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- Kung, Mei-Lang; Lin, Pei-Ying; Huang, Shih-Tsung; Tai, Ming-Hong; Hsieh, Shu-Ling; Wu, Chih-Chung; Yeh, Bi-Wen; Wu, Wen-Jeng; Hsieh, Shuchen
- ACS applied materials & interfaces 2018 v.11 no.1 pp. 137-150
- hepatoma, etc ; DNA damage; antineoplastic activity; apoptosis; caspases; cell cycle; drugs; human cell lines; nanoparticles; particle size; signal transduction; therapeutics; transcription factor NF-kappa B; Show all 13 Subjects
- ... We base this study on the concept of drug repositioning to reconstitute the natural product of zingerone as zingerone nanoparticles (zingerone NPs) through a one-pot synthesized process. The as-fabricated zingerone NPs were characterized; they possessed a particle size of 1.42 ± 0.67 nm and a reconstituted structure of zingerone nanotetramer. We further validate the effects of zingerone NPs on the ...