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You searched for: Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Subject term demethylation Remove constraint Subject term: demethylation
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1. A concise synthesis of (±)-7-O-galloyltricetiflavan

Author:
Wenxuan Zhang; Wenjie Xue; Yuqing Jia; Gang Wen; Xu Lian; Jing Shen; Ailin Liu; Song Wu
Source:
RSC advances 2018 v.8 no.26 pp. 14389-14392
ISSN:
2046-2069
Subject:
acylation; demethylation; flavones; hydrolysis; organochlorine compounds
Abstract:
... (±)-7-O-galloyltricetiflavan (1a) was synthesized successfully in five steps from the commercially available trihydroxyacetophenone (2) and trimethoxybenzoyl chloride (3). The flavone 4a was prepared in a one-pot reaction and it gave hex-O-methylflavan 6 followed by acylation and reduction. However, the demethylation of flavan 6, 5-O-acetylflavan 10 and 5-O-phenylacetylflavan 11 by BBr₃ gave all t ...
DOI:
10.1039/c8ra01606b

2. ALKBH5-induced demethylation of mono- and dimethylated adenosine

Author:
Timm T. EnsfelderEqual contributions.; Matthias Q. Kurz; Katharina Iwan; Simon Geiger; Sarah Matheisl; Markus Müller; Roland Beckmann; Thomas Carell
Source:
Chemical communications 2018 v.54 no.62 pp. 8591-8593
ISSN:
1364-548X
Subject:
adenosine; alpha-ketoglutaric acid; demethylation; enzymes; homeostasis; messenger RNA; methylation; ribosomal RNA
Abstract:
... RNA contains methylated A-base derivatives. A methylation to m⁶A and then demethylation regulate homeostasis in mRNA. It is assumed that m⁶A is mainly demethylated by the α-ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m⁶₂A, which is a non-canonical base present in ribosomal RNA. ...
DOI:
10.1039/c8cc03980a

3. Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons

Author:
Bing Yao; Yujing Li; Zhiqin Wang; Li Chen; Mickael Poidevin; Can Zhang; Li Lin; Feng Wang; Han Bao; Bin Jiao; Junghwa Lim; Ying Cheng; Luoxiu Huang; Brittany Lynn Phillips; Tianlei Xu; Ranhui Duan; Kenneth H. Moberg; Hao Wu; Peng Jin
Source:
Molecular cell 2018 v.71 no.5 pp. 848-857.e6
ISSN:
1097-2765
Subject:
DNA; Drosophila; brain; demethylation; enzymes; epigenetics; gene expression; genes; neurodevelopment; neurons; proteins; transcription (genetics); transcriptomics
Abstract:
... A ten-eleven translocation (TET) ortholog exists as a DNA N⁶-methyladenine (6mA) demethylase (DMAD) in Drosophila. However, the molecular roles of 6mA and DMAD remain unexplored. Through genome-wide 6mA and transcriptome profiling in Drosophila brains and neuronal cells, we found that 6mA may epigenetically regulate a group of genes involved in neurodevelopment and neuronal functions. Mechanistica ...
DOI:
10.1016/j.molcel.2018.07.005
PubMed:
30078725
PubMed Central:
PMC6136845

4. Alkaloids Reactivity: DFT Analysis of Selective Demethylation Reactions

Author:
Olatz Larrañaga; José I. Miranda; Fernando P. Cossío; Abel de Cózar
Source:
Journal of organic chemistry 2018 v.83 no.24 pp. 15101-15109
ISSN:
1520-6904
Subject:
alkaloids; chemical reactions; chemical structure; demethylation; organic chemistry; theoretical models
Abstract:
... All possible demethylation reactions of a diverse family of quaternary alkaloids by means of DFT calculations are here described. We aim to develop a rational model that allows the explanation of the high selectivity observed experimentally and predicts the occurrence of new alkaloid derivatives. To this end, we have performed a detailed analysis of the initial reagents and products. In addition, ...
DOI:
10.1021/acs.joc.8b02364

5. An uncondensed lignin depolymerized in the solid state and isolated from lignocellulosic biomass: a mechanistic study

Author:
Ning Li; Yanding Li; Chang Geun Yoo; Xiaohui Yang; Xuliang Lin; John Ralph; Xuejun Pan
Source:
Green chemistry 2018 v.20 no.18 pp. 4224-4235
ISSN:
1463-9270
Subject:
biomass; cellulose; condensation reactions; demethylation; dioxane; feedstocks; grasses; green chemistry; hardwood; hemicellulose; hydrochloric acid; ketones; lignocellulose; lithium; models; moieties; softwood
Abstract:
... This study demonstrated that lignin could be efficiently depolymerized in the solid state with minimal condensation and separated from biomass with high purity by dissolving and hydrolyzing cellulose and hemicelluloses, using an acidic lithium bromide trihydrate (ALBTH) system under mild conditions (with 40 mM HCl at 110 °C). The ALBTH lignins isolated from biomass sources representing the three p ...
DOI:
10.1039/c8gc00953h
CHORUS:
10.1039/c8gc00953h

6. Analysis of sulphur and chlorine induced DNA cytosine methylation alterations in fresh corn (Zea mays L. saccharata and rugosa) leaf tissues by methylation sensitive amplification polymorphism (MSAP) approach

Author:
Tinashe Zenda; Songtao Liu; Daxuan Yao; Huijun Duan
Source:
Genes & genomics 2018 v.40 no.9 pp. 913-925
ISSN:
1976-9571
Subject:
DNA; DNA methylation; Zea mays; abiotic stress; chlorine; corn; crops; cultivars; cytosine; demethylation; filling period; genome; hybrids; leaves; loci; oligodeoxyribonucleotides; photosynthates; soil fertility; stress response; sulfur; tissues
Abstract:
... DNA (cytosine) methylation mechanism is another way through which plants respond to various cues including soil fertility amendments and abiotic stresses, and the mechanism has been used to infer some physiological, biochemical or adaptation processes. Despite numerous studies on global DNA methylation profiling in various crop species, however, researches on fresh corn (Zea mays L. saccharata or ...
DOI:
10.1007/s13258-018-0685-1

7. Baseline sensitivity and control efficacy of propiconazole against Sclerotinia sclerotiorum

Author:
Jun Zhang; Simin Hu; Qianru Xu; Hong You; Fuxing Zhu
Source:
Crop protection 2018 v.114 pp. 208-214
ISSN:
0261-2194
Subject:
Brassica napus; Sclerotinia sclerotiorum; boscalid; carbendazim; culture media; demethylation; hyphae; median effective concentration; membrane permeability; microsatellite repeats; microscopy; mycelium; normal distribution; pathogens; propiconazole; sclerotia; stem rot; tebuconazole; China
Abstract:
... Sclerotinia sclerotiorum, the causal agent of Sclerotinia stem rot (SSR) of oilseed rape, is a broad-host-range pathogen. The demethylation inhibitor (DMI) fungicide propiconazole was officially approved in China in 2014 for control of this pathogen. In this study, baseline sensitivity of S. sclerotiorum to propiconazole was established. The distribution of the 50% effective concentration (EC50) v ...
DOI:
10.1016/j.cropro.2018.08.034

8. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:
Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
Source:
Life sciences 2018 v.214 pp. 136-144
ISSN:
0024-3205
Subject:
DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:
... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:
10.1016/j.lfs.2018.10.044

9. Brassinosteroid Signaling Recruits Histone 3 Lysine-27 Demethylation Activity to FLOWERING LOCUS C Chromatin to Inhibit the Floral Transition in Arabidopsis

Author:
Zicong Li; Yang Ou; Zhicheng Zhang; Jianming Li; Yuehui He
Source:
Molecular plant 2018 v.11 no.9 pp. 1135-1146
ISSN:
1674-2052
Subject:
Arabidopsis; brassinosteroids; chromatin; demethylation; flowering; gene expression regulation; growth retardation; histones; introns; loci; mutants; oxygenases; steroid hormones; transcription factors; vegetative growth
Abstract:
... The steroid hormone brassinosteroid (BR) plays a broad role in plant growth and development. As the retarded growth in BR-insensitive and BR-deficient mutants causes a strong delay in days to flowering, BR signaling has been thought to promote the floral transition in Arabidopsis. In this study, using a developmental measure of flowering time, we show that BR signaling inhibits the floral transiti ...
DOI:
10.1016/j.molp.2018.06.007

10. Brood size influences patterns of DNA methylation in wild Zebra Finches (Taeniopygia guttata)

Author:
Elizabeth L. Sheldon; Aaron W. Schrey; Alexandria K. Ragsdale; Simon C. Griffith
Source:
Auk 2018 v.135 no.4 pp. 1113-1122
ISSN:
1938-4254
Subject:
DNA methylation; Taeniopygia guttata; adults; blood; demethylation; early development; epigenetics; life history; loci; nestlings; nests; phenotype; siblings; wild birds
Abstract:
... Both natural and experimentally manipulated brood size can influence the competition dynamics among siblings in a nest and alter the environment during early development in birds. Brood size affects a variety of life-history and fitness-related traits, but relatively little is known about the mechanisms that might mediate these effects. There is accumulating evidence that early-life environments c ...
DOI:
10.1642/AUK-18-61.1

11. Can Reprogramming of Overall Epigenetic Memory and Specific Parental Genomic Imprinting Memory within Donor Cell-Inherited Nuclear Genome be a Major Hindrance for the Somatic Cell Cloning of Mammals? – A Review

Author:
Marcin Samiec; Maria Skrzyszowska
Source:
Annals of animal science 2018 v.18 no.3 pp. 623-638
ISSN:
2300-8733
Subject:
DNA; acetylation; animal science; chromatin; cytosine; demethylation; early development; gene expression; genetic engineering; genomics; germ cells; histones; humans; lysine; medicine; memory; nuclear genome; somatic cells; transcription (genetics)
Abstract:
... Successful cloning of animals by somatic cell nuclear transfer (SCNT) requires epigenetic transcriptional reprogramming of the differentiated state of the donor cell nucleus to a totipotent embryonic ground state. It means that the donor nuclei must cease its own program of gene expression and restore a particular program of the embryonic genome expression regulation that is necessary for normal d ...
DOI:
10.2478/aoas-2018-0015

12. Catalytic pyrolysis of lignin with red mud derived hierarchical porous catalyst for alkyl-phenols and hydrocarbons production

Author:
Shaoqing Wang; Zhihe Li; Xueyuan Bai; Weiming Yi; Peng Fu
Source:
Journal of analytical and applied pyrolysis 2018 v.136 pp. 8-17
ISSN:
0165-2370
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; X-ray fluorescence spectroscopy; absorption; acidity; agricultural wastes; alkylation; alkylphenols; aluminum oxide; biofuels; catalysts; demethylation; energy-dispersive X-ray analysis; ferric oxide; hydrocarbons; lignin; porosity; pyrolysis; scanning electron microscopy; surface area; temperature; texture; titanium dioxide; transmission electron microscopy; vapors
Abstract:
... Red mud (RM) was activated by a feasible digestion-precipitation method followed by calcination at 600 °C (denoted as ACRM), which was used as a novel catalyst during the thermal degradation of the lignin. The prepared catalyst was then applied to the lignin derived from agricultural waste using a vertical fixed-bed microreactor between 350–650 °C. The texture characteristics of the activated RM w ...
DOI:
10.1016/j.jaap.2018.10.024

13. Cationic peroxidase from proso millet induces human colon cancer cell necroptosis by regulating autocrine TNF-α and RIPK3 demethylation

Author:
Xiaodong Cui; Ru Wang; Zhuanhua Wang
Source:
Food & function 2018 v.9 no.3 pp. 1878-1888
ISSN:
2042-650X
Subject:
Panicum miliaceum subsp. miliaceum; ammonium sulfate; apoptosis; autocrine signaling; cation exchange; colorectal neoplasms; demethylation; fractionation; gel chromatography; humans; necroptosis; neoplasm cells; nucleotide sequences; peroxidase; protein kinases; seeds; toxicity; transcription (genetics); tumor necrosis factor-alpha
Abstract:
... A cationic peroxidase (POD) was purified from proso millet seeds (PmPOD) using ammonium sulfate fractionation, cation exchange, and size exclusion chromatography. The purified PmPOD showed toxicity to normal cells and tumor cells, but was more sensitive in HT29 cells. Furthermore, the mechanism driving HCT116 and HT29 cell death by PmPOD was the induction of receptor interacting protein kinase 1 ( ...
DOI:
10.1039/c7fo01040k

14. Comparison of DNA methylation in developing seeds of Ricinus communis L. using MSAP analysis

Author:
Fenglan Huang; Mu Peng; Xiaofeng Chen; Guorui Li; Jianjun Di; Yong Zhao; Tongtong Jiang; Ruihui Chang; Lifeng Yang; Yongshen Chen
Source:
Biotechnology, biotechnological equipment 2018 v.32 no.4 pp. 858-864
ISSN:
1314-3530
Subject:
DNA methylation; Ricinus communis; adenosinetriphosphatase; biotechnology; demethylation; endosperm; epigenetics; equipment; gene expression; gene expression regulation; methyltransferases; seed maturation
Abstract:
... DNA methylation plays an important role in endosperm development and is involved in the epigenetic regulation of gene expression. However, the epigenetic regulation of castor seed development has not yet been reported. In this study, methylation-sensitive amplification polymorphism (MSAP) analysis was used to investigate the methylation level in castor. In 20-day-old castor seeds, 41.17% of the fr ...
DOI:
10.1080/13102818.2018.1470034

15. Dehydroleucodine inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest

Author:
S. Abood; M. L. Veisaga; L. A. López; M. A. Barbieri
Source:
Phytotherapy research 2018 v.32 no.8 pp. 1583-1592
ISSN:
0951-418X
Subject:
adipocytes; adipogenesis; biomarkers; cell cycle checkpoints; cyclin-dependent kinase; cyclins; demethylation; droplets; histones; hyperplasia; hypertrophy; interphase; metabolic diseases; methylation; methyltransferases; mitosis; obesity; peroxisome proliferator-activated receptor gamma; phenotype; phosphorylation; risk factors; transcriptional activation; triacylglycerols
Abstract:
... Aberrant levels of preadipocyte differentiation, triggered by adipocyte hyperplasia and hypertrophy, results in the obesogenic phenotype. Obesity is a risk factor for several metabolic disorders. In this paper, dehydroleucodine inhibited the accumulation of lipid droplets and decreased the elevations of triglycerides, and this inhibitory effect occurred during the early stage of adipogenesis. Thus ...
DOI:
10.1002/ptr.6089

16. Demethylation and other modifications of industrial softwood kraft lignin by laccase-mediators

Author:
Miao Wang; Yadong Zhao; Jiebing Li
Source:
Holzforschung 2018 v.72 no.5 pp. 357-365
ISSN:
1437-434X
Subject:
catechol; depolymerization; laccase; lignin; methanol; molecular weight; phenol; polymerization; quinones; softwood; triazoles
Abstract:
... Substitution of phenol in phenol-formaldehyde (PF) resin preparations by technical lignins is hindered by the inherently lower reactivity of lignin compared to phenol. Demethylation of an industrial softwood kraft lignin (SKL) to improve its reactivity is the focus of this paper. To this purpose, kraft lignin (KL) was treated with two commercial laccases, NS51002 (L1) and NS51003 (L2), for 24 h in ...
DOI:
10.1515/hf-2017-0096

17. Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

Author:
Jiangbo Wei; Fange Liu; Zhike Lu; Qili Fei; Yuxi Ai; P. Cody He; Hailing Shi; Xiaolong Cui; Rui Su; Arne Klungland; Guifang Jia; Jianjun Chen; Chuan He
Source:
Molecular cell 2018 v.71 no.6 pp. 973-985.e5
ISSN:
1097-2765
Subject:
cell lines; cell nucleus; cytoplasm; demethylation; enzymes; messenger RNA; small nuclear RNA; transfer RNA
Abstract:
... FTO, the first RNA demethylase discovered, mediates the demethylation of internal N⁶-methyladenosine (m⁶A) and N⁶, 2-O-dimethyladenosine (m⁶Am) at the +1 position from the 5′ cap in mRNA. Here we demonstrate that the cellular distribution of FTO is distinct among different cell lines, affecting the access of FTO to different RNA substrates. We find that FTO binds multiple RNA species, including mR ...
DOI:
10.1016/j.molcel.2018.08.011
PubMed:
30197295
PubMed Central:
PMC6151148

18. Early diagenesis of triterpenoids derived from mangroves in a subtropical estuary

Author:
Ding He; Bernd R.T. Simoneit; Joshua B. Cloutier; Rudolf Jaffé
Source:
Organic geochemistry 2018 v.125 pp. 196-211
ISSN:
0146-6380
Subject:
demethylation; isomerization; rivers; salinity; photolysis; diagenesis; soil; lupane; fungi; leaves; aromatization; leaf abscission; death; oxidation; estuaries; bacteria; Rhizophora mangle; United States
Abstract:
... Leaves from three mangrove species, and surface and deeper soils along salinity gradients in the Shark River estuary, USA, were analyzed to determine numerous diagenetic degradation products and pathways for mangrove derived triterpenoids. The dehydration of pentacyclic triterpenols was observed in mangrove leaves, leading to pentacyclic triterpadienes with Δ²,¹² and Δ²,¹⁴ unsaturations. Surprisin ...
DOI:
10.1016/j.orggeochem.2018.09.005

19. Effect of Fusarium Head Blight Management Practices on Mycotoxin Contamination of Wheat Straw

Author:
Kaitlyn M. Bissonnette; Frederic L. Kolb; Keith A. Ames; Carl A. Bradley
Source:
Plant disease 2018 v.102 no.6 pp. 1141-1147
ISSN:
0191-2917
Subject:
15-acetyldeoxynivalenol; 3-acetyldeoxynivalenol; Fusarium; Fusarium head blight; cultivars; demethylation; deoxynivalenol; disease control; fungicides; quinones; wheat; wheat straw
Abstract:
... Management of Fusarium graminearum-associated mycotoxins in wheat grain has been extensively evaluated, but little is known about management of mycotoxins in straw. Two research trials were conducted at four locations from 2011 to 2014. The objective of the first trial was to determine the efficacy of fungicides, and the objective of the second trial was to evaluate the use of integrated disease m ...
DOI:
10.1094/PDIS-09-17-1385-RE

20. Effects of Pre- and Postanthesis Applications of Demethylation Inhibitor Fungicides on Fusarium Head Blight and Deoxynivalenol in Spring and Winter Wheat

Author:
Pierce A. Paul; Carl A. Bradley; Laurence V. Madden; Felipe Dalla Lana; Gary C. Bergstrom; Ruth Dill-Macky; Kiersten A. Wise; Paul D. Esker; Marcia McMullen; Arvydas Grybauskas; William W. Kirk; Eugene Milus; Kay Ruden
Source:
Plant disease 2018 v.102 no.12 pp. 2500-2510
ISSN:
0191-2917
Subject:
Fusarium head blight; demethylation; deoxynivalenol; grain yield; heading; models; spikelets; spring; spring wheat; tebuconazole; winter wheat
Abstract:
... Anthesis is generally recommended as the optimum growth stage for applying a foliar fungicide to manage Fusarium head blight (FHB) and the Fusarium-associated toxin deoxynivalenol (DON) in wheat. However, because it is not always possible to treat fields at anthesis, studies were conducted to evaluate pre- and postanthesis treatment options for managing FHB and DON in spring and winter wheat. Netw ...
DOI:
10.1094/PDIS-03-18-0466-RE

21. Effects of ethephon on DNA methylation and gene expressions associated with shortened internodes in maize

Author:
Daxuan Yao; Xiuai Huo; Tinashe Zenda; Songtao Liu; Yunting Liu; Liang Dai; Huijun Duan
Source:
Biotechnology, biotechnological equipment 2018 v.32 no.1 pp. 30-40
ISSN:
1314-3530
Subject:
DNA methylation; amplified fragment length polymorphism; apoptosis; biotechnology; corn; demethylation; energy; equipment; ethephon; gene expression regulation; leaves; signal transduction; start codon
Abstract:
... In this study, the molecular mechanism underlying ethephon-induced shortened internodes in maize was investigated using Zhengdan958 maize variety. The ethephon treatment was performed by spraying 225 mL/ha Ethephon 40% SL onto the foliage at the eight-expanded-leaves stage. The differentially expressed genes in the young internodes under ethephon treatment were identified through methylation-sensi ...
DOI:
10.1080/13102818.2017.1386591

22. Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis

Author:
Jiaxing He; Weiqin Chang; Chunyang Feng; Manhua Cui; Tianmin Xu
Source:
International Journal of Genomics 2018 v.2018 pp. -
ISSN:
2314-4378
Subject:
DNA methylation; animal ovaries; carcinogenesis; demethylation; endometrium; epigenetics; histones; microRNA; ovarian neoplasms; pain; risk factors; women
Abstract:
... Endometriosis, defined as the presence of ectopic endometrial glands and stroma outside the uterine cavity, is a chronic, hormone-dependent gynecologic disease affecting millions of women across the world, with symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, and subfertility. In addition, there is well-established evidence that, although endometriosis is considered beni ...
DOI:
10.1155/2018/1465348
PubMed:
29780815
PubMed Central:
PMC5892233

23. Enzymatic Kraft lignin demethylation and fungal O-demethylases like vanillate-O-demethylase and syringate O-demethylase catalyzed catechol-Fe3+ complexation method

Author:
Balaji Venkatesagowda
Source:
Journal of microbiological methods 2018 v.152 pp. 126-134
ISSN:
0167-7012
Subject:
Aspergillus; Galerina; absorbance; ammonium sulfate; caffeic acid; catechol; chemical bonding; culture filtrates; demethylation; deprotonation; enzyme activity; enzymes; fungi; gallic acid; glycols; hydrogen peroxide; iron; lignin; models; moieties; nitrous acid; pH; pyrocatechol; titanium; vanillin
Abstract:
... The ability of enzymatic Kraft Lignin (KL) demethylation was determined using catechol and ferric ion coordination (catechol-Fe³⁺ complexes) by reduction of Fe³⁺ to Fe²⁺ and formation of mono, bis- and/or tris-catechol-Fe³⁺ complexes has been investigated to identify enzyme that can strip-off O-methyl groups from lignin such as O-demethylase. To detect fungal demethylation and release of catechol- ...
DOI:
10.1016/j.mimet.2018.07.021

24. Epigallocatechin Gallate Preferentially Inhibits O⁶-Methylguanine DNA-Methyltransferase Expression in Glioblastoma Cells Rather than in Nontumor Glial Cells

Author:
Chao-Ran Xie; Chao-Guo You; Nu Zhang; Han-Song Sheng; Xue-Sheng Zheng
Source:
Nutrition and cancer 2018 v.70 no.8 pp. 1339-1347
ISSN:
1532-7914
Subject:
beta catenin; cell culture; cell lines; clinical trials; cytotoxicity; demethylation; epigallocatechin gallate; glioblastoma; messenger RNA; methylation; neuroglia; protein content; protein synthesis; tissues; transcription factors; transferases
Abstract:
... Objective: O⁶-methylguanine (O6-meG) DNA-methyltransferase (MGMT) is a main regulator of temozolomide (TMZ) resistance in glioblastomas. Some MGMT inhibitors have been studied in clinical trials but with very little success, because their inhibiting effects were not tumor-selective, and often cause severe toxicity in normal tissues in the presence of TMZ. The goal of this study is to explore wheth ...
DOI:
10.1080/01635581.2018.1539189

25. Escherichia coli single-stranded DNA binding protein SSB promotes AlkB-mediated DNA dealkylation repair

Author:
Richa Nigam; Roy Anindya
Source:
Biochemical and biophysical research communications 2018 v.496 no.2 pp. 274-279
ISSN:
0006-291X
Subject:
DNA adducts; DNA repair; DNA replication; DNA-binding domains; DNA-binding proteins; Escherichia coli; alkylation; demethylation; genome; oligonucleotides; single-stranded DNA
Abstract:
... Repair of alkylation damage in DNA is essential for maintaining genome integrity. Escherichia coli (E.coli) protein AlkB removes various alkyl DNA adducts including N1-methyladenine (N1meA) and N3-methylcytosine (N3meC) by oxidative demethylation. Previous studies showed that AlkB preferentially removes N1meA and N3meC from single-stranded DNA (ssDNA). It can also remove N1meA and N3meC from doubl ...
DOI:
10.1016/j.bbrc.2018.01.043

26. Excellent degradation performance of 3D hierarchical nanoporous structures of copper towards organic pollutants

Author:
Chong Yang; Cheng Zhang; Lin Liu
Source:
Journal of materials chemistry 2018 v.6 no.42 pp. 20992-21002
ISSN:
2050-7496
Subject:
azo dyes; catalysts; catalytic activity; chemical oxygen demand; copper; copper nanoparticles; demethylation; geometry; hydrogen peroxide; ligaments; liquids; nanopores; oxidation; pollutants; remediation; spectroscopy; surface area; wastewater
Abstract:
... Advanced oxidation processes provide a promising way to the degradation of organic pollutants in wastewater, wherein developing highly efficient catalysts is of paramount importance. Herein, three-dimensional (3D) hierarchical nanoporous structures of Cu catalysts with desirable geometries were synthesized by laser 3D printing combined with chemical dealloying. The resulting 3D nanoporous Cu (3D N ...
DOI:
10.1039/c8ta07973k

27. Experimental Treatment with a Hypomethylating Agent Alters Life History Traits and Fitness in Brassica rapa

Author:
Emily J. Kottler; Acer VanWallendael; Steven J. Franks
Source:
Journal of botany 2018 v.2018 pp. -
ISSN:
2090-0139
Subject:
Brassica rapa; DNA; DNA hypomethylation; biennials; demethylation; epigenetics; evolution; flowering date; germination; inheritance (genetics); life history; phenotype; photoperiod; reproductive fitness
Abstract:
... Epigenetic modifications to DNA can be inherited and may play a key role in evolution, with epigenetic influences on life history traits such as the timing of germination and flowering thought to be particularly important in plants. However, few studies have examined the effects of epigenetic modifications through experimental alteration of the methylome under differential growth conditions. In th ...
DOI:
10.1155/2018/7836845

28. Hepatic metabolite profiling of polychlorinated biphenyl (PCB)-resistant and sensitive populations of Atlantic killifish (Fundulus heteroclitus)

Author:
Lilah Glazer; Melissa C. Kido Soule; Krista Longnecker; Elizabeth B. Kujawinski; Neelakanteswar Aluru
Source:
Aquatic toxicology 2018 v.205 pp. 114-122
ISSN:
0166-445X
Subject:
DNA; DNA methylation; Fundulus heteroclitus; adults; amino acid metabolism; biosynthesis; coasts; demethylation; estuaries; fish; gene expression; genes; habitats; liver; metabolites; metabolomics; methyltransferases; nucleotides; polychlorinated biphenyls; rivers; sediments; streams; tissues; toxicity; Massachusetts
Abstract:
... Atlantic killifish inhabiting polluted sites along the east coast of the U.S. have evolved resistance to toxic effects of contaminants. One such contaminated site is the Acushnet River estuary, near New Bedford Harbor (NBH), Massachusetts, which is characterized by very high PCB concentrations in the sediments and in the tissues of resident killifish. Though killifish at this site appear to be thr ...
DOI:
10.1016/j.aquatox.2018.10.007
PubMed:
30368057
PubMed Central:
PMC6246827

29. High-pressure pyrolysis of isoprenoid hydrocarbon p-menthane in a tandem micro-reactor with online GC–MS/FID

Author:
Siyuan Gong; Yutong Wang; Hongyan Wang; Xiangwen Zhang; Guozhu Liu
Source:
Journal of analytical and applied pyrolysis 2018 v.135 pp. 122-132
ISSN:
0165-2370
Subject:
activation energy; benzene; biomass; carbon; cleavage (chemistry); dehydrogenation; demethylation; ethylene; fuel combustion; fuels; gas chromatography-mass spectrometry; hosts; isomerization; isoprenoids; kinetics; metabolic engineering; microorganisms; propylene; pyrolysis; temperature; toluene
Abstract:
... Isoprenoids have been synthesized in large quantities through metabolic engineering method using some microorganisms as hosts and biomass as carbon resources. An isoprenoid cyclic hydrocarbon, p-menthane, is considered as a promising “drop-in” fuel to substitute traditional cycloalkane components, however, its pyrolysis data is lacking so far which is a significant part of the fuel combustion chem ...
DOI:
10.1016/j.jaap.2018.09.011

30. Hormetic Effects of Flusilazole Preconditioning on Mycelial Growth and Virulence of Sclerotinia sclerotiorum

Author:
Xiaoming Lu; Shun He; Hongju Ma; Jianhong Li; Fuxing Zhu
Source:
Plant disease 2018 v.102 no.6 pp. 1165-1170
ISSN:
0191-2917
Subject:
Sclerotinia sclerotiorum; carbendazim; culture media; demethylation; flusilazole; hormesis; leaves; mycelium; pesticide application; plant pathogenic fungi; prochloraz; rapeseed; spraying; tebuconazole; virulence
Abstract:
... Hormetic effects of fungicides are highly relevant to fungicide applications and management of plant-pathogenic fungi. Preconditioning (i.e., early exposure to relatively low doses of a toxicant) is a special form of hormesis, and fungicide preconditioning of phytopathogenic fungi is inevitable in the field. The present study showed that spraying the demethylation inhibitor (DMI) fungicide flusila ...
DOI:
10.1094/PDIS-10-17-1638-RE

31. Human histone demethylase KDM6B can catalyse sequential oxidations

Author:
Richard J. Hopkinson; Gareth W. Langley; Roman Belle; Louise J. Walport; Kate Dunne; Martin Münzel; Eidarus Salah; Akane Kawamura; Timothy D. W. Claridge; Christopher J. Schofield
Source:
Chemical communications 2018 v.54 no.57 pp. 7975-7978
ISSN:
1364-548X
Subject:
alcohols; aldehydes; carboxylic acids; chemical reactions; demethylation; enzymes; genes; histones; humans; lysine
Abstract:
... Jumonji domain-containing demethylases (JmjC-KDMs) catalyse demethylation of Nᵋ-methylated lysines on histones and play important roles in gene regulation. We report selectivity studies on KDM6B (JMJD3), a disease-relevant JmjC-KDM, using synthetic lysine analogues. The results unexpectedly reveal that KDM6B accepts multiple Nᵋ-alkylated lysine analogues, forming alcohol, aldehyde and carboxylic a ...
DOI:
10.1039/c8cc04057e
PubMed:
29961803
PubMed Central:
PMC6044289

32. Hydrogen peroxide redistributes the localization of protein phosphatase methylesterase 1

Author:
Shen Tang; Cailing Lu; Laiming Mo; Xinhang Wang; Ziwei Liang; Fu Qin; Yinpin Liu; Yuyang Liu; Haiyan Huang; Yue Huang; Haiqing Cai; Deqiang Xiao; Songchao Guo; Yiqiang Ouyang; Bin Sun; Xiyi Li
Source:
Life sciences 2018 v.213 pp. 166-173
ISSN:
0024-3205
Subject:
Western blotting; catalytic activity; cell lines; cysteine; cytoplasm; demethylation; fibroblasts; fluorescent antibody technique; humans; hydrogen peroxide; leucine; methylation; methyltransferases; oxidative stress; phosphoprotein phosphatase; physiological transport; protein phosphatase methylesterase-1; protein synthesis; proteins
Abstract:
... Protein phosphatase methylesterase-1 (PME-1) is a serine hydrolase that catalyzes protein phosphatase 2A (PP2A) demethylation and negatively regulates its activity. PME-1 is compartmentalized within cells to precisely control the demethylation of PP2A. This study investigated the localization of PME-1 in human fibroblast cells (HDF) under oxidative stress.Alkaline demethylation and peptide competi ...
DOI:
10.1016/j.lfs.2018.10.029

33. Identification of a consensus motif in Erg28p required for C-4 demethylation in yeast ergosterol biosynthesis based on mutation analysis

Author:
Xia Ke; Xiao-Yuan Xia; Ren-Chao Zheng; Yu-Guo Zheng
Source:
FEMS microbiology letters 2018 v.365 no.5 pp. -
ISSN:
1574-6968
Subject:
Saccharomyces cerevisiae; amino acids; biosynthesis; consensus sequence; demethylation; endoplasmic reticulum; enzymes; ergosterol; growth retardation; membrane proteins; models; moieties; mutants; mutational analysis; plasmids; prediction; topology; yeasts
Abstract:
... The Erg28p protein is localized to the endoplasmic reticulum, where it acts as a scaffold to tether the C-4 demethylase complex involved in the sterol biosynthesis pathway of Saccharomyces cerevisiae. However, due to the challenges involved in characterizing the interactions of membrane proteins, the precise region of Erg28p that is responsible for the assembly of this enzyme complex remains unkno ...
DOI:
10.1093/femsle/fny002

34. In vivo fractionation of mercury isotopes in tissues of a mammalian carnivore (Neovison vison)

Author:
Lan Ma; R. Douglas Evans; Wei Wang; R. Bastian Georg
Source:
Science of the total environment 2018 v.627 pp. 1228-1233
ISSN:
0048-9697
Subject:
Neovison vison; biochemical pathways; blood; brain; carnivores; demethylation; diet; fractionation; fur; isotopes; kidneys; liver; mercury; methylmercury compounds; mink; tissues
Abstract:
... The use of isotope ratios to trace Hg contamination sources in environmental compartments is now generally accepted. However, for biota and especially for mammals, it is still unknown if and/or how Hg isotopes fractionate in vivo and which tissue is most representative of the source(s) of contamination. We measured fractionation of Hg in mink (Neovison vison) tissues (fur, brain, blood, liver, kid ...
DOI:
10.1016/j.scitotenv.2018.01.296

35. Inherent Resistance to 14α-Demethylation Inhibitor Fungicides in Colletotrichum truncatum Is Likely Linked to CYP51A and/or CYP51B Gene Variants

Author:
Shuning Chen; Yunyun Wang; Guido Schnabel; Congyue Annie Peng; Satyanarayana Lagishetty; Kerry Smith; Chaoxi Luo; Huizhu Yuan
Source:
Phytopathology 2018 v.108 no.11 pp. 1263-1275
ISSN:
0031-949X
Subject:
Begonia; Citrus; Colletotrichum fructicola; Colletotrichum truncatum; amino acids; anthracnose; demethylation; difenoconazole; disease control; enzymes; fenbuconazole; fruits; gene expression; genes; mechanism of action; median effective concentration; models; peaches; phenotype; postharvest storage; propiconazole; soybeans; sterols; tebuconazole; vegetables; China; United States
Abstract:
... Anthracnose disease, caused by Colletotrichum truncatum, affects marketable yield during preharvest production and postharvest storage of fruits and vegetables worldwide. Demethylation inhibitor (DMI) fungicides are among the very few chemical classes of single-site mode of action fungicides that are effective in controlling anthracnose disease. However, some species are inherently resistant to DM ...
DOI:
10.1094/PHYTO-02-18-0054-R

36. Insights into the Biochemistry, Evolution, and Biotechnological Applications of the Ten-Eleven Translocation (TET) Enzymes

Author:
Mackenzie J. Parker; Peter R. Weigele; Lana Saleh
Source:
Biochemistry 2018 v.58 no.6 pp. 450-467
ISSN:
1520-4995
Subject:
DNA; DNA methylation; carbon; cytosine; demethylation; enzymes; epigenetics; evolution; gene expression regulation; human diseases; mammals; neoplasms; oxidation; tissues
Abstract:
... A tight link exists between patterns of DNA methylation at carbon 5 of cytosine and differential gene expression in mammalian tissues. Indeed, aberrant DNA methylation results in various human diseases, including neurologic and immune disorders, and contributes to the initiation and progression of various cancers. Proper DNA methylation depends on the fidelity and control of the underlying mechani ...
DOI:
10.1021/acs.biochem.8b01185

37. JMJ30‐mediated demethylation of H3K9me3 drives tissue identity changes to promote callus formation in Arabidopsis

Author:
Kyounghee Lee; Ok‐Sun Park; Pil Joon Seo
Source:
plant journal 2018 v.95 no.6 pp. 961-975
ISSN:
0960-7412
Subject:
Arabidopsis; auxins; callus; callus formation; catalytic activity; chromatin; demethylation; epigenetics; explants; genes; histones; leaves; loci; methylation; moieties; mutants; root primordia; somatic cells; tissue culture
Abstract:
... Plant somatic cells can be reprogrammed by in vitro tissue culture methods, and massive genome‐wide chromatin remodeling occurs, particularly during callus formation. Since callus tissue resembles root primordium, conversion of tissue identity is essentially required when leaf explants are used. Consistent with the fact that the differentiation state is defined by chromatin structure, which permit ...
DOI:
10.1111/tpj.14002

38. Low Benefits from Fungicide Use on Hard Red Wheat in Low-Disease Environments

Author:
Andrew Friskop; Shashi Yellareddygari; Neil C. Gudmestad; Kate Binzen Fuller; Mary Burrows
Source:
Plant health progress 2018 v.19 no.4 pp. 288-294
ISSN:
1535-1025
Subject:
application timing; demethylation; disease outbreaks; economic analysis; enzyme inhibitors; foliar diseases; fungicides; growers; hard red spring wheat; hard red winter wheat; mechanism of action; meta-analysis; pesticide application; prices; quinones; risk; succinate dehydrogenase (quinone)
Abstract:
... The use of fungicides on hard red wheat in the northern Great Plains increased in part owing to inexpensive fungicide options and several years of foliar disease epidemics. In some instances, fungicides are used in the absence of disease, prompting questions on the perceived value of these applications. This study analyzed yield data from 46 fungicide trials conducted in low-disease environments f ...
DOI:
10.1094/PHP-06-18-0028-RS

39. Manganese(iv) oxide amendments reduce methylmercury concentrations in sediment porewater

Author:
Dimitri Vlassopoulos; Masakazu Kanematsu; Elizabeth A. Henry; Jessica Goin; Alexander Leven; David Glaser; Steven S. Brown; Peggy A. O'Day
Source:
Environmental science 2018 v.20 no.12 pp. 1746-1760
ISSN:
2050-7895
Subject:
acetates; adsorption; birnessite; carbon dioxide; community structure; demethylation; environmental science; iron; labile carbon; lakes; manganese; manganese oxides; mercuric chloride; mercury; methylation; methylmercury compounds; microbial activity; microbial communities; polymerase chain reaction; salt marshes; sand; seasonal wetlands; sequence analysis; slurries; sulfates
Abstract:
... Manganese(iv) oxide (pyrolusite, birnessite) mineral amendments can reduce dissolved MeHg concentrations in sediment theoretically by inhibiting microbial sulfate reduction, which is a major methylation pathway in sediments. Anaerobic sediment slurry microcosms in which Hg methylation was stimulated by addition of labile organic carbon (acetate) and HgCl₂ showed that manganese(iv) oxide reduced th ...
DOI:
10.1039/c7em00583k

40. Meta-Analysis of the Effects of QoI and DMI Fungicide Combinations on Fusarium Head Blight and Deoxynivalenol in Wheat

Author:
P. A. Paul; C. A. Bradley; L. V. Madden; F. Dalla Lana; G. C. Bergstrom; R. Dill-Macky; P. D. Esker; K. A. Wise; M. McMullen; A. Grybauskas; W. W. Kirk; E. Milus; K. Ruden
Source:
Plant disease 2018 v.102 no.12 pp. 2602-2615
ISSN:
0191-2917
Subject:
Fusarium head blight; active ingredients; demethylation; deoxynivalenol; field experimentation; fungicides; heading; meta-analysis; models; quinones; risk; wheat; United States
Abstract:
... Field trials were conducted in 17 U.S. states to evaluate the effects of quinone outside inhibitor (QoI) and demethylation inhibitor (DMI) fungicide programs on Fusarium head blight index (IND) and deoxynivalenol (DON) toxin in wheat. Four DMI-only treatments applied at Feekes 10.5.1, five QoI-only treatments applied between Feekes 9 or Feekes 10.5, three QoI+DMI mixtures applied at Feekes 10.5, a ...
DOI:
10.1094/PDIS-02-18-0211-RE

41. Meta-Analytic Modeling of the Decline in Performance of Fungicides for Managing Soybean Rust after a Decade of Use in Brazil

Author:
Felipe Dalla Lana; Pierce A. Paul; Claudia V. Godoy; Carlos M. Utiamada; Luís Henrique C. P. da Silva; Fabiano V. Siqueri; Carlos A. Forcelini; David de Souza Jaccoud-Filho; Dulândula S. Miguel-Wruck; Edson P. Borges; Fernando C. Juliatti; Hercules D. Campos; José Nunes; Luciana C. Carneiro; Marcelo G. Canteri; Margarida F. Ito; Maurício C. Meyer; Mônica C. Martins; Ricardo S. Balardin; Silvânia H. Furlan; Valtemir J. Carlin; Emerson M. Del Ponte
Source:
Plant disease 2018 v.102 no.4 pp. 807-817
ISSN:
0191-2917
Subject:
Phakopsora pachyrhizi; active ingredients; cyproconazole; demethylation; models; pyraclostrobin; quinones; soybean rust; tebuconazole; trifloxystrobin; yields; Brazil
Abstract:
... An apparent decline of fungicide performance for the control of soybean rust in Brazil has been reported but the rate at which it has occurred has not been formally quantified. Control efficacy and yield response to three fungicides applied as single active ingredients (a.i.)—azoxystrobin (AZOX), cyproconazole (CYPR), and tebuconazole (TEBU)—and four applied as mixtures—AZOX+CYPR, picoxystrobin + ...
DOI:
10.1094/PDIS-03-17-0408-RE

42. Metabolism profiling of nevadensin in vitro and in vivo by UHPLC-Q-TOF-MS/MS

Author:
Caijuan Liang; Xia Zhang; Xinpeng Diao; Man Liao; Yupeng Sun; Lantong Zhang
Source:
Journal of chromatography 2018 v.1084 pp. 69-79
ISSN:
1570-0232
Subject:
biochemical pathways; data collection; demethylation; high performance liquid chromatography; hydrolysis; ions; metabolites; methylation; oxidation; sulfates; tandem mass spectrometry; tuberculosis; ultra-performance liquid chromatography
Abstract:
... Nevadensin is major constituents of Lysionotus pauciflorus Maxim. (Chinese name: Shidiaolan), which has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive. In this paper, we investigated the metabolism of nevadensin in vitro and in vivo. A strategy was firstly developed to identify the metabolites of nevaden ...
DOI:
10.1016/j.jchromb.2018.03.032

43. Methylenetetrahydrofolate reductase modulates methyl metabolism and lignin monomer methylation in maize

Author:
Zhenying Wu; Hao Ren; Wangdan Xiong; Sanja Roje; Yuchen Liu; Kunlong Su; Chunxiang Fu
Source:
Journal of experimental botany 2018 v.69 no.16 pp. 3963-3973
ISSN:
1460-2431
Subject:
alcohols; biosynthesis; caffeate O-methyltransferase; corn; demethylation; enzyme activity; feedstocks; gene expression regulation; genes; glucose; homocysteine; lignin; lignocellulose; methionine; methylation; methylenetetrahydrofolate reductase; moieties; mutants; mutation; tetrahydrofolic acid; transposons
Abstract:
... The brown midrib2 (bm2) mutant of maize, which has a modified lignin composition, contains a mutation in the methylenetetrahydrofolate reductase (MTHFR) gene. Here, we show that a MITE transposon insertion caused down-regulation of MTHFR, with an accompanying decrease in 5-methyl-tetrahydrofolate and an increase in 5, 10-methylene-tetrahydrofolate and tetrahydrofolate in the bm2 mutant. Furthermor ...
DOI:
10.1093/jxb/ery208

44. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation

Author:
Maria Dafne Cardamone; Bogdan Tanasa; Carly T. Cederquist; Jiawen Huang; Kiana Mahdaviani; Wenbo Li; Michael G. Rosenfeld; Marc Liesa; Valentina Perissi
Source:
Molecular cell 2018 v.69 no.5 pp. 757-772.e7
ISSN:
1097-2765
Subject:
G-proteins; RNA; adipocytes; biogenesis; brown adipose tissue; demethylation; gene expression; histones; mice; mitochondria; mitochondrial genes; proteome; stress response; transactivators; transcription (genetics); transcriptional activation; ubiquitination
Abstract:
... As most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions critically depend on nuclear gene expression and bidirectional mito-nuclear communication. However, mitochondria-to-nucleus communication pathways in mammals are incompletely understood. Here, we identify G-Protein Pathway Suppressor 2 (GPS2) as a mediator of mitochondrial retrograde signaling and a transcript ...
DOI:
10.1016/j.molcel.2018.01.037
PubMed:
29499132
PubMed Central:
PMC6022402

45. New Insights into the Methylation Status of Virulent Diuraphis noxia (Hemiptera: Aphididae) Biotypes

Author:
Kelly Breeds; N Francois V Burger; Anna-Maria Botha
Source:
Journal of economic entomology 2018 v.111 no.3 pp. 1395-1403
ISSN:
1938-291X
Subject:
DNA methylation; Diuraphis noxia; Triticum aestivum; biotypes; demethylation; epigenetics; fluorescence; genetic variation; genome; reproduction; virulence
Abstract:
... Epigenetic modifications provide a means for aphid biotype development that a lack of genetic variation, owing to an anholocyclic reproduction lifecycle, fails to do. Here we present data on the DNA methylation status in four South African Russian wheat aphids (RWA), Diuraphis noxia (Kurdjomov) (Hemiptera: Aphididae) biotypes expressing different levels of virulence against its host, Triticum aest ...
DOI:
10.1093/jee/toy039

46. Nontargeted SWATH acquisition mode for metabolites identification of osthole in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

Author:
Man Liao; Xinpeng Diao; Xiaoye Cheng; Yupeng Sun; Lantong Zhang
Source:
RSC advances 2018 v.8 no.27 pp. 14925-14935
ISSN:
2046-2069
Subject:
Cnidium monnieri; acetylcysteine; bile; biochemical pathways; computer software; coumarins; dehydrogenation; demethylation; feces; high performance liquid chromatography; information processing; ions; liver microsomes; mass spectrometry; metabolites; neuroprotective effect; phosphorylation; rats; sulfates; ultra-performance liquid chromatography; urine
Abstract:
... Osthole (OST), 7-methoxy-8-isopentenoxycoumarin, is the characteristic constituent found in Cnidium monnieri (L.) Cuss. and possesses excellent pharmacological activities, including anticancer, anti-apoptosis and neuroprotection. In this study, a rapid and reliable method based on ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) a ...
DOI:
10.1039/c8ra01221k

47. Nucleic adaptability of heterokaryons to fungicides in a multinucleate fungus, Sclerotinia homoeocarpa

Author:
Dylan Kessler; Hyunkyu Sang; Amanda Bousquet; Jonathan P. Hulvey; Dawlyn Garcia; Siyeon Rhee; Yoichiro Hoshino; Toshihiko Yamada; Geunhwa Jung
Source:
Fungal genetics and biology 2018 v.115 pp. 64-77
ISSN:
1087-1845
Subject:
Sclerotinia homoeocarpa; alleles; benzimidazole; confocal laser scanning microscopy; demethylation; fungi; fungicides; genotype; heterokaryon; image analysis; microsatellite repeats; pathogens; phenotypic plasticity; single nucleotide polymorphism; tubulin; turf grasses
Abstract:
... Sclerotinia homoeocarpa is the causal organism of dollar spot in turfgrasses and is a multinucleate fungus with a history of resistance to multiple fungicide classes. Heterokaryosis gives rise to the coexistence of genetically distinct nuclei within a cell, which contributes to genotypic and phenotypic plasticity in multinucleate fungi. We demonstrate that field isolates, resistant to either a dem ...
DOI:
10.1016/j.fgb.2018.01.005
CHORUS:
10.1016/j.fgb.2018.01.005

48. Opal promotes hydrothermal carbonization of hydroxypropyl methyl cellulose and formation of carbon nanospheres

Author:
Yuanjun Xu; Maosheng Xia; Yinshan Jiang; Fangfei Li; Bing Xue
Source:
RSC advances 2018 v.8 no.36 pp. 20095-20107
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; adsorption; carbon; crosslinking; demethylation; energy-dispersive X-ray analysis; furans; gas chromatography-mass spectrometry; hydrochars; hydrogen; hydrolysis; hydrothermal carbonization; methylcellulose; nanospheres; nitrogen; opal; oxygen; scanning electron microscopy; surface area
Abstract:
... Hydrothermal carbon nanospheres were prepared by introducing opal into the hydrothermal carbonization system of hydroxypropyl methyl cellulose (HPMC). Then the effects of opal on hydrothermal carbonization of HPMC were investigated after different reaction durations (105–240 min). The reaction products were characterized by elemental analysis, gas chromatography-mass spectrometry (GC-MS), scanning ...
DOI:
10.1039/c8ra01138a

49. PIP2 epigenetically represses rRNA genes transcription interacting with PHF8

Author:
Livia Ulicna; Alzbeta Kalendova; Ilona Kalasova; Tomas Vacik; Pavel Hozák
Source:
Biochimica et biophysica acta 2018 v.1863 no.3 pp. 266-275
ISSN:
1388-1981
Subject:
cell nucleus; cytoplasm; demethylation; epigenetics; genes; histones; lysine; mutants; plasma membrane; ribosomal DNA; ribosomal RNA; transcription (genetics); trypsin
Abstract:
... Phosphoinositides are present in the plasma membrane, cytoplasm and inside the cell nucleus. Here we identify phosphatidylinositol-4,5-bisphosphate (PIP2) as a regulator of rRNA genes transcription at the epigenetic level. We show that PIP2 directly interacts with histone lysine demethylase PHF8 (PHD finger protein 8) and represses demethylation of H3K9me2 through this interaction. We identify the ...
DOI:
10.1016/j.bbalip.2017.12.008

50. PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

Author:
Dongha Kim; Hye Jin Nam; Wonhwa Lee; Hwa Young Yim; Jun-Yeong Ahn; Se Won Park; Hi-Jai R. Shin; Reynold Yu; Kyoung-Jae Won; Jong-Sup Bae; Keun Il Kim; Sung Hee Baek
Source:
Molecular cell 2018 v.69 no.3 pp. 398-411.e6
ISSN:
1097-2765
Subject:
demethylation; epigenetics; genetic analysis; inflammation; lungs; mice; mortality; pathogens; phosphorylation; protein kinase C; sepsis (infection); therapeutics; transcription factor NF-kappa B
Abstract:
... The inflammatory response mediated by nuclear factor κB (NF-κB) signaling is essential for host defense against pathogens. Although the regulatory mechanism of NF-κB signaling has been well studied, the molecular basis for epigenetic regulation of the inflammatory response is poorly understood. Here we identify a new signaling axis of PKCα-LSD1-NF-κB, which is critical for activation and amplifica ...
DOI:
10.1016/j.molcel.2018.01.002

51. Plasma upgrading of guaiacol as lignin pyrolytic-oil model compound through a combination of hydrogen production and hydrodeoxygenation reaction

Author:
Hamed Taghvaei; Mohammad Reza Rahimpour
Source:
Journal of analytical and applied pyrolysis 2018 v.135 pp. 422-430
ISSN:
0165-2370
Subject:
demethylation; hydrogen production; free radicals; pyrolysis; energy use and consumption; ambient temperature; catalysts; guaiacol; models; phenol; hydrogen; catechol; hydrogenation; lignin; chemical structure; atmospheric pressure
Abstract:
... In this study, hydrodeoxygenation reaction is conducted without using hydrogen as a feed. The required hydrogen was provided in situ through plasma decomposition of methoxyl and methyl radicals which exist in the chemical structure of lignin pyrolytic-oil at room temperature. Operating parameters including applied voltage, Ar flow rate and discharge length were carefully studied in order to maximi ...
DOI:
10.1016/j.jaap.2018.04.011

52. Poly(arylene ether nitrile) anion exchange membranes with dense flexible ionic side chain for fuel cells

Author:
En Ning Hu; Chen Xiao Lin; Fang Hua Liu; Xiu Qin Wang; Qiu Gen Zhang; Ai Mei Zhu; Qing Lin Liu
Source:
Journal of membrane science 2018 v.550 pp. 254-265
ISSN:
0376-7388
Subject:
Lewis bases; anion-exchange membranes; condensation reactions; demethylation; dimensional stability; fuel cells; hydrophilicity; hydrophobicity; potassium hydroxide; water uptake
Abstract:
... To resolve the excessive swelling and undesirable alkaline stability of densely functionalized type anion exchange membranes (AEMs) and to obtain high performance AEMs, quaternary ammonium-functionalized poly(arylene ether nitrile) (QPAEN) AEMs with dense flexible ionic side chain are prepared via nucleophilic substitution polycondensation, demethylation reaction and Williamson reaction. The dense ...
DOI:
10.1016/j.memsci.2018.01.010

53. Proposal for a new nomenclature for CYP51 haplotypes in Zymoseptoria tritici and analysis of their distribution in Europe

Author:
A. Huf; A. Rehfus; K. H. Lorenz; R. Bryson; R. T. Voegele; G. Stammler
Source:
Plant pathology 2018 v.67 no.8 pp. 1706-1712
ISSN:
0032-0862
Subject:
Mycosphaerella graminicola; demethylation; evolution; fungicides; genes; haplotypes; in vitro studies; mutation; wheat; France; Germany; Ireland; Netherlands; Poland; United Kingdom
Abstract:
... Zymoseptoria tritici causes septoria tritici blotch (STB), one of the most devastating diseases of wheat worldwide. C‐14 demethylation inhibitors (DMIs) belong to the most relevant fungicides in the control of STB. Intensive and long‐lasting exposure to DMIs has led to an adaptation of Z. tritici towards these fungicides. The most important mechanism leading to reduced DMI sensitivity is based on ...
DOI:
10.1111/ppa.12891

54. S-adenosylmethionine reduces the inhibitory effect of Aβ on BDNF expression through decreasing methylation level of BDNF exon Ⅳ in rats

Author:
Dandan Cao; Jing Cui; Chenjia Guo; Guowen Min; Min Liu; Liang Li
Source:
Biochemical and biophysical research communications 2018 v.495 no.4 pp. 2609-2615
ISSN:
0006-291X
Subject:
DNA methylation; DNA methyltransferase; S-adenosylmethionine; demethylation; epigenetics; exons; messenger RNA; rats; research; transcription (genetics)
Abstract:
... The structure of brain-derived neurotrophic factor (BDNF) gene is complex, which is composed of eight non-coding exons and one coding exon, each of them has its own unique promoter. Multiple BDNF transcripts have distinct functional properties and epigenetic modulation of BDNF gene transcription is implicated in the neurological disorders. In the present study, rat models with amyloid-β (Aβ) intra ...
DOI:
10.1016/j.bbrc.2017.12.166

55. Sensitivity of Cochliobolus heterostrophus to three demethylation inhibitor fungicides, propiconazole, diniconazole and prochloraz, and their efficacy against southern corn leaf blight in Fujian Province, China

Author:
Yuli Dai; Lin Gan; Hongchun Ruan; Niuniu Shi; Yixin Du; Lei Liao; Zhixia Wei; Zhenyong Teng; Furu Chen; Xiujuan Yang
Source:
European journal of plant pathology 2018 v.152 no.2 pp. 447-459
ISSN:
0929-1873
Subject:
Bipolaris maydis; active ingredients; chlorothalonil; corn; cross resistance; demethylation; diniconazole; evolution; fungi; greenhouses; iprodione; leaf blight; mancozeb; monitoring; prochloraz; propiconazole; pyraclostrobin; seedlings; therapeutics; China
Abstract:
... Southern corn leaf blight (SCLB) caused by Cochliobolus heterostrophus is a fungal disease that impacts production of corn in China. Fungicides have been the main strategy to manage SCLB. In this study, 276 isolates of C. heterostrophus from seven locations in Fujian Province of China were tested for sensitivity to three demethylation inhibitor (DMI) fungicides. The results indicated that most of ...
DOI:
10.1007/s10658-018-1490-z

56. Shaping Plant Adaptability, Genome Structure and Gene Expression through Transposable Element Epigenetic Control: Focus on Methylation

Author:
Leonardo Galindo-González; Felipe Sarmiento; Mauricio A. Quimbaya
Source:
Agronomy 2018 v.8 no.9 pp. -
ISSN:
2073-4395
Subject:
demethylation; elicitors; epigenetics; essential genes; gene expression; genomics; methylation; microRNA; promoter regions; stress response; transposition (genetics); transposons
Abstract:
... In plants, transposable elements (TEs) represent a large fraction of the genome, with potential to alter gene expression and produce genomic rearrangements. Epigenetic control of TEs is often used to stop unrestricted movement of TEs that would result in detrimental effects due to insertion in essential genes. The current review focuses on the effects of methylation on TEs and their genomic contex ...
DOI:
10.3390/agronomy8090180

57. Simultaneous removal of ciprofloxacin, norfloxacin, sulfamethoxazole by co-producing oxidative enzymes system of Phanerochaete chrysosporium and Pycnoporus sanguineus

Author:
Nan Gao; Chun-Xiao Liu; Qiu-Man Xu; Jing-Sheng Cheng; Ying-Jin Yuan
Source:
Chemosphere 2018 v.195 pp. 146-155
ISSN:
0045-6535
Subject:
Phanerochaete chrysosporium; Pycnoporus sanguineus; antibacterial properties; antibiotics; biosorption; biotransformation; ciprofloxacin; coculture; cytochrome P-450; cytotoxicity; decarboxylation; demethylation; laccase; manganese peroxidase; metabolites; mycelium; norfloxacin; oxidation; sulfamethoxazole
Abstract:
... Pycnoporus sanguineus could remove 98.5% ciprofloxacin (CIP), 96.4% norfloxacin (NOR), 100% sulfamethoxazole (SMX), and 100% their mixture through biotransformation within 2 d, while Phanerochaete chrysosporium could only remove 64.5% CIP, 73.2% NOR, and 63.3% SMX through biosorption and biotransformation within 8 d, respectively. The efficiencies of antibiotic bioremoval under co-culture were mor ...
DOI:
10.1016/j.chemosphere.2017.12.062

58. Sodium Hydrosulfide Mitigates Cadmium Toxicity by Promoting Cadmium Retention and Inhibiting Its Translocation from Roots to Shoots in Brassica napus

Author:
Yan Yu; Xiangyu Zhou; Zonghe Zhu; Kejin Zhou
Source:
Journal of agricultural and food chemistry 2018 v.67 no.1 pp. 433-440
ISSN:
1520-5118
Subject:
Brassica napus; cadmium; cell wall components; cell walls; chlorosis; cysteine; demethylation; hemicellulose; hydrogen sulfide; leaves; pectinesterase; pectins; plant growth; roots; shoots; sodium; stems; toxicity
Abstract:
... The association between hydrogen sulfide (H₂S) and cell wall composition with regard to the mitigation of cadmium (Cd) toxicity in Brassica napus L. was investigated. Cd caused growth retardation, leaf chlorosis, and decreased endogenous H₂S content in Brassica napus roots. Stimulating l-cysteine desulfhydrase (LCD)-mediated H₂S production with H₂S releaser (NaHS) markedly improved plant growth, r ...
DOI:
10.1021/acs.jafc.8b04622

59. Solvent-controlled selective hydrodeoxygenation of bio-derived guaiacol to arenes or phenols over a biochar supported Co-doped MoO2 catalyst

Author:
Guang-Hui Liu; Zhi-Min Zong; Zhong-Qiu Liu; Fang-Jing Liu; Yang-Yang Zhang; Xian-Yong Wei
Source:
Fuel processing technology 2018 v.179 pp. 114-123
ISSN:
0378-3820
Subject:
alkylation; aromatic hydrocarbons; bagasse; biochar; catalysts; catalytic activity; catechol; cobalt; demethylation; ethanol; guaiacol; hydrogen; magnetism; pyrolysis; solvents
Abstract:
... A novel magnetic Co-doped MoO₂@C was prepared by in-situ co-pyrolysis and used for catalyzing hydrodeoxygenation (HDO) of bio-derived guaiacol to arenes or substituted phenols controlled by solvent type. Considering the variation of product distributions from the HDO of guaiacol using different solvents, the reaction intermediates of each stage were traced to explore its HDO pathways over Co-MoO₂@ ...
DOI:
10.1016/j.fuproc.2018.05.035

60. Stimulatory Effects of Flusilazole on Virulence of Sclerotinia sclerotiorum

Author:
Xiaoming Lu; Ran Zhang; Menglong Cong; Jianhong Li; Fuxing Zhu
Source:
Plant disease 2018 v.102 no.1 pp. 197-201
ISSN:
0191-2917
Subject:
Sclerotinia sclerotiorum; culture media; demethylation; flusilazole; hydrogen peroxide; leaves; mycelium; rapeseed; scanning electron microscopes; spraying; virulence
Abstract:
... Flusilazole, a member of the demethylation inhibitor fungicides, is highly efficacious for control of Sclerotinia sclerotiorum. To achieve judicious applications of flusilazole, its hormetic effects on virulence of S. sclerotiorum were investigated. Flusilazole sprayed at concentrations from 0.02 to 0.5 μg/ml caused statistically significant (P < 0.05) stimulatory effects on virulence of S. sclero ...
DOI:
10.1094/PDIS-07-17-1041-RE

61. Synthesis of (+)-salvianolic acid A from sodium Danshensu

Author:
Kai Xu; Hao Liu; Delong Liu; Cheng Sheng; Jiefeng Shen; Wanbin Zhang
Source:
Tetrahedron 2018 v.74 no.40 pp. 5996-6002
ISSN:
0040-4020
Subject:
Oriental traditional medicine; aluminum chloride; catalytic activity; chemical reactions; chemical structure; danshensu; demethylation
Abstract:
... (+)-Salvianolic acid A, one of the most active components in the traditional Chinese medicine Danshen, has been synthesized over 10 steps in 6.5% overall yield. Starting from inexpensive ortho-vanillin and sodium Danshensu (synthesized via asymmetric catalysis in our group), the process consists of the following: A Wittig reaction that gives the desire product with absolute E-configuration, a deme ...
DOI:
10.1016/j.tet.2018.08.044

62. Temperature and photoperiod changes affect cucumber sex expression by different epigenetic regulations

Author:
Yun-Song Lai; Di Shen; Wei Zhang; Xiaohui Zhang; Yang Qiu; Haiping Wang; Xinxin Dou; Sigeng Li; Yuanqi Wu; Jiangping Song; Guanyu Ji; Xixiang Li
Source:
BMC plant biology 2018 v.18 no.1 pp. 268
ISSN:
1471-2229
Subject:
Cucumis sativus; DNA; DNA methylation; autumn; chromosomes; cucumbers; demethylation; epigenetics; female flowers; flowering; gene expression regulation; genes; germplasm conservation; photoperiod; seasonal variation; sex reversal; spring; temperature; transcriptome
Abstract:
... BACKGROUND: Cucumbers (Cucumis sativus) are known for their plasticity in sex expression. DNA methylation status determines gene activity but is susceptible to environmental condition changes. Thus, DNA methylation-based epigenetic regulation may at least partially account for the instability of cucumber sex expression. Do temperature and photoperiod that are the two most important environmental f ...
DOI:
10.1186/s12870-018-1490-3
PubMed:
30400867
PubMed Central:
PMC6220452

63. The differences of cell wall in roots between two contrasting soybean cultivars exposed to cadmium at young seedlings

Author:
Peng Wang; Bing Yang; Haibo Wan; Xiaolong Fang; Cunyi Yang
Source:
Environmental science and pollution research international 2018 v.25 no.29 pp. 29705-29714
ISSN:
0944-1344
Subject:
absorption; cadmium; cell wall components; cell walls; cellulose; cultivars; demethylation; enzyme activity; genotype; hemicellulose; hydroponics; lignin; pectinesterase; pectins; roots; seedlings; soybeans; uronic acids
Abstract:
... The plant root cell wall (CW) is the first structure that comes into contact with extracellular cadmium (Cd), and it plays an important role in the absorption, immobilization, and translocation of Cd in the roots. However, the differences in the cell wall components between Cd-tolerant and Cd-sensitive cultivars are unclear. A hydroponic experiment was carried out to investigate the differences in ...
DOI:
10.1007/s11356-018-2956-4

64. The influence of Al3+ on DNA methylation and sequence changes in the triticale (× Triticosecale Wittmack) genome

Author:
Agnieszka Niedziela
Source:
Journal of applied genetics 2018 v.59 no.4 pp. 405-417
ISSN:
1234-1983
Subject:
DNA; DNA methylation; Triticosecale; abiotic stress; aluminum; crops; demethylation; drought; epigenetics; genes; heavy metals; leaves; mutation; phenotype; reversed-phase high performance liquid chromatography; roots; salinity; triticale
Abstract:
... Abiotic stressors such as drought, salinity, and exposure to heavy metals can induce epigenetic changes in plants. In this study, liquid chromatography (RP-HPLC), methylation amplified fragment length polymorphisms (metAFLP), and methylation-sensitive amplification polymorphisms (MSAP) analysis was used to investigate the effects of aluminum (Al) stress on DNA methylation levels in the crop specie ...
DOI:
10.1007/s13353-018-0459-0

65. The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus)

Author:
Yinghuan Wang; Yongtao Han; Yun Xie; Peng Xu; Wei Li
Source:
Chemosphere 2018 v.211 pp. 591-599
ISSN:
0045-6535
Subject:
aldehydes; biochemical pathways; brain; demethylation; dinotefuran; environmental fate; enzymes; excretion; kidneys; knowledge; liver; lizards; metabolites; oral administration; oxidative stress; risk; urine
Abstract:
... The Chinese lizards (Eremias argus) were used to evaluate the metabolism, distribution and effect of dinotefuran following oral exposed. The HPLC equipped with Q Exactive focus was used for metabolite identification and concentration analysis. After single oral administration, the time-concentration curves of dinotefuran and its metabolites were tissue-dependent. The liver and kidney were the majo ...
DOI:
10.1016/j.chemosphere.2018.07.181

66. Total Synthesis of Onitin

Author:
Muthiah Suresh; Anusueya Kumari; Debjit Das; Raj Bahadur Singh
Source:
Journal of natural products 2018 v.81 no.9 pp. 2111-2114
ISSN:
1520-6025
Subject:
Suzuki reaction; aldehydes; chemoselectivity; demethylation; indans; organobromine compounds; oxidation; sesquiterpenoids; styrene
Abstract:
... The total synthesis of the phenolic sesquiterpene onitin using dimethylated indanone as the key intermediate is reported. Key to the success of this synthesis route is the Suzuki–Miyaura cross-coupling reaction of aryl bromide to introduce the vinyl side chain followed by formyl selective Wacker oxidation to generate the aldehyde. The target aldehyde was also obtained in high overall yield via an ...
DOI:
10.1021/acs.jnatprod.8b00335

67. Transformation of naproxen during the chlorination process: Products identification and quantum chemistry validation

Author:
Erdeng Du; Jiaqi Li; Siqi Zhou; Lu Zheng; Xinxin Fan
Source:
Chemosphere 2018 v.211 pp. 1007-1017
ISSN:
0045-6535
Subject:
active ingredients; byproducts; chlorination; chlorine; dehydrogenation; demethylation; hydrogen; mass spectrometry; naphthalene; nuclear magnetic resonance spectroscopy; propionic acid; quantum mechanics; risk; sodium hypochlorite; toxicity
Abstract:
... The by-products produced by pharmaceutically active compounds (PhACs) during chlorination are attracting wide concern. Thus, the transformation and toxicity of naproxen (NAP) during the chlorination process were assessed in this study. The transformation of NAP was found to follow pseudo-first-order kinetics, and the first-order rate constant was improved by increasing the NaOCl dose. High-resolut ...
DOI:
10.1016/j.chemosphere.2018.08.036

68. Transgene‐independent heredity of RdDM‐mediated transcriptional gene silencing of endogenous genes in rice

Author:
Yuhya Wakasa; Taiji Kawakatsu; Takeo Harada; Fumio Takaiwa
Source:
Plant biotechnology journal 2018 v.16 no.12 pp. 2007-2015
ISSN:
1467-7644
Subject:
DNA methylation; Oryza sativa; RNA; biotechnology; calnexin; demethylation; endoplasmic reticulum; endosperm; gene expression; glutelins; inheritance (genetics); multigene family; progeny; promoter regions; protein disulfide-isomerase; rice; transcription (genetics)
Abstract:
... To induce transcriptional gene silencing (TGS) of endogenous genes of rice (Oryza sativa L.), we expressed double‐strand RNA of each promoter region and thus induced RNA‐directed DNA methylation (RdDM). We targeted constitutively expressed genes encoding calnexin (CNX), protein disulphide isomerase (PDIL1‐1) and luminal binding protein (BiP1); an endoplasmic reticulum stress‐inducible gene (OsbZIP ...
DOI:
10.1111/pbi.12934
PubMed:
29704881
PubMed Central:
PMC6230945

69. rhPLD2 inhibits airway inflammation in an asthmatic murine model through induction of stable CD25+ Foxp3+ Tregs

Author:
Chuan-Xing Yu; Ling-Yu Bai; Jun-Jin Lin; Song-Bo Li; Jun-Ying Chen; Wen-Juan He; Xiu-Ming Yu; Xi-Ping Cui; Hui-Li Wang; Yi-Zhong Chen; Ling Zhu
Source:
Molecular immunology 2018 v.101 pp. 539-549
ISSN:
0161-5890
Subject:
CD4-positive T-lymphocytes; animal models; demethylation; epigenetics; guinea pigs; humans; inflammation; lungs; mice; ovalbumin; patients; phenotypic variation; phospholipase D; protein kinase C; respiratory tract diseases; signal transduction; therapeutics; transcription factor NF-kappa B; transcriptomics
Abstract:
... Our previous studies have shown that recombinant human phospholipase D2 (rhPLD2) plays a modulator role on NF-κB and PKC signaling pathways. It also inhibits IL-5-induced inflammatory response in chronic asthmatic guinea pigs. Additionally, increasing evidence also has revealed that the adoptive transfer of induced regulatory T cells (Tregs) may be a therapeutic solution to airway allergic disease ...
DOI:
10.1016/j.molimm.2018.07.030