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- Urbanc, Brigita, et al. Show all 3 Authors
- TheJournal of physical chemistry 2019 v.123 no.5 pp. 1068-1084
- Alzheimer disease; amyloid; chemical bonding; copper; crosslinking; histidine; hydrogen peroxide; hydroxylation; lysine; neurotoxicity; phenylalanine; solvents; tyrosine
- ... Amyloid β-protein (Aβ) oligomers play a seminal role in Alzheimer’s disease (AD). Cross-linking (X-linking), which can be used to determine Aβ oligomer size distributions experimentally, was reported to stabilize Aβ oligomers. Aβ oligomers X-linked in the presence of copper and hydrogen peroxide may represent the proximate neurotoxic species in AD. Our previous computational study demonstrated tha ...