Publication year rev: 7982-2018 / Subject term: adipocytes

1. 1,25-Dihydroxyvitamin D regulates lipid metabolism and glucose utilization in differentiated 3T3-L1 adipocytes

Author:: Brienna M. Larrick; Kee-Hong Kim; Shawn S. Donkin; Dorothy Teegarden
Source:: Nutrition research 2018 v.58 pp. 72-83
ISSN:: 0271-5317
Subject:: adipocytes; adipose tissue; beta oxidation; gene expression; glucose; glycerol; inflammation; lipogenesis; messenger RNA; metabolic diseases; palmitic acid; pyruvate carboxylase; triacylglycerols; vitamin D
Abstract:: ... It is well established that adipose tissue can both store and metabolize vitamin D. The active form of vitamin D, 1,25 dihydroxyvitamin D [1,25(OH)2D], regulates adipocyte differentiation and inflammation, highlighting the multifaceted role that vitamin D plays in adipose tissue physiology. However, there is limited evidence regarding vitamin D regulation of mature adipocyte lipid metabolism. We h ...
DOI:: 10.1016/j.nutres.2018.07.004
: https://doi.org/10.1016/j.nutres.2018.07.004

2. 5‐Hydroxyferulic acid methyl ester isolated from wasabi leaves inhibits 3T3‐L1 adipocyte differentiation

Author:: Naoki Misawa; Takahiro Hosoya; Shuhei Yoshida; Osamu Sugimoto; Tomoe Yamada‐Kato; Shigenori Kumazawa
Source:: Phytotherapy research 2018 v.32 no.7 pp. 1304-1310
ISSN:: 0951-418X
Subject:: Eutrema japonica; adipocytes; catechol; cytotoxicity; fractionation; gene expression; genes; glucose transporters; leaves; lipids; messenger RNA; moieties; phenylpropanoids; protein synthesis
Abstract:: ... To investigate the compounds present in wasabi leaves (Wasabia japonica Matsumura) that inhibit the adipocyte differentiation, activity‐guided fractionation was performed on these leaves. 5‐Hydroxyferulic acid methyl ester (1: 5‐HFA ester), one of the phenylpropanoids, was isolated from wasabi leaves as a compound that inhibits the adipocyte differentiation. Compound 1 suppressed the intracellular ...
DOI:: 10.1002/ptr.6060
: https://doi.org/10.1002/ptr.6060

3. 7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet

Author:: Giorgio Biasiotto; Isabella Zanella; Federica Predolini; Ivonne Archetti; Moris Cadei; Eugenio Monti; Marcello Luzzani; Barbara Pacchetti; Paola Mozzoni; Roberta Andreoli; Giuseppe De Palma; Federico Serana; Annika Smeds; Diego Di Lorenzo
Source:: British journal of nutrition 2018 v.120 no.7 pp. 751-762
ISSN:: 1475-2662
Subject:: Picea abies; adipocytes; adipogenesis; blood lipids; cholesterol; dietary supplements; epididymis; foods; genes; hepatoma; high fat diet; insulin resistance; insulin secretion; lactones; lignans; liver; low density lipoprotein; males; metabolic syndrome; metabolism; metabolites; mice; models; obesity; oral administration; peroxisome proliferator-activated receptor gamma; sugars
Abstract:: ... 7-Hydroxymatairesinol (7-HMR) is a plant lignan abundant in various concentrations in plant foods. The objective of this study was to test HMRLignan™, a purified form of 7-HMR, and the corresponding Picea abies extract (total extract P. abies; TEP) as dietary supplements on a background of a high-fat diet (HFD)-induced metabolic syndrome in mice and in the 3T3-L1 adipogenesis model. Mice, 3 weeks ...
DOI:: 10.1017/S0007114518001824
PubMed:: 30105962 30105962
: https://doi.org/10.1017/S0007114518001824

4. Inula japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed a High-Fat Diet

Author:: So-Hyun Park; Da-Hye Lee; Min Jung Kim; Jiyun Ahn; Young-Jin Jang; Tae-Youl Ha; Chang Hwa Jung
Source:: Nutrients 2018 v.11 no.1 pp. -
ISSN:: 2072-6643
Subject:: AMP-activated protein kinase; Inula britannica; adipocytes; adipose tissue; antioxidant activity; body fat; body weight changes; enzyme activity; ethanol; exercise; flower extracts; flowers; gene expression; high fat diet; lactones; lipids; liver; luteolin; messenger RNA; mice; muscles; myoblasts; obesity; protein content; China; Japan; Korean Peninsula
Abstract:: ... Inula japonica Thunb. (Asteraceae) is a flowering plant that grows mainly in Korea, Japan, and China and its flower extract has diverse biological effects such as anti-inflammatory and antioxidative activities. However, the effects on obesity and enhancement of endurance capacity have not been explored yet. This study aims to reveal the effects of I. japonica flower ethanol extract (IJE) on obesit ...
DOI:: 10.3390/nu11010017
PubMed:: 30577560
PubMed Central:: PMC6356276
: https://doi.org/10.3390/nu11010017

5. Lactobacillus plantarum Strain Ln4 Attenuates Diet-Induced Obesity, Insulin Resistance, and Changes in Hepatic mRNA Levels Associated with Glucose and Lipid Metabolism

Author:: Eunjung Lee; So-Ra Jung; So-Young Lee; Na-Kyoung Lee; Hyun-Dong Paik; Seong-Il Lim
Source:: Nutrients 2018 v.10 no.5 pp. -
ISSN:: 2072-6643
Subject:: adipocytes; high fat diet; Lactobacillus plantarum; chemokine CCL2; noninsulin-dependent diabetes mellitus; obesity; oral administration; digestive system; C-reactive protein; biomarkers; glucose; cabbage; gene expression; insulin resistance; adipokines; ecosystems; epididymis; messenger RNA; adipose tissue; triacylglycerols; mice; insulin; yogurt; lipid metabolism; kimchi; glucose tolerance; weight gain; cardiovascular diseases; somatomedins; lactic acid bacteria; probiotics; protein content
Abstract:: ... The prevalence of obesity and associated metabolic disorders, including diabetes and cardiovascular disease, is rapidly becoming a severe global health problem. Recent reports have suggested that the alteration of the gut ecosystem through the consumption of probiotics and fermented foods, such as yogurt and Kimchi, can significantly impact obesity and Type 2 diabetes (T2D)-related biomarkers. In ...
DOI:: 10.3390/nu10050643
PubMed:: 29783731
PubMed Central:: PMC5986522
: https://doi.org/10.3390/nu10050643

6. Tetragonia tetragonoides (Pall.) Kuntze (New Zealand Spinach) Prevents Obesity and Hyperuricemia in High-Fat Diet-Induced Obese Mice

Author:: Young-Sil Lee; Seung-Hyung Kim; Heung Joo Yuk; Geung-Joo Lee; Dong-Seon Kim
Source:: Nutrients 2018 v.10 no.8 pp. -
ISSN:: 2072-6643
Subject:: Garcinia gummi-guta; Tetragonia tetragonoides; adipocytes; adiponectin; animal disease models; beta oxidation; blood lipids; body weight changes; digestive system diseases; enzymes; food plants; genes; high fat diet; hyperuricemia; leptin; lipid composition; liver; mice; obesity; proteins; salads; traditional medicine; uric acid; white adipose tissue; xanthine
Abstract:: ... Tetragonia tetragonoides (Pall.) Kuntze, called New Zealand spinach (NZS), is an edible plant used in salad in Western countries and has been used to treat gastrointestinal diseases in traditional medicine. We examined the anti-obesity and anti-hyperuricemic effects of NZS and the underlying mechanisms in high-fat diet (HFD)-induced obese mice. Mice were fed a normal-fat diet (NFD); high-fat diet ...
DOI:: 10.3390/nu10081087
PubMed:: 30110943
PubMed Central:: PMC6116159
: https://doi.org/10.3390/nu10081087

7. A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor

Author:: Francoise A. Gourronc; Larry W. Robertson; Aloysius J. Klingelhutz
Source:: Environmental science and pollution research international 2018 v.25 no.17 pp. 16481-16492
ISSN:: 0944-1344
Subject:: B-lymphocytes; adipocytes; adipogenesis; adipose tissue; environmental factors; genes; humans; hypertrophy; inflammation; noninsulin-dependent diabetes mellitus; persistent organic pollutants; polychlorinated biphenyls; transcription factor NF-kappa B
Abstract:: ... Inflammation in adipose tissue is recognized as a causative factor in the development of type II diabetes. Adipocyte hypertrophy as well as bacterial and environmental factors have been implicated in causing inflammation in mature adipocytes. Exposure to persistent organic pollutants such as polychlorinated biphenyls (PCBs) has been associated with the development of type II diabetes. We show here ...
DOI:: 10.1007/s11356-017-9676-z
PubMed:: 28699004
PubMed Central:: PMC5764822
: https://doi.org/10.1007/s11356-017-9676-z

8. A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes

Author:: Phiwayinkosi V. Dludla; Babalwa Jack; Amsha Viraragavan; Carmen Pheiffer; Rabia Johnson; Johan Louw; Christo J.F. Muller
Source:: Toxicology reports 2018 v.5 pp. 1014-1020
ISSN:: 2214-7500
Subject:: adipocytes; antioxidant activity; apoptosis; cell viability; cytotoxicity; dimethyl sulfoxide; dose response; fluorescence; glutathione; lipid content; membrane potential; mitochondrial membrane; models; necrosis; oxidative stress; reactive oxygen species; solvents; toxicology
Abstract:: ... Dimethyl sulfoxide (DMSO) is an effective solvent and cytoprotectant agent that can induce diverse actions in experimental settings, ranging from metabolic stress to cytotoxic effects depending on the concentration used. Therefore, for the quality of experiments and reproducibility of results it is essential to establish a precise and non-toxic dose of DMSO within a specific cell system. 3T3-L1 ad ...
DOI:: 10.1016/j.toxrep.2018.10.002
: https://doi.org/10.1016/j.toxrep.2018.10.002

9. A high-fat diet increases body fat mass and up-regulates expression of genes related to adipogenesis and inflammation in a genetically lean pig

Author:: Xue-fen Yang; Yue-qin Qiu; Li Wang; Kai-guo Gao; Zong-yong Jiang
Source:: Journal of Zhejiang University 2018 v.19 no.11 pp. 884-894
ISSN:: 1673-1581
Subject:: adipocytes; adipogenesis; adiposity; backfat; beta oxidation; carnitine palmitoyltransferase; diacylglycerol acyltransferase; energy intake; fatty acid-binding proteins; fatty-acid synthase; gene expression; gene expression regulation; genes; high density lipoprotein cholesterol; high fat diet; humans; immune response; inflammation; insulin; leptin; liver; low density lipoprotein cholesterol; messenger RNA; microarray technology; models; obesity; swine; swine feeding; triacylglycerols
Abstract:: ... Because of their physiological similarity to humans, pigs provide an excellent model for the study of obesity. This study evaluated diet-induced adiposity in genetically lean pigs and found that body weight and energy intake did not differ between controls and pigs fed the high-fat (HF) diet for three months. However, fat mass percentage, adipocyte size, concentrations of total cholesterol (TC), t ...
DOI:: 10.1631/jzus.B1700507
PubMed:: 30387338
PubMed Central:: PMC6238112
: https://doi.org/10.1631/jzus.B1700507

10. A long-term maternal diet intervention is necessary to avoid the obesogenic effect of maternal high-fat diet in the offspring

Author:: Huiting Xu; Qiang Fu; Yi Zhou; Chengbin Xue; Patrick Olson; Ernest C. Lynch; Ke K. Zhang; Chaodong Wu; Peter Murano; Lanjing Zhang; Linglin Xie
Source:: Journal of nutritional biochemistry 2018 v.62 pp. 210-220
ISSN:: 0955-2863
Subject:: adipocytes; females; genes; glucose; high fat diet; homeostasis; hypertrophy; insulin; lipogenesis; maternal nutrition; mice; mothers; nutritional intervention; obesity; pregnancy; progeny; weaning; weight control
Abstract:: ... Although a pre-pregnancy dietary intervention is believed to be able to prevent offspring obesity, research evidence is absent. We hypothesize that a long period of pre-pregnancy maternal diet transition from a high-fat (HF) diet to a normal-fat (NF) diet effectively prevents offspring obesity, and this preventive effect is independent of maternal body weight change. In our study, female mice were ...
DOI:: 10.1016/j.jnutbio.2018.09.008
PubMed:: 30316166
PubMed Central:: PMC6263780
CHORUS:: 10.1016/j.jnutbio.2018.09.008
: https://doi.org/10.1016/j.jnutbio.2018.09.008

11. A new cinnamic acid glycoside from roots of Heracleum dissectum

Author:: Zhi-Gang Wang; Jie Mi; Xin-Rui Wang; Ya-Yu Huo; Ya-Jie Peng; Hai-Min Zhang; Yang Gao; Hai-Long Zhang
Source:: Natural product research 2018 v.32 no.2 pp. 133-140
ISSN:: 1478-6427
Subject:: Heracleum dissectum; adipocytes; adipogenesis; chromatography; cinnamic acid; glycosides; mass spectrometry; nuclear magnetic resonance spectroscopy; physicochemical properties; roots; screening; triacylglycerols
Abstract:: ... From the roots of Heracleum dissectum Lebb., one new cinnamic acid glycoside derivative named dissectumoside (1), together with eight known compounds including three phenolics, three phenolic glycosides and two phenylpropanoic glycoside were isolated using various chromatographic methods. Among them compound 2–9 was isolated from the plant for the first time. Their structures were elucidated and i ...
DOI:: 10.1080/14786419.2017.1340285
: https://doi.org/10.1080/14786419.2017.1340285

12. A new indanedione derivative alleviates symptoms of diabetes by modulating RAGE-NF-kappaB pathway in db/db mice

Author:: Gulnaz Khan; Meha Fatima Aftab; Bilquees Bano; Khalid Mohammed Khan; Munazza Murtaza; Sonia Siddiqui; M.Hafizur Rehman; Rizwana Sanaullah Waraich
Source:: Biochemical and biophysical research communications 2018 v.501 no.4 pp. 863-870
ISSN:: 0006-291X
Subject:: adipocytes; adiponectin; advanced glycation end products; age; animal disease models; blood serum; diabetes; glucose; glucose tolerance; glycogen; insulin; insulin receptor substrate proteins; insulin resistance; mechanism of action; mice; mitogen-activated protein kinase; muscle tissues; phosphorylation; reactive oxygen species; serine; transcription factor NF-kappa B
Abstract:: ... Accumulating evidence indicates that a number of tissues are damaged due to build-up of abnormal amount of Advanced Glycation End products (AGEs) in several diseases including diabetes. Currently AGE inhibitors are scarce in clinical use indicating a need for development of new anti-AGE agents. The aim of the current study is to identify the new AGE inhibitors and to decipher their mechanism of ac ...
DOI:: 10.1016/j.bbrc.2018.05.043
: https://doi.org/10.1016/j.bbrc.2018.05.043

13. A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction

Author:: Elizabeth A. Killion; Andrew R. Reeves; Mahmoud A. El Azzouny; Qing-Wu Yan; Defne Surujon; John D. Griffin; Thomas A. Bowman; Chunyan Wang; Nirupa R. Matthan; Eric L. Klett; Dong Kong; John W. Newman; Xianlin Han; Mi-Jeong Lee; Rosalind A. Coleman; Andrew S. Greenberg
Source:: Molecular Metabolism 2018 v.9 no. pp. 43-56
ISSN:: 2212-8778
Subject:: acyl coenzyme A; adipocytes; arachidonic acid; body composition; death; electrodes; energy expenditure; food intake; free fatty acids; glucose tolerance; gonads; high fat diet; inflammation; insulin; insulin resistance; lipid peroxidation; lipidomics; liver; mice; obesity; oxygen consumption; phenotype; phospholipids; quantitative polymerase chain reaction; recombinases; white adipose tissue
Abstract:: ... Objective: Regulation of fatty acid (FA) metabolism is central to adipocyte dysfunction during diet-induced obesity (DIO). Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown. The purpose of our studies was to determine the in vivo role of adipocyte ...
Handle:: 10113/7330886
DOI:: 10.1016/j.molmet.2018.01.012
CHORUS:: 10.1016/j.molmet.2018.01.012
: https://doi.org/10.1016/j.molmet.2018.01.012

14. A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice

Author:: Juliana de Carvalho Marchesin; Larissa Sbaglia Celiberto; Allan Botinhon Orlando; Alexandra Ivo de Medeiros; Roseli Aparecida Pinto; José Antônio Sampaio Zuanon; Luis Carlos Spolidorio; Andrey dos Santos; Maria Pía Taranto; Daniela Cardoso Umbelino Cavallini
Source:: Journal of functional foods 2018 v.48 pp. 302-313
ISSN:: 1756-4646
Subject:: Bacteroidetes; Bifidobacterium longum; Enterococcus faecium; Lactobacillus; adipocytes; animal disease models; body weight changes; high fat diet; interleukin-10; interleukin-6; intestinal microorganisms; mice; obesity; probiotics
Abstract:: ... This work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body weight and inflammatory parameters in diet-induced obese mice. The probiotic group had a lower body weight until 9th week of the study, reduced area and diameter of adipocytes, and showed a significant increase of IL-6 and I ...
DOI:: 10.1016/j.jff.2018.07.010
: https://doi.org/10.1016/j.jff.2018.07.010

15. A system for the expression and release of heterologous proteins from the core of Bacillus subtilis spores

Author:: Mohamed Y H Mohamed; Graham Christie
Source:: FEMS microbiology letters 2018 v.365 no.23 pp. -
ISSN:: 1574-6968
Subject:: Bacillus subtilis; adipocytes; biodegradation; biopharmaceuticals; cell lines; durability; germination; proteins; somatotropin; spores; vaccines
Abstract:: ... Methodologies that exploit the durability of Bacillus subtilis spores by displaying heterologous proteins or antigenic molecules on the spore surface for mucosal vaccine delivery and other applications are well established. Here we extend the concept by engineering spores intended as oral delivery vehicles for therapeutic proteins. The method is exemplified by the expression and deposition of huma ...
DOI:: 10.1093/femsle/fny270
: https://doi.org/10.1093/femsle/fny270

16. AMPK promotes survival and adipogenesis of ischemia-challenged ADSCs in an autophagy-dependent manner

Author:: Chichi Li; Kewei Chen; Minghui Jia; Xi Ding; Zipei Jiang; Liqun Li; Dan Zhang
Source:: Biochimica et biophysica acta 2018 v.1863 no.12 pp. 1498-1510
ISSN:: 1388-1981
Subject:: AMP-activated protein kinase; adipocytes; adipogenesis; adipose tissue; adults; apoptosis; autophagy; energy; metabolism; models; protective effect; rapamycin; receptors; stem cells
Abstract:: ... Some studies have shown that transplanted fat tissues usually cannot survive for long if adipose-derived stem cells (ADSCs) are removed from the tissues in advance. It is more meaningful to explore the mechanism mediating survival and differentiation of ADSCs in the transplanted microenvironment. AMP-activated protein kinase (AMPK) has been shown to be one of the energy receptors that regulate man ...
DOI:: 10.1016/j.bbalip.2018.10.002
: https://doi.org/10.1016/j.bbalip.2018.10.002

17. Acetate alters the process of lipid metabolism in rabbits

Author:: C. Fu; L. Liu; F. Li
Source:: Animal 2018 v.12 no.9 pp. 1895-1902
ISSN:: 1751-732X
Subject:: AMP-activated protein kinase; G-protein coupled receptors; New Zealand White rabbit; acetates; adipocytes; adiponectin; adiponectin receptors; carboxylic ester hydrolases; carnitine palmitoyltransferase; dose response; gene expression; gene expression regulation; glucose; insulin; leptin; leptin receptors; lipid content; lipid metabolism; mitogen-activated protein kinase; peroxisome proliferator-activated receptor gamma; protein content; rabbits; subcutaneous injection; triacylglycerols
Abstract:: ... An experiment was conducted to investigate the effect of acetate treatment on lipid metabolism in rabbits. New Zealand Rabbits (30 days, n=80) randomly received a subcutaneous injection (2 ml/injection) of 0, 0.5, 1.0 or 2.0 g/kg per day body mass acetate (dissolved in saline) for 4 days. Our results showed that acetate induced a dose-dependent decrease in shoulder adipose (P<0.05). Although aceta ...
DOI:: 10.1017/S1751731117003275
PubMed:: 29198236 29198236
: https://doi.org/10.1017/S1751731117003275

18. Activation of bombesin receptor Subtype-3 by [D-Tyr6,β-Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes

Author:: Zaida Moreno-Villegas; Antonio Martín-Duce; César Aparicio; Sergio Portal-Núñez; Raúl Sanz; Samuel A. Mantey; Robert T. Jensen; Oscar Lorenzo; Jesús Egido; Nieves González
Source:: Molecular and cellular endocrinology 2018 v.474 pp. 10-19
ISSN:: 0303-7207
Subject:: adipocytes; adipose tissue; agonists; animal disease models; bombesin receptors; diabetes; gene expression; genes; glucose; homeostasis; humans; insulin; lipogenesis; mitogen-activated protein kinase; mutation; obesity; patients; protein content; protein synthesis; rats; skeletal muscle; therapeutics
Abstract:: ... BRS-3 has an important role in glucose homeostasis. Its expression was reduced in skeletal muscle from obese and/or diabetic patients, and BRS-3 KO-mice developed obesity. In this work, focused on rat/human adipose tissue, BRS-3 gene-expression was lower than normal-levels in hyperlipidemic, type-2-diabetic (T2D), and type-1-diabetic rats and also in obese (OB) and T2D patients. Moreover, BRS-3 pr ...
DOI:: 10.1016/j.mce.2018.01.028
: https://doi.org/10.1016/j.mce.2018.01.028

19. Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis

Author:: Dhite Bayu Nugroho; Koji Ikeda; Kazuaki Kajimoto; Ken-ichi Hirata; Noriaki Emoto
Source:: Biochemical and biophysical research communications 2018 v.504 no.2 pp. 427-433
ISSN:: 0006-291X
Subject:: adipocytes; adipokines; angiogenesis; blood vessels; homeostasis; hypoxia; inflammation; metabolic diseases; mice; nanocarriers; obesity; white adipose tissue
Abstract:: ... Obesity often causes systemic metabolic disorders in close association with adipose tissue dysfunction. Adipose tissue contains well-developed vasculatures, and obesity mediates vascular rarefaction that causes hypoxia and triggers inflammation in adipose tissue. Adipose tissue-derived neuregulin-4 (Nrg4) is an immerging factor that is critically involved in metabolic homeostasis. We recently iden ...
DOI:: 10.1016/j.bbrc.2018.08.197
: https://doi.org/10.1016/j.bbrc.2018.08.197

20. Acute and chronic cold exposure differentially affects the browning of porcine white adipose tissue

Author:: Y. Gao; N. R. Qimuge; J. Qin; R. Cai; X. Li; G. Y. Chu; W. J. Pang; G. S. Yang
Source:: Animal 2018 v.12 no.7 pp. 1435-1441
ISSN:: 1751-732X
Subject:: adipocytes; biogenesis; body temperature; cold; cold stress; genes; heat production; mitochondria; mortality; piglets; proteins; white adipose tissue
Abstract:: ... Piglets are characteristically cold intolerant and thus susceptible to high mortality. However, browning of white adipose tissue (WAT) can induce non-shivering thermogenesis as a potential strategy to facilitate the animal’s response to cold. Whether cold exposure can induce browning of subcutaneous WAT (sWAT) in piglets in a similar manner as it can in humans remains largely unknown. In this stud ...
DOI:: 10.1017/S1751731117002981
PubMed:: 29143709
: https://doi.org/10.1017/S1751731117002981

21. Acute high-intensity interval exercise induces comparable levels of circulating cell-free DNA and Interleukin-6 in obese and normal-weight individuals

Author:: Peter J. Ferrandi; Brandon G. Fico; Michael Whitehurst; Michael C. Zourdos; Fanchen Bao; Katelyn M. Dodge; Alexandra L. Rodriguez; Gabriel Pena; Chun-Jung Huang
Source:: Life sciences 2018 v.202 pp. 161-166
ISSN:: 0024-3205
Subject:: DNA; adipocytes; blood sampling; exercise; inflammation; interleukin-6; lipids; macrophages; males; obesity; oxidative stress
Abstract:: ... Obesity is associated with lipid aggregation in adipocytes and macrophage infiltration, leading to increased oxidative stress and inflammation. Increased cell-free DNA (cfDNA) concentrations have been observed in clinical conditions of systemic inflammation. While the beneficial effects of regular physical activity on the release of circulating cfDNA still remain unknown, acute intense exercise ha ...
DOI:: 10.1016/j.lfs.2018.04.007
: https://doi.org/10.1016/j.lfs.2018.04.007

22. Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice

Author:: Yongyong Hou; Zhiyuan Liu; Zhuo Zuo; Tianchang Gao; Jingqi Fu; Huihui Wang; Yuanyuan Xu; Dianxin Liu; Masayuki Yamamoto; Beibei Zhu; Yiguo Zhang; Melvin E. Andersen; Qiang Zhang; Jingbo Pi
Source:: Biochemical and biophysical research communications 2018 v.503 no.1 pp. 264-270
ISSN:: 0006-291X
Subject:: adipocytes; adipose tissue; energy; genes; homeostasis; hypertrophy; inflammation; insulin resistance; mice
Abstract:: ... The maintenance of healthy adipose tissues is essential for efficient regulation of energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a CNC-bZIP protein, is a master regulator of the cellular adaptive response to stresses. To investigate the role of NFE2L1 in adipocytes, we bred a line of mice with adipocyte-specific Nfe2l1 knockout (Nfe2l1(f)-KO), and f ...
DOI:: 10.1016/j.bbrc.2018.06.013
: https://doi.org/10.1016/j.bbrc.2018.06.013

23. Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in Hypogonadal Men Vary According to Estradiol Levels

Author:: Georgia Colleluori; Lina E. Aguirre; Clifford Qualls; Rui Chen; Nicola Napoli; Dennis T. Villareal; Reina Armamento-Villareal
Source:: Nutrients 2018 v.10 no.9 pp. -
ISSN:: 2072-6643
Subject:: adipocytes; adipose tissue; biopsy; blood serum; dual-energy X-ray absorptiometry; estradiol; estrogen receptors; gene expression; lipolysis; men; messenger RNA; quantitative polymerase chain reaction; testosterone; visceral fat
Abstract:: ... Estradiol (E2), mainly produced from Testosterone (T) in men, promotes visceral lipolysis. However, high visceral fat and hyperestrogenemia are features of obese hypogonadal (HG) men. Our study objectives are to evaluate relationships between circulating E2 and: (1) fat mass; (2) Estrogen Receptor α (ESR1) expression in subcutaneous adipose tissue; (3) changes in body fat after 6 months (M) ...
DOI:: 10.3390/nu10091226
PubMed:: 30181488
PubMed Central:: PMC6164305
: https://doi.org/10.3390/nu10091226

24. Adipogenic genes expression in relation to hepatic steatosis in the liver of two duck species

Author:: F. Hérault; C. Duby; E. Baéza; C. Diot
Source:: Animal 2018 v.12 no.12 pp. 2571-2577
ISSN:: 1751-732X
Subject:: Anas platyrhynchos; Cairina moschata; Pekin; ad libitum feeding; adipocytes; adipogenesis; adiponectin; adipose tissue; animal disease models; biochemical pathways; duck feeding; ducks; fatty acid-binding proteins; fatty liver; gene expression; gene expression regulation; genes; hepatocytes; leptin receptors; lipids; liver; mice; obesity; overfeeding; peroxisome proliferator-activated receptor gamma
Abstract:: ... Some studies have shown that expression of peroxisome proliferator-activated receptor gamma (PPARG), a key regulator of adipogenesis, and of some adipocyte-specific genes or adipokines are expressed in hepatic steatosis, leading to the concept of ‘adipogenic hepatic steatosis’ or ‘hepatic adiposis.’ Most of these studies were conducted in genetic obese mouse models or after manipulation of gene ex ...
DOI:: 10.1017/S1751731118000897
PubMed:: 29720294 29720294
: https://doi.org/10.1017/S1751731118000897

25. Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation

Author:: Wenjun Hu; Zeyuan Ru; Wen Xiao; Zhiyong Xiong; Cheng Wang; Changfei Yuan; Xiaoping Zhang; Hongmei Yang
Source:: Biochemical and biophysical research communications 2018 v.506 no.1 pp. 122-129
ISSN:: 0006-291X
Subject:: adipocytes; adipose tissue; cachexia; enzyme inhibitors; exosomes; lipolysis; lung neoplasms; mice; muscular atrophy; neoplasm cells; skeletal muscle; weight loss
Abstract:: ... Cancer-associated cachexia (CAC) is a disorder characterized by unintended weight loss due to skeletal muscle wasting and adipose tissue loss. Although muscle atrophy in this condition has been well studied, the mechanisms underlying adipose tissue loss, which include browning, have not been investigated in detail. In this respect, though recent studies have shown that exosomes from cancer cells c ...
DOI:: 10.1016/j.bbrc.2018.09.139
: https://doi.org/10.1016/j.bbrc.2018.09.139

26. Adipose tissue complement factor B promotes adipocyte maturation

Author:: Hiroaki Matsunaga; Misaki Iwashita; Takanori Shinjo; Akiko Yamashita; Mitsudai Tsuruta; Shoichiro Nagasaka; Ataru Taniguchi; Mitsuo Fukushima; Naoya Watanabe; Fusanori Nishimura
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 740-748
ISSN:: 0006-291X
Subject:: adipocytes; adipose tissue; coculture; complement; droplets; endotoxins; gene overexpression; genes; immunity; insulin resistance; macrophages; mice; obesity; observational studies; peroxisome proliferator-activated receptors; sterols; transgenic animals
Abstract:: ... It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters. In this study, we investigated the role of adipocyte-derived CfB in adipose tissue metabolism.We investigated the e ...
DOI:: 10.1016/j.bbrc.2017.11.069
: https://doi.org/10.1016/j.bbrc.2017.11.069

27. Adipose-specific expression of mouse Rbp7 gene and its developmental and metabolic changes

Author:: Jinsoo Ahn; Dong-Hwan Kim; Yeunsu Suh; Jeong-Woong Lee; Kichoon Lee
Source:: Gene 2018 v.670 pp. 38-45
ISSN:: 0378-1119
Subject:: acid treatment; adipocytes; adipogenesis; adiposity; alternative splicing; brown adipose tissue; cold stress; diet therapy; gene expression; genes; messenger RNA; mice; protein isoforms; protein synthesis; retinoic acid; retinol-binding protein; reverse transcriptase polymerase chain reaction; trans-splicing; vitamin A
Abstract:: ... Alternative splicing and alternative promoter usage have been shown to have an integral role in creating flexibility in the regulation of gene expression. Previous studies collectively showed that expression of the retinol binding protein 7 (Rbp7) gene was adipose tissue-specific across species. Nevertheless, alternative splicing and alternative promoter usage of the Rbp7 gene in adipose tissue an ...
DOI:: 10.1016/j.gene.2018.05.101
CHORUS:: 10.1016/j.gene.2018.05.101
: https://doi.org/10.1016/j.gene.2018.05.101

28. Aged Oolong Tea Reduces High-Fat Diet-Induced Fat Accumulation and Dyslipidemia by Regulating the AMPK/ACC Signaling Pathway

Author:: Erdong Yuan; Xuefei Duan; Limin Xiang; Jiaoyan Ren; Xingfei Lai; Qiuhua Li; Lingli Sun; Shili Sun
Source:: Nutrients 2018 v.10 no.2 pp. -
ISSN:: 2072-6643
Subject:: Western blotting; adipocytes; beta oxidation; blood chemistry; blood serum; energy expenditure; eosin; epididymis; fatty acids; fatty liver; fatty-acid synthase; hepatocytes; high density lipoprotein cholesterol; high fat diet; hyperlipidemia; immunohistochemistry; inducible nitric oxide synthase; inflammation; low density lipoprotein cholesterol; mice; obesity; oolong tea; phosphorylation; signal transduction; triacylglycerols; tumor necrosis factor-alpha; weight loss
Abstract:: ... While oolong tea (OT) has been shown to induce weight loss and reduce fat accumulation, the mechanisms remain poorly defined, especially for aged OT. In this study, five groups of mice (n = 9/group) were used including a normal diet with vehicle treatment, and a high-fat diet (HFD) with vehicle or the water extracts from aged OTs (EAOTs, three different storage years) by oral gavage at 1000 mg/kg· ...
DOI:: 10.3390/nu10020187
PubMed:: 29419789
PubMed Central:: PMC5852763
: https://doi.org/10.3390/nu10020187

29. Aged black garlic extract regulates lipid metabolism by inhibiting lipogenesis and promoting lipolysis in mature 3T3-L1 adipocytes

Author:: Hajin Nam; Harry Jung; Yooyeon Kim; Boyoung Kim; Kyeong Hee Kim; Sang Jae Park; Jun Gyo Suh
Source:: Food science and biotechnology 2018 v.27 no.2 pp. 575-579
ISSN:: 1226-7708
Subject:: adipocytes; carboxylic ester hydrolases; dose response; garlic; lipogenesis; lipolysis; protein synthesis; proteins; viability
Abstract:: ... As the mechanism of aged black garlic (ABG) extract affecting lipid metabolism in adipocytes remains unclear, this study evaluated the effect of ABG extract on lipid metabolism and the expression of related proteins in mature 3T3-L1 adipocytes. ABG extract treatments at 0, 0.625, 1.25, and 2.5, and 5 mg/mL had no effect on cell morphology or viability in adipocytes. ABG extract suppressed lipogene ...
DOI:: 10.1007/s10068-017-0268-y
PubMed:: 30263782
PubMed Central:: PMC6049635
: https://doi.org/10.1007/s10068-017-0268-y

30. Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1

Author:: Vuong Cat Khanh; Amin Firman Zulkifli; Chiho Tokunaga; Toshiharu Yamashita; Yuji Hiramatsu; Osamu Ohneda
Source:: Biochemical and biophysical research communications 2018 v.500 no.3 pp. 682-690
ISSN:: 0006-291X
Subject:: adipocytes; adipose tissue; cell senescence; elderly; energy; infants; mesenchymal stromal cells; stem cells; therapeutics
Abstract:: ... In the body, different types of adipose tissue perform different functions, with brown and beige adipose tissues playing unique roles in dissipating energy. Throughout life, adipocytes are regenerated from progenitors, and this process is impaired by aging. One of the progenitors of adipocytes are mesenchymal stem cells (MSCs), which have recently become a promising tool for stem cell therapy. How ...
DOI:: 10.1016/j.bbrc.2018.04.136
: https://doi.org/10.1016/j.bbrc.2018.04.136

31. Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model

Author:: Lisa Rein-Fischboeck; Elisabeth M. Haberl; Rebekka Pohl; Verena Schmid; Susanne Feder; Sabrina Krautbauer; Gerhard Liebisch; Christa Buechler
Source:: Biochimica et biophysica acta 2018 v.1863 pp. 526-537
ISSN:: 1388-1981
Subject:: adipocytes; adipose tissue; ceramides; cholesterol; diet; droplets; fatty liver; genes; genotype; immigration; liver; macrophages; malondialdehyde; mice; models; mutants; oxidative stress; pathogenesis; phosphatidylethanolamines; phosphatidylserines; protective effect; proteins; sphingomyelins
Abstract:: ... Adipose tissue dysfunction contributes to the pathogenesis of non-alcoholic steatohepatitis (NASH). The adapter protein alpha-syntrophin (SNTA) is expressed in adipocytes. Knock-down of SNTA increases preadipocyte proliferation and formation of small lipid droplets, which are both characteristics of healthy adipose tissue. To elucidate a potential protective role of SNTA in NASH, SNTA null mice we ...
DOI:: 10.1016/j.bbalip.2018.02.006
: https://doi.org/10.1016/j.bbalip.2018.02.006

32. An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

Author:: Clair Crewe; Nolwenn Joffin; Joseph M. Rutkowski; Min Kim; Fang Zhang; Dwight A. Towler; Ruth Gordillo; Philipp E. Scherer
Source:: Cell 2018 v.175 no.3 pp. 695-708.e13
ISSN:: 0092-8674
Subject:: adipocytes; adipose tissue; animal models; endothelial cells; genes; lipids; obesity; proteins; refeeding; signal transduction
Abstract:: ... We have uncovered the existence of extracellular vesicle (EV)-mediated signaling between cell types within the adipose tissue (AT) proper. This phenomenon became evident in our attempts at generating an adipocyte-specific knockout of caveolin 1 (cav1) protein. Although we effectively ablated the CAV1 gene in adipocytes, cav1 protein remained abundant. With the use of newly generated mouse models, ...
DOI:: 10.1016/j.cell.2018.09.005
PubMed:: 30293865
PubMed Central:: PMC6195477
: https://doi.org/10.1016/j.cell.2018.09.005

33. An ameloblastin C-terminus variant is present in human adipose tissue

Author:: Øystein Stakkestad; Catherine Heyward; Ståle Petter Lyngstadaas; Tirill Medin; Jiri Vondrasek; Aina-Mari Lian; Gita Pezeshki; Janne Elin Reseland
Source:: Heliyon 2018 v.4 no.12 pp. e01075
ISSN:: 2405-8440
Subject:: adipocytes; adipogenesis; adipose tissue; fluorescent antibody technique; humans; leptin; mice; quantitative polymerase chain reaction; transcription (genetics)
Abstract:: ... Transcriptional regulatory elements in the ameloblastin (AMBN) promoter indicate that adipogenesis may influence its expression. The objective here was to investigate if AMBN is expressed in adipose tissue, and have a role during differentiation of adipocytes.AMBN expression was examined in adipose tissue and adipocytes by real-time PCR and ELISA. Distribution of ameloblastin was investigated by i ...
DOI:: 10.1016/j.heliyon.2018.e01075
PubMed:: 30603708
PubMed Central:: PMC6307104
: https://doi.org/10.1016/j.heliyon.2018.e01075

34. Analysis of LncRNA expression in cell differentiation

Author:: Qin Yang; Qi Wan; Letian Zhang; Yibo Li; Pei Zhang; Dong Li; Chao Feng; Fan Yi; Liangren Zhang; Xianfeng Ding; Hua Li; Quan Du
Source:: RNA biology 2018 v.15 no.3 pp. 413-422
ISSN:: 1555-8584
Subject:: adipocytes; cell differentiation; loss-of-function mutation; non-coding RNA
Abstract:: ... Lineage-specific cell differentiation is a precise and coordinated biological process. To explore the roles of long noncoding RNA (lncRNA) in this process, the expression of polyA-minus RNAs was comparatively studied during the course of myocyte and adipocyte differentiation. In addition to identifying thousands of novel lncRNAs, distinct lncRNA profiles were revealed during lineage-specific diffe ...
DOI:: 10.1080/15476286.2018.1441665
PubMed:: 29508657
PubMed Central:: PMC5927722
: https://doi.org/10.1080/15476286.2018.1441665

35. Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds

Author:: Jun Yin; Chang-Seob Seo; In Hyeok Hwang; Min Won Lee; Kwang Hoon Song
Source:: Nutrients 2018 v.10 no.9 pp. -
ISSN:: 2072-6643
Subject:: Lablab purpureus subsp. purpureus; adipocytes; anti-obesity agents; body fat; cell differentiation; fatty acid-binding proteins; fatty-acid synthase; functional foods; high fat diet; messenger RNA; obesity; peroxisome proliferator-activated receptor gamma; protein synthesis; seed extracts; seeds
Abstract:: ... Obesity, a condition where excess body fat accumulates to the extent, causes a negative effect on health. Previously, we reported the extract of Dolichos lablab L. (DLL-Ex) inhibited high-fat diet (HFD)-induced increases in body weight and body fat mass and ameliorated increases in body weight. In the present work, we studyed the molecular mechanism for the inhibitory effect of DLL-Ex or Chikusets ...
DOI:: 10.3390/nu10091221
PubMed:: 30177649
PubMed Central:: PMC6164478
: https://doi.org/10.3390/nu10091221

36. Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1

Author:: Myeong-Gang Heo; Se-Young Choung
Source:: Food & function 2018 v.9 no.9 pp. 4906-4915
ISSN:: 2042-650X
Subject:: AMP-activated protein kinase; Spirulina maxima; adipocytes; adiponectin; animal disease models; blood serum; glucose; green tea; high fat diet; insulin; leptin; lipid composition; lipid peroxidation; lipids; obesity; phenotype; rats; skeletal muscle; tumor necrosis factor-alpha; weight gain; white adipose tissue
Abstract:: ... To evaluate the anti-obesity effect of Spirulina maxima (SM), obese rats fed with a high-fat diet for 6 weeks were orally treated with SM or green tea extract (GTE, positive control) for an additional 4 weeks. The results demonstrated that the administration of SM not only prevented weight gain and reduced the index of white adipose tissues, but also attenuated changes of metabolic parameters in s ...
DOI:: 10.1039/c8fo00986d
: https://doi.org/10.1039/c8fo00986d

37. Antiadipogenic effects of a standardized quassinoids‐enriched fraction and eurycomanone from Eurycoma longifolia

Author:: D. Balan; Kit‐Lam Chan; D. Murugan; Sazaly AbuBakar; Pooi‐Fong Wong
Source:: Phytotherapy research 2018 v.32 no.7 pp. 1332-1345
ISSN:: 0951-418X
Subject:: Eurycoma longifolia; adipocytes; adipogenesis; bioactive compounds; body weight changes; cholesterol; droplets; epididymis; gene expression regulation; glucose; high fat diet; lipolysis; liver; mice; obesity; omentum; rats; transcription factors; triacylglycerols
Abstract:: ... Bioactive compounds of Eurycoma longifolia (EL) jack were previously shown to reduce omentum fat mass and oestradiol‐induced fatty uterine adhesion in rats. However, the exact role of EL on adipogenesis remains unknown. This study sought to investigate the effects of an EL standardized quassinoids‐enriched fraction (SQEL) and the pure compound, eurycomanone, on adipogenesis in 3T3‐L1 preadipocyte ...
DOI:: 10.1002/ptr.6065
: https://doi.org/10.1002/ptr.6065

38. Antiobesity Effect of Prebiotic Polyphenol-Rich Grape Seed Flour Supplemented with Probiotic Kefir-Derived Lactic Acid Bacteria

Author:: Yun-Ju Cho; Hyeon Gyu Lee; Kun-Ho Seo; Wallace Yokoyama; Hyunsook Kim
Source:: Journal of agricultural and food chemistry 2018 v.66 no.47 pp. 12498-12511
ISSN:: 1520-5118
Subject:: adipocytes; adipose tissue; blood lipids; body weight changes; cecum; cellulose; cholesterol; flour; gene expression; genes; glucose; grape seeds; high fat diet; immunologic diseases; inflammasomes; inflammation; insulin; insulin resistance; kefir; lactic acid bacteria; lipid content; liver; metabolic diseases; mice; microarray technology; obesity; oral administration; permeability; prebiotics; probiotics; propionic acid; synergism; weight gain; wine grapes
Abstract:: ... The interaction between prebiotics and probiotics may exert synergistic health benefits. This study investigated the combined effects of polyphenol-rich wine grape seed flour (GSF), a prebiotic, and lactic acid bacteria (LAB) derived from kefir, a probiotic, on obesity-related metabolic disease in high-fat diet (HFD) induced obese (DIO) mice. DIO mice were fed with HFD with 6% microcrystalline cel ...
DOI:: 10.1021/acs.jafc.8b03720
: https://doi.org/10.1021/acs.jafc.8b03720

39. Antiobesity Effect of Tricin, a Methylated Cereal Flavone, in High-Fat-Diet-Induced Obese Mice

Author:: Dabeen Lee; Jee-Young Imm
Source:: Journal of agricultural and food chemistry 2018 v.66 no.38 pp. 9989-9994
ISSN:: 1520-5118
Subject:: adenosine; adipocytes; animal disease models; blood serum; body fat; diacylglycerol acyltransferase; fatty-acid synthase; flavones; glycerol-3-phosphate acyltransferase; high fat diet; liver; long chain fatty acids; methylation; mice; obesity; peroxisome proliferator-activated receptor gamma; protein kinases; stearoyl-CoA desaturase; triacylglycerols
Abstract:: ... The antiobesity potential of tricin, a methylated cereal flavonoid, was examined using a high-fat-diet-induced obese mice model. The body weight (P < 0.01) and body fat mass (P < 0.05) were significantly decreased in the high-dose tricin supplementation group (TH: 200 mg/kg diet) in comparison to the high fat diet control group (CON) after a 12-week feeding trial. The serum (60.9 ± 2.09 mg/dL) and ...
DOI:: 10.1021/acs.jafc.8b03312
: https://doi.org/10.1021/acs.jafc.8b03312

40. Antiobesity Effects of Ginsenoside Rg1 on 3T3-L1 Preadipocytes and High Fat Diet-Induced Obese Mice Mediated by AMPK

Author:: Huimin Liu; Jing Wang; Meihong Liu; Hongyu Zhao; Sanabil Yaqoob; Mingzhu Zheng; Dan Cai; Jingsheng Liu
Source:: Nutrients 2018 v.10 no.7 pp. -
ISSN:: 2072-6643
Subject:: AMP-activated protein kinase; Panax; adipocytes; animal disease models; antioxidants; cardiovascular diseases; cholesterol; diabetes; dose response; droplets; epididymis; genes; ginsenosides; high fat diet; lipid content; lipogenesis; liver; medicinal properties; mice; obesity; phosphorylation; transcription factors; triacylglycerols; white adipose tissue
Abstract:: ... Ginsenosides Rg1 is one of the major pharmacologically active saponins in ginseng, which as an antioxidant reduces oxidative damage in the liver and can also be used to prevent cardiovascular diseases and diabetes. However, there is no research targeting the effect of lipid metabolism in high-fat diet (HFD)-induced mice. In this study, we evaluated the anti-obesity effects of Rg1 in 3T3-L1 adipocy ...
DOI:: 10.3390/nu10070830
PubMed:: 29954059
PubMed Central:: PMC6073290
: https://doi.org/10.3390/nu10070830

41. Antiobesity Effects of Purple Perilla (Perilla frutescens var. acuta) on Adipocyte Differentiation and Mice Fed a High‐fat Diet

Author:: Shalom Sara Thomas; Mina Kim; Seung Je Lee; Youn‐Soo Cha
Source:: Journal of food science 2018 v.83 no.9 pp. 2384-2393
ISSN:: 0022-1147
Subject:: Perilla frutescens var. purpurascens; adipocytes; adipose tissue; beta oxidation; blood lipids; body weight changes; epididymis; fatty acids; functional foods; gene expression; gene expression regulation; genes; high fat diet; lipolysis; liver; medicinal plants; mice; obesity; polyphenols; rosmarinic acid; staining; triacylglycerols
Abstract:: ... Purple perilla (PE) is a medicinal plant that has several health benefits. In this study, the antiobesity effect of PE was studied in 3T3‐L1 preadipocytes and C57BL/6J mice fed high‐fat diets. Triglyceride quantification and Oil Red O staining in matured adipocytes revealed that PE reduced lipid accumulation in differentiated adipocytes by downregulating adipogenic gene and upregulating lipolytic ...
DOI:: 10.1111/1750-3841.14288
: https://doi.org/10.1111/1750-3841.14288

42. Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression

Author:: Yuwen Ting; Wei-Tang Chang; Duen-Kai Shiau; Pei-Hsuan Chou; Mei-Fang Wu; Chin-Lin Hsu
Source:: Journal of agricultural and food chemistry 2018 v.66 no.1 pp. 70-80
ISSN:: 1520-5118
Subject:: Litchi; adipocytes; antioxidant activity; antioxidants; bioactive compounds; blood lipids; blood serum; body composition; disease prevention; enzymes; excretion; feces; flowers; gene expression; high fat diet; histology; lipid composition; lipids; liver; lycopene; obesity; quercetin; rats; taurine; thiobarbituric acid-reactive substances
Abstract:: ... The antiobesity effects of quercetin-rich supplement (QRS), which contain quercetin, lycopene, taurine, and litchi flower extract, on a high-fat diet (HFD)-induced obese rats were investigated. The rats that consume HFD with QRS (185 mg/kg rat) have significantly modulated the final body weights [490 ± 11 (HFD) → 441 ± 11 (HFD+QRS) g], total body fat [112.9 ± 4.5 (HFD) → 86.6 ± 5.7 (HFD+QRS) g], l ...
DOI:: 10.1021/acs.jafc.7b03551
: https://doi.org/10.1021/acs.jafc.7b03551

43. Antioxidant effect, glucose uptake activity in cell lines and cytotoxic potential of Melicope lunu-ankenda leaf extract

Author:: Mizher Hezam AL-Zuaidy; Amin Ismail; Suhaila Mohamed; Ahmad Faizal Abdul Razis; Muhammad Waseem Mumtaz; Azizah Abdul Hamid
Source:: Journal of herbal medicine 2018 v.14 pp. 55-60
ISSN:: 2210-8033
Subject:: Melicope; adipocytes; antineoplastic agents; antioxidant activity; cell lines; cytotoxicity; dose response; fluorescence; glucose; hepatoma; herbal medicines; inhibitory concentration 50; iron; leaf extracts; medicinal plants; phenolic compounds; rutin; tetrazolium
Abstract:: ... The present study describes the antioxidant effect, glucose uptake activity and cytotoxicity of Melicope lunu-ankenda (ML) leaf extract using cell lines. Results of the study revealed that 60% ethanolic ML extract demonstrated the highest antioxidant activity with total phenolics and flavonoid contents of 354 mg GAE/g DW and 313 mg rutin equivalent (RE)/g DW, respectively. Ferric reducing antioxid ...
DOI:: 10.1016/j.hermed.2018.06.002
: https://doi.org/10.1016/j.hermed.2018.06.002

44. Apo-12′-lycopenal, a Lycopene Metabolite, Promotes Adipocyte Differentiation via Peroxisome Proliferator-Activated Receptor γ Activation

Author:: Shingo Takahashi; Naoko Waki; Shinsuke Mohri; Haruya Takahashi; Takeshi Ara; Koichi Aizawa; Hiroyuki Suganuma; Teruo Kawada; Tsuyoshi Goto
Source:: Journal of agricultural and food chemistry 2018 v.66 no.50 pp. 13152-13161
ISSN:: 1520-5118
Subject:: adipocytes; adiponectin; dose response; enzymes; glucose; lipid metabolism; lycopene; messenger RNA; metabolites; peroxisome proliferator-activated receptor gamma; secretion; transcriptional activation
Abstract:: ... Apo-lycopenals, lycopene metabolites produced by an initial cleavage by β,β-carotene-9′,10′-oxygenase, exhibit diverse biologically active effects. In this study, we investigated the effect of apo-lycopenals on the activation of nuclear receptors involved in glucose and lipid metabolism. Only apo-12′-lycopenal exhibited selective and dose-dependent transactivation activity for peroxisome prolifera ...
DOI:: 10.1021/acs.jafc.8b04736
: https://doi.org/10.1021/acs.jafc.8b04736

45. Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice

Author:: Yoon Hee Chung; Joon Seok Bang; Chang Muk Kang; Ji Won Goh; Ho Sung Lee; Seok Myeong Hong; Dong-Seok Kim; Eon Sub Park; Tae Woo Jung; Yong Kyoo Shin; Jong Hyuk Lee; Ji Hoon Jeong
Source:: Journal of medicinal food 2018 v.21 no.10 pp. 999-1008
ISSN:: 1557-7600
Subject:: Humulus japonicus; adipocytes; adipogenesis; alanine transaminase; animal disease models; aspartate transaminase; blood serum; dose response; fat globules; fatty liver; fatty-acid synthase; high fat diet; hyperlipidemia; liver; low density lipoprotein; messenger RNA; obesity; palmitates; staining; stearoyl-CoA desaturase; triacylglycerols; weight gain
Abstract:: ... In this study, the effects of Humulus japonicus (HJ) aqueous extract on 3T3-L1 preadipocytes and HepG2 cells (in vitro model) as well as on C57BL/6 mice fed on high-fat diet (HFD) (in vivo model) were evaluated. Mice fed on HFD for 12-weeks were taken the HJ water extract (HJW) at various doses, 50, 150, and 250 mg/kg, orally for 8 weeks. We have noticed the accumulation of fat globules in preadip ...
DOI:: 10.1089/jmf.2017.4135
: https://doi.org/10.1089/jmf.2017.4135

46. Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity

Author:: Yoon-Young Sung; Dong-Seon Kim; Seung-Hyung Kim; Ho Kyoung Kim
Source:: BMC complementary and alternative medicine 2018 v.18 no.1 pp. 105
ISSN:: 1472-6882
Subject:: AMP-activated protein kinase; Allium fistulosum; Garcinia; Japanese bunching onions; adipocytes; adiponectin; adipose tissue; alternative medicine; anti-obesity agents; blood lipids; blood serum; common cold; conjugated linoleic acid; ferulic acid; functional foods; headache; heart diseases; high fat diet; high performance liquid chromatography; influenza; insulin-like growth factor I; leptin; lipid composition; liver; males; medicinal plants; mice; obesity; oral administration; quercetin; tissue weight; weight control; weight loss
Abstract:: ... BACKGROUND: Allium fistulosum (Welsh onion) is a traditional medicinal plant used for the treatment of colds, influenza, abdominal pain, headache, and heart disease. This study evaluated the effects of A. fistulosum ethanolic extract (AFE) and aqueous extract (AFW) on body weight and other obesity-related parameters. METHODS: Male 8-week-old C57BL/6 J mice were fed either a standard chow diet (nor ...
DOI:: 10.1186/s12906-018-2152-6
PubMed:: 29558911
PubMed Central:: PMC5861601
: https://doi.org/10.1186/s12906-018-2152-6

47. Arginine pretreatment enhances circulating endothelial progenitor cell population and attenuates inflammatory response in high-fat diet–induced obese mice with limb ischemia

Author:: Yu-Fan Kuo; Chiu-Li Yeh; Juey-Ming Shih; Yao-Ming Shih; Sung-Ling Yeh
Source:: Nutrition research 2018 v.53 pp. 67-76
ISSN:: 0271-5317
Subject:: adipocytes; animal disease models; arginine; chemokine CXCL12; dietary energy sources; gene expression regulation; high fat diet; inflammation; interleukin-10; interleukin-1beta; ischemia; leptin; messenger RNA; mice; muscles; obesity; stem cells; tumor necrosis factor-alpha
Abstract:: ... Obesity is a global health problem with an up-regulated inflammatory reaction. Obesity-induced endothelial progenitor cells (EPCs) dysfunction is associated with vascular complications that may contribute to critical limb ischemia. Arginine (Arg) is an amino acid with immune-modulatory property and has been found to promote EPCs mobilization in disease conditions. Thus in the present investigation ...
DOI:: 10.1016/j.nutres.2018.03.010
: https://doi.org/10.1016/j.nutres.2018.03.010

48. Atf3 induction is a therapeutic target for obesity and metabolic diseases

Author:: Suji Kim; No-Joon Song; Gahee Bahn; Seo-Hyuk Chang; Ui Jeong Yun; Jin-Mo Ku; Dong-Gyu Jo; Kye Won Park
Source:: Biochemical and biophysical research communications 2018 v.504 no.4 pp. 903-908
ISSN:: 0006-291X
Subject:: adipocytes; chemical constituents of plants; glucose; glucose tolerance; high fat diet; lipids; metabolic diseases; mice; obesity; therapeutics; transcription factors; weight gain
Abstract:: ... Activating transcription factor 3 (Atf3) has been previously demonstrated to impact obesity and metabolism. However, a metabolic role of Atf3 in mice remains debatable. We investigated the role of Atf3 in mice and further investigated Atf3 expression as a therapeutic target for obesity and metabolic diseases. Atf3 knockout (KO) mice fed with a high fat diet (HFD) aggravated weight gain and impaire ...
DOI:: 10.1016/j.bbrc.2018.09.048
: https://doi.org/10.1016/j.bbrc.2018.09.048

49. Autophagy in turnover of lipid stores: trans-kingdom comparison

Author:: Pernilla H Elander; Elena A Minina; Peter V Bozhkov; Christine Raines
Source:: Journal of experimental botany 2018 v.69 no.6 pp. 1301-1311
ISSN:: 1460-2431
Subject:: adipocytes; animals; autophagy; cell viability; energy; lipids; longevity; physical properties
Abstract:: ... Lipids and their cellular utilization are essential for life. Not only are lipids energy storage molecules, but their diverse structural and physical properties underlie various aspects of eukaryotic biology, such as membrane structure, signalling, and trafficking. In the ever-changing environment of cells, lipids, like other cellular components, are regularly recycled to uphold the housekeeping p ...
DOI:: 10.1093/jxb/erx433
: https://doi.org/10.1093/jxb/erx433

50. BCAA Metabolism and Insulin Sensitivity – Dysregulated by Metabolic Status?

Author:: Nicholas P. Gannon; Jamie K. Schnuck; Roger A. Vaughan
Source:: Molecular nutrition & food research 2018 v.62 no.6 pp. e1700756
ISSN:: 1613-4125
Subject:: adipocytes; amino acids; athletes; cell communication; energy; glucose; hypertrophy; insulin resistance; lean body mass; lipids; mammals; metabolic diseases; mitochondria; models; muscles; phenotype; protein synthesis; skeletal muscle
Abstract:: ... Branched‐chain amino acids (BCAAs) appear to influence several synthetic and catabolic cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most notably known to increase protein synthesis through modulating protein translation, explaining their appeal to resistance and endurance athletes for muscle hypertrophy, expedited recovery, and preservation of lean body mass. In ...
DOI:: 10.1002/mnfr.201700756
: https://doi.org/10.1002/mnfr.201700756

51. BIX-01294 promotes the differentiation of adipose mesenchymal stem cells into adipocytes and neural cells in Arbas Cashmere goats

Author:: Qing Wang; Xiao Wang; Defang Lai; Jin Deng; Zhuang Hou; Hao Liang; Dongjun Liu
Source:: Research in veterinary science 2018 v.119 pp. 9-18
ISSN:: 0034-5288
Subject:: DNA methylation; adipocytes; apoptosis; cell proliferation; chromatin; droplets; gene expression; goats; histones; leptin; lipids; lysine; methyltransferases; stem cells; transcription (genetics)
Abstract:: ... Chromatin remodeling plays an essential role in regulating gene transcription. BIX-01294 is a specific inhibitor of histone methyltransferase G9a, which is responsible for methylation of histone H3 lysine 9 (H3K9) that can also regulate DNA methylation and chromatin remodeling. The purpose of this study was to investigate the effects of BIX-01294 on the potential of goat adipose derived stem cells ...
DOI:: 10.1016/j.rvsc.2018.05.009
: https://doi.org/10.1016/j.rvsc.2018.05.009

52. Beneficial effects of a selected probiotic mixture administered to high fat-fed mice before and after the development of obesity

Author:: Marianna Roselli; Alberto Finamore; Elisa Brasili; Rita Rami; Fabio Nobili; Carla Orsi; Angelo Vittorio Zambrini; Elena Mengheri
Source:: Journal of functional foods 2018 v.45 pp. 321-329
ISSN:: 1756-4646
Subject:: Bifidobacterium animalis subsp. lactis; CD4-positive T-lymphocytes; Lactobacillus rhamnosus; adipocytes; adipose tissue; bacteria; cytokines; dairy products; high fat diet; leptin; lipid composition; macrophages; mice; obesity; probiotics; secretion; weight gain
Abstract:: ... We investigated the efficacy of different probiotics and bacteria used in dairy products to prevent the development of obesity and ameliorate established obesity in C57BL/6J mice fed a high fat diet (HFD). For the preventive efficacy, Lactobacillus rhamnosus GG, L. acidophilus LA1/K8, a mixture of Bifidobacterium lactis Bi1, B. breve Bbr8 and B. breve BL10 (B. mix), or a mixture of L. bulgaricus L ...
DOI:: 10.1016/j.jff.2018.03.039
: https://doi.org/10.1016/j.jff.2018.03.039

53. Benzyl isothiocyanate ameliorates lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation

Author:: Ying Liang; Ikumi Sasaki; Yuki Takeda; Beiwei Zhu; Shintaro Munemasa; Toshiyuki Nakamura; Yoshiyuki Murata; Yoshimasa Nakamura
Source:: Bioscience, biotechnology, and biochemistry 2018 v.82 no.12 pp. 2130-2139
ISSN:: 1347-6947
Subject:: 2-deoxyglucose; AMP-activated protein kinase; Brassicaceae; adipocytes; benzyl isothiocyanate; biotechnology; calves; fetal bovine serum; gene expression; glucose; glucose transporters; lactate dehydrogenase; lipids; mitogen-activated protein kinase; phosphorylation
Abstract:: ... Benzyl isothiocyanate (BITC) is an organosulfur compound derived from cruciferous vegetables and papaya seeds. In this study, we investigated the effect of BITC on the lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation. The treatment of BITC during the differentiation-inducing stage significantly ameliorated the lipid accumulation, whereas it had no inhibitory effect durin ...
DOI:: 10.1080/09168451.2018.1514247
: https://doi.org/10.1080/09168451.2018.1514247

54. Bioassay-guided purification of Lippia citriodora polyphenols with AMPK modulatory activity

Author:: María de la Luz Cádiz-Gurrea; Mariló Olivares-Vicente; María Herranz-López; David Arraez-Roman; Salvador Fernández-Arroyo; Vicente Micol; Antonio Segura-Carretero
Source:: Journal of functional foods 2018 v.46 pp. 514-520
ISSN:: 1756-4646
Subject:: AMP-activated protein kinase; Aloysia citrodora; adipocytes; enzyme activity; flavonoids; fluorescence microscopy; ionization; iridoids; models; nutrients; polyphenols; purification methods; reversed-phase high performance liquid chromatography; verbascoside
Abstract:: ... Recently, the relationship between nutrients and health is becoming since natural dietary products as polyphenols are being considered by their potential for the management of several diseases. We aimed to investigate the capacity of Lippia citriodora compounds to modulate AMP-activated protein kinase activity (AMPK) on a hypertrophic adipocyte model. HPLC semi-preparative purification method and ...
DOI:: 10.1016/j.jff.2018.05.026
: https://doi.org/10.1016/j.jff.2018.05.026

55. Biological effects of adipocytes in sulfur mustard induced toxicity

Author:: Hua Xu; Zhongcai Gao; Peng Wang; Bin Xu; Yajiao Zhang; Long Long; Cheng Zong; Lei Guo; Weijian Jiang; Qinong Ye; Lili Wang; Jianwei Xie
Source:: Toxicology 2018 v.393 pp. 140-149
ISSN:: 0300-483X
Subject:: adipocytes; adipokines; adipose tissue; adverse effects; antidotes; blood serum; coculture; dose response; enzyme-linked immunosorbent assay; in vivo studies; inflammation; messenger RNA; models; poisoning; rats; reverse transcriptase polymerase chain reaction; sulfides; toxicity
Abstract:: ... Sulphur mustard (2,2′-dichloroethyl sulfide; SM) is a vesicant chemical warfare agent whose mechanism of acute or chronic action is not known with any certainty and to date there is no effective antidote. SM accumulation in adipose tissue (AT) has been originally verified in our previous study. To evaluate the biological effect caused by the presence of abundant SM in adipocyte and assess the biol ...
DOI:: 10.1016/j.tox.2017.11.011
: https://doi.org/10.1016/j.tox.2017.11.011

56. Bioprospection of immature salivary glands of Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae)

Author:: Ronaldo Roberto Tait Caleffe; Stefany Rodrigues de Oliveira; Adriana Aparecida Sinópolis Gigliolli; Maria Claudia Colla Ruvolo-Takasusuki; Helio Conte
Source:: Micron 2018 v.112 pp. 55-62
ISSN:: 0968-4328
Subject:: Chrysomya megacephala; adipocytes; disinfection; electrophoresis; histology; instars; larvae; microvilli; mitochondria; molecular weight; mouth; protein content; protein synthesis; proteins; proteolysis; ribosomes; rough endoplasmic reticulum; salivary glands; secretion; secretory granules; ultrastructure; vacuoles
Abstract:: ... Larval therapy (LT) comprises the application of sterile Calliphoridae larvae for wound debridement, disinfection, and healing in humans and animals. Larval digestion plays a key role in LT, where the salivary glands and gut produce and secrete proteolytic and antimicrobial substances. The objective of this work was to bioprospect the salivary glands of Chrysomya megacephala (Fabricius, 1794) larv ...
DOI:: 10.1016/j.micron.2018.06.007
: https://doi.org/10.1016/j.micron.2018.06.007

57. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:: Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
Source:: Life sciences 2018 v.214 pp. 136-144
ISSN:: 0024-3205
Subject:: DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:: ... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:: 10.1016/j.lfs.2018.10.044
: https://doi.org/10.1016/j.lfs.2018.10.044

58. Bta-miR-130a/b regulates preadipocyte differentiation by targeting PPARG and CYP2U1 in beef cattle

Author:: Xueyao Ma; Dawei Wei; Gong Cheng; Shijun Li; Li Wang; Yaning Wang; Xiaoyu Wang; Song Zhang; Hongbao Wang; Linsen Zan
Source:: Molecular and cellular probes 2018 v.42 pp. 10-17
ISSN:: 0890-8508
Subject:: 3' untranslated regions; Western blotting; adipocytes; adipogenesis; beef; beef carcasses; beef cattle; beef quality; biosynthesis; carcass quality; droplets; gene overexpression; genes; intramuscular fat; luciferase; microRNA; milk fat; muscles; non-coding RNA; peroxisome proliferator-activated receptor gamma; quantitative polymerase chain reaction; triacylglycerols
Abstract:: ... Deposition of intramuscular fat (IMF) is one of the most important traits for the evaluation of beef carcass quality grade. MicroRNA (miRNA) is an endogenous non-coding RNA that can play a role in the post-transcriptional regulation of mammalian preadipocyte differentiation. Previously, we identified that bta-miR-130a regulates milk fat biosynthesis by targeting PPARG mRNA. However, the role of mi ...
DOI:: 10.1016/j.mcp.2018.10.002
: https://doi.org/10.1016/j.mcp.2018.10.002

59. Caffeic Acid Phenethyl Ester Improves Metabolic Syndrome by Activating PPAR‐γ and Inducing Adipose Tissue Remodeling in Diet‐Induced Obese Mice

Author:: Soon‐Hee Kim; Hee‐Sook Park; Moon Ju Hong; Haeng Jeon Hur; Dae Young Kwon; Myung‐Sunny Kim
Source:: Molecular nutrition & food research 2018 v.62 no.10 pp. e1700701
ISSN:: 1613-4125
Subject:: adipocytes; adipogenesis; adipokines; adipose tissue; angiogenesis; animal disease models; bioactive compounds; blood lipids; caffeic acid; fatty liver; high fat diet; honey bees; hyperlipidemia; hypoxia; inflammation; insulin resistance; metabolic syndrome; mice; obesity; secretion
Abstract:: ... SCOPE: This study investigated the effects of caffeic acid phenethyl ester (CAPE), a bioactive component of honeybee hives, on the prevention and treatment of metabolic syndrome (MetS) by comparing the efficacy of CAPE intake at the beginning of obesity and after obesity. The functional mechanism of CAPE was also investigated. METHODS AND RESULTS: C57BL/6 mice were fed a high‐fat diet (HFD) contai ...
DOI:: 10.1002/mnfr.201700701
: https://doi.org/10.1002/mnfr.201700701

60. Capsaicin in Metabolic Syndrome

Author:: Sunil K. Panchal; Edward Bliss; Lindsay Brown
Source:: Nutrients 2018 v.10 no.5 pp. -
ISSN:: 2072-6643
Subject:: AMP-activated protein kinase; adipocytes; agonists; body fat; capsaicin; cardiovascular diseases; fatty liver; glucagon-like peptide 1; heart; insulin resistance; lipid metabolism; liver function; metabolic syndrome; noninsulin-dependent diabetes mellitus; obesity; peroxisome proliferator-activated receptor alpha; tissues; transient receptor potential vanilloid channels
Abstract:: ... Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1). TRPV1 is present on many metabolically active tissues, making it a potentially relevant target for metabolic interventions. Insulin resistance and obesity, being the major components of metabolic syndrome, increase the risk for the development of cardiovascular disease, typ ...
DOI:: 10.3390/nu10050630
PubMed:: 29772784
PubMed Central:: PMC5986509
: https://doi.org/10.3390/nu10050630

61. Carnosic Acid Modulates Increased Hepatic Lipogenesis and Adipocytes Differentiation in Ovariectomized Mice Fed Normal or High-Fat Diets

Author:: Yoon-Hee Lee; Whasun Lim; Mi-Kyung Sung
Source:: Nutrients 2018 v.10 no.12 pp. -
ISSN:: 2072-6643
Subject:: abdominal fat; adipocytes; adipose tissue; blood serum; cardiovascular diseases; estradiol; gene expression regulation; high fat diet; insulin; interleukin-6; leptin; lipogenesis; lipoprotein lipase; liver; messenger RNA; mice; nutritional intervention; obesity; ovariectomy; peroxisome proliferator-activated receptor gamma; postmenopause; triacylglycerols; tumor necrosis factor-alpha; uterus; women
Abstract:: ... As postmenopausal women experience a rapid increase in cardiovascular disease (CVD) risk with an increase in abdominal fat, dietary interventions to reduce CVD risk have been emphasized. This study was aimed at investigating the effect of a high-fat diet (HFD) in combination with an ovariectomy on liver and adipose tissue fat metabolism. The efficacy of carnosic acid (CA) supplementation in the su ...
DOI:: 10.3390/nu10121984
PubMed:: 30558262
PubMed Central:: PMC6315337
: https://doi.org/10.3390/nu10121984

62. Catechin supplemented in a FOS diet induces weight loss by altering cecal microbiota and gene expression of colonic epithelial cells

Author:: Jianming LuoAuthors contributed equally to this work.; Lulu Han; Liu Liu; Lijuan Gao; Bin Xue; Yong Wang; Shiyi Ou; Michael Miller; Xichun Peng
Source:: Food & function 2018 v.9 no.5 pp. 2962-2969
ISSN:: 2042-650X
Subject:: Lachnospira; Oscillospira; Peptococcaceae; Phascolarctobacterium; Prevotella; Ruminococcus; adipocytes; animal disease models; bacteria; body weight changes; catechin; colon; energy metabolism; epithelial cells; epithelium; food intake; gene expression; gene expression regulation; genes; intestinal absorption; intestinal microorganisms; lipolysis; obesity; oral administration; rats; weight loss
Abstract:: ... Our previous study showed that catechin controlled rats’ body weights and changed gut microbiota composition when supplemented into a high-fructo-oligosaccharide (FOS) diet. This experiment is devised to further confirm the relationship between specific bacteria in the colon and body weight gain, and to investigate how specific bacteria impact body weight by changing the expression of colonic epit ...
DOI:: 10.1039/c8fo00035b
: https://doi.org/10.1039/c8fo00035b

63. Causes and mechanisms of adipocyte enlargement and adipose expansion

Author:: F. Haczeyni; K. S. Bell‐Anderson; G. C. Farrell
Source:: Obesity reviews 2018 v.19 no.3 pp. 406-420
ISSN:: 1467-7881
Subject:: adipocytes; adipose tissue; blood glucose; cholesterol metabolism; diabetes; energy; fatty acids; fatty liver; homeostasis; hyperplasia; metabolic syndrome; overeating; phenotype; toxicity
Abstract:: ... Adipose tissue plays a significant role in whole body energy homeostasis. Obesity‐associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress and dysfunction. Genetic predisposition, overeating and physical inactivity influence the expansion of adipose tissues. Under conditions of constant energy surplus, adipocytes become hypertrophic and adipose tissues undergo h ...
DOI:: 10.1111/obr.12646
: https://doi.org/10.1111/obr.12646

64. Caveolar targeting links Kv1.3 with the insulin-dependent adipocyte physiology

Author:: Mireia Pérez-Verdaguer; Jesusa Capera; María Ortego-Domínguez; Joanna Bielanska; Núria Comes; Rafael J. Montoro; Marta Camps; Antonio Felipe
Source:: Cellular and molecular life sciences 2018 v.75 no.21 pp. 4059-4075
ISSN:: 1420-682X
Subject:: adipocytes; adipogenesis; cell lines; glucose; humans; insulin; insulin resistance; lipids; noninsulin-dependent diabetes mellitus; obesity; phenotype; phosphorylation; potassium channels; rodents; weight gain; white adipose tissue
Abstract:: ... The voltage-dependent potassium channel Kv1.3 participates in peripheral insulin sensitivity. Genetic ablation of Kv1.3 triggers resistance to diet-induced weight gain, thereby pointing to this protein as a pharmacological target for obesity and associated type II diabetes. However, this role is under intense debate because Kv1.3 expression in adipose tissue raises controversy. We demonstrated tha ...
DOI:: 10.1007/s00018-018-2851-7
: https://doi.org/10.1007/s00018-018-2851-7

65. Characterization and in vitro evaluation of seaweed species as potential functional ingredients to ameliorate metabolic syndrome

Author:: Daniel Rico; Ana Belén Martín Diana; Iñaki Milton-Laskibar; Alfredo Fernández-Quintela; Jose Manuel Silván; Dilip K. Rai; Alka Choudhary; Elena Peñas; Daniel Antonio de Luis; Cristina Martínez-Villaluenga
Source:: Journal of functional foods 2018 v.46 pp. 185-194
ISSN:: 1756-4646
Subject:: Himanthalia elongata; Palmaria palmata; Ulva; adipocytes; antioxidant activity; functional foods; in vitro studies; ingredients; inhibitory concentration 50; macroalgae; macrophages; mannitol; mass spectrometry; metabolic syndrome; prostaglandins; triacylglycerols; xylitol
Abstract:: ... This study aimed at identifying seaweed species with optimal characteristics to develop multifunctional foods for metabolic syndrome (MetS) management. Mass spectrometry chemical characterization and bioactive profile evaluation of methanolic extracts from seven commonly consumed seaweeds were compared. Monomeric sugars namely mannitol, fucitol, xylitol and their sulphated analogs as well as lipid ...
DOI:: 10.1016/j.jff.2018.05.010
: https://doi.org/10.1016/j.jff.2018.05.010

66. Chemical Characterization of Novel Natural Products from the Roots of Asian Rice (Oryza sativa) that Control Adipocyte and Osteoblast Differentiation

Author:: Hee Rae Kang; Hyung Sik Yun; Tae Kyoung Lee; Seulah Lee; Seon-Hee Kim; Eunjung Moon; Ki-Moon Park; Ki Hyun Kim
Source:: Journal of agricultural and food chemistry 2018 v.66 no.11 pp. 2677-2684
ISSN:: 1520-5118
Subject:: Oryza sativa; adipocytes; adipogenesis; chemical analysis; circular dichroism spectroscopy; ethanol; fever; fractionation; human cell lines; humans; lignans; lungs; mass spectrometry; metabolites; nuclear magnetic resonance spectroscopy; osteoblasts; peroxisome proliferator-activated receptors; protocols; roots; spectral analysis; staple foods; stem cells; stomach; vomiting
Abstract:: ... Oryza sativa L. is consumed globally as a staple food, and its roots have been used as a Korean and Chinese medical supplement for protection of the stomach and lungs and for amelioration of vomiting and fever. In our continuing search for biologically effective metabolites from Korean natural materials, we found that an EtOH extract of O. sativa root reciprocally regulated adipocyte and osteoblas ...
DOI:: 10.1021/acs.jafc.7b05030
: https://doi.org/10.1021/acs.jafc.7b05030

67. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice

Author:: Junping Zheng; Xubing Yuan; Gong Cheng; Siming Jiao; Cui Feng; Xiaoming Zhao; Heng Yin; Yuguang Du; Hongtao Liu
Source:: Carbohydrate polymers 2018 v.190 pp. 77-86
ISSN:: 0144-8617
Subject:: Helicobacter; adipocytes; animal disease models; bacteria; biochemical pathways; blood glucose; chitosan; diabetes mellitus; digestive system; dysbiosis; glucose; hyperglycemia; hyperlipidemia; inflammation; insulin resistance; intestinal microorganisms; lipogenesis; mice; occludins; oligosaccharides; white adipose tissue
Abstract:: ... The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P < 0.01) and reversed the insulin resistance (P < 0.05) in db/db mice, which was accompanied by suppressing the inflammation medi ...
DOI:: 10.1016/j.carbpol.2018.02.058
: https://doi.org/10.1016/j.carbpol.2018.02.058

68. Chlamydia pneumoniae exploits adipocyte lipid chaperone FABP4 to facilitate fat mobilization and intracellular growth in murine adipocytes

Author:: Nirwana Fitriani Walenna; Yusuke Kurihara; Bin Chou; Kazunari Ishii; Toshinori Soejima; Ryota Itoh; Akinori Shimizu; Takeshi Ichinohe; Kenji Hiromatsu
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 353-359
ISSN:: 0006-291X
Subject:: Chlamydophila pneumoniae; adenosine triphosphate; adipocytes; animal models; atherosclerosis; bacterial infections; beta oxidation; carboxylic ester hydrolases; energy; fatty acid-binding proteins; free fatty acids; genetic engineering; lipids; lipolysis; macrophages; mice; microbial growth; nutrients; pathogenesis; pathogens
Abstract:: ... Fatty acid-binding protein 4 (FABP4), a cytosolic lipid chaperone predominantly expressed in adipocytes and macrophages, modulates lipid fluxes, trafficking, signaling, and metabolism. Recent studies have demonstrated that FABP4 regulates metabolic and inflammatory pathways, and in mouse models its inhibition can improve type 2 diabetes mellitus and atherosclerosis. However, the role of FABP4 in b ...
DOI:: 10.1016/j.bbrc.2017.11.005
: https://doi.org/10.1016/j.bbrc.2017.11.005

69. Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice

Author:: Na-Hyun Kim; Jonghwan Jegal; Yun Na Kim; Jeong-Doo Heo; Jung-Rae Rho; Min Hye Yang; Eun Ju Jeong
Source:: Nutrients 2018 v.10 no.11 pp. -
ISSN:: 2072-6643
Subject:: Aronia melanocarpa; adipocytes; adipogenesis; amygdalin; animal disease models; binding proteins; blood serum; fatty-acid synthase; fruit extracts; high fat diet; insulin resistance; low density lipoprotein cholesterol; methanol; mice; obesity; peroxisome proliferator-activated receptor gamma; phytochemicals; polyphenols; prunasin; small fruits; triacylglycerols
Abstract:: ... Berries of Aronia melanocarpa (chokeberry) are known to be a rich source of biologically active polyphenols. In the present study, the effects of seven anti-adipogenic polyphenolic phytochemicals isolated from A. melanocarpa methanol extract on adipogenic transcription factors were investigated. Amygdalin and prunasin were found to inhibit 3T3-L1 adipocyte differentiation by suppressing the expres ...
DOI:: 10.3390/nu10111734
PubMed:: 30424495
PubMed Central:: PMC6266992
: https://doi.org/10.3390/nu10111734

70. Chungkookjang with High Contents of Poly-γ-Glutamic Acid Improves Insulin Sensitizing Activity in Adipocytes and Neuronal Cells

Author:: Seong-Yeop Jeong; Do Yeon Jeong; Da Sol Kim; Sunmin Park
Source:: Nutrients 2018 v.10 no.11 pp. -
ISSN:: 2072-6643
Subject:: Bacillus amyloliquefaciens; Bacillus subtilis; acetyl-CoA carboxylase; adipocytes; brain; cell proliferation; cell viability; ethanol; fatty-acid synthase; gene expression; glucose; insulin; insulin resistance; insulin secretion; nerve growth factor; neurons; noninsulin-dependent diabetes mellitus; peroxisome proliferator-activated receptor gamma; polyglutamic acid; soybeans; triacylglycerols; tumor necrosis factor-alpha
Abstract:: ... We hypothesized that soybeans fermented with Bacillus spp. for 48 h (chungkookjang) would be rich in poly-γ-glutamate (γ-PGA) and would have greater efficacy for improving insulin sensitivity and insulin secretion in 3T3-L1 adipocytes, min6 cells, and PC12 neuronal cells. We screened 20 different strains of B. subtillus and B. amyloliquefaciens spp. for γ-polyglutamate (PGA) prod ...
DOI:: 10.3390/nu10111588
PubMed:: 30380669
PubMed Central:: PMC6266770
: https://doi.org/10.3390/nu10111588

71. Cissus quadrangularis extract (CQR-300) inhibits lipid accumulation by downregulating adipogenesis and lipogenesis in 3T3-L1 cells

Author:: Hae Jin Lee; Bao Le; Dong-Ryung Lee; Bong-Keun Choi; Seung Hwan Yang
Source:: Toxicology reports 2018 v.5 pp. 608-614
ISSN:: 2214-7500
Subject:: Cissus quadrangularis; Western blotting; acetyl-CoA carboxylase; adipocytes; adipogenesis; anti-obesity effects; cytotoxicity; fatty acids; fatty-acid synthase; gene expression; lipogenesis; lipoprotein lipase; quantitative polymerase chain reaction; stearoyl-CoA desaturase; sterols; toxicology
Abstract:: ... The objective of this study was to evaluate the anti-obesity activity and the action mechanism of Cissus quadrangularis extracts (CQR-300) in 3T3-L1 adipocytes. Cissus quadrangularis was extracted with hot water, resulting in CQR-300. The anti-obesity activity of CQR-300 in 3T3-L1 adipocytes was examined by Oil-red O staining. Possible mechanisms of CQR-300 in 3T3-L1 adipocytes were determined by ...
DOI:: 10.1016/j.toxrep.2018.02.008
: https://doi.org/10.1016/j.toxrep.2018.02.008

72. Citrus peel extracts attenuated obesity and modulated gut microbiota in mice with high-fat diet-induced obesity

Author:: Yen-Chen Tung; Wei-Tien Chang; Shiming Li; Jia-Ching Wu; Vladimir Badmeav; Chi-Tang Ho; Min-Hsiung Pan
Source:: Food & function 2018 v.9 no.6 pp. 3363-3373
ISSN:: 2042-650X
Subject:: Prevotella; adipocytes; adipose tissue; bacteria; binding proteins; citrus peels; droplets; high fat diet; in vivo studies; intestinal microorganisms; lipid content; mice; obesity; polymethoxyflavones; sterols; supercritical fluid extraction; tissue weight
Abstract:: ... Polymethoxyflavones (PMFs) and hydroxyl PMFs (HOPMFs) are mainly found in citrus peel and have shown anti-obesity potential in in vitro and in vivo studies. Herein, we have investigated the anti-obesity effects of two citrus peel extracts obtained via supercritical fluid extraction: PMF A, with a lower content of PMFs and HOPMFs, and PMF B, with a higher content of PMFs and HOPMFs. PMF A and PMF B ...
DOI:: 10.1039/c7fo02066j
: https://doi.org/10.1039/c7fo02066j

73. Co-transplantation of exosomes derived from hypoxia-preconditioned adipose mesenchymal stem cells promotes neovascularization and graft survival in fat grafting

Author:: Yu-di Han; Yun Bai; Xin-long Yan; Jing Ren; Quan Zeng; Xiao-dong Li; Xue-tao Pei; Yan Han
Source:: Biochemical and biophysical research communications 2018 v.497 no.1 pp. 305-312
ISSN:: 0006-291X
Subject:: adipocytes; angiogenesis; animal models; blood; exosomes; fluorescent antibody technique; human umbilical vein endothelial cells; immunohistochemistry; in vitro studies; inflammation; staining; stem cells; stromal cells; subcutaneous fat
Abstract:: ... Adipose-derived stromal cells (ADSCs)-derived exosomes (ADSC-Exos) account for the proangiogenic potential of stem cell. This study aimed to investigate the effect of ADSC-derived exosomes (ADSC-Exos) on the survival in fat grafting.A nude mouse model of subcutaneous fat grafting was adopted. Hypoxic preconditioned ADSC-Exos and ADSC-Exos were injected around the grafted tissue. The fat graft samp ...
DOI:: 10.1016/j.bbrc.2018.02.076
: https://doi.org/10.1016/j.bbrc.2018.02.076

74. Combination of Capsaicin and Hesperidin Reduces the Effectiveness of Each Compound To Decrease the Adipocyte Size and To Induce Browning Features in Adipose Tissue of Western Diet Fed Rats

Author:: Andrea Mosqueda-Solís; Juana Sánchez; María P. Portillo; Andreu Palou; Catalina Picó
Source:: Journal of agricultural and food chemistry 2018 v.66 no.37 pp. 9679-9689
ISSN:: 1520-5118
Subject:: Western diets; adipocytes; adults; bioactive compounds; body weight; capsaicin; hesperidin; laboratory animals; males; rats; weight control; white adipose tissue
Abstract:: ... We explored the potential of hesperidin and capsaicin, separately and in combination, to induce white adipose tissue (WAT) browning and to help body weight management in Western diet-fed rats. Adult male Wistar rats were fed for 8 weeks with Western diet and treated daily with hesperidin (100 mg/kg/day), capsaicin (4 mg/kg/day), hesperidin (100 mg/kg/day) + capsaicin (4 mg/kg/day), or the vehicle. ...
DOI:: 10.1021/acs.jafc.8b02611
: https://doi.org/10.1021/acs.jafc.8b02611

75. Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats

Author:: Ariclecio Cunha de Oliveira; Sandra Andreotti; Rogério António Laurato Sertie; Amanda Baron Campana; André Ricardo Gomes de Proença; Renata Prado Vasconcelos; Keciany Alves de Oliveira; Andrelina Noronha Coelho-de-Souza; José Donato-Junior; Fábio Bessa Lima
Source:: Life sciences 2018 v.199 pp. 158-166
ISSN:: 0024-3205
Subject:: adipocytes; androgen receptors; blood sampling; body weight; diabetes; drinking water; epididymis; gene expression; genes; glucose; glycemic control; hypothalamus; insulin; insulin resistance; lipids; males; melatonin; messenger RNA; morphometry; oxidation; rats; white adipose tissue
Abstract:: ... Melatonin treatment has been reported to be capable of ameliorating metabolic diabetes-related abnormalities but also to cause hypogonadism in rats. We investigated whether the combined treatment with melatonin and insulin can improve insulin resistance and other metabolic disorders in rats with streptozotocin-induced diabetes during neonatal period and the repercussion of this treatment on the hy ...
DOI:: 10.1016/j.lfs.2018.02.040
: https://doi.org/10.1016/j.lfs.2018.02.040

76. Comparative Analysis of Long Noncoding RNAs Expressed during Intramuscular Adipocytes Adipogenesis in Fat-Type and Lean-Type Pigs

Author:: Yunmei Sun; Xiaochang Chen; Jin Qin; Shuge Liu; Rui Zhao; Taiyong Yu; Guiyan Chu; Gongshe Yang; Weijun Pang
Source:: Journal of agricultural and food chemistry 2018 v.66 no.45 pp. 12122-12130
ISSN:: 1520-5118
Subject:: Large White; adipocytes; adipogenesis; evolution; germplasm conservation; intramuscular fat; non-coding RNA; piglets; pork quality; sequence analysis
Abstract:: ... The meat quality of local breed pigs is more tender and juicier than the imported varieties. The important reason is that the intramuscular fat content is high. Even through modest sequence conservation and evolution, the expression pattern and function of long noncoding RNAs (lncRNAs) seem to be conserved. In spite of that, analysis of lncRNAs associated with intramuscular fat development remains ...
DOI:: 10.1021/acs.jafc.8b04243
: https://doi.org/10.1021/acs.jafc.8b04243

77. Comparative analysis of human Wharton’s jelly mesenchymal stem cells derived from different parts of the same umbilical cord

Author:: Dinesh Bharti; Sharath Belame Shivakumar; Ji-Kwon Park; Imran Ullah; Raghavendra Baregundi Subbarao; Ji-Sung Park; Sung-Lim Lee; Bong-Wook Park; Gyu-Jin Rho
Source:: Cell and tissue research 2018 v.372 no.1 pp. 51-65
ISSN:: 0302-766X
Subject:: adipocytes; cell differentiation; chondrocytes; ethics; fetus; genes; humans; immunomodulators; medicine; placenta; stem cells; umbilical cord; vimentin
Abstract:: ... Easy isolation, lack of ethical issues, high proliferation, multi-lineage differentiation potential and immunomodulatory properties of umbilical cord (UC)-derived mesenchymal stem cells (MSCs) make them a valuable tool in stem cell research. Recently, Wharton’s jelly (WJ) was proven as the best MSC source among various compartments of UC. However, it is still unclear whether or not Wharton’s jelly ...
DOI:: 10.1007/s00441-017-2699-4
PubMed:: 29204746
PubMed Central:: PMC5862947
: https://doi.org/10.1007/s00441-017-2699-4

78. Comparison of Antiobesity Effects Between Gochujangs Produced Using Different Koji Products and Tabasco Hot Sauce in Rats Fed a High-Fat Diet

Author:: Hee-Kyoung Son; Hye-Won Shin; Eun-Seok Jang; Byoung-Seok Moon; Choong-Hwan Lee; Jae-Joon Lee
Source:: Journal of medicinal food 2018 v.21 no.3 pp. 233-243
ISSN:: 1557-7600
Subject:: adipocytes; alcohol oxidoreductases; blood serum; body weight changes; capsaicin; cholesterol; epididymis; fatty liver; fatty-acid synthase; high fat diet; isoflavones; koji; laboratory animals; leptin; lipogenesis; liver; lysophosphatidylcholine; males; messenger RNA; obesity; rats; rice; secondary metabolites; soybeans; triacylglycerols
Abstract:: ... In this study, we compared the antiobesity effects between gochujangs prepared using different koji products and Tabasco hot sauce in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were fed HFD containing four different types of 10% gochujang powder or 0.25% commercial Tabasco sauce powder for 8 weeks. The body weight gain, liver and epididymal and mesenteric fat pad weights, serum lepti ...
DOI:: 10.1089/jmf.2017.4007
: https://doi.org/10.1089/jmf.2017.4007

79. Complex toxicity as disruption of adipocyte or osteoblast differentiation in human mesenchymal stem cells under the mixed condition of TBBPA and TCDD

Author:: Hideki Kakutani; Tomohiro Yuzuriha; Ema Akiyama; Teruyuki Nakao; Souichi Ohta
Source:: Toxicology reports 2018 v.5 pp. 737-743
ISSN:: 2214-7500
Subject:: adipocytes; breast milk; calcium; dose response; humans; lipids; osteoblasts; toxicity; toxicity testing
Abstract:: ... People are frequently and unintentionally exposed to many chemical compounds, such as environmental pollutants and endocrine-disrupting chemicals (EDCs), in food and from the atmosphere. In particular, endocrine-disrupting TBBPA and dioxins are found in human breast milk and in the body. Conventional studies evaluate toxicity by administering a single substance to cells or animals, but evaluation ...
DOI:: 10.1016/j.toxrep.2018.06.007
: https://doi.org/10.1016/j.toxrep.2018.06.007

80. Construction of lentiviral RNAi vector of PPARγ gene in cashmere goats and comparison with the transcriptome analysis of adipose cells treatments

Author:: Chen Du; Zhiying Wang; Wenguang Zhang; Shaoyin Fu; Bin Liu; Zhihong Liu; Xiujuan Chen; Jinquan Li
Source:: Small ruminant research 2018 v.164 pp. 87-93
ISSN:: 0921-4488
Subject:: RNA interference; Western blotting; adipocytes; fatty acid-binding proteins; gene expression; genes; glucose; goats; high-throughput nucleotide sequencing; homeostasis; interleukin-21; intramuscular fat; lipid metabolism; meat quality; mitogen-activated protein kinase; quantitative polymerase chain reaction; signal transduction; staining; toxicity testing; transcriptome; transcriptomics; transfection; tumor necrosis factors
Abstract:: ... As an important trait influencing meat quality, the deposition of Intramuscular fat (IMF) is affected by preadipocyte differentiation. Nuclear receptor peroxisome proliferator-activated receptorγ(PPARγ) plays an important role in the regulation of glucose homeostasis and lipid metabolism. In this study, lentivirus-mediated RNA interference (RNAi) was applied to inhibit PPARγ gene expression, which ...
DOI:: 10.1016/j.smallrumres.2018.04.008
: https://doi.org/10.1016/j.smallrumres.2018.04.008

81. Consumption of Black Legumes Glycine soja and Glycine max Lowers Serum Lipids and Alters the Gut Microbiome Profile in Mice Fed a High-Fat Diet

Author:: Changliang Jing; Zhiguo Wen; Ping Zou; Yuan Yuan; Weiran Jing; Yiqiang Li; Chengsheng Zhang
Source:: Journal of agricultural and food chemistry 2018 v.66 no.28 pp. 7367-7375
ISSN:: 1520-5118
Subject:: Bacteroidetes; Glycine max; Glycine soja; Verrucomicrobia; adipocytes; blood lipids; butyrates; dietary supplements; fatty liver; fermentation; high fat diet; histology; intestinal microorganisms; legumes; lipid composition; liver; mice; microbiome; obesity; propionic acid; public health; ribosomal RNA; sequence analysis; weight gain
Abstract:: ... This study investigated the potential health benefits of two different species of black legume [Glycine soja Sieb. et Zucc. and Glycine max (L.) Merr.] on diet-induced obesity. C57BL/6 mice were fed a high-fat diet (HFD) supplemented with 20% (w/w) black legume for 12 weeks, and the effects on weight gain, serum lipid levels, liver histology, gut fermentation, and microbiome profile were examined. ...
DOI:: 10.1021/acs.jafc.8b02016
: https://doi.org/10.1021/acs.jafc.8b02016

82. Consumption of Cherry out of Season Changes White Adipose Tissue Gene Expression and Morphology to a Phenotype Prone to Fat Accumulation

Author:: Albert Gibert-Ramos; Anna Crescenti; M. Josepa Salvadó
Source:: Nutrients 2018 v.10 no.8 pp. -
ISSN:: 2072-6643
Subject:: adipocytes; biometry; blood serum; cafeteria foods; cherries; gene expression; gene expression regulation; genes; glucose; histology; insulin; lipogenesis; lipolysis; nutrition risk assessment; obesity; obesogenic diet; peroxisome proliferator-activated receptor alpha; phenotype; rats; white adipose tissue
Abstract:: ... The aim of this study was to determine whether the consumption of cherry out of its normal harvest photoperiod affects adipose tissue, increasing the risk of obesity. Fischer 344 rats were held over a long day (LD) or a short day (SD), fed a standard diet (STD), and treated with a cherry lyophilizate (CH) or vehicle (VH) (n = 6). Biometric measurements, serum parameters, gene expression in white ( ...
DOI:: 10.3390/nu10081102
PubMed:: 30115853
PubMed Central:: PMC6115965
: https://doi.org/10.3390/nu10081102

83. Consumption of virgin coconut oil in Wistar rats increases saturated fatty acids in the liver and adipose tissue, as well as adipose tissue inflammation

Author:: Mariana de Moura e Dias; Nathane Pais Siqueira; Lisiane Lopes da Conceição; Sandra Aparecida dos Reis; Flávia Xavier Valente; Manoela Maciel dos Santos Dias; Carla de Oliveira Barbosa Rosa; Sérgio Oliveira de Paula; Sérgio Luís Pinto da Matta; Leandro Licursi de Oliveira; Josefina Bressan; Maria do Carmo Gouveia Peluzio
Source:: Journal of functional foods 2018 v.48 pp. 472-480
ISSN:: 1756-4646
Subject:: adipocytes; adipose tissue; antimicrobial properties; antioxidants; blood lipids; body measurements; coconut oil; dose response; food intake; genes; inflammation; laboratory animals; lipid composition; liver; morphometry; rats; saturated fatty acids; soybean oil
Abstract:: ... The recommended amount of intake of virgin coconut oil (VCO) for health benefits has not been defined. This study aims to evaluate the effects of partial dietary substitution of lipid source by VCO in the health of Wistar rats. The animals were divided as: G1, 100% of soybean oil; G2, 10.4% of VCO; G3, 50% of VCO; and G4, 95% of VCO. Weight and body measurements were not affected by substitution, ...
DOI:: 10.1016/j.jff.2018.07.036
: https://doi.org/10.1016/j.jff.2018.07.036

84. Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes

Author:: Jie-yun Hong; Chu-gang Mei; Shi-jun Li; Hong-bao Wang; Chun-ping Zhao; Lin-sen Zan
Source:: Archives of biochemistry and biophysics 2018 v.659 pp. 1-12
ISSN:: 0003-9861
Subject:: DNA methylation; adipocytes; binding sites; cattle; gel electrophoresis; gene expression; glucose; insulin secretion; lipid metabolism; longissimus muscle; luciferase; messenger RNA; moieties; neoplasms; promoter regions; proto-oncogenes; subcutaneous fat; testes; transactivators; transcription (genetics); transferases
Abstract:: ... Sirtuin6 (SIRT6) is an ADP-ribosyltransferase and NAD⁺-dependent deacylase of acetyl groups and long-chain fatty acyl groups, and has been shown as a regulator of insulin secretion, glucose metabolism, lipid metabolism, and cancer. In this study, we determined that the bovine SIRT6 showed higher levels of mRNA expression in the testis, longissimus thoracis, and subcutaneous fat tissue. To elucidat ...
DOI:: 10.1016/j.abb.2018.09.018
: https://doi.org/10.1016/j.abb.2018.09.018

85. Cross-talk between the transcription factor Sp1 and C/EBPβ modulates TGFβ1 production to negatively regulate the expression of chemokine RANTES

Author:: Arisa Sakamoto; Rui Yamaguchi; Reona Yamaguchi; Shinji Narahara; Hiroyuki Sugiuchi; Yasuo Yamaguchi
Source:: Heliyon 2018 v.4 no.7 pp. e00679
ISSN:: 2405-8440
Subject:: adipocytes; antagonists; atherosclerosis; chemokine CCL5; dynamins; glucose; humans; macrophages; obesity; protein content; protein synthesis; substance P; transcription (genetics); transcription factors
Abstract:: ... RANTES is a key chemokine for atherosclerosis, and obesity is associated with progression of atherosclerosis. Substance P (SP) increases glucose uptake and accumulation of lipids in adipocytes, and SP may upregulate RANTES expression. This study investigated the mechanism of RANTES expression by human M1 macrophages stimulated with SP.SP upregulated RANTES protein expression, whereas aprepitant (a ...
DOI:: 10.1016/j.heliyon.2018.e00679
PubMed:: 29998198
PubMed Central:: PMC6037877
: https://doi.org/10.1016/j.heliyon.2018.e00679

86. Cumulus cells of camel (Camelus dromedarius) antral follicles are multipotent stem cells

Author:: Islam M. Saadeldin; Ayman Abdel-Aziz Swelum; Mona Elsafadi; Amer Mahmood; Musaad Alfayez; Abdullah N. Alowaimer
Source:: Theriogenology 2018 v.118 pp. 233-242
ISSN:: 0093-691X
Subject:: Camelus dromedarius; adipocytes; camels; cell proliferation; follicular fluid; granulosa cells; humans; longevity; luteinization; medicine; messenger RNA; models; neurons; osteoblasts; ovulation; stem cells; tissue engineering
Abstract:: ... The mammalian ovary is a highly dynamic organ, in which proliferation and differentiation occur constantly during the entire life span, particularly in camels that are characterized by a follicular wave pattern and induced ovulation. Granulosa cells are the main cells of mature follicles. Two distinct cell types, namely, the mural and cumulus granulosa cells are distinguished on the basis of antra ...
DOI:: 10.1016/j.theriogenology.2018.06.009
: https://doi.org/10.1016/j.theriogenology.2018.06.009

87. Curculigoside and polyphenol-rich ethyl acetate fraction of Molineria latifolia rhizome improved glucose uptake via potential mTOR/AKT activated GLUT4 translocation

Author:: Der Jiun Ooi; Nur Hanisah Azmi; Mustapha Umar Imam; Noorjahan Banu Alitheen; Maznah Ismail
Source:: Yàowù shípǐn fēnxī 2018 v.26 no.4 pp. 1253-1264
ISSN:: 1021-9498
Subject:: adipocytes; adipogenesis; adipose tissue; ethyl acetate; glucose; glucose transporters; insulin; mice; models; peroxisome proliferator-activated receptors; phosphorylation; plasma membrane; protein content; rhizomes; signal transduction; transcription (genetics); translation (genetics)
Abstract:: ... Adipose tissue is one of the major organs responsible for rapid restoration of postprandial glucose fluxes. Being the major isoform of glucose transporter in adipose tissue, regulations of insulin-dependent GLUT4 trafficking have always been of research interest. The present study aimed to examine the molecular mechanisms underlying the efficacy of curculigoside and polyphenol-rich ethyl acetate f ...
DOI:: 10.1016/j.jfda.2018.03.003
: https://doi.org/10.1016/j.jfda.2018.03.003

88. Curcuma comosa reduces visceral adipose tissue and improves dyslipidemia in ovariectomized rats

Author:: Nareerat Sutjarit; Jetjamnong Sueajai; Nittaya Boonmuen; Nilubon Sornkaew; Apichart Suksamrarn; Patoomratana Tuchinda; Weiming Zhu; Jittima Weerachayaphorn; Pawinee Piyachaturawat
Source:: Journal of ethnopharmacology 2018 v.215 pp. 167-175
ISSN:: 0378-8741
Subject:: Curcuma comosa; adipocytes; adiponectin; adipose tissue; adiposity; beta oxidation; blood lipids; blood serum; estradiol; fatty acids; females; gene expression regulation; genes; health promotion; hyperlipidemia; leptin; lipemic effect; messenger RNA; ovariectomy; plant estrogens; postmenopause; protein content; proteins; rats; traditional medicine; visceral fat; women
Abstract:: ... Curcuma comosa Roxb. (C. comosa) or Wan chak motluk Zingiberaceae family, is widely used in Thai traditional medicine for treatment of gynecological problems as well as relief of postmenopausal symptoms. Since C. comosa contains phytoestrogen and causes lipid lowering effect by an unknown mechanism, we investigated its effect on adiposity and lipid metabolism in estrogen-deprived rats.Adult female ...
DOI:: 10.1016/j.jep.2017.12.027
: https://doi.org/10.1016/j.jep.2017.12.027

89. Cystathionine gamma-lyase/hydrogen sulfide system is essential for adipogenesis and fat mass accumulation in mice

Author:: Guangdong Yang; Youngjun Ju; Ming Fu; Yanjie Zhang; Yanxi Pei; Mélanie Racine; Simran Baath; Thomas J.S. Merritt; Rui Wang; Lingyun Wu
Source:: Biochimica et biophysica acta 2018 v.1863 pp. 165-176
ISSN:: 1388-1981
Subject:: DNA-binding domains; adipocytes; adipogenesis; carbon monoxide; cystathionine; cystathionine gamma-lyase; cysteine; energy; fruit flies; gene expression; glucose; homeostasis; hydrogen sulfide; insulin resistance; messenger RNA; metabolism; mice; nitric oxide; obesity; pathogenesis; transcription (genetics); transcriptional activation
Abstract:: ... Hydrogen sulfide (H2S) has been recognized as an important gasotransmitter analogous to nitric oxide and carbon monoxide. Cystathionine gamma-lyase (CSE)-derived H2S is implicated in the regulation of insulin resistance and glucose metabolism, but the involvement of CSE/H2S system in energy homeostasis and fat mass has not been extensively explored. In this study, a potential functional role of th ...
DOI:: 10.1016/j.bbalip.2017.11.008
: https://doi.org/10.1016/j.bbalip.2017.11.008

90. DNA methylation status of CRABP2 promoter down-regulates its expression

Author:: Gui-Min Zhang; Cheng-Chuang Song; Li-Juan Li; Hua He; Shu-Yue Shi; Chu-Zhao Lei; Li Zheng; Shu-Jun Peng; Yi-Ran Tian; Rui-Hua Dang; Xian-Yong Lan; Xing-Lei Qi; Hong Chen; Yong-Zhen Huang
Source:: Gene 2018 v.676 pp. 243-248
ISSN:: 0378-1119
Subject:: DNA methylation; absorption; adipocytes; beef quality; binding proteins; bisulfites; cattle; cattle breeds; cell differentiation; epigenetics; fibroblasts; gene expression; gene expression regulation; genes; genomic islands; homeostasis; hybrids; messenger RNA; metabolism; methyltransferases; muscles; neoplasms; phenotype; purebreds; quantitative polymerase chain reaction; retinoic acid; sequence analysis; therapeutics; transcription (genetics)
Abstract:: ... As an important epigenetic modification DNA methylation is catalyzed by DNA methylation transferases (DNMTs) and occurs mainly in CpG islands. DNA methylation plays an important role in regulates gene expression, cell differentiation, genetic imprinting and tumor therapy. Retinoic acid-binding proteins (RAC) is vital for the absorption, transport, metabolism and maintenance of homeostasis of retin ...
DOI:: 10.1016/j.gene.2018.07.049
: https://doi.org/10.1016/j.gene.2018.07.049

91. DXA-Rectified Appendicular Lean Mass: Development of Ultrasound Prediction Models in Older Adults

Author:: Takashi Abe; R. S. Thiebaud; J. P. Loenneke; E. Fujita; T. Akamine
Source:: journal of nutrition, health & aging 2018 v.22 no.9 pp. 1080-1085
ISSN:: 1279-7707
Subject:: adipocytes; adipose tissue; cross-sectional studies; dual-energy X-ray absorptiometry; elderly; equations; least squares; models; muscles; prediction; sarcopenia
Abstract:: ... OBJECTIVE: Dual-energy X-ray absorptiometry (DXA)-derived appendicular lean soft tissue mass (aLM) is used to diagnose sarcopenia. However, DXA-derived aLM includes non-skeletal muscle components, such as fat-free component of adipose tissue fat cell. These components, if not accounted for, could falsely inflate the aLM in individuals with a high amount of adipose tissue mass. B-mode ultrasound ac ...
DOI:: 10.1007/s12603-018-1053-1
: https://doi.org/10.1007/s12603-018-1053-1

92. Data on hypoxia-induced VEGF, leptin and NF-kB p65 expression

Author:: Azizah Al-Anazi; Ranjit Parhar; Soad Saleh; Reem Al-Hijailan; Angela Inglis; Mansour Al-Jufan; Mohammed Bazzi; Sarwar Hashmi; Walter Conca; Kate Collison; Futwan Al-Mohanna
Source:: Data in Brief 2018 v.21 pp. 2395-2397
ISSN:: 2352-3409
Subject:: RNA; adipocytes; adiponectin; calcium; chelating agents; data collection; humans; hypoxia; interleukin-6; leptin; oxygen; polymerase chain reaction; transcription factor NF-kappa B
Abstract:: ... The data set presented here is associated with the article “Intracellular calcium and NF-ₖB regulate hypoxia-induced leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes” (Al-Anazi et al., 2018). Data illustrate hypoxia-induced VEGF and leptin expression in human adipocytes treated with the calcium chelator BAPTA-AM (1 µM). It also shows NF-κB p65 induced expression by hypoxia. Preadip ...
DOI:: 10.1016/j.dib.2018.10.147
: https://doi.org/10.1016/j.dib.2018.10.147

93. De novo lipogenesis and desaturation of fatty acids during adipogenesis in bovine adipose-derived mesenchymal stem cells

Author:: Yongli Yue; Lichun Zhang; Xiang Zhang; Xueling Li; Haiquan Yu
Source:: In vitro cellular & developmental biology 2018 v.54 no.1 pp. 23-31
ISSN:: 1071-2690
Subject:: adipocytes; adipogenesis; cattle; energy metabolism; fluorescent antibody technique; gas chromatography-mass spectrometry; gene expression; genes; growth curves; histology; in vitro studies; lipogenesis; lipolysis; long chain fatty acids; models; polyunsaturated fatty acids; quantitative polymerase chain reaction; staining; stem cells; vimentin
Abstract:: ... Adipose-derived mesenchymal stem cells (ADSCs) are useful cell model to study adipogenesis and energy metabolism. However, the biological characteristics of bovine ADSCs (bADSCs) remain unclear. This study aimed to isolate and identify bADSCs and further investigate fatty acid (FA)-related gene expression and composition of FAs during adipogenesis. The growth curve showed the bADSCs of P5 cells ha ...
DOI:: 10.1007/s11626-017-0205-7
: https://doi.org/10.1007/s11626-017-0205-7

94. Dehydroleucodine inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest

Author:: S. Abood; M. L. Veisaga; L. A. López; M. A. Barbieri
Source:: Phytotherapy research 2018 v.32 no.8 pp. 1583-1592
ISSN:: 0951-418X
Subject:: adipocytes; adipogenesis; biomarkers; cell cycle checkpoints; cyclin-dependent kinase; cyclins; demethylation; droplets; histones; hyperplasia; hypertrophy; interphase; metabolic diseases; methylation; methyltransferases; mitosis; obesity; peroxisome proliferator-activated receptor gamma; phenotype; phosphorylation; risk factors; transcriptional activation; triacylglycerols
Abstract:: ... Aberrant levels of preadipocyte differentiation, triggered by adipocyte hyperplasia and hypertrophy, results in the obesogenic phenotype. Obesity is a risk factor for several metabolic disorders. In this paper, dehydroleucodine inhibited the accumulation of lipid droplets and decreased the elevations of triglycerides, and this inhibitory effect occurred during the early stage of adipogenesis. Thus ...
DOI:: 10.1002/ptr.6089
: https://doi.org/10.1002/ptr.6089

95. Deletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma Cells

Author:: Tamara Tomin; Katarina Fritz; Juergen Gindlhuber; Linda Waldherr; Bettina Pucher; Gerhard G. Thallinger; Daniel K. Nomura; Matthias Schittmayer; Ruth Birner-Gruenberger
Source:: Journal of proteome research 2018 v.17 no.4 pp. 1415-1425
ISSN:: 1535-3907
Subject:: Western blotting; adipocytes; carcinogenesis; catalytic activity; droplets; enzyme activity; gene expression; humans; lung neoplasms; messenger RNA; models; neoplasm cells; phenotype; phospholipids; protein content; proteome; proteomics; tissues; triacylglycerol lipase; triacylglycerols
Abstract:: ... Adipose triglyceride lipase (ATGL) catalyzes the rate limiting step in triacylglycerol breakdown in adipocytes but is expressed in most tissues. The enzyme was shown to be lost in many human tumors, and its loss may play a role in early stages of cancer development. Here, we report that loss of ATGL supports a more-aggressive cancer phenotype in a model system in which ATGL was deleted in A549 lun ...
DOI:: 10.1021/acs.jproteome.7b00782
: https://doi.org/10.1021/acs.jproteome.7b00782

96. Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice

Author:: Keisuke Okabe; Isao Usui; Keisuke Yaku; Yoshio Hirabayashi; Kazuyuki Tobe; Takashi Nakagawa
Source:: Biochemical and biophysical research communications 2018 v.504 no.1 pp. 309-314
ISSN:: 0006-291X
Subject:: adipocytes; animal disease models; biosynthesis; diabetes; diet; glucose; glucose tolerance; humans; knockout mutants; mice; nervous system; obesity; phosphoglycerate dehydrogenase; serine; therapeutics; white adipose tissue
Abstract:: ... Serine is a nonessential amino acid and plays an important role in cellular metabolism. In mammalian serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH) is considered a rate-limiting enzyme and is required for normal development. Although the biological functions of PHGHD in the nervous system have been intensively studied, its function in adipose tissue is unknown. In this study, we fou ...
DOI:: 10.1016/j.bbrc.2018.08.180
: https://doi.org/10.1016/j.bbrc.2018.08.180

97. Dendritic peptide bolaamphiphiles for siRNA delivery to primary adipocytes

Author:: Alexander C. Eldredge; Mark E. Johnson; Yang Cao; Lin Zhang; Can Zhao; Zhengxia Liu; Qin Yang; Zhibin Guan
Source:: Biomaterials 2018 v.178 pp. 458-466
ISSN:: 0142-9612
Subject:: adipocytes; adipose tissue; beta oxidation; diabetes; gene therapy; genes; heart diseases; hepatocytes; histidine; lipids; lipogenesis; lipolysis; lysine; obesity; perfluorocarbons; risk factors; small interfering RNA; toxicity; tryptophan
Abstract:: ... Obesity is a major risk factor for diabetes, heart disease and other health problems. Adipose tissue plays a central role in the development of obesity and obesity-associated diseases. Gene therapy targeting adipose tissue may provide a promising strategy for obesity treatment. However, nucleic acid delivery to adipose tissue or even cultured adipocytes is challenging due to low delivery efficacy ...
DOI:: 10.1016/j.biomaterials.2018.04.024
PubMed:: 29705001
PubMed Central:: PMC6054800
: https://doi.org/10.1016/j.biomaterials.2018.04.024

98. Deregulation of obesity-relevant genes is associated with progression in BMI and the amount of adipose tissue in pigs

Author:: Caroline M. Junker Mentzel; Tainã Figueiredo Cardoso; Christian Bressen Pipper; Mette Juul Jacobsen; Claus Bøttcher Jørgensen; Susanna Cirera; Merete Fredholm
Source:: Molecular genetics and genomics 2018 v.293 no.1 pp. 129-136
ISSN:: 1617-4615
Subject:: RNA; adipocytes; adipose tissue; biosynthesis; body mass index; females; gene expression; genes; inflammation; linear models; lipids; lipolysis; liver; metabolic diseases; muscles; obesity; phenotype; quantitative polymerase chain reaction; risk; skeletal muscle; statistical analysis; swine
Abstract:: ... The aim of this study was to elucidate the relative impact of three phenotypes often used to characterize obesity on perturbation of molecular pathways involved in obesity. The three obesity-related phenotypes are (1) body mass index (BMI), (2) amount of subcutaneous adipose tissue (SATa), and (3) amount of retroperitoneal adipose tissue (RPATa). Although it is generally accepted that increasing a ...
DOI:: 10.1007/s00438-017-1369-2
: https://doi.org/10.1007/s00438-017-1369-2

99. Desalted Salicornia europaea powder and its active constituent, trans-ferulic acid, exert anti-obesity effects by suppressing adipogenic-related factors

Author:: Md. Mahbubur Rahman; Myung-Jin Kim; Jin-Hyoung Kim; Sok-Ho Kim; Hyeon-Kyu Go; Mee-Hyang Kweon; Do-Hyung Kim
Source:: Pharmaceutical biology 2018 v.56 no.1 pp. 183-191
ISSN:: 1744-5116
Subject:: Garcinia gummi-guta; Salicornia europaea; abdominal fat; adipocytes; blood lipids; dietary supplements; fatty-acid synthase; feed intake; gene expression; gene expression regulation; high fat diet; ingredients; laboratory animals; mechanism of action; obesity; peroxisome proliferator-activated receptor gamma; rats; salt content; sodium chloride; sterols
Abstract:: ... Context: Salicornia europaea (Amaranthaceae) (SE) has been shown to reduce obesity, but it remains a problem as a food supplement because of its high salt content (25–35% NaCl). Objectives: This study investigated the anti-obesity effects and mechanism of action of desalted SE powder (DSP). Materials and methods: Sprague–Dawley rats (n = 50) were divided into a normal control group (NC), a high-fa ...
DOI:: 10.1080/13880209.2018.1436073
PubMed:: 29521146
PubMed Central:: PMC6130585
: https://doi.org/10.1080/13880209.2018.1436073

100. Dietary Restriction Ameliorates Age-Related Increase in DNA Damage, Senescence and Inflammation in Mouse Adipose Tissuey

Author:: A. Ishaq; J. Schröder; N. Edwards; T. von Zglinicki; Gabriele Saretzki
Source:: journal of nutrition, health & aging 2018 v.22 no.4 pp. 555-561
ISSN:: 1279-7707
Subject:: DNA damage; adipocytes; adipose tissue; dietary restriction; gene expression; inflammation; interleukin-1beta; interleukin-6; macrophages; metabolic syndrome; mice; nutritional intervention; obesity; quantitative polymerase chain reaction; tumor necrosis factor-alpha; visceral fat
Abstract:: ... Ageing is associated with redistribution of fat around the body and saturation of visceral adipose depots. Likewise, the presence of excess fat in obesity or during ageing places extra stress on visceral depots, resulting in chronic inflammation and increased senescence. This process can contribute to the establishment of the metabolic syndrome and accelerated ageing. Dietary restriction (DR) is k ...
DOI:: 10.1007/s12603-017-0968-2
PubMed:: 29582897
PubMed Central:: PMC5866821
: https://doi.org/10.1007/s12603-017-0968-2

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1. 1,25-Dihydroxyvitamin D regulates lipid metabolism and glucose utilization in differentiated 3T3-L1 adipocytes

2. 5‐Hydroxyferulic acid methyl ester isolated from wasabi leaves inhibits 3T3‐L1 adipocyte differentiation

3. 7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet

4. Inula japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed a High-Fat Diet

5. Lactobacillus plantarum Strain Ln4 Attenuates Diet-Induced Obesity, Insulin Resistance, and Changes in Hepatic mRNA Levels Associated with Glucose and Lipid Metabolism

6. Tetragonia tetragonoides (Pall.) Kuntze (New Zealand Spinach) Prevents Obesity and Hyperuricemia in High-Fat Diet-Induced Obese Mice

7. A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor

8. A dose-dependent effect of dimethyl sulfoxide on lipid content, cell viability and oxidative stress in 3T3-L1 adipocytes

9. A high-fat diet increases body fat mass and up-regulates expression of genes related to adipogenesis and inflammation in a genetically lean pig

10. A long-term maternal diet intervention is necessary to avoid the obesogenic effect of maternal high-fat diet in the offspring

11. A new cinnamic acid glycoside from roots of Heracleum dissectum

12. A new indanedione derivative alleviates symptoms of diabetes by modulating RAGE-NF-kappaB pathway in db/db mice

13. A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction

14. A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice

15. A system for the expression and release of heterologous proteins from the core of Bacillus subtilis spores

16. AMPK promotes survival and adipogenesis of ischemia-challenged ADSCs in an autophagy-dependent manner

17. Acetate alters the process of lipid metabolism in rabbits

18. Activation of bombesin receptor Subtype-3 by [D-Tyr6,β-Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes

19. Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis

20. Acute and chronic cold exposure differentially affects the browning of porcine white adipose tissue

21. Acute high-intensity interval exercise induces comparable levels of circulating cell-free DNA and Interleukin-6 in obese and normal-weight individuals

22. Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice

23. Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in Hypogonadal Men Vary According to Estradiol Levels

24. Adipogenic genes expression in relation to hepatic steatosis in the liver of two duck species

25. Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation

26. Adipose tissue complement factor B promotes adipocyte maturation

27. Adipose-specific expression of mouse Rbp7 gene and its developmental and metabolic changes

28. Aged Oolong Tea Reduces High-Fat Diet-Induced Fat Accumulation and Dyslipidemia by Regulating the AMPK/ACC Signaling Pathway

29. Aged black garlic extract regulates lipid metabolism by inhibiting lipogenesis and promoting lipolysis in mature 3T3-L1 adipocytes

30. Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1

31. Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model

32. An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

33. An ameloblastin C-terminus variant is present in human adipose tissue

34. Analysis of LncRNA expression in cell differentiation

35. Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds

36. Anti-obesity effects of Spirulina maxima in high fat diet induced obese rats via the activation of AMPK pathway and SIRT1

37. Antiadipogenic effects of a standardized quassinoids‐enriched fraction and eurycomanone from Eurycoma longifolia

38. Antiobesity Effect of Prebiotic Polyphenol-Rich Grape Seed Flour Supplemented with Probiotic Kefir-Derived Lactic Acid Bacteria

39. Antiobesity Effect of Tricin, a Methylated Cereal Flavone, in High-Fat-Diet-Induced Obese Mice

40. Antiobesity Effects of Ginsenoside Rg1 on 3T3-L1 Preadipocytes and High Fat Diet-Induced Obese Mice Mediated by AMPK

41. Antiobesity Effects of Purple Perilla (Perilla frutescens var. acuta) on Adipocyte Differentiation and Mice Fed a High‐fat Diet

42. Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression

43. Antioxidant effect, glucose uptake activity in cell lines and cytotoxic potential of Melicope lunu-ankenda leaf extract

44. Apo-12′-lycopenal, a Lycopene Metabolite, Promotes Adipocyte Differentiation via Peroxisome Proliferator-Activated Receptor γ Activation

45. Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice

46. Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity

47. Arginine pretreatment enhances circulating endothelial progenitor cell population and attenuates inflammatory response in high-fat diet–induced obese mice with limb ischemia

48. Atf3 induction is a therapeutic target for obesity and metabolic diseases

49. Autophagy in turnover of lipid stores: trans-kingdom comparison

50. BCAA Metabolism and Insulin Sensitivity – Dysregulated by Metabolic Status?

51. BIX-01294 promotes the differentiation of adipose mesenchymal stem cells into adipocytes and neural cells in Arbas Cashmere goats

52. Beneficial effects of a selected probiotic mixture administered to high fat-fed mice before and after the development of obesity

53. Benzyl isothiocyanate ameliorates lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation

54. Bioassay-guided purification of Lippia citriodora polyphenols with AMPK modulatory activity

55. Biological effects of adipocytes in sulfur mustard induced toxicity

56. Bioprospection of immature salivary glands of Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae)

57. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

58. Bta-miR-130a/b regulates preadipocyte differentiation by targeting PPARG and CYP2U1 in beef cattle

59. Caffeic Acid Phenethyl Ester Improves Metabolic Syndrome by Activating PPAR‐γ and Inducing Adipose Tissue Remodeling in Diet‐Induced Obese Mice

60. Capsaicin in Metabolic Syndrome

61. Carnosic Acid Modulates Increased Hepatic Lipogenesis and Adipocytes Differentiation in Ovariectomized Mice Fed Normal or High-Fat Diets

62. Catechin supplemented in a FOS diet induces weight loss by altering cecal microbiota and gene expression of colonic epithelial cells

63. Causes and mechanisms of adipocyte enlargement and adipose expansion

64. Caveolar targeting links Kv1.3 with the insulin-dependent adipocyte physiology

65. Characterization and in vitro evaluation of seaweed species as potential functional ingredients to ameliorate metabolic syndrome

66. Chemical Characterization of Novel Natural Products from the Roots of Asian Rice (Oryza sativa) that Control Adipocyte and Osteoblast Differentiation

67. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice

68. Chlamydia pneumoniae exploits adipocyte lipid chaperone FABP4 to facilitate fat mobilization and intracellular growth in murine adipocytes

69. Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice

70. Chungkookjang with High Contents of Poly-γ-Glutamic Acid Improves Insulin Sensitizing Activity in Adipocytes and Neuronal Cells