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1. A big pertussis outbreak in a primary school with high vaccination coverage in northern China: An evidence of the emerging of the disease in China

Author:
Huang, Haitao; Gao, Ping; Gao, Zhigang; Wang, Lijuan; Hao, Baoyun; Liu, Yong; Yang, Aaimin; Liu, Peng; Guo, Liru; Zhang, Ying
Source:
Vaccine 2018 v.36 no.52 pp. 7950-7955
ISSN:
0264-410X
Subject:
vaccination,   etc   ; antibodies; blood sampling; children; disease outbreaks; disease transmission; elementary schools; enzyme-linked immunosorbent assay; immunity; risk factors; secondary immunization; students; teachers; vaccines; whooping cough; China;     Show all 16 Subjects
Abstract:
... A big pertussis outbreak occurred in a primary school with high vaccination coverage in northern China. An investigation was carried out in order to calculate the attack rate and identify the risk factors.Between May 12 and July 29, an investigation was carried out in the primary school, which included 383 students and 27 teachers. Three definitions were used to distinguish the cases: confirmed, e ...
DOI:
10.1016/j.vaccine.2018.11.009

2. A canine adenovirus type 2 vaccine vector confers protection against foot-and-mouth disease in guinea pigs

Author:
De Vleeschauwer, Annebel R.; Zhou, Xiaocui; Lefebvre, David J.; Garnier, Annabelle; Watier, Fleur; Pignon, Charly; Lacour, Sandrine A.; Zientara, Stephan; Bakkali-Kassimi, Labib; De Clercq, Kris; Klonjkowski, Bernard
Source:
Vaccine 2018 v.36 no.16 pp. 2193-2198
ISSN:
0264-410X
Subject:
vaccination,   etc   ; vector vaccines; antigens; humoral immunity; capsid; antibodies; hosts; models; disease control; Canine mastadenovirus A; mice; structural proteins; foot-and-mouth disease; immune response; Foot-and-mouth disease virus; guinea pigs; emulsions;     Show all 17 Subjects
Abstract:
... Vaccination is a key element in the control of foot-and-mouth disease (FMD). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. In the present study, recombinant canine adenovirus type 2 (CAV2)-based FMD vaccines, Cav-P1/3C R° and Cav-VP1 R°, respectively expr ...
DOI:
10.1016/j.vaccine.2018.02.074

3. Accelerated onset of chronic wasting disease in elk (Cervus canadensis) vaccinated with a PrPSc-specific vaccine and housed in a prion contaminated environment

Author:
Wood, Mary E.; Griebel, Philip; Huizenga, Matthew L.; Lockwood, Samuel; Hansen, Cole; Potter, Andrew; Cashman, Neil; Mapletoft, John W.; Napper, Scott
Source:
Vaccine 2018 v.36 no.50 pp. 7737-7743
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Cervus canadensis; PrPSc proteins; antibodies; biopsy; blood serum; calves; chronic wasting disease; elks; epitopes; females; genes; genotype; genotyping; signs and symptoms (animals and humans); vaccines; wildlife; Wyoming;     Show all 18 Subjects
Abstract:
... Chronic wasting disease (CWD) is a fatal prion disease affecting multiple cervid species. Effective management tools for this disease, particularly in free-ranging populations, are currently limited. We evaluated a novel CWD vaccine in elk (Cervus canadensis) naturally exposed to CWD through a prion-contaminated environment. The vaccine targets a YYR disease-specific epitope to induce antibody res ...
DOI:
10.1016/j.vaccine.2018.10.057

4. A cross-sectional study of Bordetella pertussis seroprevalence and estimated duration of vaccine protection against pertussis in St. Petersburg, Russia

Author:
Kurova, Natalia; Timofeeva, Elena V.; Guiso, Nicole; Macina, Denis
Source:
Vaccine 2018 v.36 no.52 pp. 7936-7942
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Bordetella pertussis; antibodies; cross-sectional studies; disease susceptibility; enzyme-linked immunosorbent assay; immunity; pertussis toxin; school children; seroprevalence; urban areas; vaccines; whooping cough; Russia;     Show all 14 Subjects
Abstract:
... In Russia as in other countries introduction of infant vaccination against pertussis in 1950s led to dramatic decrease of whooping cough. The current vaccination schedule includes a 3-dose infant series and toddler booster; the pre-school booster was cancelled in 1980s and never reintroduced. Whole-cell vaccines, and in a smaller proportion acellular vaccines are used for all doses. However, pertu ...
DOI:
10.1016/j.vaccine.2018.11.007

5. A DNA prime/protein boost vaccine protocol developed against Campylobacter jejuni for poultry

Author:
Meunier, Marine; Guyard-Nicodème, Muriel; Vigouroux, Estelle; Poezevara, Typhaine; Béven, Véronique; Quesne, Ségolène; Amelot, Michel; Parra, Alberto; Chemaly, Marianne; Dory, Daniel
Source:
Vaccine 2018 v.36 no.16 pp. 2119-2125
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Campylobacter jejuni; DNA; antibodies; bacterial antigens; broiler chickens; disease incidence; flagellin; immune response; intestines; specific pathogen-free animals; subunit vaccines; vaccine development;     Show all 13 Subjects
Abstract:
... Vaccination of broilers is one of the potential ways to decrease Campylobacter intestinal loads and therefore may reduce human disease incidence. Despite many studies, no efficient vaccine is available yet. Using the reverse vaccinology strategy, we recently identified new vaccine candidates whose immune and protective capacities need to be evaluated in vivo. Therefore, the goal of the present stu ...
DOI:
10.1016/j.vaccine.2018.03.004

6. A Functional Food Mixture “Protector” Reinforces the Protective Immune Parameters against Viral Flu Infection in Mice

Author:
Mansoor, Kenza A.; Qadan, Fadi; Schmidt, Mathias; Qinna, Nidal A.; Badr, Mujtaba; Matalka, Khalid Z.
Source:
Nutrients 2018 v.10 no.6
ISSN:
2072-6643
Subject:
vaccination,   etc   ; antibodies; blood; children; clinical trials; elderly; figs; fruits; functional foods; ginger; grapes; hemagglutinins; human diseases; influenza; influenza vaccines; interferon-gamma; interleukin-12; interleukin-6; lungs; mice; olives; oral administration; pomegranates; secondary immunization; spleen; toxicology; water solubility;     Show all 27 Subjects
Abstract:
... Background: Viral influenza infection causes serious health issues especially when an outbreak occurs. Although influenza virus vaccines are available and each year manufactures modify the vaccine depending on the expected mutated strain, it is still far from satisfactory, mainly in young children and older adults. Therefore, a product that can support and shape the immune system to protect agains ...
DOI:
10.3390/nu10060743

7. A lentiviral vaccine expressing KMP11-HASPB fusion protein increases immune response to Leishmania major in BALB/C

Author:
Mortazavidehkordi, Nahid; Fallah, Ali; Abdollahi, Abbas; Kia, Vahid; Khanahmad, Hossein; Najafabadi, ZahraGhayour; Hashemi, Nooshin; Estiri, Bahareh; Roudbari, Zahra; Najafi, Ali; Farjadfar, Akbar; Hejazi, SeyedHossein
Source:
Parasitology research 2018 v.117 no.7 pp. 2265-2273
ISSN:
0932-0113
Subject:
vaccination,   etc   ; Leishmania major; Lentivirus; Western blotting; amastigotes; antibodies; antigens; cell-mediated immunity; enzyme-linked immunosorbent assay; hydrophilicity; immune response; immunoglobulin G; interferon-gamma; interleukin-10; leishmaniasis; lymph nodes; macrophages; membrane proteins; mice; parasite load; promastigotes; recombinant vaccines; reverse transcriptase polymerase chain reaction; spleen; surface proteins; vaccine development;     Show all 26 Subjects
Abstract:
... Hydrophilic acylated surface protein B (HASPB) is an immunogenic Leishmania-specific protein that antibodies are produced against it in the sera of Leishmania-infected individuals. Kinetoplastid membrane protein 11 (KMP11) is another Leishmania antigen and considered as the suitable candidate for vaccine development Leishmaniasis. It is a highly conserved surface protein expressed in both promasti ...
DOI:
10.1007/s00436-018-5915-6

8. Allergic patients with and without allergen-specific immunotherapy mount protective immune responses to tick-borne encephalitis vaccination in absence of enhanced side effects or propagation of their Th2 bias

Author:
Garner-Spitzer, Erika; Seidl-Friedrich, Claudia; Zwazl, Ines; Hofer, Michael; Kinaciyan, Tamar; Jarisch, Reinhart; Stiasny, Karin; Zlabinger, Gerhard J.; Kundi, Michael; Wiedermann, Ursula
Source:
Vaccine 2018 v.36 no.20 pp. 2816-2824
ISSN:
0264-410X
Subject:
vaccination,   etc   ; adverse effects; antibodies; cell-mediated immunity; clinical trials; hypersensitivity; immune response; immunoglobulin G; immunomodulation; interleukin-10; interleukin-5; neutralization; patients; tick-borne encephalitis; vaccines;     Show all 15 Subjects
Abstract:
... Allergic diseases are caused by Th2-driven immune responses and their treatment with specific immunotherapy (SIT) leads to immunomodulation via IL10, TGF-ß and Th1/Tr1 shift. This phase IV, open-label clinical trial investigated whether allergies and SIT treatment influenced immune responses to routine vaccination.We studied three groups: 49 allergic patients (allergic group), 21 allergic patients ...
DOI:
10.1016/j.vaccine.2018.03.076

9. Aluminum hydroxide colloid vaccine encapsulated in yeast shells with enhanced humoral and cellular immune responses

Author:
Liu, Hui; Jia, Zhenghu; Yang, Chengmao; Song, Mei; Jing, Zhe; Zhao, Yapu; Wu, Zhenzhou; Zhao, Liqing; Wei, Dongsheng; Yin, Zhinan; Hong, Zhangyong
Source:
Biomaterials 2018 v.167 pp. 32-43
ISSN:
0142-9612
Subject:
vaccination,   etc   ; adjuvants; alum; aluminum hydroxide; animal models; antibodies; antigens; beta-glucans; cell-mediated immunity; colloids; cytokines; dendritic cells; humans; humoral immunity; immune response; infectious diseases; mixing; neoplasms; proteins; secretion; vaccines; yeasts;     Show all 22 Subjects
Abstract:
... Aluminum salt (Alum) is one of the most important immune adjuvants approved for use in humans, however it is not suitable for vaccination against various chronic infectious diseases and cancers for not being able to induce cell-mediated (Th1) immunity. Here, we encapsulated an Alum colloid inside β-glucan particles (GPs), which are a type of natural particles derived from the yeast glucan shells, ...
DOI:
10.1016/j.biomaterials.2018.03.014

10. Aluminum is a powerful adjuvant in teleost fish despite failing to induce interleukin-1β release

Author:
Angosto, Diego; López-Muñoz, Azucena; García-Alcazar, Alicia; Meseguer, José; Sepulcre, María P.; Mulero, Victoriano
Source:
Developmental and comparative immunology 2018 v.85 pp. 18-24
ISSN:
0145-305X
Subject:
vaccination,   etc   ; Dicentrarchus labrax; NADP (coenzyme); Sparus aurata; alum; aluminum; antibodies; aquaculture; caspases; death; fish; genes; granulocytes; humans; interleukin-1beta; keyhole limpet hemocyanin; macrophages; mechanism of action; models; reactive oxygen species; vaccine adjuvants; vaccines;     Show all 22 Subjects
Abstract:
... Although aluminum salts (Alum) have been extensively used in human vaccination for decades, its mechanism of action is controversial. In fish, the use of Alum as a vaccine adjuvant is scarce and there are no studies aimed at identifying its mechanism of action. In the present study we report that Alum is a powerful adjuvant in the gilthead seabream (Sparus aurata L., Sparidae) and the European sea ...
DOI:
10.1016/j.dci.2018.03.017

11. A modified dose–response model that describes the relationship between haemagglutination inhibition titre and protection against influenza infection

Author:
Huang, Y.; Anderson, S.A.; Forshee, R.A.; Yang, H.
Source:
Journal of applied microbiology 2018 v.124 no.1 pp. 294-301
ISSN:
1364-5072
Subject:
vaccination,   etc   ; Orthomyxoviridae; antibodies; dose response; hemagglutination; humans; influenza; influenza vaccines; models; protective effect; risk; statistical analysis;     Show all 12 Subjects
Abstract:
... AIMS: Develop a model for quantifying the risk of an adverse human response to influenza virus infection as a function of exposure dose and pre‐exposure antibody titre level. METHODS AND RESULTS: We evaluated the relationship between haemagglutination inhibition (HI) titre (as a measure of specific antibody response) and protection against influenza infection and modelled this relationship by inco ...
DOI:
10.1111/jam.13628

12. A mouse model with age-dependent immune response and immune-tolerance for HBV infection

Author:
Yi, Xuerui; Yuan, Youcheng; Li, Na; Yi, Lu; Wang, Cuiling; Qi, Ying; Gong, Liang; Liu, Guangze; Kong, Xiangping
Source:
Vaccine 2018 v.36 no.6 pp. 794-801
ISSN:
0264-410X
Subject:
vaccination,   etc   ; B-lymphocytes; adults; alanine transaminase; animal models; antibiotics; antibodies; blood serum; cytokines; hepatitis B; hepatitis B antigens; hepatocytes; histology; human diseases; humans; immune response; immunosuppression; intestinal microorganisms; liver; mice; seroconversion; splenocytes; tissues; vaccines; viral load;     Show all 25 Subjects
Abstract:
... Viral clearance of human HBV infection largely depends on the age of exposure. Thus, a mouse model with age-dependent immune response and immune-tolerance for HBV infection was established.HBVRag1 mice were generated by crossing Rag1−/− mice with HBV-Tg mice. Following adoptive transfer of splenocytes adult (8–9 weeks old) and young (3 weeks old) HBVRag1 mice were named as HBVRag-ReA and HBVRag-Re ...
DOI:
10.1016/j.vaccine.2017.12.071

13. Amphiphilic block copolymer delivery of a DNA vaccine against Zika virus

Author:
Hraber, Peter; Bradfute, Steven; Clarke, Elizabeth; Ye, Chunyan; Pitard, Bruno
Source:
Vaccine 2018 v.36 no.46 pp. 6911-6917
ISSN:
0264-410X
Subject:
vaccination,   etc   ; DNA; Zika virus; abnormal development; acute course; antibodies; antigens; central nervous system; composite polymers; infectious diseases; mice; neutralization; recombinant vaccines; viremia; women;     Show all 15 Subjects
Abstract:
... Zika virus (ZIKV) is a mosquito-borne flavivirus that was first discovered in 1947. Since then, outbreaks have been reported in tropical Africa, Southeast Asia, the Pacific Islands, and, in 2015, in the Americas. Since 2013, many countries have reported cases of microcephaly and other central nervous system malformation associated with ZIKV. Because the initial target population for a ZIKV vaccine ...
DOI:
10.1016/j.vaccine.2018.10.022

14. An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature

Author:
Huijbers, Elisabeth J.M.; van Beijnum, Judy R.; Lê, Chung T.; Langman, Sofya; Nowak-Sliwinska, Patrycja; Mayo, Kevin H.; Griffioen, Arjan W.
Source:
Vaccine 2018 v.36 no.21 pp. 3054-3060
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Escherichia coli; active immunity; adjuvants; amino acid sequences; antibodies; antibody formation; antigens; bioengineering; cancer vaccines; fibronectins; growth retardation; immunogenicity; leukocytes; neoplasms; proteome; solubility; thioredoxins;     Show all 18 Subjects
Abstract:
... The induction of an antibody response against self-antigens requires a conjugate vaccine technology, where the self-antigen is conjugated to a foreign protein sequence, and the co-application of a potent adjuvant. The choice of this foreign sequence is crucial as a very strong antibody response towards it may compromise the anti-self immune response. Here, we aimed to optimize the conjugate design ...
DOI:
10.1016/j.vaccine.2018.03.064

15. An influenza A virus vaccine based on an M2e-modified alphavirus

Author:
Krishnavajhala, HarithaRamya; Williams, Jacqueline; Heidner, Hans
Source:
Archives of virology 2018 v.163 no.2 pp. 483-488
ISSN:
0304-8608
Subject:
vaccination,   etc   ; Influenza A virus; Sindbis virus; antibodies; antigens; glycoproteins; mice; vaccines; virion; virulence; viruses;     Show all 11 Subjects
Abstract:
... The 23-residue external domain of the influenza A virus M2 protein (M2e) has significant potential as a vaccine antigen. Here, we describe the construction and characterization of an M2e-modified Sindbis virus designated E2S1-M2e. E2S1-M2e virions contain M2e as an N-terminal extension of the E2 glycoprotein and therefore express 240 copies of the M2e peptide on their surface. The E2S1-M2e virus e ...
DOI:
10.1007/s00705-017-3578-8

16. A novel antigen of Mycobacterium tuberculosis and MPLA adjuvant co-entrapped into PLGA:DDA hybrid nanoparticles stimulates mucosal and systemic immunity

Author:
Khademi, Farzad; Derakhshan, Mohammad; Yousefi-Avarvand, Arshid; Najafi, Adel; Tafaghodi, Mohsen
Source:
Microbial pathogenesis 2018 v.125 pp. 507-513
ISSN:
0882-4010
Subject:
vaccination,   etc   ; Mycobacterium tuberculosis; adjuvants; antibodies; antigens; blood serum; emulsions; enzyme-linked immunosorbent assay; evaporation; immune response; immunoglobulin A; immunoglobulin G; interferon-gamma; interleukin-17; interleukin-4; intranasal administration; mice; mucosal immunity; nanoparticles; nose; solvents; splenocytes; transforming growth factor beta; tuberculosis; vaccines;     Show all 25 Subjects
Abstract:
... Due to initiation of Mycobacterium tuberculosis infection via the mucosal tissue of the respiratory tract, intranasal administration of new tuberculosis vaccines is highly regarded to enhance mucosal immunity. Our outline was evaluation of mucosal and systemic immune responses in BALB/c mice after nasal delivery of HspX/EsxS fused antigen of Mycobacterium tuberculosis along with MPLA adjuvant entr ...
DOI:
10.1016/j.micpath.2018.10.023

17. A novel food‐grade lactococcal expression system and its use for secretion and delivery of an oral vaccine antigen

Author:
Zhang, Rongguang; Qiao, Dan; Peng, Xiaoyan; Duan, Guangcai; Shi, Qingfeng; Zhang, Linghan; Wang, Chen; Liang, Wenjuan; Chen, Shuaiyin; Fan, Qingtang
Source:
Journal of chemical technology and biotechnology 2018 v.93 no.6 pp. 1655-1660
ISSN:
0268-2575
Subject:
oral vaccination,   etc   ; antibodies; antigens; blood serum; edible vaccines; heterologous gene expression; mice; protein synthesis; proteins; secretion; vaccine development; vector vaccines;     Show all 12 Subjects
Abstract:
... BACKGROUND: Food‐grade bacterial expression systems are relatively rare, and increasing evidence indicates that subcellular location of antigens in bacterial vector vaccines may markedly affect the immune efficacy. RESULTS: This study developed a novel food‐grade secretory expression system for heterologous protein production and oral vaccine delivery. Furthermore, by using the expression system, ...
DOI:
10.1002/jctb.5536

18. A novel genotype VII Newcastle disease virus vaccine candidate generated by mutation in the L and F genes confers improved protection in chickens

Author:
Ji, Yanhong; Liu, Tao; Du, Yingying; Cui, Xiaole; Yu, Qingzhong; Wang, Zhengxiang; Zhang, Jinjin; Li, Yu; Zhu, Qiyun
Source:
Veterinary microbiology 2018 v.216 pp. 99-106
ISSN:
0378-1135
Subject:
vaccination,   etc   ; chickens; Newcastle disease; biosecurity; interferon-gamma; antibodies; serotypes; vaccines; mutation; Avian orthoavulavirus 1; genes; genotype; mutants; cell proliferation; virulence; virus replication; CD8-positive T-lymphocytes;     Show all 17 Subjects
Abstract:
... Administration of vaccines combined with the good management and strict biosecurity is an effective way for Newcastle disease (ND) control. However, vaccine failure is continuously reported in some countries mainly because the antigenic difference between the used vaccine and field strains even they are of one serotype. Therefore, development of antigen-matched ND vaccines is needed to improve the ...
DOI:
10.1016/j.vetmic.2018.01.021

19. A Novel Human Papillomavirus 16 L1 Pentamer-Loaded Hybrid Particles Vaccine System: Influence of Size on Immune Responses

Author:
Jia, Chengcheng; Yang, Tingyuan; Liu, Yongjiang; Zhu, Ali; Yin, Fei; Wang, Yajun; Xu, Lan; Wang, Yan; Yan, Mei; Cai, Qingman; Liang, Xiaoxu; Ju, Ruijun; Chen, Jianping; Wang, Lianyan
Source:
ACS applied materials & interfaces 2018 v.10 no.42 pp. 35745-35759
ISSN:
1944-8252
Subject:
vaccination,   etc   ; adjuvants; lipids; chemokines; uterine cervical neoplasms; antibodies; dendritic cells; lymphocytes; lymph nodes; females; Escherichia coli; Human papillomavirus type 16; antigens; humans; developing countries; immune response; markets; mortality; salts; vaccines; particle size; aluminum; polymers; cost effectiveness;     Show all 24 Subjects
Abstract:
... Cervical cancer remains the second-most prevalent female malignancy around the world, leading to a great majority of cancer-related mortality that occurs mainly in developing countries. Developing an effective and low-cost vaccine against human papillomavirus (HPV) infection, especially in medically underfunded areas, is urgent. Compared with vaccines based on HPV L1 viruslike particles (VLPs) in ...
DOI:
10.1021/acsami.8b11556

20. Antibody and cytokine response to Cystoisospora suis infections in immune-competent young pigs

Author:
Freudenschuss, Barbara; Ruttkowski, Bärbel; Shrestha, Aruna; Abd-Elfattah, Ahmed; Pagès, Marc; Ladinig, Andrea; Joachim, Anja
Source:
Parasites & vectors 2018 v.11 no.1 pp. 390
ISSN:
1756-3305
Subject:
oral vaccination,   etc   ; antibodies; antibody formation; blood serum; excretion; fluorescent antibody technique; immunoglobulin A; immunoglobulin G; interferon-alpha; interleukin-10; interleukin-12; interleukin-2; interleukin-4; interleukin-6; lymph nodes; lymphocytes; merozoites; messenger RNA; models; mucus; oocysts; parasites; piglets; polymerase chain reaction; protein content; protocols; signs and symptoms (animals and humans); sows; sporozoites; suckling; transforming growth factor beta; tumor necrosis factor-alpha;     Show all 32 Subjects
Abstract:
... BACKGROUND: To date, investigations on the immune response to Cystoisospora suis infections focused on suckling piglets, the age group clinically most affected. Actively immunizing piglets is unfeasible due to their immature immune system and the typically early infection in the first days after birth. Therefore, understanding and possibly enhancing the immune response of immune-competent animals ...
DOI:
10.1186/s13071-018-2974-6
PubMed:
29973271
PubMed Central:
PMC6031197