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1. Erythropoietin as a performance-enhancing drug: Its mechanistic basis, detection, and potential adverse effects

Author:
Saugy, Martial,   et al.   ; Salamin, Olivier; Kuuranne, Tiia; Leuenberger, Nicolas;     Show all 4 Authors
Source:
Molecular and cellular endocrinology 2018 v.464 pp. 75-87
ISSN:
0303-7207
Subject:
adverse effects; athletes; biomarkers; drugs; erythrocytes; erythropoiesis; erythropoietin; humans; marketing; patient compliance; patients; pharmaceutical industry; risk; sports; transcriptomics
Abstract:
... Erythropoietin (EPO) is the main hormone regulating red blood cell (RBC) production. The large-scale production of a recombinant human erythropoietin (rHuEPO) by biotechnological methods has made possible its widespread therapeutic use as well as its misuse in sports. Since the marketing of the first epoetin in 1989, the development has progressed to the third-generation analogs. However, the prod ...
DOI:
10.1016/j.mce.2017.01.033

2. Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon

Author:
Yonga Wansi, Gide Martial,   et al.   ; Sadeuh-Mba, Serge Alain; Demanou, Maurice; Gessain, Antoine; Njouom, Richard;     Show all 5 Authors
Source:
Virology journal 2018 v.15 no.1 pp. 63
ISSN:
1743-422X
Subject:
Crimean-Congo hemorrhagic fever; Phlebovirus; Rift Valley fever; antibodies; enzootic diseases; enzyme-linked immunosorbent assay; humans; immunoglobulin G; livestock; rain forests; rural areas; seroprevalence; urban areas; villages; Cameroon
Abstract:
... BACKGROUND: Rift Valley Fever Phlebovirus (RVFV) and Crimean-Congo Hemorrhagic Fever Orthonairovirus (CCHFV) specific antibodies had been documented among humans in urban settings of the southwestern and northern Cameroon in the late 1980s. Recently, evidence for enzootic circulation of RVFV was reported among livestock in both rural and urban settings in Cameroon. However, current estimates of hu ...
DOI:
10.1186/s12985-018-0977-8
PubMed:
29625611
PubMed Central:
PMC5889602