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- Author:
- Xin Xin; Hopen Yang; Fengli Zhang; Shang-Tian Yang
- Source:
- Process biochemistry 2019 v.78 pp. 148-160
- ISSN:
- 1359-5113
- Subject:
- antineoplastic agents; carcinogenesis; coculture; endothelial cells; fibroblasts; models; neoplasm cells; neoplasms; screening; stromal cells
- Abstract:
- ... It is recognized that tumors do not exist and grow as isolated entities of neoplastic cells, but rather in continuous and bidirectional communication with adjacent stromal cells. Stromal cellular components, like fibroblasts, endothelial cells and multiple immune cells, have been proven to play critical roles in tumor development. In the past decade, a variety of in vitro three-dimensional (3D) tu ...
- DOI:
- 10.1016/j.procbio.2018.12.028
- https://doi.org/10.1016/j.procbio.2018.12.028
- Author:
- Min Zhang; Yi Ma; Zhaohui Wang; Zhihao Han; Weidong Gao; Qiumei Zhou; Yueqing Gu
- Source:
- ACS applied materials & interfaces 2019 v.11 no.6 pp. 5851-5861
- ISSN:
- 1944-8252
- Subject:
- P-glycoproteins; antineoplastic agents; chondroitin sulfate; crosslinking; cytotoxicity; drug delivery systems; drug resistance; drug therapy; hydrogels; hydrophobicity; nanoparticles; neoplasm cells; neoplasms; synergism
- Abstract:
- ... Programmable drug delivery systems hold great promise to enhance cancer treatment. Herein, a programmable drug delivery system using a chondroitin sulfate (CS)-based composite nanoparticle was developed for enhancing and sensitizing chemotherapy to drug-resistant cancer. The nanoparticle was composed of a cross-linked CS hydrogel shell and hydrophobic cores containing both free drugs and CS-linked ...
- DOI:
- 10.1021/acsami.8b19798
- https://doi.org/10.1021/acsami.8b19798
- Author:
- Xiao Sun; Guilong Zhang; Ruohong Du; Rui Xu; Dongwang Zhu; Junchao Qian; Guo Bai; Chi Yang; Zhiyuan Zhang; Xin Zhang; Duohong Zou; Zhengyan Wu
- Source:
- Biomaterials 2019 v.194 pp. 151-160
- ISSN:
- 0142-9612
- Subject:
- antineoplastic activity; antineoplastic agents; apoptosis; biodegradability; catalytic activity; glutathione; human cell lines; hydroxyl radicals; iron oxides; magnetic resonance imaging; manganese; nanocrystals; nanoparticles; neoplasm cells; neoplasms; surface area; therapeutics; toxicity
- Abstract:
- ... In this work, a tumor microenvironment (TME)-responsive biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging (MRI)-guided combinatorial cancer therapy was constructed. Fe3O4 nanoparticles decorated on the surface of MnSiO3 could effectively obstruct the pores of MnSiO3 and reduce the leakage of anticancer drugs under physiological conditions. The structure of the nanopl ...
- DOI:
- 10.1016/j.biomaterials.2018.12.004
- https://doi.org/10.1016/j.biomaterials.2018.12.004
- Author:
- Mohamed Ali Seyed
- Source:
- Biocatalysis and agricultural biotechnology 2019 v.17 pp. 529-537
- ISSN:
- 1878-8181
- Subject:
- Phyllanthus; T-lymphocytes; antineoplastic agents; chemical constituents of plants; chemoprevention; drug therapy; human diseases; humans; immune response; immunomodulation; immunomodulators; mechanism of action; metastasis; neoplasm cells; neoplasms; patients; plant extracts; remission
- Abstract:
- ... Treatment options for most cancers are still insufficient, despite developments and technology advancements. It has been postulated that the immune response to progressive tumors is insufficient due to a deficiency in afferent mechanisms responsible for the development of tumor-reactive T cells. Many patients treated for cancer will have their cancer recurrence, often after a long remission period ...
- DOI:
- 10.1016/j.bcab.2019.01.008
- https://doi.org/10.1016/j.bcab.2019.01.008
- Author:
- Gargi Biswas; Bikash Chandra Jena; Satyagopal Sahoo; Pousali Samanta; Mahitosh Mandal; Dibakar Dhara
- Source:
- Green chemistry 2019 v.21 no.20 pp. 5624-5638
- ISSN:
- 1463-9270
- Subject:
- Fourier transform infrared spectroscopy; antineoplastic agents; atomic force microscopy; biocompatibility; cancer therapy; catalysts; composite polymers; copper; crosslinking; cycloaddition reactions; drug carriers; green chemistry; nanoparticles; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; scanning electron microscopy; solvents; water solubility
- Abstract:
- ... Polymer based core cross-linked nanoparticles (CCNPs) have generated a lot of interest as potential stimuli-responsive drug delivery systems. In the present work, we have synthesized smart redox-responsive water soluble polymeric CCNPs by cross-linking water-soluble PEG based copolymers with bis(acryloyl)cystamine via isoxazoline bond formation through a 1,3-dipolar cycloaddition reaction (click r ...
- DOI:
- 10.1039/c9gc01863h
- https://doi.org/10.1039/c9gc01863h
- Author:
- Yating Zhang; Yan Zhang; Luqi Zhu; Pingang He; Qingjiang Wang
- Source:
- Electrophoresis 2019 v.40 no.3 pp. 425-430
- ISSN:
- 0173-0835
- Subject:
- DNA; DNA methylation; adenines; antineoplastic agents; electrophoresis; enzyme activity; enzyme inhibitors; epigenetics; fluorescence; gold; methyltransferases; microchip technology; neoplasms; screening
- Abstract:
- ... DNA methylation is a significant epigenetic modification and the methods for the detection of DNA methyltransferase (MTase) activity are important due to aberrant methylation closely related to the occurrence of cancer. In this study, a simple and rapid microchip electrophoresis (ME) coupled with LED‐induced fluorescence (LEDIF) method was presented for the detection of Dam MTase activity. This st ...
- DOI:
- 10.1002/elps.201800236
- https://doi.org/10.1002/elps.201800236
- Author:
- Zhe Zhang; Na Niu; Xi Gao; Fuqin Han; Zhijun Chen; Shujun Li; Jian Li
- Source:
- Colloids and surfaces 2019 v.173 pp. 335-345
- ISSN:
- 0927-7765
- Subject:
- antineoplastic activity; antineoplastic agents; colloids; drug resistance; drug therapy; gold; hypoxia; iron oxides; irradiation; magnetic fields; magnetic materials; nanocarriers; neoplasm cells; neoplasms; oxygen; oxygen production; pH; porous media; reactive oxygen species; silica
- Abstract:
- ... Hypoxia is the main characteristic of tumor microenvironment, and the one of the key factors that cause the drug resistance of cancer cells for chemotherapy. Anticancer drug such as DOX cannot react with sufficient oxygen to produce reactive oxygen species (ROS) in hypoxic environment, which affects the therapeutic efficiency of the drug. In this work, we constructed a multi-functional nano-carrie ...
- DOI:
- 10.1016/j.colsurfb.2018.10.008
- https://doi.org/10.1016/j.colsurfb.2018.10.008
- Author:
- Jianmin Xiao; Guilong Zhang; Rui Xu; Hui Chen; Huijuan Wang; Geng Tian; Bin Wang; Chi Yang; Guo Bai; Zhiyuan Zhang; Hongyi Yang; Kai Zhong; Duohong Zou; Zhengyan Wu
- Source:
- Biomaterials 2019 v.216 pp. 119254
- ISSN:
- 0142-9612
- Subject:
- adenosine triphosphate; antineoplastic agents; apoptosis; catalytic activity; free radicals; hydrogen peroxide; hydroxyl radicals; in vivo studies; ions; iron oxides; magnetic resonance imaging; manganese; monitoring; nanoparticles; neoplasm cells; neoplasms; superoxide anion; superoxide dismutase; therapeutics
- Abstract:
- ... Chemodynamic therapy (CDT) was widely exploited for cancer therapy and expected to replace traditional anticancer drug therapies. Generally, CDT needs to combine with extra therapeutic methods for obtaining the optimal therapeutic efficacy of cancer. Herein, a multifunctional theranostic platform combing CDT with limotherapy was developed via nanoselenium (nano-Se)-coated manganese carbonate-depos ...
- DOI:
- 10.1016/j.biomaterials.2019.119254
- https://doi.org/10.1016/j.biomaterials.2019.119254
- Author:
- Rushikesh S. Ambekar; Balasubramanian Kandasubramanian
- Source:
- Biomaterials science 2019 v.7 no.5 pp. 1776-1793
- ISSN:
- 2047-4849
- Subject:
- acoustics; antineoplastic agents; biocompatibility; blood; cost effectiveness; death; developing countries; drug carriers; economic costs; economic impact; magnetism; neoplasm cells; neoplasms; pH; photochemotherapy; photothermotherapy; polymers
- Abstract:
- ... Cancer is the second leading cause of death in the world with around 9.6 million deaths in 2018, approximately 70% of which occurred in the middle- and low-income countries; moreover, the economic impact of cancer is significant and escalating day by day. The total annual economic cost of cancer treatment in 2010 was estimated at approximately US$ 1.16 trillion. Researchers have explored cancer mi ...
- DOI:
- 10.1039/c8bm01642a
- https://doi.org/10.1039/c8bm01642a
- Author:
- Fatima Zohra Dahmani; Danni Zhong; Yuchen Qi; Aboubaker El G. Dahmani; Tingting Xie; Bo Zhou; Wanli Li; Ke Yao; Lei Li; Min Zhou
- Source:
- Journal of materials chemistry B 2019 v.7 no.29 pp. 4484-4498
- ISSN:
- 2050-7518
- Subject:
- antineoplastic agents; apoptosis; chemistry; cytotoxicity; drug therapy; enzymes; hyaluronic acid; models; nanogold; nanoparticles; neoplasm cells; neoplasms; particle size; radiotherapy
- Abstract:
- ... Nowadays, the design of multistimuli-responsive and deep penetrating nanotherapeutics remains an auspicious means for improving the efficiency of anticancer therapeutics. Herein, we develop a targeted size-tunable nanosystem that would concurrently and uniformly release its therapeutic cargo into tumor cells by exploiting both extracellular and intracellular signals. This nanosystem (HPDAu) is com ...
- DOI:
- 10.1039/c9tb00716d
- https://doi.org/10.1039/c9tb00716d
- Author:
- Dongqing Wang; Hui Huang; Mengxue Zhou; Huiru Lu; Jun Chen; Young-Tae Chang; Jimin Gao; Zhifang Chai; Yi Hu
- Source:
- Chemical communications 2019 v.55 no.28 pp. 4051-4054
- ISSN:
- 1364-548X
- Subject:
- antineoplastic agents; chemical reactions; mitochondria; nanocarriers; neoplasm cells; neoplasms; paclitaxel; temperature
- Abstract:
- ... Mitochondria emerge as an important target for cancer therapy. Herein, by taking advantage of the recently reported high temperature of mitochondria, a well-tuned thermoresponsive nanocarrier was developed for specifically delivering the anticancer drug, paclitaxel (PTX), to mitochondria in cancer cells. The temperature-dependent delivery of drugs to mitochondria represents a novel anticancer stra ...
- DOI:
- 10.1039/c9cc00603f
- https://doi.org/10.1039/c9cc00603f
- Author:
- Jun HuThese authors contribute equally to this work.; Weihua Zhuang; BoXuan Ma; Xin Su; Li Yang; Gaocan Li; Yunbing Wang
- Source:
- Journal of materials chemistry B 2019 v.7 no.24 pp. 3894-3908
- ISSN:
- 2050-7518
- Subject:
- antineoplastic agents; composite polymers; curcumin; cytoplasm; disulfides; encapsulation; fluorescent dyes; folic acid; ibuprofen; image analysis; inflammation; micelles; nanocarriers; nanomedicine; neoplasm cells; neoplasms
- Abstract:
- ... Functional drug carriers with simultaneous effective delivery of therapeutic agents to target sites and great imaging ability have attracted great attention in nanomedicine research. In this work, we developed a multi-functional polymeric micelle based on a folate (FA)-modified triblock copolymer P(TPF-co-Ibup)–PAEMA–PPEG@FA as a smart drug delivery system with anti-tumor and anti-inflammatory abi ...
- DOI:
- 10.1039/c9tb00583h
- https://doi.org/10.1039/c9tb00583h
- Author:
- Tian-Tian Wang; Qi-Chun Wei; Zhen-Tao Zhang; Meng-Ting Lin; Jie-Jian Chen; Yi Zhou; Ning-Ning Guo; Xin-Cheng Zhong; Wen-Hong Xu; Zhan-Xiang Liu; Min Han; Jian-Qing Gao
- Source:
- Biomaterials science 2019 v.8 no.1 pp. 118-124
- ISSN:
- 2047-4849
- Subject:
- antineoplastic agents; cancer therapy; cell death; energy transfer; fluorescence; microfilaments; monitoring; nanomedicine; nanoparticles; neoplasms; polyethylene; polypeptides
- Abstract:
- ... On account of the biological significance of self-assembling peptides in blocking the cellular mass exchange as well as impeding the formation for actin filaments resulting in program cell death, stimuli-responsive polypeptide nanoparticles have attracted more and more attention. In this work, we successfully fabricated doxorubicin-loaded polyethylene glycol-block-peptide (FFKY)-block-tetraphenyle ...
- DOI:
- 10.1039/c9bm01546a
- https://doi.org/10.1039/c9bm01546a
- Author:
- Sung Min Cho; Ho Jeong Kwon
- Source:
- Archives of pharmacal research 2019 v.42 no.3 pp. 232-243
- ISSN:
- 0253-6269
- Subject:
- G-protein coupled receptors; G-proteins; angiogenesis; antineoplastic agents; apoptosis; ceramides; glucosylceramides; human diseases; humans; metabolism; metabolites; mitogen-activated protein kinase; neoplasms; signal transduction; sphingomyelins; sphingosine; therapeutics
- Abstract:
- ... Sphingolipid metabolism plays an important role in determining the fate of a cell. Among several sphingolipid metabolites, ceramide is a key player in intracellular signal transduction. Ceramide is usually converted to various metabolites such as sphingomyelin, sphingosine, ceramide-1-phosphate, and glucosylceramide. If ceramide is accumulated in the cell, it induces apoptosis. On the other hand, ...
- DOI:
- 10.1007/s12272-019-01114-3
- https://doi.org/10.1007/s12272-019-01114-3
- Author:
- Li Li; Yue Zhao; Ran Cao; Lin Li; Gaihong Cai; Jiaojiao Li; Xiangbing Qi; She Chen; Zhiyuan Zhang
- Source:
- Chemical communications 2019 v.55 no.30 pp. 4407-4410
- ISSN:
- 1364-548X
- Subject:
- antineoplastic agents; cell death; chemical compounds; chemical reactions; neoplasm cells; neoplasms; protein composition; screening; therapeutics
- Abstract:
- ... Through systematic target identification for piperlongumine, a cancer-selective killing molecule, we identified GSTO1 as its major covalent target for cancer cell death induction. We also reveal that GSTO1 inhibition is a promising combination strategy with other anti-cancer agents by drug combination screening in which piperlongumine exhibits broad-spectrum synergistic effects with a large propor ...
- DOI:
- 10.1039/c9cc00917e
- https://doi.org/10.1039/c9cc00917e
- Author:
- Enhui Zhang; Ronge Xing; Song Liu; Yukun Qin; Kecheng Li; Pengcheng Li
- Source:
- Carbohydrate polymers 2019 v.222 pp. 115004
- ISSN:
- 0144-8617
- Subject:
- DNA; antineoplastic agents; biocompatibility; biodegradability; chitosan; drug carriers; drug therapy; nanoparticles; neoplasms; photosensitizing agents; proteins; small interfering RNA; tissues
- Abstract:
- ... Chitosan has attracted considerable attention as an anti-tumor drug carrier material in recent years, which is due to its biocompatibility and biodegradability, as well as the simple and mild preparing techniques of drug-loaded nanoparticles. Chitosan-based nanoparticles can deliver various anti-tumor agents to specific tumor tissues by passive and active targeting mechanisms, including traditiona ...
- DOI:
- 10.1016/j.carbpol.2019.115004
- https://doi.org/10.1016/j.carbpol.2019.115004
- Author:
- Zhicheng Pan; Xueling He; Nijia Song; Danxuan Fang; Zhen Li; Jiehua Li; Feng Luo; Jianshu Li; Hong Tan; Qiang Fu
- Source:
- ACS applied materials & interfaces 2019 v.11 no.18 pp. 16421-16429
- ISSN:
- 1944-8252
- Subject:
- adverse effects; albumins; antineoplastic agents; bioavailability; biosecurity; macrophages; micelles; nanocarriers; nanoparticles; neoplasm cells; neoplasms; nucleic acids; polymers; protein corona; tissues; toxicity
- Abstract:
- ... Cationic nanocarriers have emerged as promising nanoparticle systems for the effective delivery of nucleic acid and anticancer drugs to cancer cells. A positive charge is desirable for promoting cell internalization, whereas it also causes some adverse effects, such as toxicity and rapid clearance by mononuclear phagocytic systems. Herein, a new strategy of modifying cationic polymer micelles with ...
- DOI:
- 10.1021/acsami.9b05599
- https://doi.org/10.1021/acsami.9b05599
- Author:
- Yahya Asemani; Nasrindokht Zamani; Maryam Bayat; Zahra Amirghofran
- Source:
- Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
- ISSN:
- 0951-418X
- Subject:
- Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
- Abstract:
- ... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
- DOI:
- 10.1002/ptr.6490
- https://doi.org/10.1002/ptr.6490
- Author:
- Chuchu Zhou; Xu Song; Chenqi Guo; Yulu Tan; Juan Zhao; Qin Yang; Dan Chen; Tiantian Tan; Xun Sun; Tao Gong; Zhirong Zhang
- Source:
- ACS applied materials & interfaces 2019 v.11 no.45 pp. 42534-42548
- ISSN:
- 1944-8252
- Subject:
- antineoplastic agents; biomimetics; chemical reactions; cytotoxicity; dissociation; drug delivery systems; films (materials); half life; human serum albumin; intravenous injection; nanoparticles; neoplasms; paclitaxel; patients; pharmacokinetics
- Abstract:
- ... Biomimetic design has been extensively investigated. The only FDA-approved biomimetic albumin-bound paclitaxel may not be beneficial to some treated patients due to rapid dissociation upon intravenous infusion and no substantial improvement in the drug’s pharmacokinetics or biodistribution. Herein, we developed an alternative and injectable preformed albumin-bound anticancer drug delivery. We comb ...
- DOI:
- 10.1021/acsami.9b11307
- https://doi.org/10.1021/acsami.9b11307
- Author:
- Marjan Fallah; Mostafa Rahimnejad; Maryam Asghary; Mehrdad Mashkour
- Source:
- Analytical methods 2019 v.12 no.1 pp. 33-38
- ISSN:
- 1759-9679
- Subject:
- antineoplastic agents; blood serum; carbon electrodes; detection limit; electrochemistry; neoplasms; pH; sensors (equipment); voltammetry
- Abstract:
- ... This study presents a rapid, simple, sensitive, and selective electrochemical sensor prepared using a carbon paste electrode for the electrochemical determination of buserelin—an anti-prostate cancer drug. Differential pulse voltammetry (DPV) and cyclic voltammetry (CV) techniques were applied to analyze the anodic characterization of the aforementioned drug. Some of the common parameters such as ...
- DOI:
- 10.1039/c9ay01760g
- https://doi.org/10.1039/c9ay01760g
- Author:
- Jeong Moo Seo; Ahmed H.E. Hassan; Yong Sup Lee
- Source:
- Tetrahedron 2019 v.75 no.51 pp. 130760
- ISSN:
- 0040-4020
- Subject:
- antineoplastic agents; bioactive properties; cell lines; chemical bonding; chemical reactions; chemical structure; histamine; neoplasm cells; neoplasms
- Abstract:
- ... A single-step gateway synthesis of glochidine and its congeners that possess the rare uncommon tetrahydroimidazo[1,5-c]pyrrolo[1,2-a]pyrimidine core was developed employing histamine and readily available γ-ketoesters. Key features of the developed reaction involve tandem three C–N bonds formation and concomitant annulation of two rings in one pot to access this unique and complex tricyclic struct ...
- DOI:
- 10.1016/j.tet.2019.130760
- https://doi.org/10.1016/j.tet.2019.130760
- Author:
- Shengli Mi; Jingjing Xia; Yuanyuan Xu; Zhichang Du; Wei Sun
- Source:
- RSC advances 2019 v.9 no.16 pp. 9006-9013
- ISSN:
- 2046-2069
- Subject:
- antineoplastic agents; biocompatible materials; biosensors; carbon nanotubes; chitosan; detection limit; electrochemistry; electrodes; human cell lines; lactate 2-monooxygenase; lactic acid; metabolism; metabolites; microfluidic technology; mixing; neoplasms; organ-on-a-chip; platinum; silver; silver chloride; tissue engineering
- Abstract:
- ... In this study, we developed an electrochemical microchannel biosensor platform to analyse lactate metabolism in cells. This biosensor platform was fabricated by photolithography, thin-film deposition and microfluidic technology. A kind of functional biomaterial was prepared by mixing lactate oxidase, single-walled carbon nanotubes and chitosan, and platinum as working and blank electrodes of the b ...
- DOI:
- 10.1039/c9ra00694j
- https://doi.org/10.1039/c9ra00694j
- Author:
- Jun Hai; Xiaofan Zeng; Yanhong Zhu; Baodui Wang
- Source:
- Biomaterials 2019 v.194 pp. 161-170
- ISSN:
- 0142-9612
- Subject:
- anions; antineoplastic agents; cellulose; crosslinking; extracellular matrix; fluorescence; hydrogels; image analysis; neoplasms; screening; thiocyanates
- Abstract:
- ... Artificial stimuli-responsive hydrogels that can mimic natural extracellular matrix for growth and release of cancer spheroids (CSs) have attracted much attention. However, such hydrogels still face a challenge in regulating CSs growth and controlled release as well as keeping CSs integrity. Herein, a new class of ClO−/SCN− reversibly responsive nanocellulose hydrogel with fluorescence on-off repo ...
- DOI:
- 10.1016/j.biomaterials.2018.12.016
- https://doi.org/10.1016/j.biomaterials.2018.12.016
- Author:
- Anyi Chen; Wenbin Liang; Haijun Wang; Ying Zhuo; Yaqin Chai; Ruo Yuan
- Source:
- Analytical chemistry 2019 v.92 no.1 pp. 1379-1385
- ISSN:
- 1520-6882
- Subject:
- antineoplastic agents; biocompatibility; biosensors; carbon quantum dots; electrochemiluminescence; electrodes; energy; hydrazides; hydrogen peroxide; monitoring; neoplasm cells; neoplasms; nitrogen; pharmacodynamics
- Abstract:
- ... In this work, a kind of novel nitrogen doped hydrazide conjugated carbon dots (NHCDs) with strong anodic electrochemiluminescence (ECL) at a low excitation potential were synthesized via a one-step solvothermal approach and applied to construct biosensor for rapid cancer cell detection. The nitrogen doping induced a shift of the highest occupied molecular orbital (HOMO) to the upper energy level t ...
- DOI:
- 10.1021/acs.analchem.9b04537
- https://doi.org/10.1021/acs.analchem.9b04537
- Author:
- Bhupesh Kumar; Rajib Ghosh; Aruna K. Mora; Sukhendu Nath
- Source:
- Journal of physical chemistry 2019 v.123 no.35 pp. 7518-7527
- ISSN:
- 1520-5207
- Subject:
- DNA; DNA probes; anthracenes; antineoplastic agents; computer simulation; emissions factor; ligands; models; moieties; molecular rotors; neoplasms; quantum mechanics; spectral analysis
- Abstract:
- ... An efficient turn-on fluorescence probe for biomolecules not only helps in its sensitive detection but is also useful to understand the different interactions that are operating between biomolecules and probes. Polycyclic aromatic molecules are known to be strong interacting ligand for DNA and extensively studied as a model cancer drug. However, these molecules show large decrease in their emissio ...
- DOI:
- 10.1021/acs.jpcb.9b05570
- https://doi.org/10.1021/acs.jpcb.9b05570
- Author:
- Yan-Ping Liu; Jia-Ming Guo; Gui Yan; Ming-Ming Zhang; Wen-Hao Zhang; Lei Qiang; Yan-Hui Fu
- Source:
- Journal of agricultural and food chemistry 2019 v.67 no.17 pp. 4817-4823
- ISSN:
- 1520-5118
- Subject:
- Ficus carica; anti-inflammatory activity; antineoplastic agents; chemical composition; chemical structure; cortisol; figs; fruits; health promotion; human cell lines; inhibitory concentration 50; isoflavones; neoplasm cells; neoplasms; nitric oxide; spectroscopy; Middle East; West Asia
- Abstract:
- ... Ficus carica is an Asian species of flowering plant belonging to the genus Ficus of the family Moraceae, native to Western Asia and the Middle East. Its fruits, usually known as common fig or fig, have been consumed as a very popular health-promoting fruit worldwide since ancient times. To investigate the potential health-promoting chemical constituents of the fruits of F. carica, a systematic phy ...
- DOI:
- 10.1021/acs.jafc.9b00865
- https://doi.org/10.1021/acs.jafc.9b00865
- Author:
- Jiří Voller; Tibor Béres; Marek Zatloukal; Petr Džubák; Marián Hajdúch; Karel Doležal; Thomas Schmülling; Strnad Miroslav
- Source:
- Phytochemistry reviews 2019 v.18 no.4 pp. 1101-1113
- ISSN:
- 1568-7767
- Subject:
- antineoplastic activity; antineoplastic agents; apoptosis; cell lines; cytokinins; genes; growth and development; immune response; in vivo studies; mutants; neoplasms; patients; plant development; plant growth; plant hormones; stem cells
- Abstract:
- ... Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived ...
- DOI:
- 10.1007/s11101-019-09620-4
- https://doi.org/10.1007/s11101-019-09620-4
- Author:
- Xiaohong Yang; Jiangsheng Gao; Jian Guo; Zimeng Zhao; Shao-Lin Zhang; Yun He
- Source:
- Life sciences 2019 v.219 pp. 20-30
- ISSN:
- 0024-3205
- Subject:
- DNA topoisomerase; antineoplastic activity; antineoplastic agents; apoptosis; autophagy; caspases; cell cycle checkpoints; cell movement; cytochrome c; cytotoxicity; humans; inhibitory concentration 50; interphase; mitochondria; mitogen-activated protein kinase; models; neoplasm cells; neoplasms; plasmids
- Abstract:
- ... CAA45 is a calothrixin A (CAA) analogue with anti-cancer activity at nanomolar concentration. This study aimed to investigate the anti-lung cancer activity of CAA45 and explore its mechanisms of actions.CAA and CAA45 were synthesized and their inhibition on DNA topoisomerase I (Topo I) performed by evaluating the relaxation of supercoiled pBR322 plasmid DNA and their anti-lung cancer capacity dete ...
- DOI:
- 10.1016/j.lfs.2018.12.052
- https://doi.org/10.1016/j.lfs.2018.12.052
- Author:
- Venugopal SenthilKumar; Subramanian Kumaresan; Manoharan Muthu Tamizh; Villianur Ibrahim Hairul Islam; Krishnaraj Thirugnanasambantham
- Source:
- Phytomedicine 2019 pp. 152830
- ISSN:
- 0944-7113
- Subject:
- Chaetomium globosum; DNA; DNA fragmentation; Western blotting; adverse effects; antineoplastic agents; apoptosis; cell lines; cytotoxicity; dose response; endophytes; fractionation; fungi; gene expression regulation; genes; inhibitory concentration 50; metabolites; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; quantitative polymerase chain reaction; shrinkage; transcription factor NF-kappa B
- Abstract:
- ... Anticancer compounds from natural sources have drawn attention due to their structural diversity and relatively lesser side effects. Endophytic fungi are one such natural resource from, which plethoras of anticancerous compounds have been isolated.The objective of the study was to isolate and characterize the bioactive metabolite from Chaetomium globosum that exhibits astonishing antiproliferative ...
- DOI:
- 10.1016/j.phymed.2019.152830
- https://doi.org/10.1016/j.phymed.2019.152830
- Author:
- Elena Catanzaro; Cinzia Calcabrini; Anupam Bishayee; Carmela Fimognari
- Source:
- Marine drugs 2019 v.18 no.1 pp. -
- ISSN:
- 1660-3397
- Subject:
- algae; antineoplastic activity; antineoplastic agents; biodiversity; cell death; cell proliferation; clinical trials; freshwater; glycoproteins; lectins; marine environment; neoplasm cells; neoplasms; sugars; toxicity; toxicology; vertebrates
- Abstract:
- ... Often, even the most effective antineoplastic drugs currently used in clinic do not efficiently allow complete healing due to the related toxicity. The reason for the toxicity lies in the lack of selectivity for cancer cells of the vast majority of anticancer agents. Thus, the need for new potent anticancer compounds characterized by a better toxicological profile is compelling. Lectins belong to ...
- DOI:
- 10.3390/md18010011
- https://doi.org/10.3390/md18010011
31. Apoferritin encapsulation of cysteine protease inhibitors for cathepsin L inhibition in cancer cells
- Author:
- José C. Quilles Junior; Fernanda dos Reis Rocho Carlos; A. Montanari; Andrei Leitão; Viviane W. Mignone; Maria Augusta Arruda; Lyudmila Turyanska; Tracey D. Bradshaw
- Source:
- RSC advances 2019 v.9 no.63 pp. 36699-36706
- ISSN:
- 2046-2069
- Subject:
- antineoplastic activity; antineoplastic agents; carcinogenesis; cathepsin L; cell cycle checkpoints; cysteine proteinase inhibitors; encapsulation; enzyme inhibition; ferritin; fibroblasts; humans; in vivo studies; neoplasm cells; neoplasms; protein degradation; transferrin receptors
- Abstract:
- ... Cysteine proteases play a key role in tumorigenesis causing protein degradation and promoting invasive tumour growth. Cathepsin L is overexpressed in cancer cells and could provide a specific target for delivery of anticancer agents. We encapsulated novel dipeptidyl nitrile based cysteine protease inhibitors (Neq0551, Neq0554 and Neq0568) into biocompatible apoferritin (AFt) protein nanocages to a ...
- DOI:
- 10.1039/c9ra07161j
- https://doi.org/10.1039/c9ra07161j
- Author:
- Cong Li; Huanli Xu; Xiaoliang Chen; Jijun Chen; Xiao Li; Gan Qiao; Ye Tian; Ru Yuan; Shuonan Su; Xiaohui Liu; Xiukun Lin
- Source:
- Phytotherapy research 2019 v.33 no.7 pp. 1794-1804
- ISSN:
- 0951-418X
- Subject:
- Syzygium aromaticum; adjuvants; animal models; antineoplastic agents; autophagy; bioactive properties; cell growth; chromatography; cloves; colon; drug therapy; flow cytometry; fluorescence microscopes; fluorescence microscopy; in vivo studies; inhibitory concentration 50; medicinal plants; neoplasm cells; neoplasms; spectrometers; transmission electron microscopes
- Abstract:
- ... Cloves (Syzygium aromaticum), a traditional Chinese medicinal herb, displays broad biological activity. In the present study, the aqueous extract of clove (AEC) was prepared, and its anticancer affects were studied. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetra‐zolium (MTS) analysis revealed that AEC was able to inhibit cancer cell growth in vitro on several ca ...
- DOI:
- 10.1002/ptr.6367
- https://doi.org/10.1002/ptr.6367
- Author:
- A.B. Oyenihi; C. Smith
- Source:
- Journal of ethnopharmacology 2019 v.229 pp. 54-72
- ISSN:
- 0378-8741
- Subject:
- active ingredients; adverse effects; antineoplastic agents; antioxidant activity; antioxidants; chronic diseases; mechanism of action; medicinal plants; neoplasms; pharmaceutical industry; plant products; polyphenols; therapeutics; toxicity; traditional medicine
- Abstract:
- ... Given the severe side effects associated with most of the conventional cancer medications, as well as the expanding body of evidence indicating secondary toxicity of these drugs, individuals with cancer are increasingly turning to natural alternatives. Similarly, the pharmaceutical industry is in search of natural products to treat cancer. An understanding of the specific active components in plan ...
- DOI:
- 10.1016/j.jep.2018.09.037
- https://doi.org/10.1016/j.jep.2018.09.037
- Author:
- Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
- Source:
- Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
- ISSN:
- 1557-7600
- Subject:
- 2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
- Abstract:
- ... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
- DOI:
- 10.1089/jmf.2019.0098
- https://doi.org/10.1089/jmf.2019.0098
- Author:
- Ning Ding; Zhao Li; Xinwei Tian; Jiahang Zhang; Kaili Guo; Pan Wang
- Source:
- Chemical communications 2019 v.55 no.87 pp. 13172-13175
- ISSN:
- 1364-548X
- Subject:
- anaerobic conditions; antineoplastic agents; chemical compounds; chemical reactions; drug therapy; fluorescence; fluorescent dyes; human cell lines; mice; neoplasms
- Abstract:
- ... A novel azo-based near-infrared fluorescent theranostic probe was synthesized, which is selectively activated under hypoxic conditions, resulting in the release of an active anticancer drug and a near-infrared fluorophore turn-on. Notably, the probe has been applied successfully to real-time visualization of drug delivery in 4T1, HepG2 cells, and mice. ...
- DOI:
- 10.1039/c9cc06727b
- https://doi.org/10.1039/c9cc06727b
- Author:
- Anna Hordyjewska; Aleksandra Ostapiuk; Anna Horecka; Jacek Kurzepa
- Source:
- Phytochemistry reviews 2019 v.18 no.3 pp. 929-951
- ISSN:
- 1568-7767
- Subject:
- Betula; antineoplastic activity; antineoplastic agents; apoptosis; bark; betulin; betulinic acid; mechanism of action; metabolites; neoplasm cells; neoplasms; oxidation; therapeutics
- Abstract:
- ... Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid, obtained by betulin oxidation, is also abundantly present in nature. Both compounds show a wide spectrum of biological and pharmacological properties, such as anti-HIV, anti-inflammatory, and, considered the most im ...
- DOI:
- 10.1007/s11101-019-09623-1
- https://doi.org/10.1007/s11101-019-09623-1
- Author:
- Xiuli Zheng; Weimin Liu; Jiechao Ge; Qingyan Jia; Fuchun Nan; Ying Ding; Jiasheng Wu; Wenjun Zhang; Chun-Sing Lee; Pengfei Wang
- Source:
- ACS applied materials & interfaces 2019 v.11 no.20 pp. 18178-18185
- ISSN:
- 1944-8252
- Subject:
- antineoplastic agents; bioactive properties; biocompatibility; biodegradability; biodegradation; chemical structure; fluorescence; image analysis; nanoparticles; neoplasms; reactive oxygen species; therapeutics; ultrasonics; water solubility
- Abstract:
- ... Natural products show high potential for clinical translation because of their specific biological activities and molecular structure diversities. Sonosensitizers that originate from natural products play a crucial role as anti-inflammatory and anticancer agents. Herein, hypocrellin-derivative nanoparticles (APHB NPs) were constructed for synchronous near-infrared fluorescence (NIR FL) imaging and ...
- DOI:
- 10.1021/acsami.9b03270
- https://doi.org/10.1021/acsami.9b03270
- Author:
- Yuxing Lin; Zhao Ma; Zhenzhen Li; Yuqi Gao; Xiaojun Qin; Zheng Zhang; Guankai Wang; Lupei Du; Minyong Li
- Source:
- Analytical chemistry 2019 v.91 no.23 pp. 14873-14878
- ISSN:
- 1520-6882
- Subject:
- antineoplastic agents; bioluminescence; detection limit; drug design; fibroblasts; fibrosis; glycoproteins; lungs; mice; monitoring; neoplasms; therapeutics; transgenic animals
- Abstract:
- ... Fibroblast activation protein-α (FAP), as a crucial member of cell surface glycoprotein, highly expresses in reactive fibroblasts of tumors and several fibrosis diseases. It is a potential target for drug design and also reported as a prodrug strategy to increase the therapeutic window of some anticancer agents. In this work, we developed the first bioluminogenic probe for FAP with a limit-of-dete ...
- DOI:
- 10.1021/acs.analchem.9b02117
- https://doi.org/10.1021/acs.analchem.9b02117
- Author:
- Deep Pooja; Anusha Gunukula; Nitin Gupta; David J. Adams; Hitesh Kulhari
- Source:
- international journal of biochemistry & cell biology 2019 v.114 pp. 105567
- ISSN:
- 1357-2725
- Subject:
- adverse effects; antineoplastic agents; bombesin; bombesin receptors; breasts; drug delivery systems; gene transfer; humans; image analysis; ligands; lungs; neoplasm cells; neoplasms; peptides
- Abstract:
- ... The biggest challenge in delivering anticancer agents is the ability to direct these molecules specifically to cancer cells. With this in mind, modern research is focussing on improving the precision of cancer drug delivery by incorporating a ligand that has the ability to specifically recognize cancer cells. Peptides are emerging as a new tool in drug and gene delivery. Peptide-drug conjugates, p ...
- DOI:
- 10.1016/j.biocel.2019.105567
- https://doi.org/10.1016/j.biocel.2019.105567
- Author:
- Yu-Hui Zhang; Ying-Ming Zhang; Jie Yu; Jie Wang; Yu Liu
- Source:
- Chemical communications 2019 v.55 no.8 pp. 1164-1167
- ISSN:
- 1364-548X
- Subject:
- antineoplastic agents; chemical compounds; chemical reactions; cytotoxicity; hyaluronic acid; neoplasm cells; neoplasms; pH
- Abstract:
- ... A pH-responsive and targeted polysaccharide conjugate was fabricated from the boronate linkage of N-(2-aminoethyl)-gluconamide-grafted hyaluronic acid with anticancer drug bortezomib, which could exhibit targeted drug release behaviors at acidic pH and possess lower cytotoxicity and a higher inhibition effect toward cancer cells. ...
- DOI:
- 10.1039/c8cc09956a
- https://doi.org/10.1039/c8cc09956a
- Author:
- Lenka Molčanová; Dominika Janošíková; Stefano Dall´Acqua; Karel Šmejkal
- Source:
- Phytochemistry reviews 2019 v.18 no.4 pp. 1051-1100
- ISSN:
- 1568-7767
- Subject:
- antineoplastic activity; antineoplastic agents; bioassays; cell culture; cell lines; chemoprevention; cytotoxicity; drug therapy; flavanones; flavonols; in vitro studies; isoflavonoids; neoplasm cells; neoplasms; oxygen; secondary metabolites
- Abstract:
- ... Natural products of plant origin or their semisynthetic derivatives acting as chemopreventive or chemotherapeutic agents for various types of cancer are under study as potential new anticancer drugs. Within the huge class of plant phenolic secondary metabolites, the subclass of prenylated flavonoids is quite rich in structural variety and pharmacological activity. One of their most prominent chara ...
- DOI:
- 10.1007/s11101-019-09641-z
- https://doi.org/10.1007/s11101-019-09641-z
- Author:
- Dan Huang; Bin He; Peng Mi
- Source:
- Biomaterials science 2019 v.7 no.10 pp. 3942-3960
- ISSN:
- 2047-4849
- Subject:
- antineoplastic agents; biocompatibility; biodegradability; calcium phosphates; gene transfer; image analysis; moieties; nanocarriers; neoplasms; nucleic acids; photosensitizing agents; precision medicine
- Abstract:
- ... Calcium phosphate (CaP) was engineered as a drug delivery nanocarrier nearly 50 years ago due to its biocompatibility and biodegradability. In recent years, several approaches have been developed for the preparation of size-controllable, stable and multifunctional CaP nanocarriers, and several targeting moieties have also been decorated on the surface of these nanocarriers for active targeting. Th ...
- DOI:
- 10.1039/c9bm00831d
- https://doi.org/10.1039/c9bm00831d
- Author:
- Faisal Raza; Hajra Zafar; Xinru You; Asifullah Khan; Jun Wu; Liang Ge
- Source:
- Journal of materials chemistry B 2019 v.7 no.48 pp. 7639-7655
- ISSN:
- 2050-7518
- Subject:
- antineoplastic agents; biocompatibility; dendrimers; micelles; nanocarriers; nanomedicine; nanotubes; neoplasms; peptides
- Abstract:
- ... The applications of nanoparticulate drug delivery have received abundant interest in the field of cancer diagnosis and treatment. By virtue of their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine has spanned multitudes of drug delivery systems that possess high tumor targeting ability, sensitivity towards tumo ...
- DOI:
- 10.1039/c9tb01842e
- https://doi.org/10.1039/c9tb01842e
- Author:
- Yongjuan Li; Juanjuan Dang; Qiujun Liang; Lichen Yin
- Source:
- Biomaterials 2019 v.209 pp. 138-151
- ISSN:
- 0142-9612
- Subject:
- anaerobic conditions; antineoplastic activity; antineoplastic agents; apoptosis; blood circulation; carbon monoxide; drug therapy; hypoxia; iron; irradiation; mitochondria; nanoparticles; neoplasm cells; neoplasms; oxygen consumption; porous media
- Abstract:
- ... Bioreductive chemodrugs require hypoxic conditions to activate their anti-cancer efficacy. The insufficient and heterogeneous hypoxic condition in tumor tissues hurdles the therapeutic potency of bioreductive chemodrugs. We herein report a NIR light-triggered CO release system based on mesoporous Prussian blue nanoparticles (PB NPs) to enable cancer-selective hypoxia aggravation and hypoxia-respon ...
- DOI:
- 10.1016/j.biomaterials.2019.04.004
- https://doi.org/10.1016/j.biomaterials.2019.04.004
- Author:
- Chunhua Ren; Yang Gao; Yong Guan; Zhongyan Wang; Lijun Yang; Jie Gao; Huirong Fan; Jianfeng Liu
- Source:
- ACS applied materials & interfaces 2019 v.11 no.37 pp. 33706-33715
- ISSN:
- 1944-8252
- Subject:
- P-glycoproteins; antineoplastic activity; antineoplastic agents; biocompatibility; cancer therapy; caudal vein; drug delivery systems; drug resistance; drug therapy; histone deacetylase; hydrogels; hydrophilicity; hydrophobicity; nanofibers; neoplasm cells; neoplasms; paclitaxel
- Abstract:
- ... The resistance of tumor cells to anticancer drugs has become one of the principal causes of the failure in clinical chemotherapy. To overcome this issue, developing feasible drug delivery systems for effective cancer therapy is urgently needed. In this work, we construct an amphiphilic drug self-delivery system consisting of Taxol and tyroservatide (YSV) to overcome drug resistance. The carrier-fr ...
- DOI:
- 10.1021/acsami.9b12530
- https://doi.org/10.1021/acsami.9b12530
- Author:
- J.J. Nair; J. Van Staden
- Source:
- South African journal of botany 2019 v.120 pp. 33-38
- ISSN:
- 0254-6299
- Subject:
- Amaryllidaceae; alkaloids; antineoplastic agents; apoptosis; caspases; cytotoxicity; death; neoplasm cells; neoplasms; phagocytosis; signal transduction
- Abstract:
- ... Cancer is a leading cause of death worldwide. This, in spite of the tremendous gains made in cancer chemotherapies over the past several decades. The identification and development of new targets with greater structural diversities and better potencies are at the forefront of drug discovery endeavors across disciplines. Plants have afforded a significant number of successful anticancer drugs, seve ...
- DOI:
- 10.1016/j.sajb.2018.05.016
- https://doi.org/10.1016/j.sajb.2018.05.016
- Author:
- Munmun Panda; Bijesh K. Biswal
- Source:
- Molecular biology reports 2019 v.46 no.5 pp. 5645-5659
- ISSN:
- 0301-4851
- Subject:
- antineoplastic agents; cancer therapy; dimerization; drug resistance; epigenetics; headache; molecular biology; mutation; neoplasms
- Abstract:
- ... Drug resistance is a major setback for advanced therapeutics in multiple cancers. The increasing prevalence of this resistance is a growing concern and bitter headache for the researchers since a decade. Hence, it is essential to revalidate the existing strategies available for cancer treatment and to look after a novel therapeutic approach for target based killing of cancer cells at the genetic l ...
- DOI:
- 10.1007/s11033-019-04958-6
- https://doi.org/10.1007/s11033-019-04958-6
- Author:
- Ke Li; Zhongping John Lin; Honglan Shi; Yinfa Ma
- Source:
- Analytical chemistry 2019 v.91 no.13 pp. 8558-8563
- ISSN:
- 1520-6882
- Subject:
- antineoplastic agents; cysteine; drug development; mass spectrometry; neoplasms; positional isomers; therapeutics; toxicity
- Abstract:
- ... Interchain cysteine linked antibody–drug conjugates (ADCs) are emerging therapeutic products that antagonize cancers. The toxic payloads are selectively linked to the interchain cysteines and generate heterogeneous mixtures of positional isomers. These positional isomers might contribute differently to the therapeutic efficacy because of the variation in conjugation stability, and thus they need t ...
- DOI:
- 10.1021/acs.analchem.9b01808
- https://doi.org/10.1021/acs.analchem.9b01808
- Author:
- Shazia Parveen; Farukh Arjmand; Sartaj Tabassum
- Source:
- RSC advances 2019 v.9 no.43 pp. 24699-24721
- ISSN:
- 2046-2069
- Subject:
- adverse effects; antineoplastic agents; drug carriers; drug therapy; half life; immunogenicity; micelles; nanoparticles; neoplasm cells; neoplasms; polymers; tissues; water solubility
- Abstract:
- ... Polymer therapeutics encompasses polymer–drug conjugates that are nano-sized, multicomponent constructs already in the clinic as antitumor compounds, either as single agents or in combination with other organic drug scaffolds. Nanoparticle-based polymer-conjugated therapeutics are poised to become a leading delivery strategy for cancer treatments as they exhibit prolonged half-life, higher stabili ...
- DOI:
- 10.1039/c9ra04358f
- https://doi.org/10.1039/c9ra04358f
- Author:
- Thomas Efferth; Mohamed E.M. Saeed; Onat Kadioglu; Ean-Jeong Seo; Samira Shirooie; Armelle T. Mbaveng; Seyed Mohammad Nabavi; Victor Kuete
- Source:
- Biotechnology advances 2019 pp. -
- ISSN:
- 0734-9750
- Subject:
- Escherichia coli; Saccharomyces; adenosine triphosphate; antibiotics; antineoplastic agents; biopharmaceuticals; chemical constituents of plants; drug therapy; enzymes; heat shock proteins; hydrolysis; hypersensitivity; mechanism of action; medicinal plants; mitotic spindle apparatus; multiple drug resistance; mutation; neoplasm cells; neoplasms; phenotype; protocols; reactive oxygen species; tubulin
- Abstract:
- ... Cancer chemotherapy is frequently hampered by drug resistance. Concepts to combine anticancer drugs with different modes of action to avoid the development of resistance did not provide the expected success in the past, because tumors can be simultaneously non-responsive to many drugs (e.g. the multidrug resistance phenotype). However, tumors may be specifically hypersensitive to other drugs – a p ...
- DOI:
- 10.1016/j.biotechadv.2019.01.009
- https://doi.org/10.1016/j.biotechadv.2019.01.009
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