoplastic activity; antioxidant activity; apigenin; breast neoplasms; cell lines; colon; dose response; endo-1,4-beta-glucanase; flavanols; gene expression; genes; glycosides; green tea; kaempferol; macrophages; mass spectrometry; messenger RNA; mice; models; myricetin; neoplasm cells; oxidative stress; paclitaxel; quercetin; tannase; viability
- Abstract:
- ... (1) Background: Extensive research has focused on flavan-3-ols, but information about the bioactivities of green tea flavonols is limited. (2) Methods: In this study, we investigated the antioxidative, anti-inflammatory, and anticancer effects of flavonol glycosides and aglycones from green tea using in vitro cell models. The fractions rich in flavonol glycoside (FLG) and flavonol aglycone (FLA) w ...
- DOI:
- 10.3390/antiox8080278
- PubMed:
- 31387266
- PubMed Central:
- PMC6719943
- https://doi.org/10.3390/antiox8080278
30. Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells
- Author:
- Luana Paula Pelinson; Charles Elias Assmann; Taís Vidal Palma; Ivana Beatrice Mânica da Cruz; Micheli Mainardi Pillat; Aline Mânica; Naiara Stefanello; Grazielle Castagna Cezimbra Weis; Audrei de Oliveira Alves; Cinthia Melazzo de Andrade; Henning Ulrich; Vera Maria Melchiors Morsch; Maria Rosa Chitolina Schetinger; Margarete Dulce Bagatini
- Source:
- Molecular biology reports 2019 v.46 no.2 pp. 2085-2092
- ISSN:
- 0301-4851
- Subject:
- acid treatment; antibiotics; antineoplastic activity; apoptosis; caffeic acid; caspases; cell cycle; cell lines; cell viability; culture media; drug therapy; drugs; fetal bovine serum; humans; melanoma; mortality; neoplasm cells; patients
- Abstract:
- ... Cutaneous melanoma (CM) is an extremely aggressive cancer presenting low survival and high mortality. The vast majority of patients affected by this disease does not respond or show resistance to the chemotherapeutic drugs, which makes the treatment ineffective. In this sense, the necessity for the development of new agents to assist in CM therapy is extremely important. One of the sources of grea ...
- DOI:
- 10.1007/s11033-019-04658-1
- https://doi.org/10.1007/s11033-019-04658-1
- Author:
- Donghwa Kim; Cai Yi Wang; Ruoci Hu; Ji Yun Lee; Thi-Thu-Trang Luu; Hee-Juhn Park; Sang Kook Lee
- Source:
- Journal of natural products 2019 v.82 no.11 pp. 3140-3149
- ISSN:
- 1520-6025
- Subject:
- Persicaria; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell lines; cyclin-dependent kinase; mice; molecular models; neoplasm cells; proteins; quercitrin; signal transduction; sucrose; toxicity
- Abstract:
- ... A flavonoid glycoside, quercitrin (1), and two phenylpropanoyl sucrose derivatives, vanicoside B (2) and lapathoside C (3), were isolated for the first time from the herb Persicaria dissitiflora. Vanicoside B (2) exhibited antiproliferative activity against a panel of cancer cell lines in triple-negative breast cancer (TNBC) MDA-MB-231 cells. The underlying mechanisms of the antitumor activity of ...
- DOI:
- 10.1021/acs.jnatprod.9b00720
- https://doi.org/10.1021/acs.jnatprod.9b00720
- Author:
- Jianli Liu; Zhijun Yang; Yuchi Kong; Yin He; Yongliang Xu; Xiangyu Cao
- Source:
- Journal of food biochemistry 2019 v.43 no.9 pp. e12972
- ISSN:
- 0145-8884
- Subject:
- Inula helenium; antineoplastic activity; apoptosis; carcinogenesis; cell lines; cell viability; chemoprevention; death; drug therapy; lung neoplasms; medicine; mitogen-activated protein kinase; neoplasm cells; sesquiterpenoid lactones; transcription factor NF-kappa B
- Abstract:
- ... Alantolactone is a sesquiterpene lactone extracted from Inula helenium L. plants possessing many biological activities, including anti‐inflammatory, antiproliferation, and antimicrobial. The inhibitory effects and the underlying mechanisms of alantolactone on lung cancer cells NCI‐H1299 and Anip973 were investigated in this study. The results showed that alantolactone could decrease cell viability ...
- DOI:
- 10.1111/jfbc.12972
- https://doi.org/10.1111/jfbc.12972
33. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients
- Author:
- Sophia J. Lang; Michael Schmiech; Susanne Hafner; Christian Paetz; Carmen Steinborn; Roman Huber; Menna El Gaafary; Katharina Werner; Christoph Q. Schmidt; Tatiana Syrovets; Thomas Simmet
- Source:
- Phytomedicine 2019 v.62 pp. 152962
- ISSN:
- 0944-7113
- Subject:
- Artemisia annua; acetonitrile; active ingredients; antineoplastic activity; apoptosis; artemisinin; breast neoplasms; breasts; carbon; caspase-3; cell cycle; cell lines; cell proliferation; cell viability; chicks; chorioallantoic membrane; detection limit; epithelial cells; flow cytometry; high performance liquid chromatography; humans; lung neoplasms; lymphocytes; maceration; mammary glands; membrane potential; metastasis; mitochondrial membrane; models; neoplasm cells; nuclear magnetic resonance spectroscopy; pancreas; stable isotopes; tandem mass spectrometry
- Abstract:
- ... Artemisia annua L. has gained increasing attention for its anticancer activity. However, beside artemisinin, less is known about the possible bioactive ingredients of Artemisia annua and respective herbal preparations. We hypothesized that, in addition to artemisinin, Artemisia annua preparations might contain multiple ingredients with potential anticancer activity.MDA-MB-231 triple negative human ...
- DOI:
- 10.1016/j.phymed.2019.152962
- https://doi.org/10.1016/j.phymed.2019.152962
- Author:
- Laura Sartori Assunção; Iara Fabrícia Kretzer; Jelver Alexander Sierra Restrepo; Leônidas João de Mello Junior; Adny Henrique Silva; Eliana de Medeiros Oliveira; Misael Ferreira; Marcus Mandolesi Sá; Tânia Beatriz Creczynski-Pasa
- Source:
- Biochimica et biophysica acta 2019 v.1863 no.9 pp. 1332-1342
- ISSN:
- 0304-4165
- Subject:
- DNA damage; antineoplastic activity; apoptosis; autophagy; caspase-8; cell lines; cytotoxicity; endoplasmic reticulum; homeostasis; mechanism of action; membrane permeability; mitochondrial membrane; mitosis; neoplasm cells; pro-apoptotic proteins; salts
- Abstract:
- ... In a previous study, we described a series of 28 aryl- and alkyl-substituted isothiouronium salts with antitumor activity and selectivity toward a leukemia cell line. Among the synthesized compounds, methyl (Z)-2-(isothioureidomethyl)-2-pentenoate hydrobromide (IS-MF08) showed conspicuous activity. In the present study, we investigated the mechanism of action of IS-MF08. Our results showed that it ...
- DOI:
- 10.1016/j.bbagen.2019.05.018
- https://doi.org/10.1016/j.bbagen.2019.05.018
35. Antitumor effect of depsidones from lichens on tumor cell lines and experimental murine melanoma
- Author:
- Caroline Almeida Farias Alexandrino; Neli Kika Honda; Maria de Fatima Cepa Matos; Luciane Candeloro Portugal; Pedro Rafael Berquó de Souza; Renata Trentin Perdomo; Rita de Cássia Avellaneda Guimarães; Monica Cristina Toffoli Kadri; Magalli Costa Barbosa Lima Silva; Danielle Bogo
- Source:
- Revista Brasileira de Farmacognosia 2019 v.29 no.4 pp. 449-456
- ISSN:
- 0102-695X
- Subject:
- acids; antineoplastic activity; caspase-3; cell lines; flow cytometry; growth retardation; lichens; melanoma; mice; models; neoplasm cells
- Abstract:
- ... Lichens have exhibited numerous biological activities, including growth inhibition of tumor cells. This study evaluated the antiproliferative activity of hypostictic and salazinic acids against tumor cell lines (B16-F10, PC-03, MCF7, HT-29, HEP-G2, K562 and 786-0) by the SRB assay in vitro and antitumor activity in experimental murine melanoma in vivo. Activation of caspase-3 was quantified by flo ...
- DOI:
- 10.1016/j.bjp.2019.04.005
- https://doi.org/10.1016/j.bjp.2019.04.005
- Author:
- Kyeong Kweon; Jin-Ok Ahn; Woo-Jin Song; Qiang Li; Bo-Yeon Lee; Hyung-Kyu Chae; Hwa-Young Youn
- Source:
- In vitro cellular & developmental biology 2019 v.55 no.1 pp. 7-16
- ISSN:
- 1071-2690
- Subject:
- Anemone cernua; Glycyrrhiza glabra; Panax ginseng; antineoplastic activity; apoptosis; cell cycle; cell lines; cell proliferation; dogs; dose response; drug therapy; drugs; flow cytometry; in vitro studies; melanoma; mononuclear leukocytes; osteosarcoma; roots; veterinary medicine; viability; animal use replacement
- Abstract:
- ... The present study was designed to evaluate the effect of SB injection, which is composed of extracts from the roots of Pulsatilla koreana, Panax ginseng, and Glycyrrhiza glabra, on the viability of canine osteosarcoma and melanoma cells and nonneoplastic canine cells. Cells were treated with SB injection, conventional chemotherapeutic drugs, or a combination of both at various concentrations. Cell ...
- DOI:
- 10.1007/s11626-018-0294-y
- https://doi.org/10.1007/s11626-018-0294-y
- Author:
- Aleksandar Dolashki; Pavlina Dolashka; Arnulf Stenzl; Stefan Stevanovic; Wilhelm K. Aicher; Lyudmila Velkova; Radostina Velikova; Wolfgang Voelter
- Source:
- Biotechnology, biotechnological equipment 2019 v.33 no.1 pp. 20-32
- ISSN:
- 1314-3530
- Subject:
- Rapana venosa; antineoplastic activity; apoptosis; biotechnology; bladder; carcinoma; cell growth; cell lines; doxorubicin; equipment; glycoproteins; glycosylation; hemocyanin; hexoses; humans; methylation; neoplasm cells; oligosaccharides; therapeutics; two-dimensional gel electrophoresis; urinary bladder neoplasms
- Abstract:
- ... Hemocyanins are oxygen-transporting glycoproteins in molluscs and arthropods. In this study, we assayed the biomacromolecules from the molluscs Helix lucorum (HlH), Rapana venosa (RvH) and Megatura crenulata (KLH) including their functional units (FUs), for therapy of bladder cancer permanent cells. In vitro studies antitumour activities of these proteins were performed with bladder cancer permane ...
- DOI:
- 10.1080/13102818.2018.1507755
- https://doi.org/10.1080/13102818.2018.1507755
- Author:
- Masaya Igase; Kazuha Shousu; Noriyuki Fujiki; Masashi Sakurai; Makoto Bonkobara; Chung C. Hwang; Matt Coffey; Shunsuke Noguchi; Yuki Nemoto; Takuya Mizuno
- Source:
- Veterinary and comparative oncology 2019 v.17 no.2 pp. 184-193
- ISSN:
- 1476-5810
- Subject:
- Reoviridae; antineoplastic activity; apoptosis; cell lines; clinical trials; dogs; interferons; mice; neoplasm cells; prognosis; sarcoma; severe combined immunodeficiency; therapeutics
- Abstract:
- ... Canine histiocytic sarcoma is an aggressive, fatal neoplastic disease with a poor prognosis. Lomustine is generally accepted as the first‐line systemic therapy, although this compound does not provide complete regression. Therefore, research into a novel approach against canine histiocytic sarcoma is needed. However, anti‐tumour effects of oncolytic therapy using reovirus against histiocytic sarco ...
- DOI:
- 10.1111/vco.12468
- https://doi.org/10.1111/vco.12468
- Author:
- Yumi Kim; Kang-Hoon Kim; In-Seung Lee; Ji Young Park; Yun-Cheol Na; Won-Seok Chung; Hyeung-Jin Jang
- Source:
- Phytomedicine 2019 v.56 pp. 48-56
- ISSN:
- 0944-7113
- Subject:
- Anemarrhena asphodeloides; active ingredients; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cell growth; cell lines; cell proliferation; chemical constituents of plants; cyclins; cytotoxicity; drug therapy; ethyl acetate; genes; humans; immunoblotting; liquid chromatography; mass spectrometry; mechanism of action; metastasis; mitogen-activated protein kinase; neoplasm cells; pancreatic neoplasms; protein content; reverse transcription; saponins; solvents; viability
- Abstract:
- ... Timosaponin A3 (TA3), one of the active components of spirostanol saponin isolated from A. asphodeloides, is widely used as an anticancer agent in a variety of cancer cell lines. However, the research on the anticancer efficacy is very limited in human pancreatic cancer models.In this study, we investigated the molecular targets in the active components of A. asphodeloides, which showed anti-cance ...
- DOI:
- 10.1016/j.phymed.2018.08.006
- https://doi.org/10.1016/j.phymed.2018.08.006
- Author:
- Hua Luo; Erwei Hao; Dechao Tan; Wei Wei; Jinling Xie; Xiaohui Feng; Zhengcai Du; Chunying Huang; Gang Bai; Yuanyuan Hou; Chuanjing Cheng; Xiangxi Yi; Yitao Wang; Xiaotao Hou; Jiagang Deng
- Source:
- Food and chemical toxicology 2019 pp. -
- ISSN:
- 0278-6915
- Subject:
- Aegiceras corniculatum; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; butanol; cell cycle checkpoints; cell lines; cell proliferation; colorectal neoplasms; dose response; flow cytometry; human diseases; leaf extracts; leaves; mechanism of action; mice; mitochondria; neoplasm cells; patients; proteins; signal transduction; viability
- Abstract:
- ... Aegiceras corniculatum (L.) Blanco is known to exhibit anticancer effects against different types of cancer; however, to the best of our knowledge, the anticancer activity and underlying mechanisms of action of A. corniculatum leaf extract on colorectal cancer have not been elucidated. In the present study, colony-forming assay, western blot analysis, flow cytometry, and a xenograft model were use ...
- DOI:
- 10.1016/j.fct.2019.110861
- https://doi.org/10.1016/j.fct.2019.110861
- Author:
- Fan Zhang; Yuan-Yuan Zhang; Ya-Sai Sun; Run-Hui Ma; Kiran Thakur; Jian-Guo Zhang; Zhao-Jun Wei
- Source:
- Journal of agricultural and food chemistry 2019 v.68 no.1 pp. 213-224
- ISSN:
- 1520-5118
- Subject:
- Asparagus officinalis; antineoplastic activity; apoptosis; carcinoma; caspases; cell cycle checkpoints; cell lines; cell proliferation; clinical trials; cytochrome c; endometrium; enzyme inhibition; functional foods; human diseases; ingredients; interphase; mitochondria; phosphatidylinositol 3-kinase; signal transduction; steroid saponins; uterine neoplasms
- Abstract:
- ... Asparanin A (AA), a steroidal saponin from Asparagus officinalis L., has anticancer activity: however, its detailed molecular mechanisms in endometrial cancer (EC) have not been studied so far. We evaluated the anticancer activity and underlying mechanism of AA on EC cell line Ishikawa in vitro and in vivo. AA inhibited the Ishikawa cell proliferation and caused cell morphology alteration and cell ...
- DOI:
- 10.1021/acs.jafc.9b07103
- https://doi.org/10.1021/acs.jafc.9b07103
- Author:
- Tsvetelina Batsalova; Diyana Basheva; Krum Bardarov; Ventzislav Bardarov; Balik Dzhambazov; Ivanka Teneva
- Source:
- Chemosphere 2019 v.218 pp. 93-103
- ISSN:
- 0045-6535
- Subject:
- Fischerella; active ingredients; antibiotics; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; cell culture; cell lines; cytotoxicity; environmental assessment; environmental impact; exposure duration; hormones; human health; immunosuppressive agents; in vitro studies; insecticides; microcystins; photosynthesis; repellents; risk assessment; saxitoxins; vitamins
- Abstract:
- ... Cyanoprokaryotes (Cyanobacteria/Cyanophyta) are ancient photosynthetic prokaryotic organisms with cosmopolitan distribution. They are producers of a number of biologically active substances with antitumor and antifungal activity, vitamins, antibiotics, algaecides, insecticides, repellents, hormones, immunosuppressants and toxins. So far, the cyanobacterium Fischerella major Gomont has not been stu ...
- DOI:
- 10.1016/j.chemosphere.2018.11.097
- https://doi.org/10.1016/j.chemosphere.2018.11.097
43. Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell
- Author:
- Mingjiang Yao; Xiaodi Fan; Bo Yuan; Norio Takagi; Sai Liu; Xiao Han; Junguo Ren; Jianxun Liu
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 216
- ISSN:
- 1472-6882
- Subject:
- Western blotting; alternative medicine; antineoplastic activity; berberine; breast neoplasms; caspase-1; cell lines; cell proliferation; cytotoxicity; dose response; females; gene expression regulation; genes; humans; inflammasomes; interleukin-18; interleukin-1alpha; interleukin-1beta; interleukin-6; lactate dehydrogenase; messenger RNA; metastasis; necrosis; purinergic receptors; quantitative polymerase chain reaction; secretion; tissue repair; tumor necrosis factor-alpha; viability
- Abstract:
- ... BACKGROUND: Breast cancer is still the most common malignant tumor that threatens the female’s life in the world, especially triple-negative breast cancer (TNBC), one of the most difficult subtypes. Lack of targeted therapies brings about urgent demand for novel treatments. In this study we aim to investigate the anti-tumor activity of Berberine (BBR), a Chinese plant-derived alkaloid, against the ...
- DOI:
- 10.1186/s12906-019-2615-4
- PubMed:
- 31412862
- PubMed Central:
- PMC6694465
- https://doi.org/10.1186/s12906-019-2615-4
- Author:
- Gajanan T. Mehetre; Vinodh J. S.; Bhushan B. Burkul; D. Desai; Santhakumari B; Mahesh S. Dharne; Syed G. Dastager
- Source:
- RSC advances 2019 v.9 no.17 pp. 9850-9859
- ISSN:
- 2046-2069
- Subject:
- Acinetobacter junii; Actinomadura; Cellulomonas; Cellulosimicrobium; Dietzia; Glycomyces; Janibacter; Klebsiella pneumoniae; Marmoricola; Micromonospora; Pseudomonas aeruginosa; Salmonella Abony; Shigella flexneri; Staphylococcus epidermidis; Streptomyces; antimicrobial properties; antineoplastic activity; biosynthesis; breast neoplasms; cell lines; drugs; fungi; hot springs; multigene family; neoplasm cells; polyketides; ribosomal RNA; screening; secondary metabolites; sequence analysis; tripeptides; India
- Abstract:
- ... The bioactive potential of Actinobacteria endemic to hot springs has rarely been investigated. This study highlights the cultivable diversity and bioactivities of Actinobacteria associated with the Unkeshwar hot springs, India. Potent strains were evaluated for their biosynthetic potentials and metabolite analysis was performed using effective dereplication molecular networking tools. A total of 8 ...
- DOI:
- 10.1039/c8ra09449g
- https://doi.org/10.1039/c8ra09449g
- Author:
- Saeed-ur-Rahman; Muhammad Khalid; Sadaf-Ilyas Kayani; Farooq Jan; Ayaz Ullah; Kexuan Tang
- Source:
- Tropical plant biology 2019 v.12 no.4 pp. 231-243
- ISSN:
- 1935-9756
- Subject:
- Artemisia annua; animal models; antineoplastic activity; artemisinin; bioactive compounds; cell lines; drug development; drugs; intravenous injection; malaria; multiple drug resistance; risk
- Abstract:
- ... Artemisinins, as a class of bioactive molecules, are mainly derived from the extracts of Artemisia annua L. and are the mainstay for malaria treatment, including severe malaria, uncomplicated malaria and multi-drug resistant malaria. They are well-known for their good tolerability, safety and rapid onset of action. Their efficacy is not only limited to malaria but also extends to a variety of huma ...
- DOI:
- 10.1007/s12042-019-09228-0
- https://doi.org/10.1007/s12042-019-09228-0
- Author:
- Pinar Mega Tiber; Sevgi Kocyigit Sevinc; Olca Kilinc; Oya Orun
- Source:
- Gene 2019 v.692 pp. 217-222
- ISSN:
- 0378-1119
- Subject:
- Zingiber officinale; antineoplastic activity; apoptosis; cell lines; cell viability; cytotoxicity; ginger; membrane potential; mitochondrial membrane; mononuclear leukocytes; myeloid leukemia; neoplasm cells; patients; pro-apoptotic proteins; proteins; rhizomes; therapeutics
- Abstract:
- ... The anticancer activity of Zingiber officinalis (ginger) is an area of active research. However, data is quite limited regarding its action and mechanism, especially in hematologic cancer types. Here, antiproliferative and apoptotic effects of whole extract of the rhizome of Zingiber officinalis (ZOWE), was investigated in K562 cell line derived from a chronic myeloid leukemia (CML) patient. Vario ...
- DOI:
- 10.1016/j.gene.2019.01.015
- https://doi.org/10.1016/j.gene.2019.01.015
- Author:
- Mohsen Tatar; Zohreh Bagheri; Masoumeh Varedi; Fakhraddin Naghibalhossaini
- Source:
- Nutrition and cancer 2019 v.71 no.3 pp. 461-471
- ISSN:
- 1532-7914
- Subject:
- antineoplastic activity; blackberries; cell free system; cell lines; colorectal neoplasms; dose response; enzyme activity; enzyme inhibition; fruit juices; gene expression; inhibitory concentration 50; messenger RNA; methylation; mononuclear leukocytes; neoplasm cells; telomerase
- Abstract:
- ... Several mechanisms have been proposed to explain berries’ anticancer effects. However, no previously published studies have investigated berries’ anti-telomerase activity. In this study, the anti-telomerase activity of blackberry crude extract was analyzed in six human colorectal cancer (CRC) cell lines by TRAP assay. The peripheral blood mononuclear cells (PBMCs) from a healthy donor were used as ...
- DOI:
- 10.1080/01635581.2018.1506491
- https://doi.org/10.1080/01635581.2018.1506491
- Author:
- Zhitao Gao; Chuan Tong; Yao Wang; Deyun Chen; Zhiqiang Wu; Weidong Han
- Source:
- Journal of genetics and genomics 2019 v.46 no.8 pp. 367-377
- ISSN:
- 1673-8527
- Subject:
- T-lymphocytes; animal disease models; antibodies; antigens; antineoplastic activity; apoptosis; cell lines; clinical trials; cytotoxicity; disease control; disease progression; glycoproteins; humans; immunotherapy; interferon-gamma; interleukin-2; manufacturing; neoplasm cells; neoplasms; tumor necrosis factor-alpha
- Abstract:
- ... Chimeric antigen receptor T-cell (CAR T) therapy is a kind of effective cancer immunotherapy. However, designing CARs remains a challenge because many targetable antigens are shared by T cells and tumor cells. This shared expression of antigens can cause CAR T cell fratricide. CD38-targeting approaches (e.g., daratumumab) have been used in clinical therapy and have shown promising results. CD38 is ...
- DOI:
- 10.1016/j.jgg.2019.06.007
- https://doi.org/10.1016/j.jgg.2019.06.007
- Author:
- Denis Amilton dos Santos; Fernanda Mosena Munari; Caroline Olivieri da Silva Frozza; Sidnei Moura; Thiago Barcellos; João Antonio Pêgas Henriques; Mariana Roesch-Ely
- Source:
- Biotechnology Research and Innovation 2019 v.3 no.1 pp. 120-130
- ISSN:
- 2452-0721
- Subject:
- active ingredients; antineoplastic activity; cell lines; chromatography; colorectal neoplasms; cytotoxicity; formononetin; fractionation; honey bees; inhibitory concentration 50; neoplasm cells; propolis; staining; tandem mass spectrometry; viability assays
- Abstract:
- ... Red propolis is a natural resin mixture produced by honeybees and presents a source of active compounds with a variety of biological activities. In this study, we describe the chemical characterization and potential antitumor activity of total extract of Brazilian red propolis and its fractions. Fractions were obtained through column chromatography revealing 14 different compounds in all samples, ...
- DOI:
- 10.1016/j.biori.2019.02.001
- https://doi.org/10.1016/j.biori.2019.02.001
- Author:
- Lenka Molčanová; Dominika Janošíková; Stefano Dall´Acqua; Karel Šmejkal
- Source:
- Phytochemistry reviews 2019 v.18 no.4 pp. 1051-1100
- ISSN:
- 1568-7767
- Subject:
- antineoplastic activity; antineoplastic agents; bioassays; cell culture; cell lines; chemoprevention; cytotoxicity; drug therapy; flavanones; flavonols; in vitro studies; isoflavonoids; neoplasm cells; neoplasms; oxygen; secondary metabolites
- Abstract:
- ... Natural products of plant origin or their semisynthetic derivatives acting as chemopreventive or chemotherapeutic agents for various types of cancer are under study as potential new anticancer drugs. Within the huge class of plant phenolic secondary metabolites, the subclass of prenylated flavonoids is quite rich in structural variety and pharmacological activity. One of their most prominent chara ...
- DOI:
- 10.1007/s11101-019-09641-z
- https://doi.org/10.1007/s11101-019-09641-z