You searched for:
Publication year rev
7981-2019
Remove constraint Publication year rev: 7981-2019
Subject term
glycogen
Remove constraint Subject term: glycogen
Subject term
glucose
Remove constraint Subject term: glucose
Subject term
glycemic effect
Remove constraint Subject term: glycemic effect
PubAg
Main content area
Limit your search
Search
15 Search Results
1 - 15 of 15
Search Results
- Author:
- Xiaoyong Chen; Xiong Li; Xiaobo Zhang; Lijun You; Peter Chi-Keung Cheung; Riming Huang; Jianbo Xiao
- Source:
- Food & function 2019 v.10 no.8 pp. 4868-4876
- ISSN:
- 2042-650X
- Subject:
- Physalis pubescens; alpha-glucosidase; animal disease models; arabinose; ascorbic acid; c-peptide; diabetes; enzyme inhibition; fucose; galactose; glucose; glucose tolerance; glycemic effect; glycogen; lipid metabolism; mannose; mice; molecular weight; rhamnose; streptozotocin; superoxide dismutase; vitamin E; xylose
- Abstract:
- ... In this study, a polysaccharide was extracted from Physalis pubescens L. (named PP). Its antihyperglycemic and antihyperlipidemic activities were evaluated in STZ-induced diabetic mice. Results showed that PP was determined to be composed of rhamnose (Rha), arabinose (Ara), fucose (Fuc), xylose (Xyl), mannose (Man), glucose (Glc) and galactose (Gal) with molar percentages of 4.65%, 17.34%, 1.43%, ...
- DOI:
- 10.1039/c9fo00687g
- https://doi.org/10.1039/c9fo00687g
- Author:
- Hong-Yan Wang; Qiang-Ming Li; Nian-Jun Yu; Wei-Dong Chen; Xue-Qiang Zha; De-Ling Wu; Li-Hua Pan; Jun Duan; Jian-Ping Luo
- Source:
- Carbohydrate polymers 2019 v.211 pp. 39-48
- ISSN:
- 0144-8617
- Subject:
- Dendrobium; Western blotting; animal disease models; apoptosis; blood glucose; blood proteins; blood serum; fluorescent antibody technique; glucagon; gluconeogenesis; glucose; glucose tolerance; glycemic effect; glycogen; glycosylation; histology; homeostasis; insulin; insulin resistance; islets of Langerhans; mice; noninsulin-dependent diabetes mellitus; oral administration; phosphorylation; staining
- Abstract:
- ... In the present study, the hypoglycemic mechanism of a homogeneous Dendrobium huoshanense polysaccharide (GXG) was investigated using type 2 diabetic (T2D) mouse model. With a 5-week oral administration of GXG, the levels of fasting blood glucose, glycosylated serum protein and serum insulin in T2D mice were decreased, and the glucose tolerance and the insulin sensitivity were improved. The histolo ...
- DOI:
- 10.1016/j.carbpol.2019.01.101
- https://doi.org/10.1016/j.carbpol.2019.01.101
- Author:
- Yaping Liu; Yumeng Li; Wenlingzi Zhang; Mingzhe Sun; Zesheng Zhang
- Source:
- Journal of functional foods 2019 v.55 pp. 381-390
- ISSN:
- 1756-4646
- Subject:
- Ganoderma lucidum; glucose; glycemic effect; glycogen; high fat diet; hypoglycemia; insulin resistance; inulin; lipid metabolism; messenger RNA; noninsulin-dependent diabetes mellitus; nutrient transport; rats; streptozotocin
- Abstract:
- ... It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD) and streptozotocin (STZ). Then the inulin and gano ...
- DOI:
- 10.1016/j.jff.2019.02.036
- https://doi.org/10.1016/j.jff.2019.02.036
- Author:
- Xuan Liu; Jingjing Zhang; Yumeng Li; Liyang Sun; Yao Xiao; Wenge Gao; Zesheng Zhang
- Source:
- Journal of functional foods 2019 v.63 pp. 103566
- ISSN:
- 1756-4646
- Subject:
- Siraitia grosvenorii; blood glucose; fasting; gene expression regulation; glucose; glucose transporters; glycemic effect; glycogen; human cell lines; in vitro studies; in vivo studies; insulin receptor substrate proteins; insulin resistance; liver; metabolism; phosphatidylinositol 3-kinase; quantitative polymerase chain reaction; rats; triterpenoids
- Abstract:
- ... Mogroside, a triterpenoid of Siraitia grosvenorii, has been reported to play an important role in glycometabolism processes. In this study, the mechanism of mogroside was evaluated through in vitro experiments using Mogroside III (MO3), IV (MO4), V (MO5), Siamenoside I (SO1) at 1, 5, 10 μM, and in vivo experiments using MO5 at 30, 75, 150 mg/(kg·bw·day). In cell experiments, mogrosides at 5 μM sig ...
- DOI:
- 10.1016/j.jff.2019.103566
- https://doi.org/10.1016/j.jff.2019.103566
- Author:
- Changliang Cao; Bin Zhang; Chao Li; Qiang Huang; Xiong Fu; Rui Hai Liu
- Source:
- Food & function 2019 v.10 no.5 pp. 2828-2838
- ISSN:
- 2042-650X
- Subject:
- Sargassum; arabinose; fucose; galactose; galacturonic acid; glucose; glucose transporters; glucuronic acid; glycemic effect; glycogen; glycogen (starch) synthase; hexokinase; human cell lines; insulin receptor substrate proteins; insulin resistance; mannose; molecular weight; phosphatidylinositol 3-kinase; pyruvate kinase; xylose
- Abstract:
- ... This study aimed at investigating the structure, hypoglycemic activity and the underlying mechanism of a homogeneous polysaccharide (PSP-2) purified from Sargassum pallidum. Structural characterization revealed that PSP-2 with a molecular weight of 144.8 kDa was composed of fucose (21.6%), arabinose (2.5%), galactose (22.4%), glucose (2.2%), xylose (18.8%), mannose (1.2%), glucuronic acid (7.7%) a ...
- DOI:
- 10.1039/c8fo02525h
- https://doi.org/10.1039/c8fo02525h
- Author:
- Bhesh Raj Sharma; Chul Min Park; Hyeon‐A Kim; Hyun Jung Kim; Dong Young Rhyu
- Source:
- Phytotherapy research 2019 v.33 no.10 pp. 2765-2774
- ISSN:
- 0951-418X
- Subject:
- Tinospora cordifolia; Western blotting; adipocytes; adipose tissue; animal disease models; blood glucose; blood serum; body weight; cell viability; cholesterol; diabetes; diet; enzyme-linked immunosorbent assay; fluorometry; glucose; glucose transporters; glycemic effect; glycogen; insulin; insulin secretion; interferon-gamma; interleukin-1beta; islets of Langerhans; liver; phosphatidylinositol 3-kinase; protein synthesis; rats; thiobarbituric acid-reactive substances; toxicity; toxicity testing; triacylglycerols
- Abstract:
- ... The purpose of this study was to evaluate the pancreatic beta cell protective and glucose uptake enhancing effect of the water extract of Tinospora cordifolia stem (TCSE) by using rat insulinoma (RIN)‐m5F cells and 3 T3‐L1 adipocytes. RIN‐m5F cells were stimulated with interleukin‐1β and interferon‐γ, and the effect of TCSE on insulin secretion and cytokine‐induced toxicity was measured by ELISA a ...
- DOI:
- 10.1002/ptr.6462
- https://doi.org/10.1002/ptr.6462
- Author:
- Soo Jeong Park; Jisun Nam; Chul Woo Ahn; YuSik Kim
- Source:
- Journal of ethnopharmacology 2019 v.236 pp. 220-230
- ISSN:
- 0378-8741
- Subject:
- Panax; bioactive compounds; blood glucose; blood lipids; diabetes; diet; ginsenosides; glucose; glycemic control; glycemic effect; glycogen; homeostasis; inflammation; insulin; insulin secretion; lipid composition; liver; malondialdehyde; mice; obesity; oxidative stress; phosphorylase; protein content; skeletal muscle; traditional medicine
- Abstract:
- ... Korean red ginseng (KRG) has been traditionally used to treat diabetes. Ginsenosides are considered as the major bioactive components mediating anti-diabetic effects of KRG. However, considering that ginsenosides account for only about 3–4% of ginsengs, other fractions of KRG may also carry potential anti-diabetic effects. There is no study reporting the differentiated effects of ginsenosides (Spn ...
- DOI:
- 10.1016/j.jep.2019.01.044
- https://doi.org/10.1016/j.jep.2019.01.044
- Author:
- Di Zhu; Qiaojuan Yan; Yanxiao Li; Jun Liu; Haijie Liu; Zhengqiang Jiang
- Source:
- Nutrients 2019 v.11 no.8 pp. -
- ISSN:
- 2072-6643
- Subject:
- blood glucose; blood serum; brain; dietary supplements; fasting; glucose; glucose tolerance; glycemic effect; glycogen; high fat diet; homeostasis; human cell lines; insulin; insulin resistance; konjac mannan; leptin; leptin receptors; liver; mice; non-specific protein-tyrosine kinase; oligosaccharides; phosphorylation; signal transduction; triacylglycerols
- Abstract:
- ... Functional oligosaccharides, particularly konjac mannan oligosaccharides (KMOS), can regulate glucose metabolism. However, the molecular mechanisms involved in the hypoglycemic effect of KMOS remain largely unknown. Here, the effect of KMOS supplementation on glucose homeostasis was evaluated in both high-fat diet (HFD)-fed C57BL/6J mice and high-glucosamine-induced HepG2 cells. KMOS supplementati ...
- DOI:
- 10.3390/nu11081705
- PubMed:
- 31344867
- PubMed Central:
- PMC6723648
- https://doi.org/10.3390/nu11081705
- Author:
- Mirsada Dervisevic; Maja Dimitrovska; Natasa Cipanovska; Suzana Dinevska- Kjovkarovska; Biljana Miova
- Source:
- Journal of thermal biology 2019 v.79 pp. 190-198
- ISSN:
- 0306-4565
- Subject:
- animal disease models; aspirin; blood; diabetes; enzyme activity; enzymes; glucose; glycemic effect; glycogen; heat; liver; metabolism; rats
- Abstract:
- ... Heat preconditioning (HP) is a powerful adaptive and protective phenomenon and induces moderation of diabetic alterations in glycogen metabolism of rats. Aspirin (acetylsalicylic acid, ASA), as a multifunctional drug has also been reported to exert hypoglycemic effects in the treatment of diabetes. We estimated the effect of HP (45 min/41 ± 0.5 °C/24 h recovery) and single dose aspirin (100 mg/kg ...
- DOI:
- 10.1016/j.jtherbio.2018.12.005
- https://doi.org/10.1016/j.jtherbio.2018.12.005
- Author:
- Yangyang Liu; Chaorui Wang; Jinshan Li; Yuxia Mei; Yunxiang Liang
- Source:
- Nutrients 2019 v.11 no.2 pp. -
- ISSN:
- 2072-6643
- Subject:
- Phellinus linteus; adjuvants; animal models; beta oxidation; blood glucose; cholesterol; fatty acids; functional foods; gluconeogenesis; glucose; glycemic effect; glycogen; high fat diet; hydroxymethylglutaryl-CoA reductases; hyperlipidemia; insulin resistance; lipemic effect; liver; low density lipoprotein; low density lipoprotein receptors; mycelium; noninsulin-dependent diabetes mellitus; protective effect; solid state culture; streptozotocin; triacylglycerols
- Abstract:
- ... Hypoglycemic and hypolipidemic effects of P. linteus have been observed in numerous studies, but the underlying molecular mechanisms are unclear. In this study, we prepared P. linteus extract (PLE) from mycelia of solid-state culture, and evaluated its hypoglycemic and hypolipidemic effects in rat models of high-fat diet (HFD)-induced and low-dose streptozotocin (STZ)-induced type 2 diabetes. PLE ...
- DOI:
- 10.3390/nu11020296
- PubMed:
- 30704063
- PubMed Central:
- PMC6412584
- https://doi.org/10.3390/nu11020296
- Author:
- Flávia Natividade da Silva; Henver Simionato Brunetta; Maciel Alencar Bruxel; Felipe Azevedo Gomes; Alex Rafacho
- Source:
- Life sciences 2019 v.237 pp. 116913
- ISSN:
- 0024-3205
- Subject:
- adults; albumins; blood glucose; blood plasma; dexamethasone; fasting; females; food intake; glucocorticoids; glucose; glucose tolerance; glycemic effect; glycogen; homeostasis; insulin; insulin resistance; islets of Langerhans; males; pregnancy; progeny; triacylglycerols
- Abstract:
- ... To explore the impact of GC administration periconceptionally on the glucose metabolism of adult offspring (male and female) and whether this periconception exposure might influence the metabolic outcomes when the offspring are also treated with dexamethasone in adult life. Rats received a daily injection of dexamethasone (1 mg/kg, body mass) or saline solution (1 mL/kg body mass) for 7 consecutiv ...
- DOI:
- 10.1016/j.lfs.2019.116913
- https://doi.org/10.1016/j.lfs.2019.116913
- Author:
- Prabhakar Yellanur Konda; Sreenivasulu Dasari; Sreenath Konanki; Prabhusaran Nagarajan
- Source:
- Heliyon 2019 v.5 no.3 pp. e01373
- ISSN:
- 2405-8440
- Subject:
- Syzygium paniculatum; antioxidant activity; antioxidant enzymes; chemical constituents of plants; diabetes; eosin; flavor; fruits; glucose; glycemic control; glycemic effect; glycogen; histology; histopathology; hypertension; insulin; insulin resistance; insulin secretion; kidneys; lipid composition; lipids; liver; obesity; oral administration; oxidative stress; pancreas; phytochemicals; traditional medicine
- Abstract:
- ... Abnormal glucose metabolism causes various complications in many metabolic diseases such as obesity, hypertension, cardiovascular diseases and mainly diabetes. But commonly used oral hypoglycemic drugs cause severe side effects. Hence, there is a need to find the medicine without side effects. Compounds of medicinal plants were nontoxic, inexpensive and less or no side effects. Syzygium paniculatu ...
- DOI:
- 10.1016/j.heliyon.2019.e01373
- PubMed:
- 30976672
- PubMed Central:
- PMC6441845
- https://doi.org/10.1016/j.heliyon.2019.e01373
- Author:
- Changliang Cao; Chao Li; Qing Chen; Qiang Huang; Manuel Everardo Mondragón Pérez; Xiong Fu
- Source:
- International journal of biological macromolecules 2019 v.139 pp. 1009-1017
- ISSN:
- 0141-8130
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Sargassum; alpha-amylase; alpha-glucosidase; antioxidant activity; antioxidant enzymes; arabinose; dietary supplements; enzyme inhibition; fucose; galactose; galacturonic acid; glucose; glucuronic acid; glycemic effect; glycogen; hexokinase; human cell lines; hydroxyl radicals; insulin resistance; mannose; models; molecular weight; pyruvate kinase; xylose
- Abstract:
- ... A polysaccharide, designated as PSP-1, was isolated and purified from Sargassum pallidum. Physicochemical characterization showed that PSP-1 with the average molecular weight of 1.036 × 10⁶ Da was composed of fucose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid in a molar ratio of 18.45:2.15:19.06:1.89:16.07:1.00:5.74:20.09. The results of antioxidant assay ...
- DOI:
- 10.1016/j.ijbiomac.2019.08.069
- https://doi.org/10.1016/j.ijbiomac.2019.08.069
- Author:
- Ochuko L. Erukainure; Olajumoke A. Oyebode; Omamuyovwi M. Ijomone; Chika I. Chukwuma; Neil A. Koorbanally; Md. Shahidul Islam
- Source:
- Journal of ethnopharmacology 2019 v.237 pp. 159-170
- ISSN:
- 0378-8741
- Subject:
- Raphia hookeri; acetylcholinesterase; acinar cells; adenosinetriphosphatase; alanine transaminase; animal disease models; blood serum; body weight; catalase; chemical constituents of plants; diabetes mellitus; drinking water; enzyme activity; fructose; gas chromatography-mass spectrometry; genes; glucose; glucose-6-phosphatase; glycemic effect; glycogen; high fructose diet; homeostasis; insulin; insulin secretion; islets of Langerhans; males; mechanism of action; medicinal plants; metformin; myeloperoxidase; nitric oxide; phosphorylase; rats; streptozotocin; superoxide dismutase; tissues; toxicology; traditional medicine; triacylglycerols; uric acid; wines
- Abstract:
- ... Raffia palm (Raphia hookeri) wine (RPW) is amongst the natural products from plants, utilized singly or in combination with other medicinal plants for the treatment of several ailments including Diabetes Mellitus (DM). However, there is a scientific dearth on its antidiabetic activity.The antidiabetic effect of RPW and its possible mechanism of actions were investigated in diabetic rats.Four group ...
- DOI:
- 10.1016/j.jep.2019.03.039
- https://doi.org/10.1016/j.jep.2019.03.039
- Author:
- Ochuko L. Erukainure; Olakunle Sanni; Omamuyovwi M. Ijomone; Collins U. Ibeji; Chika I. Chukwuma; Md Shahidul Islam
- Source:
- Journal of ethnopharmacology 2019 v.242 pp. 112033
- ISSN:
- 0378-8741
- Subject:
- Cola nitida; acetylcholinesterase; acids; adenosinetriphosphatase; alanine transaminase; alpha-amylase; animal disease models; blood glucose; blood serum; caffeine; caspase-3; catalase; computer simulation; enzyme activity; evergreen trees; fructose; glucose; glycemic effect; glycogen; glycolysis; high density lipoprotein cholesterol; insulin; islets of Langerhans; kola nuts; lipid composition; low density lipoprotein cholesterol; myeloperoxidase; nitric oxide; noninsulin-dependent diabetes mellitus; nuclear magnetic resonance spectroscopy; oral administration; phosphorylase; rats; seeds; superoxide dismutase; theobromine; traditional medicine; triacylglycerols; Western Africa
- Abstract:
- ... Cola nitida is amongst the evergreen plants native to West Africa used in the treatment of various ailments including diabetes.Aim of the study: This study aims to investigate the antidiabetic effects of the hot water extract of C. nitida seeds in type 2 diabetic rats.Type 2 diabetic rats were orally administered with low (150 mg/kg bw) and high (300 mg/kg bw) doses of the hot water extract for 6 ...
- DOI:
- 10.1016/j.jep.2019.112033
- https://doi.org/10.1016/j.jep.2019.112033