Jump to Main Content
- Zahradka, Peter, et al. Show all 5 Authors
- Nutrients 2019 v.11 no.4
- animal disease models; diet; docosahexaenoic acid; droplets; eicosapentaenoic acid; fasting; fatty liver; fatty-acid synthase; fibrosis; hyperinsulinemia; inflammation; insulin; linoleic acid; liver; noninsulin-dependent diabetes mellitus; obesity; omega-3 fatty acids; rats
- ... Hepatic steatosis, an early stage of non-alcoholic fatty liver disease, is commonly present in obesity and type 2 diabetes, and is associated with reduced hepatic omega-3 polyunsaturated fatty acid (n3-PUFA) status that impacts on the anti-inflammatory and insulin sensitizing functions of n3-PUFA. Our objective was to directly compare plant- and marine-based n3-PUFA (α-linoleic acid (ALA)), ...
- Zahradka, Peter C., et al. Show all 4 Authors
- Journal of agricultural and food chemistry 2019 v.67 no.5 pp. 1429-1436
- adverse effects; bioavailability; blood serum; cell membranes; cytotoxicity; enzyme inhibition; enzymes; human cell lines; laboratory animals; oral administration; peptides; rats; toxicity testing; viability
- ... The aim of this work was to determine bioavailability and in vivo calmodulin-dependent-phosphodiesterase (CaMPDE)-inhibitory activity of six flaxseed-protein-derived peptides (AGA, AKLMS, QIAK, RWIQ, QQAKQ, and KQLSTGC) after oral administration to Wistar rats. Initial experiments tested the cytotoxicity and cellular-transport potentials of the peptides using Caco-2 cells. The cytotoxicity assay i ...