Jump to Main Content
- Kültz, Dietmar, et al. Show all 3 Authors
- Journal of proteomics 2019 v.194 pp. 112-124
- DNA methylation; Kryptolebias marmoratus; S-adenosylmethionine; adults; brain; dose response; endocrine-disrupting chemicals; fish; genetic variation; hatching; homozygosity; humans; inflammation; innate immunity; lipid metabolism; liver; long term effects; models; phenotype; proteins; proteome; proteomics; selfing
- ... Early-life represents a critically sensitive window to endocrine disrupting chemicals, potentially leading to long-term repercussions on the phenotype later in life. The mechanisms underlying this phenomenon, referred to as the Developmental Origins of Health and Disease (DOHaD), are still poorly understood. To gain molecular understanding of these effects, we exposed mangrove rivulus (Kryptolebia ...
- Kültz, Dietmar, et al. Show all 7 Authors
- Comparative biochemistry and physiology 2019 v.232 pp. 11-22
- Austrofundulus limnaeus; aerobiosis; anaerobiosis; biochemical pathways; cell lines; culture media; evolution; hypoxia; lactic acid; mammals; mitochondrial genome; non-coding RNA; oxygen
- ... Most animal cells rely on aerobic metabolism for survival and are damaged or die within minutes without oxygen. Embryos of the annual killifish Austrofundulus limnaeus, however, survive months without oxygen. Determining how their cells survive without oxygen has the potential to revolutionize our understanding of the cellular mechanisms supporting vertebrate anoxia tolerance and the evolution of ...