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You searched for: Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Subject term glucose Remove constraint Subject term: glucose Subject term glycemic effect Remove constraint Subject term: glycemic effect Subject term high fat diet Remove constraint Subject term: high fat diet
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1. AMPK activation is involved in hypoglycemic and hypolipidemic activities of mogroside-rich extract from Siraitia grosvenorii (Swingle) fruits on high-fat diet/streptozotocin-induced diabetic mice

Author:
Hesheng Liu; Xiangyang Qi; Keke Yu; Anjie Lu; Kaifeng Lin; Jiajing Zhu; Min Zhang; Zhida Sun
Source:
Food & function 2019 v.10 no.1 pp. 151-162
ISSN:
2042-650X
Subject:
Siraitia grosvenorii; animal disease models; blood glucose; blood proteins; blood serum; body weight; dose response; energy intake; fruits; gene expression regulation; genes; glucose; glycemic effect; high fat diet; homeostasis; insulin; insulin resistance; insulin-dependent diabetes mellitus; lipemic effect; lipid composition; lipids; messenger RNA; mice; noninsulin-dependent diabetes mellitus; protein kinases; streptozotocin
Abstract:
... Previous studies suggested the anti-diabetic effect of mogrosides in type 1 diabetes. To evaluate the potential effect of mogrosides in type 2 diabetes, we herein investigated the hypoglycemic and hypolipidemic effects and the underlying mechanism of mogroside-rich extract (MGE) using a high-fat diet in combination with streptozotocin (STZ)-induced diabetic model. MGE feeding for 5 weeks did not r ...
DOI:
10.1039/c8fo01486h

2. Glucose Metabolism and Cecal Microbiome Populations Are Improved and Hepatic Biochemical Levels Altered with Consumption of Grape Powder by High-fat Fed C57BL/6 J Mice (P06-024-19)

Author:
Neil Shay; Marlena Sturm; Alexandra Becraft; Rufa Mendez; Si-Hong Park; Gavin Pierce; Sang In Lee; Wesley Yu
Source:
Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:
2475-2991
Subject:
Western diets; beta oxidation; biomarkers; blood glucose; body weight; cholesterol; energy content; experimental diets; fasting; food intake; fructose; gene expression; gene expression regulation; glucose; glucose tolerance; glucose tolerance tests; glycemic effect; high fat diet; homeostasis; inflammation; insulin; males; metabolites; metabolomics; mice; microbiome; myo-inositol; placebos; polyphenols; remediation; table grapes; trigonelline
Abstract:
... Grapes are nutrient-dense, particularly in polyphenolic compounds. Previous research demonstrates benefits of whole grape and grape skin, seed, and polyphenol intake on glucose homeostasis along with other health benefits. We tested the hypothesis that intake of 4 servings per day of table grape would remediate metabolic complications in C57BL/6 J (C57) male mice fed a high-fat diet with added cho ...
DOI:
10.1093/cdn/nzz031.P06-024-19

3. Glycosaminoglycan from Apostichopus japonicus Improves Glucose Metabolism in the Liver of Insulin Resistant Mice

Author:
Yunmei Chen; Yuanhong Wang; Shuang Yang; Mingming Yu; Tingfu Jiang; Zhihua Lv
Source:
Marine drugs 2019 v.18 no.1 pp. -
ISSN:
1660-3397
Subject:
Apostichopus japonicus; Holothuria; blood glucose; blood serum; body weight; dose response; enzymes; gene expression; gluconeogenesis; glucose; glycemic effect; glycosaminoglycans; hepatocytes; high fat diet; hyperglycemia; insulin; insulin resistance; liver; mice; phosphorylation; protein content
Abstract:
... Holothurian glycosaminoglycan isolated from Apostichopus japonicus (named AHG) can suppress hepatic glucose production in insulin resistant hepatocytes, but its effects on glucose metabolism in vivo are unknown. The present study was conducted to investigate the effects of AHG on hyperglycemia in the liver of insulin resistant mice induced by a high-fat diet (HFD) for 12 weeks. The results ...
DOI:
10.3390/md18010001

4. Hypoglycemic effect of inulin combined with ganoderma lucidum polysaccharides in T2DM rats

Author:
Yaping Liu; Yumeng Li; Wenlingzi Zhang; Mingzhe Sun; Zesheng Zhang
Source:
Journal of functional foods 2019 v.55 pp. 381-390
ISSN:
1756-4646
Subject:
Ganoderma lucidum; glucose; glycemic effect; glycogen; high fat diet; hypoglycemia; insulin resistance; inulin; lipid metabolism; messenger RNA; noninsulin-dependent diabetes mellitus; nutrient transport; rats; streptozotocin
Abstract:
... It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD) and streptozotocin (STZ). Then the inulin and gano ...
DOI:
10.1016/j.jff.2019.02.036

5. Improving hepatic mitochondrial biogenesis as a postulated mechanism for the antidiabetic effect of Spirulina platensis in comparison with metformin

Author:
Ghaleb A. Oriquat; Mennatallah A. Ali; Shimaa A. Mahmoud; Rania M.H.M. Eid; Rania Hassan; Maher A. Kamel
Source:
Applied physiology, nutrition and metabolism 2019 v.44 no.4 pp. 357-364
ISSN:
1715-5320
Subject:
Arthrospira platensis; Spirulina; adiponectin; animal disease models; anti-inflammatory activity; biogenesis; blood glucose; blood lipids; diabetes; enzymes; glucose; glycemic effect; high fat diet; insulin; lipid composition; liver; metabolites; metformin; mitochondria; mitochondrial DNA; necrosis; neoplasms; peroxisome proliferator-activated receptor gamma; rats; sterols; streptozotocin; therapeutics; tumor necrosis factor-alpha
Abstract:
... Various nutritional and medicinal potencies have been accredited to metabolites from the cyanobacteria, Spirulina platensis (Arthrospira platensis) sp. Hence, our study was designed to examine whether the Spirulina supplementation would possess beneficial effects in type 2 diabetes mellitus (T2DM) in comparison with metformin. High-fat diet/low-dose streptozotocin (HFD/STZ) model was adopted and t ...
DOI:
10.1139/apnm-2018-0354

6. Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes

Author:
Uddipak Rai; Ramoji Kosuru; Swati Prakash; Surya Pratap Singh; Hareram Birla; Vinod Tiwari; Sanjay Singh
Source:
Life sciences 2019 v.236 pp. 116836
ISSN:
0024-3205
Subject:
C-reactive protein; Ligusticum sinense; animal disease models; blood glucose; blood lipids; blood serum; body weight changes; dose response; fasting; glucose; glucose tolerance; glycemic effect; glycosylation; hemoglobin; high fat diet; homeostasis; insulin; insulin resistance; interleukin-6; medicinal plants; noninsulin-dependent diabetes mellitus; oral administration; phosphatidylinositol 3-kinase; pyrazines; rats; signal transduction
Abstract:
... The present experiment was conceptualised to explore the therapeutic response of tetramethylpyrazine (TMP), a major active constituent of Ligusticum chuanxiong, a Chinese traditional medicinal plant, in high-fat diet (HFD)-streptozotocin (STZ)-induced diabetes in rats and to identify the possible mechanism of action.Dose-reliant effect of oral treatment of TMP (100, 150 and 200 mg/kg/day) for 28 d ...
DOI:
10.1016/j.lfs.2019.116836

7. d-chiro-Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance via PKCε-PI3K/AKT Pathway

Author:
Feier Cheng; Lin Han; Yao Xiao; Chuanying Pan; Yunlong Li; Xinhui Ge; Yao Zhang; Shaoqing Yan; Min Wang
Source:
Journal of agricultural and food chemistry 2019 v.67 no.21 pp. 5957-5967
ISSN:
1520-5118
Subject:
buckwheat; diacylglycerols; fatty liver; free fatty acids; gluconeogenesis; glucose; glycemic effect; hepatocytes; high fat diet; human cell lines; hyperglycemia; insulin resistance; liver; mice; myo-inositol; protein kinase C; signal transduction
Abstract:
... d-chiro-Inositol (DCI) is a biologically active component found in tartary buckwheat, which can reduce hyperglycemia and ameliorate insulin resistance. However, the mechanism underlying the antidiabetic effects of DCI remains largely unclear. This study investigated the effects and underlying molecular mechanisms of DCI on hepatic gluconeogenesis in mice fed a high fat diet and saturated palmitic ...
DOI:
10.1021/acs.jafc.9b01253

8. Adlay Bran Oil Suppresses Hepatic Gluconeogenesis and Attenuates Hyperlipidemia in Type 2 Diabetes Rats

Author:
Yi-Han Tseng; Ching-Wen Chang; Wenchang Chiang; Shu-Chen Hsieh
Source:
Journal of medicinal food 2019 v.22 no.1 pp. 22-28
ISSN:
1557-7600
Subject:
Coix lacryma-jobi; animal disease models; blood; blood glucose; body weight; bran; carboxy-lyases; cholesterol; dietary supplements; glucokinase; gluconeogenesis; glucose; glucose transporters; glycemic effect; high fat diet; hyperglycemia; hyperlipidemia; insulin resistance; messenger RNA; muscles; non-specific serine/threonine protein kinase; noninsulin-dependent diabetes mellitus; oils; triacylglycerols
Abstract:
... This study aimed to examine the antidiabetic effects of various concentrations of adlay bran oil (ABO) in high fat diet and streptozotocin-induced diabetic rats. Dietary supplementation with 10% ABO for 4 weeks effectively decreased the blood triacylglycerol, glucose, and total cholesterol levels in diabetic rats, although body weight remained the same. The mRNA and protein expressions of hepatic ...
DOI:
10.1089/jmf.2018.4237

9. Andrographis Paniculata Ameliorates Insulin Resistance in High Fat Diet-fed Mice and 3T3-L1 Adipocytes (P21-074-19)

Author:
Haw-wen Chen; Chih-Chieh Chen
Source:
Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:
2475-2991
Subject:
Andrographis paniculata; Western blotting; adipocytes; anti-inflammatory activity; bioactive compounds; blood; blood glucose; diabetes; fasting; glucose; glucose transporters; glycemic effect; high fat diet; hyperglycemia; insulin; insulin resistance; mice; protective effect; protein synthesis; signal transduction; tumor necrosis factor-alpha; Taiwan
Abstract:
... Previous studies have shown that Andrographis paniculata (AP) possesses antiinflammatory activity and is able to reduce blood glucose level in diabetes. The results suggested that AP reduced blood glucose level via activation of glucose transporter 4 (GLUT4) membrane translocation; however, the mechanism in adipocytes remained unclear. Proinflammatory cytokines have been shown to play a role in bl ...
DOI:
10.1093/cdn/nzz041.P21-074-19

10. Antidiabetic effects of Olea europaea L. leaves in diabetic rats induced by high-fat diet and low-dose streptozotocin

Author:
Camille Gaube Guex; Fernanda Ziegler Reginato; Patrícia Romualdo de Jesus; Juliana Calil Brondani; Gilberti Helena Hübscher Lopes; Liliane de Freitas Bauermann
Source:
Journal of ethnopharmacology 2019 v.235 pp. 1-7
ISSN:
0378-8741
Subject:
Olea europaea; animal disease models; antioxidants; blood sampling; body weight; diabetes mellitus; ethanol; glucose; glycemic effect; high fat diet; hyperglycemia; hyperlipidemia; insulin resistance; kidneys; laboratory animals; lard; leaves; metabolism; metformin; olives; rats; streptozotocin; sucrose; traditional medicine
Abstract:
... Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance, and dyslipidemia. It has broad occurrence worldwide, affecting millions of people, and can cause serious complications. The olive (Olea europaea L.) has important pharmacological functions, including anti-inflammatory, antioxidant, and hypoglycemic activities. Olive leaves are used in traditional med ...
DOI:
10.1016/j.jep.2019.02.001

11. Aster koraiensis extract lowers postprandial glucose in normoglycemic and high-fat-diet-induced obese mice

Author:
Junghyun Kim; Soo-Wang Hyun; Ik Soo Lee; Kyuhyung Jo; Young Sook Kim; Jin Sook Kim; Chan-Sik Kim
Source:
Food science and biotechnology 2019 v.28 no.2 pp. 563-568
ISSN:
1226-7708
Subject:
adipocytes; animal disease models; blood; blood glucose; gene expression; glucose; glucose tolerance tests; glucose transporters; glycemic effect; herbal medicines; high fat diet; insulin; mice; muscles; noninsulin-dependent diabetes mellitus; obesity; oral administration
Abstract:
... The Aster koraiensis extract (ASKO) is a newly developed dietary herbal supplement. In this study, the potent blood glucose-lowering activity of ASKO in vitro and in vivo was investigated. In an in vitro glucose uptake assay, ASKO was found to enhance glucose transport in 3T3-L1 adipocytes. Oral administration of ASKO significantly reduced glucose levels in normoglycemic mice during oral glucose t ...
DOI:
10.1007/s10068-018-0497-8
PubMed:
30956869
PubMed Central:
PMC6431321

12. Comparative analysis of the main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma

Author:
Xiang Cui; Yu‐meng Shen; Shu Jiang; Da‐wei Qian; Er‐xin Shang; Zhen‐hua Zhu; Jin‐ao Duan
Source:
Journal of separation science 2019 v.42 no.8 pp. 1520-1527
ISSN:
1615-9306
Subject:
acetonitrile; animal disease models; carboxy-lyases; drugs; enzyme activity; formic acid; glucokinase; glucose; glycemic effect; high fat diet; mass spectrometry; noninsulin-dependent diabetes mellitus; phosphofructokinases; pyruvate kinase; quantitative analysis; rats; rhizomes; standard deviation; streptozotocin; ultra-performance liquid chromatography
Abstract:
... In this study, a rapid and highly sensitive ultra high performance liquid chromatography with triple quadrupole mass spectrometry method with the mobile phase of acetonitrile and 0.1% aqueous formic acid was established and successfully applied to comparatively analyze main active components after their compatibility. Besides, the effects of Scutellariae Radix, Coptidis Rhizoma and combined extrac ...
DOI:
10.1002/jssc.201801204

13. Comparison of the Effects of Green and Black Tea Extracts on Na+/K+‐ATPase Activity in Intestine of Type 1 and Type 2 Diabetic Mice

Author:
Fengfeng Qu; Shuyuan Liu; Chang He; Jingtao Zhou; Shanming Zhang; Zeyi Ai; Yuqiong Chen; Zhi Yu; Dejiang Ni
Source:
Molecular nutrition & food research 2019 v.63 no.17 pp. e1801039
ISSN:
1613-4125
Subject:
adenosine triphosphate; animal disease models; black tea; enzyme activity; glucose; glycemic effect; green tea; high fat diet; hyperglycemia; intestinal absorption; intestines; mice; noninsulin-dependent diabetes mellitus; potassium; protein synthesis; sodium; sodium-potassium-exchanging ATPase; theaflavins; therapeutics
Abstract:
... SCOPE: Na⁺/K⁺‐ATPase is an important membrane‐bound enzyme and high levels of Na⁺/K⁺‐ATPase activity in intestine result in increased monosaccharide absorption and aggravated undesirable postprandial hyperglycemia in diabetic. The aim is to characterize the effects of green and black tea extracts on the intestinal Na⁺/K⁺‐ATPase. METHODS AND RESULTS: The STZ‐induced type 1 diabetic mice model and h ...
DOI:
10.1002/mnfr.201801039

14. Effect of Konjac Mannan Oligosaccharides on Glucose Homeostasis via the Improvement of Insulin and Leptin Resistance In Vitro and In Vivo

Author:
Di Zhu; Qiaojuan Yan; Yanxiao Li; Jun Liu; Haijie Liu; Zhengqiang Jiang
Source:
Nutrients 2019 v.11 no.8 pp. -
ISSN:
2072-6643
Subject:
blood glucose; blood serum; brain; dietary supplements; fasting; glucose; glucose tolerance; glycemic effect; glycogen; high fat diet; homeostasis; human cell lines; insulin; insulin resistance; konjac mannan; leptin; leptin receptors; liver; mice; non-specific protein-tyrosine kinase; oligosaccharides; phosphorylation; signal transduction; triacylglycerols
Abstract:
... Functional oligosaccharides, particularly konjac mannan oligosaccharides (KMOS), can regulate glucose metabolism. However, the molecular mechanisms involved in the hypoglycemic effect of KMOS remain largely unknown. Here, the effect of KMOS supplementation on glucose homeostasis was evaluated in both high-fat diet (HFD)-fed C57BL/6J mice and high-glucosamine-induced HepG2 cells. KMOS supplementati ...
DOI:
10.3390/nu11081705
PubMed:
31344867
PubMed Central:
PMC6723648

15. Eugenol ameliorates insulin resistance, oxidative stress and inflammation in high fat-diet/streptozotocin-induced diabetic rat

Author:
Bahaa Al-Trad; Hakam Alkhateeb; Wesam Alsmadi; Mazhar Al-Zoubi
Source:
Life sciences 2019 v.216 pp. 183-188
ISSN:
0024-3205
Subject:
AMP-activated protein kinase; animal disease models; anti-inflammatory activity; blood glucose; blood serum; cholesterol; essential oils; eugenol; glucose; glucose transporters; glutathione; glycemic effect; high fat diet; homeostasis; inflammation; insulin; insulin resistance; interleukin-6; low density lipoprotein; malondialdehyde; metformin; muscle protein; noninsulin-dependent diabetes mellitus; oxidative stress; protein content; rats; signal transduction; skeletal muscle; streptozotocin; therapeutics; triacylglycerols
Abstract:
... Eugenol, a phenolic compound present in many plant essential oils, demonstrated anti-diabetic activity but the underlying mechanisms are not fully understood. The aim of the present study was to examine the anti-diabetic, anti-oxidative and the anti-inflammatory effect of eugenol in high-fat-diet (HFD) and streptozotocin (STZ)-induced diabetic rats. Additionally, the effect of eugenol on the insul ...
DOI:
10.1016/j.lfs.2018.11.034

16. Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes

Author:
Yangyang Liu; Chaorui Wang; Jinshan Li; Yuxia Mei; Yunxiang Liang
Source:
Nutrients 2019 v.11 no.2 pp. -
ISSN:
2072-6643
Subject:
Phellinus linteus; adjuvants; animal models; beta oxidation; blood glucose; cholesterol; fatty acids; functional foods; gluconeogenesis; glucose; glycemic effect; glycogen; high fat diet; hydroxymethylglutaryl-CoA reductases; hyperlipidemia; insulin resistance; lipemic effect; liver; low density lipoprotein; low density lipoprotein receptors; mycelium; noninsulin-dependent diabetes mellitus; protective effect; solid state culture; streptozotocin; triacylglycerols
Abstract:
... Hypoglycemic and hypolipidemic effects of P. linteus have been observed in numerous studies, but the underlying molecular mechanisms are unclear. In this study, we prepared P. linteus extract (PLE) from mycelia of solid-state culture, and evaluated its hypoglycemic and hypolipidemic effects in rat models of high-fat diet (HFD)-induced and low-dose streptozotocin (STZ)-induced type 2 diabetes. PLE ...
DOI:
10.3390/nu11020296
PubMed:
30704063
PubMed Central:
PMC6412584

17. In vitro and in vivo hypoglycemic effects of cyanidin 3-caffeoyl-p-hydroxybenzoylsophoroside-5-glucoside, an anthocyanin isolated from purple-fleshed sweet potato

Author:
Hwan-Hee Jang; Heon-Woong Kim; Su-Yeon Kim; Sang-Mi Kim; Jung-Bong Kim; Young-Min Lee
Source:
Food chemistry 2019 v.272 pp. 688-693
ISSN:
0308-8146
Subject:
anthocyanins; antioxidant activity; antioxidants; blood glucose; cyanidin; diodes; gluconeogenesis; glucose; glycemic effect; high fat diet; human cell lines; liquid chromatography; males; mass spectrometry; metformin; mice; oral administration; secretion; sweet potatoes
Abstract:
... Anthocyanins are major components of purple sweet potatoes (PSP) with antioxidant, anti-obesity, and antidiabetic activity. In this study, we evaluated the hypoglycemic effects of 12 individual anthocyanins purified from PSP (Korean variety Shinzami). We separated the anthocyanins using liquid chromatography with diode array detection and electrospray ionization/mass spectrometry (LC-DAD-ESI/MS). ...
DOI:
10.1016/j.foodchem.2018.08.010

18. Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Author:
Naymul Karim; Atiar Rahman; Lanchakon Chanudom; Montakarn Thongsom; Jitbanjong Tangpong
Source:
Journal of food science 2019 v.84 no.5 pp. 1208-1215
ISSN:
0022-1147
Subject:
2,2-diphenyl-1-picrylhydrazyl; Garcinia mangostana; albino; alpha-amylase; antioxidant activity; antioxidants; apoptosis; blood; blood glucose; body weight; catalase; creatinine; diabetic nephropathy; dietary supplements; enzyme inhibition; glibenclamide; glucose; glycemic effect; high fat diet; histology; hypertrophy; insulin; insulin resistance; kidneys; malondialdehyde; maltose; mangosteens; mice; models; nephroprotective effect; noninsulin-dependent diabetes mellitus; oxidative stress; pericarp; polyphenols; staining; superoxide dismutase; tropical rain forests; urea nitrogen; vinegars; South East Asia
Abstract:
... Type II diabetes (T2D) nephropathy, a major cause of end‐stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno‐protective and anti‐apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high‐fat diet (5 g/day u ...
DOI:
10.1111/1750-3841.14511

19. Pancreastatin inhibitor, PSTi8 ameliorates metabolic health by modulating AKT/GSK-3β and PKCλ/ζ/SREBP1c pathways in high fat diet induced insulin resistance in peri-/post-menopausal rats

Author:
Guru R. Valicherla; Anand P. Gupta; Zakir Hossain; Mohammed Riyazuddin; Anees A. Syed; Athar Husain; Shibani Lahiri; Kandarp M. Dave; Jiaur R. Gayen
Source:
Peptides 2019 pp. -
ISSN:
0196-9781
Subject:
animal disease models; energy expenditure; gluconeogenesis; glucose; glycemic effect; glycogenesis; glycolysis; high fat diet; homeostasis; human cell lines; insulin resistance; lifestyle; liver; mice; noninsulin-dependent diabetes mellitus; ovariectomy; palmitates; peptides; postmenopause; rats; signal transduction; women
Abstract:
... Increase in the prevalence of insulin resistance (IR) in peri-/post-menopause women is mainly due to hormone deficiency and lifestyle. PSTi8 (PEGKGEQEHSQQKEEEEEMAV-amide) is a pancreastatin inhibitor peptide which showed potent antidiabetic activity in genetic and lifestyle induced type 2 diabetic mice. In the present work, we have investigated the antidiabetic activity of PSTi8 in rat models of p ...
DOI:
10.1016/j.peptides.2019.170147

20. Preparation of the controlled acid hydrolysates from pumpkin polysaccharides and their antioxidant and antidiabetic evaluation

Author:
Aoxue Lu; Mengen Yu; Zhiyu Fang; Bin Xiao; Li Guo; Weimin Wang; Jia Li; Shuang Wang; Yongjun Zhang
Source:
International journal of biological macromolecules 2019 v.121 pp. 261-269
ISSN:
0141-8130
Subject:
acid hydrolysis; animal models; antioxidants; arabinose; blood glucose; diabetes; enzymes; galactose; glucagon-like peptide 1; glucose; glycemic effect; high fat diet; hydrolysates; molecular weight; polysaccharides; pumpkins; rats; rhamnose; secretion; streptozotocin; weight loss
Abstract:
... Pumpkin polysaccharides (PPe) have various biological activities. This research was to optimize the acid hydrolysis process of PPe with OH scavenging ability based on central composite design (CCD), and to explore the antioxidant and antidiabetic activities of the acid hydrolysates (PPe-H). A rat model of type 2 diabetes mellitus (T2DM) using high-fat diet and low-dose streptozotocin were establis ...
DOI:
10.1016/j.ijbiomac.2018.09.158