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- Voorspoels, Stefan, et al. Show all 8 Authors
- Chemosphere 2018 v.212 pp. 1047-1057
- bioaccumulation; bisphenol A; blood serum; cytochrome P-450; environmental monitoring; enzymes; flame retardants; humans; liver microsomes; mass spectrometry; metabolism; organophosphorus compounds; phosphates; secondary metabolites; toxicity
- ... The aim of the present study was to investigate the in vitro metabolism of two emerging organophosphate flame retardants, namely tetrekis(2-chlorethyl)dichloroisopentyldiphosphate (V6) and bisphenol-A bis-diphenyl phosphate (BDP) in human liver microsomes (HLMs), HLM S9 fractions and in human serum. In particular, the role of cytochrome P450 (CYPs) enzymes and/or paraoxonases (PONs) in the formati ...