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- Aparicio, César, et al. Show all 10 Authors
- Molecular and cellular endocrinology 2018 v.474 pp. 10-19
- adipocytes; adipose tissue; agonists; animal disease models; bombesin receptors; diabetes; gene expression; genes; glucose; homeostasis; humans; insulin; lipogenesis; mitogen-activated protein kinase; mutation; obesity; patients; protein content; protein synthesis; rats; skeletal muscle; therapeutics
- ... BRS-3 has an important role in glucose homeostasis. Its expression was reduced in skeletal muscle from obese and/or diabetic patients, and BRS-3 KO-mice developed obesity. In this work, focused on rat/human adipose tissue, BRS-3 gene-expression was lower than normal-levels in hyperlipidemic, type-2-diabetic (T2D), and type-1-diabetic rats and also in obese (OB) and T2D patients. Moreover, BRS-3 pr ...
- Hernández-Rodríguez, César, et al. Show all 8 Authors
- Molecular biology reports 2018 v.45 no.5 pp. 1155-1163
- Pichia pastoris; Saccharomyces cerevisiae; Ustilago zeae; active sites; aspartic acid; bioinformatics; breast neoplasms; cathepsin D; enzyme activity; genes; hemoglobin; heterologous gene expression; humans; molecular cloning; pH; recombinant proteins; signal peptide; therapeutics; vacuoles
- ... The pep4um gene (um04926) of Ustilago maydis encodes a protein related to either vacuolar or lysosomal aspartic proteases. Bioinformatic analysis of the Pep4um protein revealed that it is a soluble protein with a signal peptide suggesting that it likely passes through the secretory pathway, and it has two probable self-activation sites, which are similar to those in Saccharomyces cerevisiae PrA. M ...