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- Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
- Life sciences 2018 v.214 pp. 136-144
- DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
- ... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
- Jin-Ha Lee; Bong-Yeon Cho; Seung-Hyun Choi; Tae-Dong Jung; Sun-Il Choi; Jeong-Ho Lim; Ok-Hwan Lee
- Journal of functional foods 2018 v.44 pp. 17-23
- adipocytes; bisphenol A; cell cycle checkpoints; cyclins; diabetes; interphase; lipolysis; mitosis; obesity; phosphorylation; pollutants; risk factors; sulforaphane
- ... Bisphenol A (BPA) may be a critical risk factor for metabolic disorders including obesity and diabetes. Sulforaphane is known to inhibit adipocyte differentiation and induce adipocyte lipolysis. This study sought to investigate the possible effects of sulforaphane on BPA-induced adipocyte differentiation in 3T3-L1 cells. During the preadipocytes differentiation process, sulforaphane suppressed the ...