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- Author:
- E.D.N.S. Abeyrathne; X. Huang; D.U. Ahn
- Source:
- Poultry science 2018 v.97 no.4 pp. 1462-1468
- ISSN:
- 0032-5791
- Subject:
- antimicrobial properties; antioxidants; avidin; chemical treatment; egg albumen; enzymatic hydrolysis; enzyme inhibition; food processing; functional properties; heat treatment; humans; lysozyme; molecular weight; ovalbumin; ovomucin; pH; peptides; peptidyl-dipeptidase A
- Abstract:
- ... Egg white contains many functionally important proteins: ovalbumin (54%), ovotransferrin (12%), ovomucoid (11%), ovoglobulin (G2 and G3, 8%), ovomucin (3.5%), and lysozyme (3.5%) are major proteins, while ovoinhibitors, ovomacroglobulin, ovoglycoprotein, ovoflavoprotein, thiamine-binding proteins, and avidin are minor proteins present in egg white. These proteins, as well as the peptides derived f ...
- DOI:
- 10.3382/ps/pex399
- https://doi.org/10.3382/ps/pex399
- Author:
- M. Mayer-Pinto; K.A. Dafforn; A.B. Bugnot; T.M. Glasby; E.L. Johnston
- Source:
- Marine environmental research 2018 v.139 pp. 136-143
- ISSN:
- 0141-1136
- Subject:
- Ecklonia radiata; anthropogenic activities; biomechanics; detritus; ecological footprint; environmental impact; estuaries; functional properties; habitats; humans; infrastructure; macroalgae; marine environment; photosynthesis; prediction; reefs; secondary productivity; sublethal effects; urbanization
- Abstract:
- ... Assessments of human impacts on natural habitats often focus on the abundance of component species, yet physiological and/or sub-lethal effects of stressors on functional attributes may be equally important to consider. Here we evaluated how artificial structures, an integral part of urbanisation in the marine environment, affects key functional properties of the habitat-forming kelp Ecklonia radi ...
- DOI:
- 10.1016/j.marenvres.2018.05.004
- https://doi.org/10.1016/j.marenvres.2018.05.004
- Author:
- Aritra Bej; Juhi A. Rasquinha; Sujoy Mukherjee
- Source:
- Biochemistry 2018 v.57 no.44 pp. 6265-6269
- ISSN:
- 1520-4995
- Subject:
- Gibbs free energy; denaturation; entropy; functional properties; humans; molecular dynamics; mutants; mutation; neoplasms; nuclear magnetic resonance spectroscopy; regression analysis; simulation models; therapeutics; tumor suppressor protein p53; urea
- Abstract:
- ... Mutations in the core domain of tumor suppressor protein p53 have been associated with ∼50% of the occurrences of human cancers. A majority of these mutations inactivate p53 function by destabilizing its native structure. Although studies have shown p53’s function can be restored by stabilizing the mutants to their wild-type conformation with immense therapeutic potential, its applicability has be ...
- DOI:
- 10.1021/acs.biochem.8b00740
- https://doi.org/10.1021/acs.biochem.8b00740
- Author:
- Giada Rossignoli; Alessandro Grottesi; Giovanni Bisello; Riccardo Montioli; Carla Borri Voltattorni; Alessandro Paiardini; Mariarita Bertoldi
- Source:
- Biochemistry 2018 v.57 no.44 pp. 6336-6348
- ISSN:
- 1520-4995
- Subject:
- active sites; amino acid sequences; bioactive compounds; bioinformatics; cell growth; cysteine; functional properties; gastrointestinal system; histamine; histidine; histidine decarboxylase; humans; molecular dynamics; oxidation; protein content; pyridoxal; pyridoxal phosphate; reducing agents; simulation models
- Abstract:
- ... Histidine decarboxylase is a pyridoxal 5′-phosphate enzyme catalyzing the conversion of histidine to histamine, a bioactive molecule exerting its role in many modulatory processes. The human enzyme is involved in many physiological functions, such as neurotransmission, gastrointestinal track function, cell growth, and differentiation. Here, we studied the functional properties of the human enzyme ...
- DOI:
- 10.1021/acs.biochem.8b00625
- https://doi.org/10.1021/acs.biochem.8b00625
- Author:
- J. H. Kim; K. J. Gellatly; B. Lueke; M. Kohler; R. Nauen; E. Murenzi; K. S. Yoon; J. M. Clark
- Source:
- Insect molecular biology 2018 v.27 no.1 pp. 73-82
- ISSN:
- 0962-1075
- Subject:
- ABC transporters; Baculoviridae; DDT (pesticide); Pediculus humanus; adenine; cytochrome P-450; evolution; functional properties; genes; humans; insecticides; insects; ivermectin; lice; liquids; metabolism; oocytes; spectral analysis; tritium; xenobiotics
- Abstract:
- ... We previously observed that ivermectin‐induced detoxification genes, including ATP binding cassette transporter C4 (PhABCC4) and cytochrome P450 6CJ1 (CYP6CJ1) were identified from body lice following a brief exposure to a sublethal dose of ivermectin using a non‐invasive induction assay. In this current study, the functional properties of PhABCC4 and CYP6CJ1 were investigated after expression in ...
- DOI:
- 10.1111/imb.12348
- https://doi.org/10.1111/imb.12348
- Author:
- Yanan Zhu; Gemma González-Ortiz; Rufino Jiménez-Díaz; Míriam Pérez-Trujillo; Teodor Parella; Paola López-Colom; Susana María Martín-Orúe
- Source:
- Food & function 2018 v.9 no.7 pp. 3884-3894
- ISSN:
- 2042-650X
- Subject:
- adhesion; arabinose; diarrhea; diet; enterotoxigenic Escherichia coli; exopolysaccharides; fermentation; fermented foods; fermenters; functional properties; galactose; glucose; humans; in vitro studies; intestinal mucosa; nuclear magnetic resonance spectroscopy; olives; pathogens; rhamnose; secondary infection
- Abstract:
- ... This study aims to explore the biological functions of the isolated exopolysaccharides (EPSs) produced during the industrial fermentation of olives against enterotoxigenic E. coli (ETEC) K88. Exopolysaccharides were isolated from five industrial fermenters. Analysis of their monosaccharide composition by GLC revealed that the main components were glucose (27%–50%) and galactose (23%–33%) followed ...
- DOI:
- 10.1039/c8fo00690c
- https://doi.org/10.1039/c8fo00690c
- Author:
- D. Dalügge; S. Remy
- Source:
- Cell 2018 v.175 no.3 pp. 635-637
- ISSN:
- 0092-8674
- Subject:
- dendrites; functional properties; humans; models; rats
- Abstract:
- ... Most functional properties of human dendrites have been inferred from data obtained in model organisms. In this issue, Beaulieu-Laroche et al. record directly from human dendrites of cortical neurons and show that the considerably larger human neurons differ from rat neurons in the way they process synaptic signals. ...
- DOI:
- 10.1016/j.cell.2018.09.052
- https://doi.org/10.1016/j.cell.2018.09.052
- Author:
- Ying Shi; Jianxin Zhao; Lee Kellingray; Hao Zhang; Arjan Narbad; Qixiao Zhai; Wei Chen
- Source:
- Food research international 2018 pp. -
- ISSN:
- 0963-9969
- Subject:
- Lactobacillus casei; Lactobacillus plantarum; carbohydrates; dairy products; duodenal juices; environmental factors; fermented foods; functional properties; genomics; humans; in vitro studies; in vivo studies; intestines; mice; multigene family; sequence analysis; survival rate
- Abstract:
- ... The presence of Lactobacillus strains in dairy products and the intestinal tracts of humans and animals is frequently considered to have beneficial effects on gut health. In this study, five L. plantarum and five L. casei strains from fermented food origin were isolated and compared to characterise their functional properties, including generation time, survival in the gastrointestinal environment ...
- DOI:
- 10.1016/j.foodres.2018.10.064
- https://doi.org/10.1016/j.foodres.2018.10.064
- Author:
- Jesica G. Mild; Lucia R. Fernandez; Odile Gayet; Juan Iovanna; Nelson Dusetti; Martin M. Edreira
- Source:
- Molecular biotechnology 2018 v.60 no.5 pp. 369-379
- ISSN:
- 1073-6085
- Subject:
- Chagas disease; Trypanosoma cruzi; bioluminescence; energy; functional properties; humans; messenger RNA; new drugs; parasites; protein-protein interactions; proteins; public health; screening; South America
- Abstract:
- ... Chagas disease, a parasitic disease caused by Trypanosoma cruzi, is a major public health burden in poor rural populations of Central and South America and a serious emerging threat outside the endemic region, since the number of infections in non-endemic countries continues to rise. In order to develop more efficient anti-trypanosomal treatments to replace the outdated therapies, new molecular ta ...
- DOI:
- 10.1007/s12033-018-0078-3
- https://doi.org/10.1007/s12033-018-0078-3
- Author:
- Mostafa Nasr; Mohamed Farghaly; Tarek Elsaba; Mohamed El-Mokhtar; Radwa Radwan; Mahmoud Elsabahy; Ahmed Abdelkareem; Hussein Fakhry; Noha Mousa
- Source:
- international journal of biochemistry & cell biology 2018 v.105 pp. 84-93
- ISSN:
- 1357-2725
- Subject:
- acetates; acute exposure; antagonists; bone formation; breast neoplasms; carcinogenesis; clinical trials; cytotoxicity; drug therapy; encapsulation; estradiol; females; functional properties; gene overexpression; humans; metastasis; nanoparticles; neoplasm cells; phenotype; progesterone; stem cells; steroid hormones; women
- Abstract:
- ... Female sex steroid hormones have a fundamental role in breast cancer. Meanwhile, current evidence supports the contribution of breast cancer stem cells in carcinogenesis, metastasis, and resistance to cytotoxic chemotherapy. Nevertheless, the interaction between breast cancer stem cells with sex hormones or key hormonal antagonists remains elusive.To investigate the effect of diverse sex hormonal ...
- DOI:
- 10.1016/j.biocel.2018.10.005
- https://doi.org/10.1016/j.biocel.2018.10.005
- Author:
- S. Lalitha Gavya; Neha Arora; Siddhartha Sankar Ghosh
- Source:
- Preparative biochemistry & biotechnology 2018 v.48 no.2 pp. 128-135
- ISSN:
- 1532-2297
- Subject:
- NAD (coenzyme); Western blotting; biomarkers; chromatography; circular dichroism spectroscopy; functional properties; glutathione transferase; humans; lactate dehydrogenase; lactic acid; neoplasms; pH; proteins; temperature
- Abstract:
- ... A paradigm shift toward fusion proteins to render multiple functionalities and applications on a single platform has been incurred in enzyme based diagnosis. Herein, we report development and systematic characterizations of glutathione-S-transferase (GST) and human lactate dehydrogenase A (hLDHA) in a fusion protein (GST–hLDHA) to achieve functional activities of GST and hLDHA simultaneously. The ...
- DOI:
- 10.1080/10826068.2017.1405022
- https://doi.org/10.1080/10826068.2017.1405022
- Author:
- Khaoula Adouni; Hassiba Chahdoura; Habib Mosbah; Celestino Santos-Buelga; Ana M. González-Paramás; María Ciudad-Mulero; Ângela Fernandes; Ricardo C. Calhelha; Patricia Morales; Guido Flamini; Isabel C. F. R. Ferreira; Lotfi Achour
- Source:
- Food & function 2018 v.9 no.3 pp. 1578-1586
- ISSN:
- 2042-650X
- Subject:
- antioxidants; chemical constituents of plants; chromatography; dietary fiber; functional properties; glycerol; human cell lines; humans; in vitro studies; liquids; neoplasm cells; nutrients; nutritive value; shoots; spectrometers; vegetables; wild plants; Tunisia
- Abstract:
- ... The nutritional values and phytochemical composition of young shoots of wild Asparagus stipularis Forssk. from Tunisia were determined in this study. The antioxidant (tested by four different in vitro assays) and antiproliferative properties (against human tumour cell lines) of aqueous and hydroalcoholic extracts of the young shoots were also investigated. The obtained results indicated that the y ...
- DOI:
- 10.1039/c7fo01687e
- https://doi.org/10.1039/c7fo01687e
- Author:
- Andrei Mocan; Cadmiel Moldovan; Gökhan Zengin; Onur Bender; Marcello Locatelli; Mario Simirgiotis; Arzu Atalay; Dan Cristian Vodnar; Sascha Rohn; Gianina Crișan
- Source:
- Food and chemical toxicology 2018 v.115 pp. 414-424
- ISSN:
- 0278-6915
- Subject:
- foods; flavonoids; dietary supplements; risk; dose response; toxicology; enzyme inhibition; cultivars; humans; small fruits; cytotoxicity; spermidine; bioactive compounds; antioxidant activity; antioxidants; oxylipins; Lycium barbarum; kidney cells; phenolic acids; healthy diet; functional properties
- Abstract:
- ... Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of organic acids, phenolic acids, flavonoids, fatty acids ...
- DOI:
- 10.1016/j.fct.2018.01.054
- https://doi.org/10.1016/j.fct.2018.01.054
- Author:
- Weisi Lu; Xuri Li
- Source:
- Cellular and molecular life sciences 2018 v.75 no.5 pp. 859-869
- ISSN:
- 1420-682X
- Subject:
- blood; blood vessels; bone marrow; eye diseases; functional properties; humans; pathophysiology; physiology; signal transduction; smooth muscle; stem cells
- Abstract:
- ... Vascular stem/progenitor cells (VSCs) are an important source of all types of vascular cells needed to build, maintain, repair, and remodel blood vessels. VSCs, therefore, play critical roles in the development, normal physiology, and pathophysiology of numerous diseases. There are four major types of VSCs, including endothelial progenitor cells (EPCs), smooth muscle progenitor cells (SMPCs), peri ...
- DOI:
- 10.1007/s00018-017-2662-2
- https://doi.org/10.1007/s00018-017-2662-2
- Author:
- Irina Rosca; Anca Roxana Petrovici; Dragos Peptanariu; Alina Nicolescu; Gianina Dodi; Mihaela Avadanei; Iuliu Cristian Ivanov; Andra Cristina Bostanaru; Mihai Mares; Diana Ciolacu
- Source:
- International journal of biological macromolecules 2018 v.107 pp. 1765-1772
- ISSN:
- 0141-8130
- Subject:
- Candida albicans; Fourier transform infrared spectroscopy; UHT milk; Weissella confusa; antibacterial properties; biofilm; biosynthesis; culture media; cytotoxicity; dextran; drugs; exopolysaccharides; fermentation; fibroblasts; freeze drying; functional properties; humans; hydrophilicity; lactic acid bacteria; nuclear magnetic resonance spectroscopy; nucleotide sequences; pharmaceutical industry; polymers; ribosomal DNA; sucrose; thermal analysis
- Abstract:
- ... The aim of this study was to monitor the influence of the fermentation conditions on the exopolysaccharides (EPS) biosynthesis. For this, different culture media compositions were tested on an isolated lactic acid bacteria (LAB) strain, identified by 16S rDNA sequence as being Weissella confusa. It was proved that this bacterial strain culture in MRS medium supplemented with 80g/L sucrose and diss ...
- DOI:
- 10.1016/j.ijbiomac.2017.10.048
- https://doi.org/10.1016/j.ijbiomac.2017.10.048
- Author:
- Astrid Borchert; Jacqueline Kalms; Sophia R. Roth; Marlena Rademacher; Andrea Schmidt; Hermann-Georg Holzhutter; Hartmut Kuhn; Patrick Scheerer
- Source:
- Biochimica et biophysica acta 2018 v.1863 no.9 pp. 1095-1107
- ISSN:
- 1388-1981
- Subject:
- Escherichia coli; X-radiation; alcohols; crystal structure; electrophoresis; enzymology; functional properties; genes; glutathione; glutathione peroxidase; humans; hydroperoxides; mice; phospholipid-hydroperoxide glutathione peroxidase; phospholipids; reaction mechanisms; selenium; selenocysteine; selenoproteins; transgenic animals
- Abstract:
- ... Glutathione peroxidases (GPX) are anti-oxidative enzymes that reduce organic and inorganic hydroperoxides to the corresponding alcohols at the expense of reduced glutathione. The human genome involves eight GPX genes and five of them encode for selenocysteine-containing enzymes. Among the human GPX-isoforms, GPX4 is unique since it is capable of reducing complex hydroperoxy ester lipids such as hy ...
- DOI:
- 10.1016/j.bbalip.2018.06.006
- https://doi.org/10.1016/j.bbalip.2018.06.006
- Author:
- Agata Los; Dana Ziuzina; Paula Bourke
- Source:
- Journal of food science 2018 v.83 no.6 pp. 1484-1493
- ISSN:
- 0022-1147
- Subject:
- decontamination; food safety; functional properties; human health; humans; microorganisms; mycotoxins; pesticides; population growth; risk; small cereal grains; staple foods
- Abstract:
- ... Cereal grains are the most important staple foods for mankind worldwide. The constantly increasing annual production and yield is matched by demand for cereals, which is expected to increase drastically along with the global population growth. A critical food safety and quality issue is to minimize the microbiological contamination of grains as it affects cereals both quantitatively and qualitativ ...
- DOI:
- 10.1111/1750-3841.14181
- https://doi.org/10.1111/1750-3841.14181
- Author:
- Thomas E. Kutcher; Graham E. Forrester
- Source:
- Journal of environmental management 2018 v.217 pp. 231-239
- ISSN:
- 0301-4797
- Subject:
- biological assessment; ecosystem management; ecosystems; freshwater; functional properties; habitat destruction; humans; indicator species; indigenous species; introduced species; models; sampling; species abundance; species richness; vegetation; wetlands
- Abstract:
- ... Biological indicators are useful tools for the assessment of ecosystem condition. Multi-metric and multi-taxa indicators may respond to a broader range of disturbances than simpler indicators, but their complexity can make them difficult to interpret, which is critical to indicator utility for ecosystem management. Floristic Quality Assessment (FQA) is an example of a biological assessment approac ...
- DOI:
- 10.1016/j.jenvman.2018.03.093
- https://doi.org/10.1016/j.jenvman.2018.03.093
- Author:
- Jagan Mohan Rao Tingirikari
- Source:
- Food & function 2018 v.9 no.10 pp. 5059-5073
- ISSN:
- 2042-650X
- Subject:
- acids; arabinans; arabinogalactans; bacteria; colon; dietary fiber; food industry; functional properties; gastric juice; humans; hydrolysis; ingredients; intestinal microorganisms; oligosaccharides; pectins; prebiotics
- Abstract:
- ... Diverse human intestinal microbiota are regarded as a prerequisite for a healthy intestine. Commercial prebiotic products have a limited ability to provide microbial diversity in the human gut, because they mostly comprise oligomers of the same monosaccharide residues and a small fraction of them can reach the distal colon. Therefore, the demand for diverse prebiotic ingredients and dietary fibers ...
- DOI:
- 10.1039/c8fo01296b
- https://doi.org/10.1039/c8fo01296b
- Author:
- Serena Viventi; Mirella Dottori
- Source:
- international journal of biochemistry & cell biology 2018 v.100 pp. 61-68
- ISSN:
- 1357-2725
- Subject:
- cell lines; fibroblasts; functional properties; humans; models; muscles; neurodegenerative diseases; pain; peripheral nervous system diseases; rodents; sensory neurons; sensory system; stem cells; temperature; vibration
- Abstract:
- ... Sensory neurons of the dorsal root ganglia (DRG) are the primary responders to stimuli inducing feelings of touch, pain, temperature, vibration, pressure and muscle tension. They consist of multiple subpopulations based on their morphology, molecular and functional properties. Our understanding of DRG sensory neurons has been predominantly driven by rodent studies and using transformed cell lines, ...
- DOI:
- 10.1016/j.biocel.2018.05.005
- https://doi.org/10.1016/j.biocel.2018.05.005
- Author:
- Yasaman Etemadian; Bahareh Shabanpour; Zohreh Ramzanpour; Amir Reza Shaviklo; Moazameh Kordjazi
- Source:
- Journal of aquatic food product technology 2018 v.27 no.2 pp. 219-235
- ISSN:
- 1547-0636
- Subject:
- Fourier transform infrared spectroscopy; Phaeophyceae; absorption; alanine; antibacterial properties; antioxidant activity; arginine; calcium; cellulose; coasts; copper; dietary supplements; drying; essential amino acids; functional properties; humans; iron; isoleucine; leucine; linolenic acid; lysine; macroalgae; magnesium; manganese; methionine; minerals; nutrient content; nutritive value; oleic acid; palmitic acid; phenol; proline; sulfates; superoxide anion; threonine; valine; zinc; Iran
- Abstract:
- ... Sirophysalis trinodis and Polycladia myrica, two brown seaweeds present on the southeast coast of Iran, were evaluated for their nutritional and functional properties after drying. Fourier transform-infrared spectroscopy (FTIR) analysis of crude polysaccharides revealed the characteristic absorption bands of phenol, O–H, C–H, C–O–S, C–O, C=O, C–H groups, and β-glycosidic linkages from cellulose, w ...
- DOI:
- 10.1080/10498850.2018.1424281
- https://doi.org/10.1080/10498850.2018.1424281
- Author:
- Fuyong Li; Andre L.A. Neves; Bibaswan Ghoshal; Le Luo Guan
- Source:
- Journal of dairy science 2018 v.101 no.6 pp. 5605-5618
- ISSN:
- 0022-0302
- Subject:
- DNA; RNA; biochemical pathways; bioinformatics; feed conversion; functional properties; genome; genome mining; humans; metagenomics; methane production; microbial ecology; microbiome; phenotype; phylotype; rumen; rumen fermentation; rumen microorganisms; ruminants; sequence analysis; transcriptome; transcriptomics
- Abstract:
- ... Metagenomics and metatranscriptomics can capture the whole genome and transcriptome repertoire of microorganisms through sequencing total DNA/RNA from various environmental samples, providing both taxonomic and functional information with high resolution. The unique and complex rumen microbial ecosystem is receiving great research attention because the rumen microbiota coevolves with the host and ...
- DOI:
- 10.3168/jds.2017-13356
- https://doi.org/10.3168/jds.2017-13356
- Author:
- Diosangeles Soto Veliz; Jens C. Luoto; Ilari Pulli; Martti Toivakka
- Source:
- Colloids and surfaces 2018 v.167 pp. 239-251
- ISSN:
- 0927-7765
- Subject:
- Fourier transform infrared spectroscopy; Western blotting; adsorption; calcium; calcium carbonate; cell culture; chemical composition; culture media; fibroblasts; fluorescent antibody technique; functional properties; growth retardation; humans; image analysis; minerals; silica; silicates; staining; titanium dioxide; toxicity; transmission electron microscopy; zeta potential
- Abstract:
- ... Minerals are versatile tools utilised to modify and control the physical-chemical and functional properties of substrates. Those properties include ones directing cell fate; thus, minerals can potentially provide a direct and inexpensive method to manipulate cell behaviour. This paper shows how different minerals influence human dermal fibroblast behaviour depending on their properties. Different ...
- DOI:
- 10.1016/j.colsurfb.2018.04.013
- https://doi.org/10.1016/j.colsurfb.2018.04.013
- Author:
- Marie Louise Jahn; Maria Abildgaard Steffensen; Jan Pravsgaard Christensen; Allan Randrup Thomsen
- Source:
- Vaccine 2018 v.36 no.20 pp. 2825-2832
- ISSN:
- 0264-410X
- Subject:
- CD8-positive T-lymphocytes; Listeria monocytogenes; antigens; functional properties; glycoproteins; humans; immunity; longevity; phenotype; phenotypic plasticity; serotypes; vaccination; vaccines
- Abstract:
- ... Defining correlates of T cell mediated protection is important in order to accelerate the development of efficient T cell based vaccines conferring long-term immunity.Extensive studies have provided important insight regarding the characteristics and functional properties of the effector and memory CD8 T cells induced by viral vector based vaccines. However, long-term protection has been difficult ...
- DOI:
- 10.1016/j.vaccine.2018.03.080
- https://doi.org/10.1016/j.vaccine.2018.03.080
- Author:
- Zeinab Heidariyan; Mohammad Hossein Ghanian; Mohsen Ashjari; Zahra Farzaneh; Mostafa Najarasl; Mehran Rezaei Larijani; Abbas Piryaei; Massoud Vosough; Hossein Baharvand
- Source:
- Biomaterials 2018 v.159 pp. 174-188
- ISSN:
- 0142-9612
- Subject:
- animal models; bioreactors; cost effectiveness; functional properties; gene expression; growth factors; humans; liver diseases; microparticles; polylactic acid; stem cells; ultrastructure
- Abstract:
- ... Biomedical application of human pluripotent stem cell-derived hepatocyte-like cells (hPSC-HLCs) relies on efficient large-scale differentiation, which is commonly performed by a suspension culture of three-dimensional (3D) multicellular spheroids in bioreactors. However, this approach requires large amounts of growth factors (GFs) and the need to overcome limited diffusional transport posed by the ...
- DOI:
- 10.1016/j.biomaterials.2018.01.005
- https://doi.org/10.1016/j.biomaterials.2018.01.005
- Author:
- Ahmed Ghannam; Hossam Murad; Marie Jazzara; Adnan Odeh; Abdul Wahab Allaf
- Source:
- International journal of biological macromolecules 2018 v.108 pp. 916-926
- ISSN:
- 0141-8130
- Subject:
- Fourier transform infrared spectroscopy; Laurencia; apoptosis; breast neoplasms; cell viability; cell walls; cytotoxicity; dose response; functional properties; humans; hydrocolloids; lambda-carrageenan; macroalgae; molecular weight; neoplasm cells; nuclear magnetic resonance spectroscopy; therapeutics
- Abstract:
- ... Hydrocolloids from seaweeds (phycocolloids) have interesting functional properties like antiproliferative activity. Marine algae consumptions are linked to law cancer incidences in countries that traditionally consume marine products. In this study, we have investigated water-soluble sulfated polysaccharides isolated from the red seaweed Laurencia papillosa and determined their chemical characteri ...
- DOI:
- 10.1016/j.ijbiomac.2017.11.001
- https://doi.org/10.1016/j.ijbiomac.2017.11.001
- Author:
- Rashmi Parihar; Anupama Rai; Subramaniam Ganesh
- Source:
- Journal of genetics 2018 v.97 no.3 pp. 611-624
- ISSN:
- 0022-1333
- Subject:
- adolescence; animal models; autophagy; biochemical pathways; childhood; cognitive disorders; death; epilepsy; functional properties; genes; genetic disorders; genotype; glycogen; humans; inflammation; neurodegenerative diseases; neurons; patients; phenotype; proteins; proteolysis; seizures; therapeutics; tissues; ubiquitin-protein ligase
- Abstract:
- ... The progressive myoclonic epilepsy of Lafora or Lafora disease (LD) is a neurodegenerative disorder characterized by recurrent seizures and cognitive deficits. With typical onset in the late childhood or early adolescence, the patients show progressive worsening of the disease symptoms, leading to death in about 10 years. It is an autosomal recessive disorder caused by the loss-of-function mutatio ...
- DOI:
- 10.1007/s12041-018-0949-1
- https://doi.org/10.1007/s12041-018-0949-1
28. Multimodal highly fluorescent-magnetic nanoplatform to target transferrin receptors in cancer cells
- Author:
- Paulo E. Cabral Filho; Mariana P. Cabrera; Ana L.C. Cardoso; Otacilio A. Santana; Carlos F.G.C. Geraldes; Beate S. Santos; Maria C. Pedroso de Lima; Giovannia A.L. Pereira; Adriana Fontes
- Source:
- Biochimica et biophysica acta 2018 v.1862 no.12 pp. 2788-2796
- ISSN:
- 0304-4165
- Subject:
- chemical bonding; fluorescence; fluorescence emission spectroscopy; functional properties; human cell lines; humans; in vivo studies; magnetic resonance imaging; nanoparticles; neoplasm cells; neoplasms; quantum dots; receptors; therapeutics; transferrin receptors
- Abstract:
- ... Site-specific multimodal nanoplatforms with fluorescent-magnetic properties have great potential for biological sciences. For this reason, we developed a multimodal nanoprobe (BNPs-Tf), by covalently conjugating an optical-magnetically active bimodal nanosystem, based on quantum dots and iron oxide nanoparticles, with the human holo-transferrin (Tf).The Tf bioconjugation efficiency was evaluated b ...
- DOI:
- 10.1016/j.bbagen.2018.08.014
- https://doi.org/10.1016/j.bbagen.2018.08.014
- Author:
- M. Antonieta Daza Millone; Romina F. Vázquez; Sabina M. Maté; María E. Vela
- Source:
- Colloids and surfaces 2018 v.172 pp. 423-429
- ISSN:
- 0927-7765
- Subject:
- bioactive compounds; biosensors; colloids; dithiothreitol; drugs; erythrocytes; functional properties; gold; humans; lipid bilayers; models; phospholipids; surface plasmon resonance
- Abstract:
- ... Model biomembranes can provide valuable insights into the properties of complex biological membranes. Among several techniques, Surface Plasmon Resonance (SPR) provides a label-free analysis of the interactions of bioactive molecules with biomembranes with an experimental setup that allows mimicking biological environments. Nevertheless, protocols that enable the preparation of stable supported me ...
- DOI:
- 10.1016/j.colsurfb.2018.08.066
- https://doi.org/10.1016/j.colsurfb.2018.08.066
- Author:
- Kundi Yang; Mengyang Xu; Fanyi Zhong; Jiangjiang Zhu
- Source:
- Journal of microbiological methods 2018 v.154 pp. 147-155
- ISSN:
- 0167-7012
- Subject:
- Lactobacillus; data quality; digestive system; functional properties; humans; lactic acid; lactic acid bacteria; metabolites; metabolomics; monitoring; probiotics; spectrometers; sugars
- Abstract:
- ... Lactobacillus, the major genus of lactic acid bacteria group, plays functional roles in the human body, for example, convert sugars to lactic acid. They are the significant microbiota which can be found at a number of human body sites, such as the digestive system, urinary system, and genital system. A number of Lactobacillus species are often used as probiotics and can benefit host health when ad ...
- DOI:
- 10.1016/j.mimet.2018.10.013
- https://doi.org/10.1016/j.mimet.2018.10.013
- Author:
- Shibu Marthandam Asokan; Ting Wang; Wei‐Ting Su; Wan‐Teng Lin
- Source:
- Journal of food biochemistry 2018 v.42 no.6 pp. e12638
- ISSN:
- 0145-8884
- Subject:
- apoptosis; blood serum; cardiomyopathy; diabetes; dietary supplements; functional foods; functional properties; glucose; health services; heart; humans; hyperglycemia; hypertrophy; insulin; islets of Langerhans; liver; low density lipoprotein cholesterol; mice; pro-apoptotic proteins; protective effect; soy protein; soy protein hydrolysates; soybean meal; staining; therapeutics; triacylglycerols
- Abstract:
- ... Various novel therapeutic interventions are evaluated to overcome hypertrophy and apoptosis associated with diabetic cardiomyopathy. In this study, the anti‐apoptotic and anti‐hypertrophic efficiency of a short peptide composed of Val‐His‐Val‐Val (VHVV) from a soy‐protein hydrolysate was investigated against high glucose (HG) challenge. H9c2 cells were challenges with 33 mM of glucose and showed e ...
- DOI:
- 10.1111/jfbc.12638
- https://doi.org/10.1111/jfbc.12638
- Author:
- Lokesh K. Narnoliya; Rajender S. Sangwan; Sudhir P. Singh
- Source:
- Molecular biology reports 2018 v.45 no.3 pp. 315-326
- ISSN:
- 0301-4851
- Subject:
- Pelargonium; active sites; amino acids; antioxidants; ascorbic acid; bioinformatics; biosynthesis; enzymes; essential oils; flavor; functional properties; genes; humans; isoelectric point; medicinal plants; metabolites; molecular models; prediction; tartaric acid; transcriptomics
- Abstract:
- ... Rose-scented geranium (Pelargonium sp.) is widely known as aromatic and medicinal herb, accumulating specialized metabolites of high economic importance, such as essential oils, ascorbic acid, and tartaric acid. Ascorbic acid and tartaric acid are multifunctional metabolites of human value to be used as vital antioxidants and flavor enhancing agents in food products. No information is available re ...
- DOI:
- 10.1007/s11033-018-4164-1
- https://doi.org/10.1007/s11033-018-4164-1