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- Shin, Jong-Shik, et al. Show all 2 Author
- Biotechnology and bioprocess engineering 2019 v.24 no.1 pp. 176-182
- Ochrobactrum anthropi; active sites; aldimines; amination; amines; drugs; engineering; enzymes; induced mutation; industrial applications; ketones; mutants; screening
- ... Chiral amines are broadly used as essential building blocks of diverse pharmaceutical drugs. ω-Transaminase (ω-TA) is one of the promising enzymes for biocatalytic preparation of chiral amines owing to its capability for reductive amination of ketones. However, industrial application of ω-TA to asymmetric synthesis of chiral amines is often limited by marginal activities for ketones. Here, we expl ...