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1. Investigation of NG-hydroxy-l-arginine interference in the quantitative determination of nitrite and nitrate in human plasma and urine by GC-NICI-MS

Author:
Hanff, Erik,   et al.   ; Bollenbach, Alexander; Tsikas, Dimitrios;     Show all 3 Authors
Source:
Journal of chromatography 2018 v.1100-1101 pp. 174-178
ISSN:
1570-0232
Subject:
acetone; arginine; blood serum; citrulline; derivatization; gas chromatography; heat; humans; intermediate product; laboratory animals; mass spectrometry; nitrates; nitric oxide; nitric oxide synthase; nitrites; quantitative analysis; urine
Abstract:
... Nᴳ-Hydroxy-l-arginine (NOHA) is the intermediate product of the conversion of l-arginine to l-citrulline and nitric oxide (NO) by nitric oxide synthase (NOS). NO is further oxidized to nitrite and nitrate which circulate in the blood and are excreted in the urine. Nitrite and nitrate may therefore serve as surrogates of NO synthesis. NOHA has been reported to occur in various cells and in blood of ...
DOI:
10.1016/j.jchromb.2018.10.007

2. GC-MS quantification of urinary symmetric dimethylarginine (SDMA), a whole-body symmetric l-arginine methylation index

Author:
Hanff, Erik,   et al.   ; Bollenbach, Alexander; Beckmann, Bibiana; Kruger, Ruan; Tsikas, Dimitrios;     Show all 5 Authors
Source:
Analytical biochemistry 2018 v.556 pp. 40-44
ISSN:
0003-2697
Subject:
anhydrides; arginine; chemical structure; derivatization; ethyl acetate; gas chromatography-mass spectrometry; humans; ionization; ions; methylation; monitoring; quantitative analysis; risk factors; urine
Abstract:
... Circulating and excretory Nᴳ,N´ᴳ-dimethyl-l-arginine (symmetric dimethylarginine, SDMA) and Nᴳ,Nᴳ-dimethyl-l-arginine (asymmetric dimethylarginine, ADMA) are cardiovascular risk factors. Despite close chemical structures, the gas chromatography-mass spectrometry (GC-MS) measurement of SDMA is remarkably more difficult than that of ADMA for as yet unknown reasons. Here, we describe an improved GC-M ...
DOI:
10.1016/j.ab.2018.06.021

3. Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications

Author:
Hanff, Erik,   et al.   ; Hafner, Patricia; Bollenbach, Alexander; Bonati, Ulrike; Kayacelebi, Arslan Arinc; Fischer, Dirk; Tsikas, Dimitrios;     Show all 7 Authors
Source:
Amino acids 2018 v.50 no.10 pp. 1391-1406
ISSN:
0939-4451
Subject:
arginine; biomarkers; blood serum; citrulline; creatinine; excretion; guanidinoacetate N-methyltransferase; humans; males; malondialdehyde; metabolites; metformin; muscular dystrophy; neuronal nitric oxide synthase; neurons; nitrates; nitric oxide; nitrites; oxidative stress; patients; skeletal muscle; urine
Abstract:
... The L-arginine/nitric oxide synthase (NOS) pathway is considered to be altered in muscular dystrophy such as Becker muscular dystrophy (BMD). We investigated two pharmacological options aimed to increase nitric oxide (NO) synthesis in 20 male BMD patients (age range 21–44 years): (1) supplementation with L-citrulline (3 × 5 g/d), the precursor of L-arginine which is the substrate of neuronal NO sy ...
DOI:
10.1007/s00726-018-2614-7