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1. Antibacterial Cyclic Lipopeptide Enamidonins with an Enamide-Linked Acyl Chain from a Streptomyces Species

Author:
Kim, Seung Min,   et al.   ; Son, Sangkeun; Ko, Sung-Kyun; Kim, Eun; Kim, Gil Soo; Lee, Byeongsan; Ryoo, In-Ja; Kim, Won-Gon; Lee, Jung-Sook; Hong, Young-Soo; Jang, Jae-Hyuk; Ahn, Jong Seog;     Show all 12 Authors
Source:
Journal of natural products 2018 v.81 no.11 pp. 2462-2469
ISSN:
1520-6025
Subject:
Gram-positive bacteria; Staphylococcus aureus; Streptomyces; acetone; amino acids; antibacterial properties; antibiotic resistance; derivatization; linkage groups; lipopeptides; liquid chromatography; mass spectrometry; methicillin; nuclear magnetic resonance spectroscopy; Korean Peninsula
Abstract:
... Three cyclic lipopeptides, including one known (1) and two new (2 and 3) compounds, that possess the rare enamide linkage group were discovered from Streptomyces sp. KCB14A132, an actinobacterium isolated from a soil sample collected from Jeung Island, Korea. The NMR and MS-based characterization showed that they differed in the amino acid residues in the peptide backbone. Application of Marfey’s ...
DOI:
10.1021/acs.jnatprod.8b00497