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- Roatt, Bruno Mendes, et al. Show all 28 Authors
- Veterinary parasitology 2019 v.271 pp. 87-97
- B-lymphocytes; CD8-positive T-lymphocytes; Leishmania infantum; animal models; antibody formation; biomarkers; cell differentiation; coculture; dogs; employment; histopathology; immunogenicity; industry; interferon-gamma; interleukin-10; interleukin-4; macrophages; natural history; parasite load; parasitism; tissues; transforming growth factor beta; tumor necrosis factor-alpha; vaccine development; vaccines; visceral leishmaniasis
- ... The natural history of canine visceral leishmaniasis (CVL) has been well described, particularly with respect to the parasite load in different tissues and immunopathological changes according to the progression of clinical forms. The biomarkers evaluated in these studies provide support for the improvement of the tools used in developing vaccines against CVL. Thus, we describe the major studies u ...