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- Hanff, Erik, et al. Show all 7 Authors
- Amino acids 2018 v.50 no.10 pp. 1391-1406
- arginine; biomarkers; blood serum; citrulline; creatinine; excretion; guanidinoacetate N-methyltransferase; humans; males; malondialdehyde; metabolites; metformin; muscular dystrophy; neuronal nitric oxide synthase; neurons; nitrates; nitric oxide; nitrites; oxidative stress; patients; skeletal muscle; urine
- ... The L-arginine/nitric oxide synthase (NOS) pathway is considered to be altered in muscular dystrophy such as Becker muscular dystrophy (BMD). We investigated two pharmacological options aimed to increase nitric oxide (NO) synthesis in 20 male BMD patients (age range 21–44 years): (1) supplementation with L-citrulline (3 × 5 g/d), the precursor of L-arginine which is the substrate of neuronal NO sy ...