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- Ohtsuki, Yuya, et al. Show all 6 Authors
- Biochemical and biophysical research communications 2019 v.509 no.1 pp. 287-293
- acetaminophen; cytochrome P-450; enzyme activity; glycoproteins; mitogen-activated protein kinase; moieties; pharmacokinetics; positional isomers; proteasome endopeptidase complex; protein degradation; protein synthesis; transcription (genetics); ubiquitin; ubiquitin-protein ligase
- ... Cytochrome P450 (CYP) 3A4 plays an important role in drug metabolism. Although transcriptional regulation of CYP3A expression by chemicals has been comprehensively studied, its post-translational regulation is not fully understood. We previously reported that acetaminophen (APAP) caused accumulation of functional CYP3A protein via inhibition of CYP3A protein degradation through reduction of glycop ...