Jump to Main Content
- Zhu, Xiao-Lei, et al. Show all 7 Authors
- Journal of agricultural and food chemistry 2019 v.67 no.10 pp. 2774-2781
- NADH dehydrogenase; chemical structure; computer simulation; diphenyl ethers; fungicides; hydrogen bonding; inhibitory concentration 50; mechanics; mechanism of action; mitochondria; molecular dynamics; molecular models; simulation models; surface area; swine
- ... The marine natural product neopeltolide was isolated from a deep-water sponge specimen of the family Neopeltidae. Neopeltolide has been proven to be a new type of inhibitor of the cytochrome bc₁ complex in the mitochondrial respiration chain. However, its detailed inhibition mechanism has remained unknown. In addition, neopeltolide is difficult to synthesize because of its very complex chemical st ...