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- Author:
- Junjun Li; Haobin Zhao; Xinzhong Hu; Junling Shi; Dongyan Shao; Mingliang Jin
- Source:
- Food hydrocolloids 2019 v.91 pp. 1-9
- ISSN:
- 0268-005X
- Subject:
- Artemisia sphaerocephala; alanine transaminase; albumins; antioxidant activity; aspartate transaminase; blood glucose; blood proteins; catalase; diabetes; free fatty acids; gene expression; gene expression regulation; glucokinase; gluconeogenesis; glucose transporters; glutathione peroxidase; glycemic effect; glycogen; hepatoprotective effect; high density lipoprotein cholesterol; histopathology; hydrocolloids; hyperglycemia; hyperlipidemia; insulin resistance; liver; low density lipoprotein cholesterol; malondialdehyde; messenger RNA; mice; non-specific serine/threonine protein kinase; oxidative stress; phosphatidylinositol 3-kinase; protein content; seeds; staining; superoxide dismutase; triacylglycerols
- Abstract:
- ... Artemisia sphaerocephala Krasch polysaccharide (ASKP) has previously been reported to ameliorate the hyperglycemia and oxidative stress in type 2 diabetes mellitus and was separated into two fractions of 60P and 60S. To determine the major functional fraction in ASKP, the antidiabetic effects of ASKP and its two fractions were investigated in diabetic db/db mice. As a result, 60P showed the highes ...
- DOI:
- 10.1016/j.foodhyd.2019.01.002
- https://doi.org/10.1016/j.foodhyd.2019.01.002
- Author:
- Hong-Yan Wang; Qiang-Ming Li; Nian-Jun Yu; Wei-Dong Chen; Xue-Qiang Zha; De-Ling Wu; Li-Hua Pan; Jun Duan; Jian-Ping Luo
- Source:
- Carbohydrate polymers 2019 v.211 pp. 39-48
- ISSN:
- 0144-8617
- Subject:
- Dendrobium; Western blotting; animal disease models; apoptosis; blood glucose; blood proteins; blood serum; fluorescent antibody technique; glucagon; gluconeogenesis; glucose; glucose tolerance; glycemic effect; glycogen; glycosylation; histology; homeostasis; insulin; insulin resistance; islets of Langerhans; mice; noninsulin-dependent diabetes mellitus; oral administration; phosphorylation; staining
- Abstract:
- ... In the present study, the hypoglycemic mechanism of a homogeneous Dendrobium huoshanense polysaccharide (GXG) was investigated using type 2 diabetic (T2D) mouse model. With a 5-week oral administration of GXG, the levels of fasting blood glucose, glycosylated serum protein and serum insulin in T2D mice were decreased, and the glucose tolerance and the insulin sensitivity were improved. The histolo ...
- DOI:
- 10.1016/j.carbpol.2019.01.101
- https://doi.org/10.1016/j.carbpol.2019.01.101
- Author:
- Wan Ma; Yunfei Feng; Li Jia; Shuhui Li; Jiahui Li; Zhenjie Wang; Xiaoyun Chen; Huahua Du
- Source:
- Biological trace element research 2019 v.189 no.1 pp. 194-200
- ISSN:
- 0163-4984
- Subject:
- adipocytes; adiponectin; adipose tissue; animal disease models; blood serum; diet; epididymis; fasting; fatty liver; gene expression; gene expression regulation; gluconeogenesis; glucose; glycogen; hepcidin; homeostasis; insulin resistance; iron; lipids; lipogenesis; liver; messenger RNA; mice; noninsulin-dependent diabetes mellitus; obesity
- Abstract:
- ... Imbalance of iron homeostasis has been involved in clinical courses of metabolic diseases such as type 2 diabetes mellitus, obesity, and nonalcoholic fatty liver, through mechanisms not yet fully elucidated. Herein, we evaluated the effect of dietary iron on the development of diabetic syndromes in genetically obese db/db mice. Mice (aged 7 weeks) were fed with high-iron (HI) diets (1000 mg/kg cho ...
- DOI:
- 10.1007/s12011-018-1446-3
- https://doi.org/10.1007/s12011-018-1446-3
- Author:
- Tingyu LuoThese authors contributed to the work equally and should be regarded as co-first authors.; Yuhui Yang; Yuncong Xu; Qiuli Gao; Guoqing Wu; Yuge Jiang; Jin Sun; Yonghui Shi; Guowei Le
- Source:
- Food & function 2019 v.10 no.5 pp. 2676-2690
- ISSN:
- 2042-650X
- Subject:
- AMP-activated protein kinase; adiponectin; animal disease models; cystathionine gamma-lyase; diet; gene expression regulation; glucose; glycogen; glycolysis; hydrogen sulfide; hyperglycemia; hyperinsulinemia; insulin; insulin resistance; lipid content; males; methionine; mice; muscles; obesity; oxidation; skeletal muscle; white adipose tissue
- Abstract:
- ... Dietary methionine restriction (MR) has many positive effects on metabolic health. Recent studies have indicated that overall insulin sensitivity is improved by dietary MR. This study aimed to determine the effects of MR on insulin signalling and glucose utilisation in the skeletal muscle of obese mice. First, male C57BL/6J mice in the CON group were fed a control diet (0.86% methionine + 4% fat) ...
- DOI:
- 10.1039/c8fo02571a
- https://doi.org/10.1039/c8fo02571a
- Author:
- Yaping Liu; Yumeng Li; Wenlingzi Zhang; Mingzhe Sun; Zesheng Zhang
- Source:
- Journal of functional foods 2019 v.55 pp. 381-390
- ISSN:
- 1756-4646
- Subject:
- Ganoderma lucidum; glucose; glycemic effect; glycogen; high fat diet; hypoglycemia; insulin resistance; inulin; lipid metabolism; messenger RNA; noninsulin-dependent diabetes mellitus; nutrient transport; rats; streptozotocin
- Abstract:
- ... It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD) and streptozotocin (STZ). Then the inulin and gano ...
- DOI:
- 10.1016/j.jff.2019.02.036
- https://doi.org/10.1016/j.jff.2019.02.036
- Author:
- Xuan Liu; Jingjing Zhang; Yumeng Li; Liyang Sun; Yao Xiao; Wenge Gao; Zesheng Zhang
- Source:
- Journal of functional foods 2019 v.63 pp. 103566
- ISSN:
- 1756-4646
- Subject:
- Siraitia grosvenorii; blood glucose; fasting; gene expression regulation; glucose; glucose transporters; glycemic effect; glycogen; human cell lines; in vitro studies; in vivo studies; insulin receptor substrate proteins; insulin resistance; liver; metabolism; phosphatidylinositol 3-kinase; quantitative polymerase chain reaction; rats; triterpenoids
- Abstract:
- ... Mogroside, a triterpenoid of Siraitia grosvenorii, has been reported to play an important role in glycometabolism processes. In this study, the mechanism of mogroside was evaluated through in vitro experiments using Mogroside III (MO3), IV (MO4), V (MO5), Siamenoside I (SO1) at 1, 5, 10 μM, and in vivo experiments using MO5 at 30, 75, 150 mg/(kg·bw·day). In cell experiments, mogrosides at 5 μM sig ...
- DOI:
- 10.1016/j.jff.2019.103566
- https://doi.org/10.1016/j.jff.2019.103566
- Author:
- M. Niibo; B. Shirouchi; M. Umegatani; Y. Morita; A. Ogawa; F. Sakai; Y. Kadooka; M. Sato
- Source:
- Journal of dairy science 2019 v.102 no.2 pp. 997-1006
- ISSN:
- 0022-0302
- Subject:
- Lactobacillus gasseri; amyloid; animal disease models; blood glucose; blood serum; c-peptide; diabetes; diet; free fatty acids; genes; glucagon; glucagon-like peptide 1; glycogen; granulocyte colony-stimulating factor; humans; insulin resistance; insulin secretion; liver; messenger RNA; metabolic syndrome; muscles; pancreas; probiotics; protective effect; rats; risk; short chain fatty acids; skim milk; transcription factors
- Abstract:
- ... The probiotic Lactobacillus gasseri SBT2055 (LG2055) has a protective effect against metabolic syndrome in rats and humans. Metabolic syndrome increases the risk of type 2 diabetes mellitus. In this study, Goto-Kakizaki rats were used as a diabetic model and fed diets containing LG2055-fermented or nonfermented skim milk for 4 wk. Indices of diabetes such as blood glucose levels, serum glucagon le ...
- DOI:
- 10.3168/jds.2018-15203
- https://doi.org/10.3168/jds.2018-15203
- Author:
- Changliang Cao; Bin Zhang; Chao Li; Qiang Huang; Xiong Fu; Rui Hai Liu
- Source:
- Food & function 2019 v.10 no.5 pp. 2828-2838
- ISSN:
- 2042-650X
- Subject:
- Sargassum; arabinose; fucose; galactose; galacturonic acid; glucose; glucose transporters; glucuronic acid; glycemic effect; glycogen; glycogen (starch) synthase; hexokinase; human cell lines; insulin receptor substrate proteins; insulin resistance; mannose; molecular weight; phosphatidylinositol 3-kinase; pyruvate kinase; xylose
- Abstract:
- ... This study aimed at investigating the structure, hypoglycemic activity and the underlying mechanism of a homogeneous polysaccharide (PSP-2) purified from Sargassum pallidum. Structural characterization revealed that PSP-2 with a molecular weight of 144.8 kDa was composed of fucose (21.6%), arabinose (2.5%), galactose (22.4%), glucose (2.2%), xylose (18.8%), mannose (1.2%), glucuronic acid (7.7%) a ...
- DOI:
- 10.1039/c8fo02525h
- https://doi.org/10.1039/c8fo02525h
- Author:
- Renchao Dong; Xiaobo Yang; Changyuan Wang; Kexin Liu; Zhihao Liu; Xiaodong Ma; Huijun Sun; Xiaokui Huo; Ting Fu; Qiang Meng
- Source:
- Phytomedicine 2019 v.53 pp. 134-142
- ISSN:
- 0944-7113
- Subject:
- Western blotting; acetyl-CoA carboxylase; beta oxidation; blood glucose; blood serum; body weight; cholesterol; fatty acids; fatty liver; fatty-acid synthase; free fatty acids; genes; gluconeogenesis; glucose-6-phosphatase; glycogen; glycogen synthase kinases; high fat diet; histopathology; homeostasis; hyperlipidemia; insulin; insulin resistance; kava; lipogenesis; lipolysis; lipoproteins; liver; mice; models; phosphoenolpyruvate carboxylase; phosphorylation; protective effect; pyruvate dehydrogenase (lipoamide); quantitative polymerase chain reaction; risk factors; small interfering RNA; staining; stearoyl-CoA desaturase; tau-protein kinase; triacylglycerols
- Abstract:
- ... Non-alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver disease worldwide. Dyslipidemia, pathoglycemia and insulin resistance are the major risk factors for the development of NAFLD. To date, no effective drug therapies for this condition have been approved.The present study was to investigate the protective effects of yangonin, a kavalactone isolated from Kava, ag ...
- DOI:
- 10.1016/j.phymed.2018.09.006
- https://doi.org/10.1016/j.phymed.2018.09.006
10. Adverse effects of noise stress on glucose homeostasis and insulin resistance in Sprague-Dawley rats
- Author:
- Ayodele Olufemi Morakinyo; Titilola Aderonke Samuel; Funmileyi Olubajo Awobajo; Daniel Abiodun Adekunbi; Idowu Olufemi Olatunji; Fortune Ucheonye Binibor; Adedotun Felicia Oni
- Source:
- Heliyon 2019 v.5 no.12 pp. e03004
- ISSN:
- 2405-8440
- Subject:
- adiposity; adults; atherosclerosis; blood serum; cholesterol; corticosterone; glucose; glucose tolerance; glycogen; health hazards; high density lipoprotein; homeostasis; hypertension; insulin; insulin resistance; liver; low density lipoprotein; males; muscles; noise pollution; noninsulin-dependent diabetes mellitus; risk; triacylglycerols
- Abstract:
- ... Noise pollution remains a pervasive health hazard that people encounter especially in large commercial metropolis and has been implicated in many adverse non-auditory health conditions such as hypertension, atherosclerosis, vascular (endothelial) dysfunction and metabolic disorders. There is a growing body of evidence showing that chronic noise exposure is associated with an increased risk of hype ...
- DOI:
- 10.1016/j.heliyon.2019.e03004
- https://doi.org/10.1016/j.heliyon.2019.e03004
- Author:
- Hui Xia; Huali Tang; Feng Wang; Xian Yang; Zhaodan Wang; Hechun Liu; Da Pan; Chao Yang; Shaokang Wang; Guiju Sun
- Source:
- Food research international 2019 v.116 pp. 20-29
- ISSN:
- 0963-9969
- Subject:
- Lycium barbarum; alanine; animal disease models; arabinitol; aspartic acid; benzoic acid; blood glucose; citric acid; creatinine; databases; diabetes; fumaric acid; galacturonic acid; glutamic acid; glycemic effect; glycogen; glycohemoglobin; high fat diet; homeostasis; insulin resistance; liver; malic acid; metabolism; metabolomics; methylmalonic acid; myo-inositol; rats; streptozotocin; superoxide dismutase; tricarboxylic acid cycle; urine; xylitol
- Abstract:
- ... Lycium barbarum polysaccharide (LBP), as one bioactive macromolecular abstracted from goji berry, has shown an abundance of potential function. The present study aimed to evaluate the metabolic effects of LBP on the urine and liver metabolomics on a high-fat diet and streptozotocin-induced diabetic rat model. After 8 weeks of high-fat diet and streptozotocin induction of diabetes, 24 diabetic rats ...
- DOI:
- 10.1016/j.foodres.2018.12.043
- https://doi.org/10.1016/j.foodres.2018.12.043
- Author:
- María Cecilia Castro; HernánVillagarcía; Ada Nazar; Luisa González Arbeláez; María Laura Massa; Héctor Del Zotto; José Luis Ríos; Guillermo R. Schinella; Flavio Francini
- Source:
- Journal of ethnopharmacology 2019 pp. -
- ISSN:
- 0378-8741
- Subject:
- Western blotting; animal models; cell proliferation; cocoa beans; diet; enzyme activity; flavanols; fructokinase; gene expression; genes; glucose; glutathione; glycogen; hypertriglyceridemia; immunohistochemistry; inflammation; insulin resistance; insulin secretion; islets of Langerhans; lipids; liver; liver protein; messenger RNA; moieties; noninsulin-dependent diabetes mellitus; oxidative stress; polyphenols; protein content; quantitative polymerase chain reaction; radioimmunoassays; rats; spectroscopy; sucrose; traditional medicine
- Abstract:
- ... Cocoa extracts rich in polyphenols are used as potential agent for treating diabetes. Cocoa polyphenols have been proved to ameliorate important hallmarks of type-2 diabetes (T2D). They can regulate glucose levels by increasing insulin secretion, promoting β-cell proliferation and a reduction of insulin resistance. In addition, epidemiological evidence indicates that consumption of flavonoid decre ...
- DOI:
- 10.1016/j.jep.2019.112263
- https://doi.org/10.1016/j.jep.2019.112263
- Author:
- Suocheng Hui; Yang Liu; Mengting Chen; Xiaolan Wang; Hedong Lang; Min Zhou; Long Yi; Mantian Mi
- Source:
- Molecular nutrition & food research 2019 v.63 no.23 pp. e1900608
- ISSN:
- 1613-4125
- Subject:
- Lactobacillus; antagonists; antibiotics; capsaicin; cholesterol; cholesterol 7alpha-monooxygenase; choloylglycine hydrolase; diet; gluconeogenesis; glucose; glucose tolerance; glycogen; homeostasis; insulin resistance; intestinal microorganisms; liver; mice; noninsulin-dependent diabetes mellitus
- Abstract:
- ... SCOPE: Previous studies have linked dietary capsaicin (CAP) intake to improved glucose homeostasis and insulin sensitivity. However, the underlying mechanisms remain unclear. METHODS AND RESULTS: Type 2 diabetic db/db mice are fed a chow diet with or without CAP treatment for 8 weeks. CAP administration markedly improves glucose tolerance and insulin sensitivity through decreasing gluconeogenesis ...
- DOI:
- 10.1002/mnfr.201900608
- https://doi.org/10.1002/mnfr.201900608
- Author:
- Mousa O. Germoush; Hassan A. Elgebaly; Sherif Hassan; Emadeldin M. Kamel; May Bin-Jumah; Ayman M. Mahmoud
- Source:
- Antioxidants 2019 v.9 no.1 pp. -
- ISSN:
- 2076-3921
- Subject:
- Padina; computer simulation; genes; glucose tolerance; glucose-6-phosphatase; glycemic effect; glycogen; hexokinase; high fat diet; hyperglycemia; hyperlipidemia; inflammation; insulin; insulin resistance; lipids; liver; noninsulin-dependent diabetes mellitus; oxidative stress; phosphorylase; phytochemicals; protein synthesis; streptozotocin; terpenoids; therapeutics
- Abstract:
- ... Seaweeds are rich in structurally diverse bioactive compounds with promising therapeutic effects. This study aimed to isolate and identify terpenes from the brown alga Padina pavonia and to investigate its antidiabetic activity, pointing to the possible involvement of peroxisome proliferator-activated receptor (PPAR)γ. Type 2 diabetes was induced by feeding rats a high fat diet (HFD) ...
- DOI:
- 10.3390/antiox9010022
- https://doi.org/10.3390/antiox9010022
- Author:
- Yu Niu; Jintian He; Hussain Ahmad; Chao Wang; Xiang Zhong; Lili Zhang; Tao Cui; Jingfei Zhang; Tian Wang
- Source:
- British journal of nutrition 2019 v.122 no.6 pp. 616-624
- ISSN:
- 1475-2662
- Subject:
- animal models; birth weight; blood serum; carboxylic ester hydrolases; cholesterol; curcumin; dietary supplements; fatty-acid synthase; free fatty acids; glucose; glycogen; glycogen synthase kinases; homeostasis; insulin; insulin receptor substrate proteins; insulin resistance; lipolysis; liver; malnutrition; non-specific serine/threonine protein kinase; peroxisome proliferator-activated receptor alpha; pyruvic acid; rats; signal transduction; tau-protein kinase
- Abstract:
- ... The objective of the present study was to investigate the effect of curcumin on insulin resistance (IR) and hepatic lipid accumulation in intra-uterine growth restriction (IUGR). Rats with a normal birth weight (NBW) or IUGR were fed basic diets (NBW and IUGR groups) or basic diets supplemented with curcumin (NBW-C and IUGR-C groups) from 6 to 12 weeks. Rats in the IUGR group showed higher levels ...
- DOI:
- 10.1017/S0007114519001508
- https://doi.org/10.1017/S0007114519001508
- Author:
- Javier T. Gonzalez; James A. Betts
- Source:
- Proceedings of the Nutrition Society 2019 v.78 no.2 pp. 246-256
- ISSN:
- 1475-2719
- Subject:
- athletes; athletic performance; blood glucose; dietary carbohydrate; exercise; fatigue strength; glucose; glycemic control; glycogen; insulin resistance; lipids; liver; metabolic diseases; overweight; physiological response; polymers; repletion
- Abstract:
- ... The present paper reviews the physiological responses of human liver carbohydrate metabolism to physical activity and ingestion of dietary sugars. The liver represents a central link in human carbohydrate metabolism and a mechanistic crux point for the effects of dietary sugars on athletic performance and metabolic health. As a corollary, knowledge regarding physiological responses to sugar ingest ...
- DOI:
- 10.1017/S0029665118002604
- PubMed:
- 30348238 30348238
- https://doi.org/10.1017/S0029665118002604
- Author:
- Shiwei Hu; Jingfeng Wang; Xiaojun Yan; Huicheng Yang; Shijie Li; Wei Jiang; Yu Liu
- Source:
- Applied physiology, nutrition and metabolism 2019 v.44 no.10 pp. 1081-1088
- ISSN:
- 1715-5320
- Subject:
- Portunus trituberculatus; animal experimentation; astaxanthin; blood glucose; blood lipids; cholesterol; docosahexaenoic acid; eggs; eicosapentaenoic acid; free fatty acids; glucose tolerance; glucose transporters; glycogen; glycogen (starch) synthase; high fat diet; insulin; insulin resistance; mice; non-specific serine/threonine protein kinase; oils; phosphatidylinositol 3-kinase; phospholipids; protective effect; skeletal muscle; tau-protein kinase; transcription (genetics); triacylglycerols
- Abstract:
- ... Marine bioactive lipids have been utilized to overcome insulin resistance. However, oil from swimming crab has never been studied. Here, we analyzed the constituents of egg oil from Portunus trituberculatus (Pt-egg oil) and investigated its protective effects against insulin resistance in mice on a high-fat diet. The results showed that Pt-egg oil contained 52.05% phospholipids, 8.61% free fatty a ...
- DOI:
- 10.1139/apnm-2018-0718
- https://doi.org/10.1139/apnm-2018-0718
- Author:
- Qian Guo; Hailong Hu; Ying Zhou; Yuheng Yan; Xiangjuan Wei; Xingpei Fan; Daqian Yang; Hongjuan He; Yuri Oh; Kun Chen; Qiong Wu; Chuanpeng Liu; Ning Gu
- Source:
- Food and chemical toxicology 2019 v.125 pp. 95-105
- ISSN:
- 0278-6915
- Subject:
- blood glucose; cytokines; diabetes; dietary supplements; endoplasmic reticulum; gene editing; gene expression; glucosamine; glucose; glycogen; in vitro studies; insulin resistance; metabolism; mice; myotubes; oral administration; phosphorylation; signal transduction; skeletal muscle; toxicology
- Abstract:
- ... Glucosamine (GlcN) is a dietary supplement that is widely used to promote joint health. Reports have demonstrated that oral GlcN adversely affects glucose metabolism. Here, we found that oral administration of GlcN induced insulin resistance (IR) and increased plasma glucose levels in mice. Musclin is a muscle-secreted cytokine that participates in the development and aggravation of diabetes. In t ...
- DOI:
- 10.1016/j.fct.2018.12.051
- https://doi.org/10.1016/j.fct.2018.12.051
- Author:
- Diana Mareta IFA Pitaloka; Chi-Hsuan Ko; Ming-Tsan Lin; Sung-Ling Yeh; Chiu-Li Yeh
- Source:
- Nutrition research 2019 v.68 pp. 45-53
- ISSN:
- 0271-5317
- Subject:
- animal disease models; blood glucose; blood sampling; gluconeogenesis; glucose; glutamine; glycogen; glycogenolysis; hepatocytes; high fat diet; homeostasis; hyperglycemia; immunomodulators; insulin; insulin resistance; ischemia; liver; mice; obesity; phosphatidylinositol 3-kinase; protein synthesis; risk factors; signal transduction; tissues
- Abstract:
- ... High-fat diet-induced obesity can lead to hepatic insulin resistance (IR) and alter glucose metabolism. The decreased protein expression involved in the PI3K-Akt pathway may enhance hepatic glycogenolysis and gluconeogenesis. Obesity-associated glucose dysregulation and IR are risk factors for the development of peripheral arterial disease. Glutamine (Gln) has immunomodulatory properties and was f ...
- DOI:
- 10.1016/j.nutres.2019.05.008
- https://doi.org/10.1016/j.nutres.2019.05.008
- Author:
- Yumeng Li; Yaping Liu; Junjie Liang; Tianxin Wang; Mingzhe Sun; Zesheng Zhang
- Source:
- Journal of agricultural and food chemistry 2019 v.67 no.47 pp. 13051-13060
- ISSN:
- 1520-5118
- Subject:
- Gymnema sylvestre; Western blotting; adenosine monophosphate; blood glucose; fasting; gene expression regulation; gluconeogenesis; glucose-6-phosphatase; glycemic effect; glycogen; hyperglycemia; insulin; mechanism of action; non-specific serine/threonine protein kinase; noninsulin-dependent diabetes mellitus; oral administration; phosphatidylinositol 3-kinase; phosphorylation; proteins; quantitative polymerase chain reaction; rats; signal transduction
- Abstract:
- ... Gymnemic acid (GA) isolated from Gymnema sylvestre (Retz.) Schult. has been shown to have antihyperglycemic activity; however, the molecular mechanisms governing these effects are unclear. In this study, GA (40 and 80 mg kg–¹ day–¹) was evaluated by type 2 diabetes mellitus (T2DM) rats to explore its hypoglycemic activity and underlying mechanisms of action. The results indicated that GA decreased ...
- DOI:
- 10.1021/acs.jafc.9b04931
- https://doi.org/10.1021/acs.jafc.9b04931
- Author:
- Du-Xin Jin; Jun-Fang He; Xue-Gang Luo; Tong-Cun Zhang
- Source:
- Journal of functional foods 2019 v.52 pp. 479-491
- ISSN:
- 1756-4646
- Subject:
- Bacteroidetes; Firmicutes; Hypericum; Proteobacteria; blood glucose; colon; glycemic effect; glycogen; inflammation; insulin resistance; intestinal microorganisms; lipid metabolism; medicinal plants; mice; noninsulin-dependent diabetes mellitus; public health; short chain fatty acids; small intestine; therapeutics
- Abstract:
- ... Hypericum attenuatum Choisy, as an edible medicinal plant, possesses multiple therapeutic effects. Type 2 diabetes is a metabolic disorder that has become a major threat to public health. The objective of this study was to investigate the hypoglycemic effect of Hypericum attenuatum Choisy extracts (HaC) on T2DM mice and modulatory effect of HaC on composition of intestinal microflora. T2DM mice we ...
- DOI:
- 10.1016/j.jff.2018.11.031
- https://doi.org/10.1016/j.jff.2018.11.031
- Author:
- Jin-Long Tian; Xiao-Jun Liao; Yue-Hua Wang; Xu Si; Chi Shu; Er-Sheng Gong; Xu Xie; Xu-Long Ran; Bin Li
- Source:
- Journal of agricultural and food chemistry 2019 v.67 no.49 pp. 13624-13634
- ISSN:
- 1520-5118
- Subject:
- anthocyanins; blood glucose; blueberries; computer simulation; enzyme activity; glycemic effect; glycogen; inhibitory concentration 50; insulin; insulin resistance; noninsulin-dependent diabetes mellitus; oleanolic acid; phosphatidylinositol 3-kinase; protein-tyrosine-phosphatase; signal transduction; structure-activity relationships; tau-protein kinase
- Abstract:
- ... Protein tyrosine phosphatase 1B (PTP1B) is an important target for type 2 diabetes. PTP1B inhibitors can reduce blood glucose levels by increasing insulin sensitivity. Anthocyanins often play a hypoglycemic effect, but the research about them have mainly focused on glucosidase. At present, the research about protein tyrosine phosphatase 1B (PTP1B) target is less, and the corresponding molecular me ...
- DOI:
- 10.1021/acs.jafc.9b06155
- https://doi.org/10.1021/acs.jafc.9b06155
- Author:
- Flávia Natividade da Silva; Henver Simionato Brunetta; Maciel Alencar Bruxel; Felipe Azevedo Gomes; Alex Rafacho
- Source:
- Life sciences 2019 v.237 pp. 116913
- ISSN:
- 0024-3205
- Subject:
- adults; albumins; blood glucose; blood plasma; dexamethasone; fasting; females; food intake; glucocorticoids; glucose; glucose tolerance; glycemic effect; glycogen; homeostasis; insulin; insulin resistance; islets of Langerhans; males; pregnancy; progeny; triacylglycerols
- Abstract:
- ... To explore the impact of GC administration periconceptionally on the glucose metabolism of adult offspring (male and female) and whether this periconception exposure might influence the metabolic outcomes when the offspring are also treated with dexamethasone in adult life. Rats received a daily injection of dexamethasone (1 mg/kg, body mass) or saline solution (1 mL/kg body mass) for 7 consecutiv ...
- DOI:
- 10.1016/j.lfs.2019.116913
- https://doi.org/10.1016/j.lfs.2019.116913
- Author:
- Nelma Cristina Silva Pacheco; Ana Paula Carli de Almeida; Kariny Cássia de Siqueira; Faena Moura de Lima; Sílvia Regina de Lima Reis; Márcia Queiroz Latorraca; Luiz Fabrizio Stoppiglia
- Source:
- Applied physiology, nutrition and metabolism 2019 v.44 no.1 pp. 13-21
- ISSN:
- 1715-5320
- Subject:
- adults; alanine transaminase; blood glucose; carboxy-lyases; casein; enzyme activity; glucagon; gluconeogenesis; glucose; glycerol kinase; glycogen; insulin resistance; lactation; liver; males; malnutrition; messenger RNA; mothers; pregnancy; progeny; protein content; pyruvic acid; rats; soy flour; soybeans; weaning
- Abstract:
- ... Nutritional recovery of early malnutrition with a soybean diet reduces liver glycogen stores in the fed state and produces liver insulin resistance. We investigated whether nutritional recovery on a soybean flour diet alters hepatic gluconeogenesis in the adult offspring of rats deprived of protein during pregnancy and lactation. Male rats from mothers that were fed either 17% (C) or 6% (L) protei ...
- DOI:
- 10.1139/apnm-2017-0859
- https://doi.org/10.1139/apnm-2017-0859
- Author:
- Changliang Cao; Chao Li; Qing Chen; Qiang Huang; Manuel Everardo Mondragón Pérez; Xiong Fu
- Source:
- International journal of biological macromolecules 2019 v.139 pp. 1009-1017
- ISSN:
- 0141-8130
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Sargassum; alpha-amylase; alpha-glucosidase; antioxidant activity; antioxidant enzymes; arabinose; dietary supplements; enzyme inhibition; fucose; galactose; galacturonic acid; glucose; glucuronic acid; glycemic effect; glycogen; hexokinase; human cell lines; hydroxyl radicals; insulin resistance; mannose; models; molecular weight; pyruvate kinase; xylose
- Abstract:
- ... A polysaccharide, designated as PSP-1, was isolated and purified from Sargassum pallidum. Physicochemical characterization showed that PSP-1 with the average molecular weight of 1.036 × 10⁶ Da was composed of fucose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid in a molar ratio of 18.45:2.15:19.06:1.89:16.07:1.00:5.74:20.09. The results of antioxidant assay ...
- DOI:
- 10.1016/j.ijbiomac.2019.08.069
- https://doi.org/10.1016/j.ijbiomac.2019.08.069
- Author:
- Xiu-Qing Han; Ling-Yu Zhang; Lin Ding; Hao-Hao Shi; Chang-Hu Xue; Tian-Tian Zhang; Yu-Ming Wang
- Source:
- Food & function 2019 v.10 no.7 pp. 3955-3964
- ISSN:
- 2042-650X
- Subject:
- Holothuroidea; animal disease models; biosynthesis; cytotoxicity; eicosapentaenoic acid; gluconeogenesis; glucose; glycogen; hemolysis; high fat diet; insulin; insulin resistance; interleukin-6; lipolysis; macrophages; males; mice; muscles; obesity; phospholipids; saponins; synergism; tumor necrosis factor-alpha; white adipose tissue
- Abstract:
- ... Sea cucumber saponins (SCS) exhibit a significant effect on ameliorating glucose and lipid disorders by inhibiting fatty acid biosynthesis; however, high cytotoxicity and hemolytic activity limit their application. Eicosapentaenoic acid-enriched phospholipids (EPA-PL) significantly ameliorate insulin resistance and elevate the level of hepatic lipolysis, which may have a synergistic effect with SC ...
- DOI:
- 10.1039/c9fo01147a
- https://doi.org/10.1039/c9fo01147a
- Author:
- Jing Xu; Kunlin Ou; Chuqiao Chen; Binshui Li; Jiaojiao Guo; Zhenghong Zuo; Chonggang Wang
- Source:
- Toxicology 2019 v.425 pp. 152242
- ISSN:
- 0300-483X
- Subject:
- animal models; blood glucose; blood serum; carboxy-lyases; diabetes mellitus; fasting; gene expression regulation; genes; glucagon; glucagon receptors; gluconeogenesis; glucose; glucose-6-phosphatase; glycogen; insulin; insulin resistance; islets of Langerhans; liver; males; mice; protein synthesis; risk; toxicity; transcription (genetics); tributyltin
- Abstract:
- ... Some previous studies showed that organotin compounds induced diabetes in animal models. The underlying mechanisms should be further revealed. In this study, male KM mice were exposed to tributyltin (TBT) at 0.5, 5 and 50 μg/kg once every three days for 45 days. The TBT-treated mice exhibited an elevation of fasting blood glucose level and glucose intolerance. The fasting serum insulin levels were ...
- DOI:
- 10.1016/j.tox.2019.152242
- https://doi.org/10.1016/j.tox.2019.152242
- Author:
- Yue Gao; Mingwei Zhang; Ruifen Zhang; Lijun You; Tong Li; Rui Hai Liu
- Source:
- Journal of agricultural and food chemistry 2019 v.67 no.42 pp. 11657-11664
- ISSN:
- 1520-5118
- Subject:
- blood glucose; brown rice; diabetes mellitus; enzyme activity; gene expression; genes; gluconeogenesis; glucose; glucose-6-phosphatase; glycogen; glycogen synthase kinases; hyperglycemia; ingredients; insulin; insulin receptor substrate proteins; insulin resistance; liver; messenger RNA; mice; non-specific serine/threonine protein kinase; phosphatidylinositol 3-kinase; phosphoenolpyruvate carboxylase; phosphorylation; rice bran; signal transduction; tau-protein kinase; therapeutics; whole grain foods
- Abstract:
- ... The therapeutic benefits of whole grains on diabetes mellitus have been continuously confirmed by in-depth research. To date, limited studies have investigated the effect of extruded products of whole grains on the insulin signaling pathway in vivo. This study investigated the effects of oral consumption of whole grain extrudate, including 97% brown rice and 3% defatted rice bran (w/w, BRD), on gl ...
- DOI:
- 10.1021/acs.jafc.9b04684
- https://doi.org/10.1021/acs.jafc.9b04684