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- Liu, Yuying, et al. Show all 10 Authors
- Biochemical engineering journal 2018 v.131 pp. 77-83
- Colletotrichum; bioavailability; biotransformation; cytotoxicity; drugs; emulsions; experimental design; oils; prasterone
- ... 7α,15α-diOH-Dehydroepiandrosterone (7α,15α-diOH-DHEA) is an important intermediate in the synthesis of steroid pharmaceutical compounds, and can be bioconverted from DHEA by Colletotrichum lini ST-1. A microemulsion system can improve substrate bioavailability and may also minimize DHEA cellular toxicity as cells and substrate are retained in the water and oil phase respectively. In this study, se ...