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- van der Kamp, Marc W., et al. Show all 10 Authors
- Biochemistry 2019 v.58 no.18 pp. 2362-2372
- Parkinson disease; absorption; active sites; amine oxidase (flavin-containing); amines; binding sites; catalytic activity; drug design; electron paramagnetic resonance spectroscopy; enzyme activity; enzyme kinetics; humans; molecular dynamics; oxidation; quinones; simulation models
- ... There is an increasing realization that structure-based drug design may show improved success by understanding the ensemble of conformations accessible to an enzyme and how the environment affects this ensemble. Human monoamine oxidase B (MAO-B) catalyzes the oxidation of amines and is inhibited for the treatment of both Parkinson’s disease and depression. Despite its clinical importance, its cata ...