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- Antunes, Bruno Cesar, et al. Show all 7 Authors
- Molecular immunology 2019 v.105 pp. 251-259
- B-lymphocytes; amino acid composition; amino acids; antibodies; antibody diversity; blood serum; disease control; genes; high-throughput nucleotide sequencing; horses; humans; immunogenetics; infectious diseases; loci; mice; rabbits; therapeutics
- ... Horse serum antibodies have been used for greater than a century for the treatment and prophylaxis of infectious diseases and envenomations. Little is known, however, about the immunogenetic diversity that produces horse serum antibodies. Here, we employed next-generation sequencing for a first-in-kind comprehensive analysis of the equine B-cell repertoire. Nearly 45,000 and 30,000 clonotypes were ...
- Hernández Rodríguez, César, et al. Show all 7 Authors
- Revista iberoamericana de micología 2019 v.36 no.1 pp. 1-8
- Candida glabrata; Saccharomyces cerevisiae; Schizosaccharomyces pombe; Ustilago zeae; active sites; antifungal properties; catalytic activity; cholesterol; coenzyme A; endoplasmic reticulum; enzymes; ergosterol; genes; humans; models; open reading frames; viability; yeasts
- ... The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgr) catalyzes the synthesis of mevalonate, a key compound for the synthesis of cholesterol in humans and ergosterol in fungi. Since the Hmgr enzymes of Saccharomyces cerevisiae, Schizosaccharomyces pombe and Candida glabrata are similar to the Hmgr enzymes of mammals, fungal Hmgr enzymes have been proposed as a model for studying antifu ...