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1. Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes

Author:
Del Rio, Daniele,   et al.   ; Mena, Pedro; Ludwig, Iziar A.; Tomatis, Virginia B.; Acharjee, Animesh; Calani, Luca; Rosi, Alice; Brighenti, Furio; Ray, Sumantra; Griffin, Julian L.; Bluck, Les J.;     Show all 11 Authors
Source:
European journal of nutrition 2019 v.58 no.4 pp. 1529-1543
ISSN:
1436-6207
Subject:
acids; bioactive compounds; bioavailability; coffee beans; excretion; flavanols; foods; green tea; health effects assessments; human nutrition; lactones; metabolites; polyphenols; statistical analysis; urine
Abstract:
... PURPOSE: There is much information on the bioavailability of (poly)phenolic compounds following acute intake of various foods. However, there are only limited data on the effects of repeated and combined exposure to specific (poly)phenol food sources and the inter-individual variability in their bioavailability. This study evaluated the combined urinary excretion of (poly)phenols from green tea an ...
DOI:
10.1007/s00394-018-1683-4

2. Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity

Author:
Del Rio, Daniele,   et al.   ; Mena, Pedro; Bresciani, Letizia; Brindani, Nicoletta; Ludwig, Iziar A.; Pereira-Caro, Gema; Angelino, Donato; Llorach, Rafael; Calani, Luca; Brighenti, Furio; Clifford, Michael N.; Gill, Chris I. R.; Crozier, Alan; Curti, Claudio;     Show all 14 Authors
Source:
Natural product reports 2019 v.36 no.5 pp. 714-752
ISSN:
1460-4752
Subject:
acids; animals; bioactive properties; bioavailability; biomarkers; digestive system; flavanols; human nutrition; metabolites; metabolomics; models; pharmacokinetics; proanthocyanidins
Abstract:
... Covering: 1958 to June 2018 Phenyl-γ-valerolactones (PVLs) and their related phenylvaleric acids (PVAs) are the main metabolites of flavan-3-ols, the major class of flavonoids in the human diet. Despite their presumed importance, these gut microbiota-derived compounds have, to date, in terms of biological activity, been considered subordinate to their parent dietary compounds, the flavan-3-ol mono ...
DOI:
10.1039/c8np00062j