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1. 3D Long-Range Triplet Migration in a Water-Stable Metal–Organic Framework for Upconversion-Based Ultralow-Power in Vivo Imaging

Author:
Park, Jihye; Xu, Ming; Li, Fuyou; Zhou, Hong-Cai
Source:
Journal of the American Chemical Society 2018 v.140 no.16 pp. 5493-5499
ISSN:
1520-5126
Subject:
lymph nodes,   etc   ; coordination polymers; harvesting; image analysis; mice; photons; solar cells;     Show all 7 Subjects
Abstract:
... Triplet–triplet annihilation upconversion (TTA-UC) has gained increasing attention because it allows for harvesting of low-energy photons in the solar spectrum with high efficiency in relevant applications including solar cells and bioimaging. However, the utilization of conventional TTA-UC systems for low-power bioapplications is significantly hampered by their general incompatibility and low eff ...
DOI:
10.1021/jacs.8b01613

2. Noninvasive Multimodal Imaging of Osteosarcoma and Lymph Nodes Using a 99mTc-Labeled Biomineralization Nanoprobe

Author:
Xu, Zhiming; Wang, Yangyun; Han, Jianshan; Xu, Qingqing; Ren, Jiawei; Xu, Jiaying; Wang, Yong; Chai, Zhifang
Source:
Analytical chemistry 2018 v.90 no.7 pp. 4529-4534
ISSN:
1520-6882
Subject:
lymph nodes,   etc   ; biocompatibility; biomineralization; fluorescence; image analysis; magnetic resonance imaging; mice; models; osteosarcoma; planning; resection;     Show all 11 Subjects
Abstract:
... The accurate imaging of the lymph nodes represents a critical indicator for tumor staging and surgical planning (e.g., osteosarcoma). Clinically, nodal tracing using a radio-nanocolloid is often limited by the inaccessibility of real-time images and inadequate anatomical information. Herein, we present a ⁹⁹ᵐTc-labeled biomineralization nanoprobe for the advanced detection of osteosarcoma and lymph ...
DOI:
10.1021/acs.analchem.7b04925

3. Mesenchymal stem cells in combination with low-dose rapamycin significantly prolong islet allograft survival through induction of regulatory T cells

Author:
Duan, Wu; Yu, Xuefeng; Ma, Dongxia; Yang, Bo; Li, Yi; Huang, Li; Liu, Li; Chen, Gang; Xu, Danmei; Ding, Yunchuan
Source:
Biochemical and biophysical research communications 2018 v.506 no.3 pp. 619-625
ISSN:
0006-291X
Subject:
lymph nodes,   etc   ; T-lymphocytes; allografting; animal models; antigens; islets of Langerhans; mesenchymal stromal cells; mice; protective effect; rapamycin;     Show all 10 Subjects
Abstract:
... We previously demonstrated the protective effect of MSCs in an adaptive transfer mouse model. However, their therapeutic potential in an allogeneic immunocompetent setting mimicking clinical context of islet transplantation remained unknown. The aim of this study was to determine whether MSCs therapy, either by itself, or combined with Rapamycin could benefit the allograft survival of fully MHC-mi ...
DOI:
10.1016/j.bbrc.2018.10.070

4. Fingolimod can act as a facilitator to establish the primary T-cell response with reduced need of adjuvants

Author:
Gao, Changxing; Zhuang, Xinpin; Zhang, Lingzhi; Li, Mingyan; Li, Jing J.; Li, Jing B.; Zhu, Qing
Source:
Vaccine 2018 v.36 no.50 pp. 7632-7640
ISSN:
0264-410X
Subject:
lymph nodes,   etc   ; CD8-positive T-lymphocytes; adaptive immunity; adjuvants; adverse effects; antigens; inflammation; injection site; mice; receptors; vaccination; vaccines;     Show all 12 Subjects
Abstract:
... The CD8+ T-cell response is an essential part of the adaptive immunity. Adjuvants are routinely required for priming of T cells against antigens encountered in lymph nodes (LNs) to generate antigen-specific immunity but may concomitantly trigger unexpected inflammatory responses. Sphingosine-1-phosphate (S1P) induces transient desensitization of S1P receptors on LN T cells and temporarily blocks t ...
DOI:
10.1016/j.vaccine.2018.10.090

5. Highly Sensitive Fluorescence and Photoacoustic Detection of Metastatic Breast Cancer in Mice Using Dual-Modal Nanoprobes

Author:
Lin, Xiangwei; Liu, Chengbo; Sheng, Zonghai; Gong, Xiaojing; Song, Liang; Zhang, Ruifang; Zheng, Hairong; Sun, Mingjian
Source:
ACS applied materials & interfaces 2018 v.10 no.31 pp. 26064-26074
ISSN:
1944-8252
Subject:
lymph nodes,   etc   ; acoustics; breast neoplasms; fluorescence; image analysis; lungs; materials science; metastasis; mice; monitoring; neoplasm cells; prognosis;     Show all 12 Subjects
Abstract:
... The biomedical imaging of metastatic breast cancer, especially in lymphatic and lung metastasis, is highly significant in cancer staging as it helps assess disease prognosis and treatment. Using an albumin-indocyanine green dual-modal nanoprobe developed in our laboratory, in vivo fluorescence imaging and photoacoustic imaging of metastatic breast cancer tumors were performed separately. Fluoresce ...
DOI:
10.1021/acsami.8b09142

6. Evaluation of Pgp (MDR1) immunohistochemistry in canine lymphoma – prognostic and clinical aspects

Author:
Vajdovich, Péter; Koltai, Zsófia; Dékay, Valéria; Kungl, Krisztina; Harnos, Andrea
Source:
Acta veterinaria Hungarica 2018 v.66 no.2 pp. 309-328
ISSN:
1588-2705
Subject:
lymph nodes,   etc   ; P-glycoproteins; T-lymphocytes; asparaginase; death; dogs; drug toxicity; immunohistochemistry; lymphoma; mice; neoplasm cells; nutritional status; prognosis; staining;     Show all 14 Subjects
Abstract:
... Permeability glycoprotein (P-glycoprotein, Pgp) immunohistochemistry (IHC) was evaluated in dogs with multicentric lymphoma treated with cyclophosphamide– doxorubicin–vincristine–prednisolone with or without L-Asparaginase. Lymph nodes of 33 untreated dogs were immunophenotyped: Ki67% and Pgp analyses (with anti-Pgp, monoclonal mouse C494 clone) were performed. Pgp positivity rate and intensity we ...
DOI:
10.1556/004.2018.028

7. Deep-Sea-Derived Butyrolactone I Suppresses Ovalbumin-Induced Anaphylaxis by Regulating Mast Cell Function in a Murine Model

Author:
Liu, Qing-Mei; Xie, Chun-Lan; Gao, Yuan-Yuan; Liu, Bo; Lin, Wei-Xiang; Liu, Hong; Cao, Min-Jie; Su, Wen-Jin; Yang, Xian-Wen; Liu, Guang-Ming
Source:
Journal of agricultural and food chemistry 2018 v.66 no.22 pp. 5581-5592
ISSN:
1520-5118
Subject:
lymph nodes,   etc   ; Aspergillus; anaphylaxis; animal models; food allergies; histamine; immunoglobulin E; mast cells; mice; molecular models; ovalbumin; proteinases; receptors; spleen;     Show all 14 Subjects
Abstract:
... Deep-sea-derived butyrolactone I (BTL-I), which was identified as a type of butanolide, was isolated from Aspergillus sp. Ovalbumin (OVA)-induced BALB/c anaphylaxis was established to explore the antifood allergic activity of BTL-I. As a result, BTL-I was able to alleviate OVA-induced allergy symptoms, reduce the levels of histamine and mouse mast cell proteinases, inhibit OVA-specific IgE, and de ...
DOI:
10.1021/acs.jafc.8b01674

8. MicroRNA-485-5p suppresses growth and metastasis in non-small cell lung cancer cells by targeting IGF2BP2

Author:
Huang, Ri-sheng; Zheng, Yuan-liang; Li, Chang; Ding, Cheng; Xu, Chun; Zhao, Jun
Source:
Life sciences 2018 v.199 pp. 104-111
ISSN:
0024-3205
Subject:
lymph nodes,   etc   ; cell cycle checkpoints; cell proliferation; in vivo studies; lung neoplasms; lungs; metastasis; mice; neoplasm cells; patients; prognosis;     Show all 11 Subjects
Abstract:
... miR-485-5p serves as a tumor suppressor in several types of cancers. However, its prognostic and biological significance in non-small cell lung cancer (NSCLC) have not been determined yet. In the present study, we checked the expression of miR-485-5p in 87 pairs of paraffin-embedded lung cancer and matched non-cancerous specimens. The associations of miR-485-5p expression with aggressive parameter ...
DOI:
10.1016/j.lfs.2018.03.005

9. Monitoring HIV DNA and cellular activation markers in HIV-infected humanized mice under cART

Author:
Rochat, Mary-Aude; Schlaepfer, Erika; Kuster, Stefan P.; Li, Duo; Audige, Annette; Ivic, Sandra; Fahrny, Audrey; Speck, Roberto F.
Source:
Virology journal 2018 v.15 no.1 pp. 191
ISSN:
1743-422X
Subject:
lymph nodes,   etc   ; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; DNA; HIV infections; Human immunodeficiency virus; animal models; antiretroviral agents; humans; mice; monitoring; patients; spleen; therapeutics;     Show all 14 Subjects
Abstract:
... BACKGROUND: The major obstacle to cure of HIV type-1 infection is the presence of the HIV reservoir, hidden from the immune system and insensitive to combined antiretroviral therapy (cART). Eradication approaches have been hindered by the difficulty for accurately monitoring its size in vivo, especially in the lymphoid organs. Humanized mouse models are a valuable tool for systematically assess th ...
DOI:
10.1186/s12985-018-1101-9

10. Phenotypic analysis of mice xenografted with canine epitheliotropic cutaneous T‐cell lymphoma cells

Author:
Ikeuchi, Miho; Asahina, Ryota; Nishida, Hidetaka; Kamishina, Hiroaki; Kitoh, Katsuya; Sakai, Hiroki; Maeda, Sadatoshi
Source:
Veterinary dermatology 2018 v.29 no.6 pp. 517
ISSN:
0959-4493
Subject:
lymph nodes,   etc   ; cell movement; liver; phenotype; skin lesions; dogs; T-cell lymphoma; veterinary medicine; metastasis; mice; spleen; animal models; neoplasm cells; lungs; blood; severe combined immunodeficiency;     Show all 16 Subjects
Abstract:
... BACKGROUND: In canine epitheliotropic cutaneous T‐cell lymphoma (ECTCL), neoplastic cells cause skin lesions and potentially metastasize to lymph nodes, blood and other organs. Murine models are potentially valuable for elucidating the molecular mechanisms responsible for regulation of ECTCL cell migration. HYPOTHESIS/OBJECTIVES: To describe a phenotype of mice xenografted with canine ECTCL cells ...
DOI:
10.1111/vde.12650

11. Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis

Author:
Li, Min; Lu, Ying; Xu, Yunchao; Wang, Jingwen; Zhang, Chenghong; Du, Yue; Wang, Lu; Li, Lianhong; Wang, Bo; Shen, Jie; Tang, Jianwu; Song, Bo
Source:
Gene 2018 v.676 pp. 101-109
ISSN:
0378-1119
Subject:
lymph nodes,   etc   ; CXCR4 receptor; cell movement; chemokine CXCL12; endothelial cells; exosomes; metalloproteinases; metastasis; mice; migratory behavior; neoplasms; secretion; therapeutics; vascular endothelial growth factor C;     Show all 14 Subjects
Abstract:
... Exosomes have been demonstrated as an important factor to influence cancer invasion and metastasis. Previous studies have shown that CXC chemokine recepter-4 (CXCR4) and stromal cell-derived factor-1α (SDF-1α) mediates matrix metalloproteinases (MMPs) secretions to facilitate lymph node metastasis of hepatocarcinoma cells. In this study, we demonstrated that exosomes containing elevated CXCR4 from ...
DOI:
10.1016/j.gene.2018.07.018

12. Gold lotion from citrus peel extract ameliorates imiquimod‐induced psoriasis‐like dermatitis in murine

Author:
Lin, Chi‐Chien; Wu, Jung‐Ju; Pan, Yi‐Gen; Chao, Ya‐Hsuan; Lin, Fang‐Chu; Lee, Ying‐Ray; Chu, Ching‐Liang
Source:
Journal of the science of food and agriculture 2018 v.98 no.14 pp. 5509-5517
ISSN:
0022-5142
Subject:
lymph nodes,   etc   ; CD4-positive T-lymphocytes; citrus fruits; citrus peels; cytokines; dendritic cells; dermatitis; immunomodulators; inflammation; interferons; keratinocytes; mice; neutrophils; psoriasis; skin lesions;     Show all 15 Subjects
Abstract:
... BACKGROUND: Gold lotion (GL), a natural mixed product made from the peels of six citrus fruits, has recently been identified as possessing anti‐oxidative, anti‐inflammatory, and immunomodulatory effects. GL has been used to protect skin against UV‐induced damage, but its activity against psoriasis, a chronic autoimmune skin disease caused by dysregulation between immune cells and keratinocytes, is ...
DOI:
10.1002/jsfa.9097

13. PEGylated tumor cell membrane vesicles as a new vaccine platform for cancer immunotherapy

Author:
Ochyl, Lukasz J.; Bazzill, Joseph D.; Park, Charles; Xu, Yao; Kuai, Rui; Moon, James J.
Source:
Biomaterials 2018 v.182 pp. 157-166
ISSN:
0142-9612
Subject:
lymph nodes,   etc   ; CD8-positive T-lymphocytes; blood serum; cell membranes; cytotoxicity; immune response; immunoglobulin G; melanoma; mice; nanoparticles; neoplasm cells; remission; subcutaneous injection; vaccination; vaccines;     Show all 15 Subjects
Abstract:
... Despite the promise and advantages of autologous cancer cell vaccination, it remains challenging to induce potent anti-tumor immune responses with traditional immunization strategies with whole tumor cell lysate. In this study, we sought to develop a simple and effective approach for therapeutic vaccination with autologous whole tumor cell lysate. Endogenous cell membranes harvested from cancer ce ...
DOI:
10.1016/j.biomaterials.2018.08.016
PubMed:
30121425
PubMed Central:
PMC6156795

14. LPA1/3 signaling mediates tumor lymphangiogenesis through promoting CRT expression in prostate cancer Molecular and cell biology of lipids

Author:
Lin, Yueh-Chien; Chen, Chien-Chin; Chen, Wei-Min; Lu, Kuan-Ying; Shen, Tang-Long; Jou, Yeong-Chin; Shen, Cheng-Huang; Ohbayashi, Norihiko; Kanaho, Yasunori; Huang, Yuan-Li; Lee, Hsinyu
Source:
Biochimica et biophysica acta 2018 v.1863 no.10 pp. 1305-1315
ISSN:
1388-1981
Subject:
lymph nodes,   etc   ; G-protein coupled receptors; angiogenesis; antagonists; blood platelets; blood serum; calreticulin; lipids; metastasis; mice; phosphorylation; prostatic neoplasms; reactive oxygen species; therapeutics; vascular endothelial growth factor C;     Show all 15 Subjects
Abstract:
... Lysophosphatidic acid (LPA) is a bioactive lipid growth factor which is present in high levels in serum and platelets. LPA binds to its specific G-protein-coupled receptors, including LPA1 to LPA6, thereby regulating various physiological functions, including cancer growth, angiogenesis, and lymphangiogenesis. Our previous study showed that LPA promotes the expression of the lymphangiogenic factor ...
DOI:
10.1016/j.bbalip.2018.07.005

15. Leishmania tropica: suggestive evidences for the effect of infectious dose on pathogenicity and immunogenicity in an experimental model

Author:
Rostamian, Mosayeb; Jafari, Davood; Abolghazi, Maryam; Farahani, Hadiseh; Niknam, Hamid M.
Source:
Parasitology research 2018 v.117 no.9 pp. 2949-2956
ISSN:
0932-0113
Subject:
lymph nodes,   etc   ; Leishmania tropica; ears; humans; immune response; immunogenicity; interferon-gamma; interleukin-10; leishmaniasis; mice; models; parasite load; parasites; pathogenesis; pathogenicity; spleen;     Show all 16 Subjects
Abstract:
... Leishmania (L.) tropica is a causative agent of cutaneous and occasionally visceral or viscerotropic leishmaniasis in humans. The dose of parasites influences the course and outcome of disease in some Leishmania species. The effect of parasite dose on L. tropica infection in an experimental model was studied in the current paper. High and low doses of L. tropica were used for ear infection of BALB ...
DOI:
10.1007/s00436-018-5991-7

16. Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Author:
Nuhn, Lutz; Van Hoecke, Lien; Deswarte, Kim; Schepens, Bert; Li, Yupeng; Lambrecht, Bart N.; De Koker, Stefaan; David, Sunil A.; Saelens, Xavier; De Geest, Bruno G.
Source:
Biomaterials 2018 v.178 pp. 643-651
ISSN:
0142-9612
Subject:
lymph nodes,   etc   ; agonists; chemical bonding; immune response; immunogenicity; in vivo studies; inflammation; mice; nanoparticles; pharmacokinetics; polymers; subunit vaccines; vaccination; vaccine adjuvants; viruses;     Show all 15 Subjects
Abstract:
... Improving the immunogenicity of subunit vaccines, in particular skewing of the immune response towards Th1 type immunity, is crucial for the development of effective vaccines against intracellular infections and for the development of anti-cancer vaccines. Small molecule TLR7/8 agonist hold high potential for this purpose, but suffer from an undesirable pharmacokinetic profile, resulting in system ...
DOI:
10.1016/j.biomaterials.2018.03.026

17. Engineered hybrid spider silk particles as delivery system for peptide vaccines

Author:
Lucke, Matthias; Mottas, Inès; Herbst, Tina; Hotz, Christian; Römer, Lin; Schierling, Martina; Herold, Heike M.; Slotta, Ute; Spinetti, Thibaud; Scheibel, Thomas; Winter, Gerhard; Bourquin, Carole; Engert, Julia
Source:
Biomaterials 2018 v.172 pp. 105-115
ISSN:
0142-9612
Subject:
lymph nodes,   etc   ; Araneae; T-lymphocytes; antigens; cytotoxicity; dendritic cells; immune response; immunostimulants; immunotoxicity; infectious diseases; mice; neoplasms; ovalbumin; spidroins; subcutaneous injection; subunit vaccines; vaccination; vaccine adjuvants;     Show all 18 Subjects
Abstract:
... The generation of strong T-cell immunity is one of the main challenges for the development of successful vaccines against cancer and major infectious diseases. Here we have engineered spider silk particles as delivery system for a peptide-based vaccination that leads to effective priming of cytotoxic T-cells. The recombinant spider silk protein eADF4(C16) was fused to the antigenic peptide from ov ...
DOI:
10.1016/j.biomaterials.2018.04.008

18. A synthetic stroma-free germinal center niche for efficient generation of humoral immunity ex vivo

Author:
Roh, Kyung-Ho; Song, Hannah W.; Pradhan, Pallab; Bai, Kevin; Bohannon, Caitlin D.; Dale, Gordon; Leleux, Jardin; Jacob, Joshy; Roy, Krishnendu
Source:
Biomaterials 2018 v.164 pp. 106-120
ISSN:
0142-9612
Subject:
lymph nodes,   etc   ; B-lymphocytes; CD4-positive T-lymphocytes; antibodies; antigen presentation; crosslinking; dendritic cells; humoral immunity; immunoglobulins; immunologic memory; medicine; mice; pathogens; phenotype; spleen; vaccination;     Show all 16 Subjects
Abstract:
... B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory. Following infection or vaccination, antibody-secreting B cells and memory B cells are generated in specialized regions of lymph nodes and spleens, called germinal centers. Here, we report a fully synthetic ex-vivo system that recapitulates the gen ...
DOI:
10.1016/j.biomaterials.2018.02.039

19. Dermotropic Leishmania donovani in Sri Lanka: visceralizing potential in clinical and preclinical studies

Author:
KARIYAWASAM, K. K. G. D. U. L.; SELVAPANDIYAN, A.; SIRIWARDANA, H. V. Y. D.; DUBE, A.; KARUNANAYAKE, P.; SENANAYAKE, S. A. S. C.; DEY, R.; GANNAVARAM, S.; NAKHASI, H. L.; KARUNAWEERA, N. D.
Source:
Parasitology 2018 v.145 no.4 pp. 443-452
ISSN:
1469-8161
Subject:
lymph nodes,   etc   ; Leishmania donovani; antimony; cell culture; cutaneous leishmaniasis; interferon-gamma; interleukin-10; macrophages; mice; models; parasites; patients; skin lesions; splenocytes; therapeutics; virulence; Sri Lanka;     Show all 17 Subjects
Abstract:
... The visceralizing potential of apparently dermotropic Leishmania donovani in Sri Lanka (L. donovani-SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) patients and in vivo and in vitro experimental infection models. CL patients (n = 250) treated effectively with intra-lesional antimony therapy were followed-up six monthly for 4 years. There was no clinical evidence of ...
DOI:
10.1017/S003118201700169X
PubMed:
29113609

20. Assessment of the Allergenic Potential of the Main Egg White Proteins in BALB/c Mice

Author:
Pablos-Tanarro, Alba; Lozano-Ojalvo, Daniel; Molina, Elena; López-Fandiño, Rosina
Source:
Journal of agricultural and food chemistry 2018 v.66 no.11 pp. 2970-2976
ISSN:
1520-5118
Subject:
lymph nodes,   etc   ; lysozyme; immunoglobulin G; adjuvants; oral administration; ovalbumin; prognosis; allergenicity; ovomucin; allergens; mice; immunoglobulin E; splenocytes; CD4-positive T-lymphocytes; cholera toxin; eggs; egg albumen; anaphylaxis;     Show all 18 Subjects
Abstract:
... This work aimed to assess the contribution of the major egg white proteins, ovalbumin, ovomucoid, and lysozyme, to the induction and elicitation of allergenic responses. For this purpose, BALB/c mice were orally administered either the individual egg allergens or a mixture of the three proteins in the same proportion, to evaluate their relative allergenicity avoiding their different abundance in e ...
DOI:
10.1021/acs.jafc.8b00402

21. An efficient protocol for in vivo labeling of proliferating epithelial cells

Author:
Michel, Chloé; Küchler, Rita; Martin, Iris; Kyewski, Bruno; Pinto, Sheena
Source:
Journal of immunological methods 2018
ISSN:
0022-1759
Subject:
lymph nodes,   etc   ; DNA replication; animal models; cell proliferation; cell suspension culture; dissociation; epithelial cells; fluorescence; intravenous injection; kidneys; mice; organogenesis; protocols; small intestine; thymus gland; tissues; toxicity;     Show all 17 Subjects
Abstract:
... The study of organogenesis, tissue-homeostasis and regeneration requires the precise assessment of in vivo cell proliferation. To this end a host of methods have been developed to detect and quantify DNA synthesis in proliferating cells. These include cell labeling with various nucleotide analogues and fluorescence reporter-based animal models with each method presenting its idiosyncratic shortcom ...
DOI:
10.1016/j.jim.2018.03.015

22. Characterization of the innate stimulatory capacity of plant-derived virus-like particles bearing influenza hemagglutinin

Author:
Won, So-Yoon; Hunt, Kristin; Guak, Hannah; Hasaj, Benedeta; Charland, Nathalie; Landry, Nathalie; Ward, Brian J.; Krawczyk, Connie M.
Source:
Vaccine 2018 v.36 no.52 pp. 8028-8038
ISSN:
0264-410X
Subject:
lymph nodes,   etc   ; B-lymphocytes; T-lymphocytes; cell-mediated immunity; dendritic cells; hemagglutinins; humans; immune response; immunization; immunostimulants; influenza; interleukin-12; interleukin-6; mice; mitogen-activated protein kinase; receptors; tumor necrosis factor-alpha; virus-like particle vaccines; virus-like particles;     Show all 19 Subjects
Abstract:
... Cell-mediated immunity is an important component of immediate and long-term anti-viral protection. Dendritic cells (DCs) are essential for the induction of cell-mediated immunity by instructing the activation and differentiation of antigen-specific T cell responses. Activated DCs that express co-stimulatory molecules and pro-inflammatory cytokines are necessary to promote the development of type 1 ...
DOI:
10.1016/j.vaccine.2018.10.099

23. Factors affecting Salmonella-based combination immunotherapy for prevention of type 1 diabetes in non-obese diabetic mice

Author:
Husseiny, Mohamed I.; Du, Weiting; Mbongue, Jacques; Lenz, Ayelet; Rawson, Jeffrey; Kandeel, Fouad; Ferreri, Kevin
Source:
Vaccine 2018 v.36 no.52 pp. 8008-8018
ISSN:
0264-410X
Subject:
lymph nodes,   etc   ; Salmonella; T-lymphocytes; animal disease models; autoimmunity; edible vaccines; glucose tolerance; hyperglycemia; insulin-dependent diabetes mellitus; interleukin-10; interleukin-2; live vaccines; mice; transforming growth factor beta; tumor necrosis factor-alpha; vaccination;     Show all 16 Subjects
Abstract:
... We previously reported the development of an oral vaccine for diabetes based on live attenuated Salmonella-expressing preproinsulin (PPI) as the autoantigen. When combined with host cell-expressed TGFβ, the vaccine prevented the onset of diabetes in non-obese diabetic (NOD) mice. Herein, we investigated factors that could affect vaccine efficacy including vaccination number, optimization of the au ...
DOI:
10.1016/j.vaccine.2018.10.101

24. Oral vaccination with Trichinella spiralis DNase II DNA vaccine delivered by attenuated Salmonella induces a protective immunity in BALB/c mice

Author:
Qi, Xin; Han, Yue; Jiang, Peng; Yue, Xin; Ren, Hua Nan; Sun, Ge Ge; Long, Shao Rong; Yu, Chuan; Cheng, Xiang Chao; Cui, Jing; Wang, Zhong Quan
Source:
Veterinary research 2018 v.49 no.1 pp. 119
ISSN:
1297-9716
Subject:
lymph nodes,   etc   ; Salmonella Typhimurium; Trichinella spiralis; adults; deoxyribonucleases; females; fluorescent antibody technique; humans; immune response; immunoglobulin G; interferon-gamma; interleukin-4; intestines; larvae; mice; molting; oral vaccination; recombinant vaccines; spleen; trichinosis; veterinary medicine; zoonoses;     Show all 22 Subjects
Abstract:
... Trichinellosis is one of the most serious foodborne parasitic zoonosis with worldwide distribution, and it is necessary to develop a vaccine to interrupt transmission from animals to humans. Trichinella spiralis adult-specific DNase II-1 (TsDNase II) were identified by immunoproteomics in surface or excretory/secretory proteins of adult worms (AW) and intestinal infective larvae (IIL). The aim of ...
DOI:
10.1186/s13567-018-0614-y

25. Rehmannia glutinosa polysaccharide functions as a mucosal adjuvant to induce dendritic cell activation in mediastinal lymph node

Author:
Kwak, Minseok; Yu, Kijin; Lee, Peter Chang-Whan; Jin, Jun-O
Source:
International journal of biological macromolecules 2018 v.120 pp. 1618-1623
ISSN:
0141-8130
Subject:
lymph nodes,   etc   ; CCR7 receptor; Rehmannia glutinosa; T-lymphocytes; adjuvants; cell proliferation; dendritic cells; genetically modified organisms; humans; immune response; interferon-gamma; lungs; melanoma; mice; ovalbumin; polysaccharides; tumor necrosis factor-alpha;     Show all 17 Subjects
Abstract:
... In our previous study, we showed that Rehmannia glutinosa polysaccharide (RGP) treatment induced activation of dendritic cells (DCs) in human and mouse subjects. In this study, we evaluated the effect of RGP as a mucosal adjuvant for inducting activation of DCs in the mediastinal lymph node (mLN) in the mouse. The C57BL/6 mice were intranasally (i.n.) treated with RGP and activation of DC in the m ...
DOI:
10.1016/j.ijbiomac.2018.09.187

26. Superimposed visceral leishmanial infection aggravates response to Heligmosomoides polygyrus

Author:
González-Sánchez, M. E.; Cuquerella, M.; Alunda, J. M.
Source:
Parasites & vectors 2018 v.11 no.1 pp. 404
ISSN:
1756-3305
Subject:
lymph nodes,   etc   ; Heligmosomoides polygyrus; Leishmania infantum; antibodies; blood serum; control methods; eggs; gastrointestinal system; helminths; humans; immunoglobulin G; larvae; longevity; mice; mixed infection; models; parasitism; pathogenicity; promastigotes; protists; visceral leishmaniasis;     Show all 21 Subjects
Abstract:
... BACKGROUND: Polyparasitism is the rule in all animal species, including humans, and has an important role in pathogenicity, diagnosis and control measures. Among them, co-infections by gastrointestinal helminths and protists are very prevalent under natural conditions but experimental infections are relatively scarce. Thus, despite the frequent association of visceral Leishmania infections and int ...
DOI:
10.1186/s13071-018-2987-1
PubMed:
29996937
PubMed Central:
PMC6042253

27. Virus-like particles of recombinant PCV2b carrying FMDV-VP1 epitopes induce both anti-PCV and anti-FMDV antibody responses

Author:
Li, Xin; Meng, Xiuping; Wang, Shengnan; Li, Zhiqin; Yang, Lei; Tu, Liqun; Diao, Wenzhen; Yu, Cheng; Yu, Yongli; Yan, Chaoying; Wang, Liying
Source:
Applied microbiology and biotechnology 2018 v.102 no.24 pp. 10541-10550
ISSN:
0175-7598
Subject:
lymph nodes,   etc   ; B-lymphocytes; Escherichia coli; Foot-and-mouth disease virus; Porcine circovirus-2; antibodies; dialysis; epitopes; guinea pigs; immune response; mice; mixed infection; recombinant proteins; swine; vaccines; virus-like particles;     Show all 16 Subjects
Abstract:
... Mixed infection of porcine circovirus type 2 (PCV2) and foot-and-mouth disease virus (FMDV) is devastating to swine populations. To develop an effective vaccine that can protect the pigs from the infection of PCV2 and FMDV, we used the neutralizing B cell epitope region (aa 135–160) of FMDV to replace the regions aa 123–151 and aa 169–194 of the PCV2b Cap protein to generate a recombinant protein ...
DOI:
10.1007/s00253-018-9361-2

28. A Water-Soluble Extract from <i>Actinidia arguta</i> Ameliorates Psoriasis-Like Skin Inflammation in Mice by Inhibition of Neutrophil Infiltration

Author:
Kim, Hyun-keun; Bae, Min Jung; Lim, Seonung; Lee, Wonwoo; Kim, Sunyoung
Source:
Nutrients 2018 v.10 no.10
ISSN:
2072-6643
Subject:
lymph nodes,   etc   ; Actinidia arguta; adverse effects; anti-inflammatory activity; antimicrobial peptides; chemokines; chemotaxis; etiology; inflammation; interleukins; kiwifruit; mice; neutrophils; psoriasis; signal transduction; signs and symptoms (animals and humans); topical application; transcription factor NF-kappa B; water solubility;     Show all 19 Subjects
Abstract:
... Psoriasis is a chronic inflammatory disease with complex etiology involving multiple factors. Current treatment methods are highly limited and there is a strong need for the development of safer and efficacious agents. We have previously shown that a water-soluble extract derived from hardy kiwifruit Actinidia arguta, called PG102, shows potent anti-inflammatory effects. Based on its reported biol ...
DOI:
10.3390/nu10101399

29. Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Author:
Wagenaar, Laura; Bol‐Schoenmakers, Marianne; Giustarini, Giulio; Vonk, Marlotte M.; van Esch, Betty C.A.M.; Knippels, Leon M.J.; Garssen, Johan; Smit, Joost J.; Pieters, Raymond H.H.
Source:
Molecular nutrition & food research 2018 v.62 no.20 pp. e1800369
ISSN:
1613-4125
Subject:
lymph nodes,   etc   ; adverse effects; anaphylaxis; animal models; antibody formation; body temperature; cecum; cholera toxin; dendritic cells; dietary supplements; food allergies; fructooligosaccharides; immunoglobulin A; immunoglobulin G; immunotherapy; mice; peanuts; short chain fatty acids;     Show all 18 Subjects
Abstract:
... SCOPE: A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support the efficacy of OIT in a peanut allergy model. METHODS AND RESULTS: After sensitization to peanut extract (PE) ...
DOI:
10.1002/mnfr.201800369

30. Vaccination with DNA encoding ES 43-kDa /45-kDa antigens significantly reduces Trichinella spiralis infection in mice

Author:
Wang, Jianzhong; Jiang, Yanlong; Yang, Wentao; Shi, Chunwei; Huang, Haibin; Sun, Hao; Liu, Gaosheng; Wang, Chunfeng; Yang, Guilian; Cai, Yanan
Source:
Research in veterinary science 2018 v.120 pp. 4-10
ISSN:
0034-5288
Subject:
lymph nodes,   etc   ; B-lymphocytes; Trichinella spiralis; antigens; dogs; excretory-secretory products; genes; genetic vectors; glycoproteins; hosts; immune response; immunogenicity; intestines; mice; muscle larvae; muscles; parasites; plasmids; recombinant vaccines; splenocytes; trichinosis; vaccination;     Show all 22 Subjects
Abstract:
... Trichinella spiralis is an intestinal nematode parasite that can cause trichinellosis in humans and animals worldwide. The most important known hosts of T. spiralis are pigs, horses, dogs and cats. Pork and its products are the main sources of infection in human trichinellosis. Vaccines against these infections are urgently needed. In this study, the genes encoding the 43-kDa or 45-kDa glycoprotei ...
DOI:
10.1016/j.rvsc.2018.08.002

31. Ginsenoside Rg3 Inhibition of Thyroid Cancer Metastasis Is Associated with Alternation of Actin Skeleton

Author:
Wu, Wenshuang; Zhou, Qian; Zhao, Wanjun; Gong, Yanping; Su, Anping; Liu, Feng; Liu, Yang; Li, Zhihui; Zhu, Jingqiang
Source:
Journal of medicinal food 2018 v.21 no.9 pp. 849-857
ISSN:
1557-7600
Subject:
lymph nodes,   etc   ; Oriental traditional medicine; Panax ginseng; actin; angiogenesis; antineoplastic activity; gelatinase A; ginsenosides; guanosinetriphosphatase; lungs; metastasis; mice; models; neoplasm cells; pseudopodia; skeleton; staining; thyroid neoplasms; vascular endothelial growth factor A; vascular endothelial growth factor C;     Show all 20 Subjects
Abstract:
... Ginsenoside Rg3, a bioactive constituent from Panax ginseng, is a worldwide well-known traditional Chinese medicine used as a tonic. It also has good antitumor activity by inhibiting tumors metastasis. Tumor metastasis is a high risk in thyroid cancer. However, the effect and molecular mechanism underlying the antimetastatic activity of Rg3 in thyroid cancer have not been reported. In our study, w ...
DOI:
10.1089/jmf.2017.4144

32. Interleukin-33 deficiency exacerbated experimental autoimmune encephalomyelitis with an influence on immune cells and glia cells

Author:
Xiao, Yifan; Lai, Lin; Chen, Huoying; Shi, Junyu; Zeng, FanFan; Li, Jun; Feng, Huiting; Mao, Jie; Zhang, Feng; Wu, Naming; Xu, Yong; Tan, Zheng; Gong, Feili; Zheng, Fang
Source:
Molecular immunology 2018 v.101 pp. 550-563
ISSN:
0161-5890
Subject:
lymph nodes,   etc   ; T-lymphocytes; astrocytes; autoimmune diseases; central nervous system; dendritic cells; encephalitis; interleukin-1; knockout mutants; macrophages; mice; natural killer cells; protective effect; sclerosis; spleen; transcription factors; tumor necrosis factor-alpha;     Show all 17 Subjects
Abstract:
... Interleukin (IL)-33, a member of the IL-1 cytokine family, is highly expressed in central nervous system (CNS), suggesting its potential role in CNS. Although some studies have focused on the role of IL-33 in multiple sclerosis (MS) / experimental autoimmune encephalomyelitis (EAE), an autoimmune disease characterized by demyelination and axonal damage in CNS, the exact role of IL-33 in MS/EAE rem ...
DOI:
10.1016/j.molimm.2018.08.026

33. Physical exercise contributes to cisplatin-induced nephrotoxicity protection with decreased CD4+ T cells activation

Author:
Miyagi, Mariana Yasue Saito; Latancia, Marcela Teatin; Testagrossa, Leonardo Abreu; Andrade-Oliveira, Vinicius de; Pereira, Welbert Oliveira; Hiyane, Meire Ioshie; Enjiu, Lucas Maceratesi; Pisciottano, Marcus; Seelaender, Marilia Cerqueira Leite; Camara, Niels Olsen Saraiva; Amano, Mariane Tami
Source:
Molecular immunology 2018 v.101 pp. 507-513
ISSN:
0161-5890
Subject:
lymph nodes,   etc   ; CD4-positive T-lymphocytes; adverse effects; bladder; blood serum; brown adipose tissue; cisplatin; creatinine; drug therapy; epididymis; exercise; head; interleukin-10; kidneys; liver; mice; neck; neoplasms; nephrotoxicity; phenotype; spleen; testes; tissue weight; tumor necrosis factors;     Show all 24 Subjects
Abstract:
... Cisplatin is a chemotherapy used to treat different types of cancer, such as testicular, bladder and head and neck. Physical exercise has been shown to improve cancer therapy and recently, it was demonstrated to be able to diminish side effects such as acute kidney injury (AKI), a common side effect in cisplatin treatment. In both cases, the modulation of inflammatory cytokines seems to be one of ...
DOI:
10.1016/j.molimm.2018.08.014

34. Absence of IL-17A in Litomosoides sigmodontis-infected mice influences worm development and drives elevated filarial-specific IFN-γ

Author:
Ritter, Manuel; Krupp, Vanessa; Wiszniewsky, Katharina; Wiszniewsky, Anna; Katawa, Gnatoulma; Tamadaho, Ruth S. E.; Hoerauf, Achim; Layland, Laura E.
Source:
Parasitology research 2018 v.117 no.8 pp. 2665-2675
ISSN:
0932-0113
Subject:
lymph nodes,   etc   ; CD4-positive T-lymphocytes; Litomosoides sigmodontis; adults; blindness; chemokine CCL11; chemokine CCL17; climate; humans; immune response; interferon-gamma; interleukin-17; interleukin-21; interleukin-4; interleukin-6; mice; onchocerciasis; parasites; public health; secretion; socioeconomics; thoracic cavity; tropical diseases;     Show all 23 Subjects
Abstract:
... Lymphatic filariasis, onchocerciasis and loiasis are widespread neglected tropical diseases causing serious public health problems and impacting the socio-economic climate in endemic communities. More than 100 million people currently suffer from filarial infections but disease-related symptoms and infection-induced immune mechanisms are still ambiguous. Although most infected individuals have dom ...
DOI:
10.1007/s00436-018-5959-7

35. Experimental bovine rotavirus-A (RV-A)infection causes intestinal and extra-intestinal pathology in suckling mice

Author:
Kashyap, Gayatri; Singh, R.; Malik, Y.S.; Agrawal, R.K.; Singh, K.P.; Kumar, P.; Sahoo, M.; Gupta, D.; Singh, Rahul
Source:
Microbial pathogenesis 2018 v.121 pp. 22-26
ISSN:
0882-4010
Subject:
lymph nodes,   etc   ; Peyer's patches; Rotavirus A; albino; brain; cell culture; diarrhea; enterocytes; eosin; fluorescence; genetically modified organisms; ileum; jejunum; kidneys; liver; lungs; mice; nucleic acids; pH; parenchyma (animal tissue); phosphates; pups; reverse transcriptase polymerase chain reaction; spleen; suckling; villi; viruses;     Show all 27 Subjects
Abstract:
... We describe here the intestinal and extra-intestinal spread of the species A rotavirus (RV-A) and associated lesions thereof in Swiss albino suckling mice pups, inoculated with a bovine-origin RV-A strain. In total, 35 suckling pups were used, wherein 20 pups received cell culture isolated RV-A @ 160 μL (TCID50/ml, 5 × 106.5) per pup [oral 80 μL and intra peritoneal (IP) 80 μL] and served as an in ...
DOI:
10.1016/j.micpath.2018.04.038

36. Immunoprotective responses against murine sarcocystosis by β - Irradiated sporocysts

Author:
Abdel-Latif, Mahmoud; Sakran, Thabet; Abdel-Haleem, Heba M.; Eissa, Mostafa F.; Al-Sayed, Shrouk E.
Source:
Experimental parasitology 2018 v.191 pp. 73-81
ISSN:
0014-4894
Subject:
lymph nodes,   etc   ; CD8-positive T-lymphocytes; RNA; Sarcocystis; blood serum; exposure duration; immunity; immunoglobulin A; immunohistochemistry; interferon-gamma; irradiation; liver; major histocompatibility complex; mice; muscle tissues; natural killer cells; parasites; polymerase chain reaction; sarcocystosis; spleen;     Show all 20 Subjects
Abstract:
... This study aimed to induce protective immunity against infection with Sarcocystis muris in experimental mice using β-irradiated sporocysts. Mice were vaccinated with 50 sporocysts of S. muris which were exposed to 1.84 μSv β-irradiation for 2, 4 and 8 h. After challenge infection, different samples were taken for evaluation. Serum and intestinal wash were assayed for IFN-γ and IgA, respectively. M ...
DOI:
10.1016/j.exppara.2018.06.008

37. Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses

Author:
Si, Youhui; Wen, Yi; Kelly, Sean H.; Chong, Anita S.; Collier, Joel H.
Source:
Journal of controlled release 2018 v.282 pp. 120-130
ISSN:
0168-3659
Subject:
lymph nodes,   etc   ; CD8-positive T-lymphocytes; adjuvants; dendritic cells; epitopes; geographical distribution; immune response; immunization; immunogenicity; inflammation; influenza; influenza vaccines; interferon-gamma; lungs; memory; mice; nanofibers; peptides; viral load;     Show all 19 Subjects
Abstract:
... Influenza vaccines that can be administered intranasally or by other needle-free delivery routes have potential advantages over injected formulations in terms of patient compliance, cost, and ease of global distribution. Supramolecular peptide nanofibers have been investigated previously as platforms for vaccines and immunotherapies and have been shown to raise immune responses in the absence of e ...
DOI:
10.1016/j.jconrel.2018.04.031

38. Effective cancer immunotherapy in mice by polyIC-imiquimod complexes and engineered magnetic nanoparticles

Author:
Bocanegra Gondan, Ana Isabel; Ruiz-de-Angulo, Ane; Zabaleta, Aintzane; Gómez Blanco, Nina; Cobaleda-Siles, Beatriz Macarena; García-Granda, María Jesús; Padro, Daniel; Llop, Jordi; Arnaiz, Blanca; Gato, María; Escors, David; Mareque-Rivas, Juan C.
Source:
Biomaterials 2018 v.170 pp. 95-115
ISSN:
0142-9612
Subject:
lymph nodes,   etc   ; Toll-like receptor 3; Toll-like receptor 7; agonists; antigens; cytokines; image analysis; immune response; immunosuppression; immunotherapy; innate immunity; iron oxides; magnetism; melanoma; mice; micelles; models; nanoparticles; neoplasm cells; ovalbumin; phospholipids; toxicity; vaccine development; vaccines;     Show all 24 Subjects
Abstract:
... Encouraging results are emerging from systems that exploit Toll like receptor (TLR) signaling, nanotechnology, checkpoint inhibition and molecular imaging for cancer immunotherapy. A major remaining challenge is developing effective, durable and tumour-specific immune responses without systemic toxicity. Here, we report a simple and versatile system based on synergistic activation of immune respon ...
DOI:
10.1016/j.biomaterials.2018.04.003

39. Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis

Author:
Tong, Xinxin; Chen, Shengjie; Zheng, Huanqin; Huang, Shiguang; Lu, Fangli
Source:
Parasitology research 2018 v.117 no.7 pp. 2255-2263
ISSN:
0932-0113
Subject:
lymph nodes,   etc   ; Toxoplasma gondii; animal models; cell lines; eyes; fluorescent antibody technique; histopathology; humans; immune response; immunopathology; interleukins; intraocular injection; mast cells; messenger RNA; mice; reverse transcriptase polymerase chain reaction; staining; surface antigens; tachyzoites; toluidine blue; toxoplasmosis;     Show all 21 Subjects
Abstract:
... Interleukin 27 (IL-27) is a member of the IL-6/IL-12 family, and IL-27 receptor (IL-27R) consists of WSX-1 (the IL-27Rα subunit) and the signal-transducing subunit gp130. Human and mouse mast cells (MCs) express the IL-27R. To explore the expressions of IL-27/IL-27R subunits (WSX-1 and gp130) during acute ocular toxoplasmosis (OT), we established mouse model by intraocular injection of 500 Toxopla ...
DOI:
10.1007/s00436-018-5914-7

40. Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

Author:
Chen, Lei; Huang, Cong-Fa; Li, Yi-Cun; Deng, Wei-Wei; Mao, Liang; Wu, Lei; Zhang, Wen-Feng; Zhang, Lu; Sun, Zhi-Jun
Source:
Cellular and molecular life sciences 2018 v.75 no.11 pp. 2045-2058
ISSN:
1420-682X
Subject:
lymph nodes,   etc   ; CD8-positive T-lymphocytes; animal models; blood serum; carcinogenesis; humans; immune response; immunosuppression; inflammasomes; interleukin-1beta; macrophages; mice; microarray technology; patients; spleen; squamous cell carcinoma; suppressor cells; therapeutics; tissues;     Show all 19 Subjects
Abstract:
... The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentra ...
DOI:
10.1007/s00018-017-2720-9

41. Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice

Author:
Deepe, George S.; Buesing, William R.; Ostroff, Gary R.; Abraham, Ambily; Specht, Charles A.; Huang, Haibin; Levitz, Stuart M.
Source:
Vaccine 2018 v.36 no.23 pp. 3359-3367
ISSN:
0264-410X
Subject:
lymph nodes,   etc   ; Histoplasma capsulatum; adjuvants; disease prevention; encapsulation; glucans; habitats; histoplasmosis; immunity; indigenous species; interferon-gamma; interleukin-17; liquid chromatography; lungs; mice; neutralization; proteins; spleen; tandem mass spectrometry; vaccination; vaccines; yeasts; South America;     Show all 23 Subjects
Abstract:
... Infection with the dimorphic fungus, Histoplasma capsulatum, occurs world-wide, but North and South America are regions of high endemicity. Interventions to mitigate exposure and consequent disease are limited to remediating a habitat harboring the fungus. The development of a vaccine to prevent infection or lessen its severity is an important advance in disease prevention. Accordingly, we prepare ...
DOI:
10.1016/j.vaccine.2018.04.047

42. Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells

Author:
Le Moignic, A.; Malard, V.; Benvegnu, T.; Lemiègre, L.; Berchel, M.; Jaffrès, P.-A.; Baillou, C.; Delost, M.; Macedo, R.; Rochefort, J.; Lescaille, G.; Pichon, C.; Lemoine, F.M.; Midoux, P.; Mateo, V.
Source:
Journal of controlled release 2018 v.278 pp. 110-121
ISSN:
0168-3659
Subject:
lymph nodes,   etc   ; CCR7 receptor; CXCR4 receptor; T-lymphocytes; antigens; cancer vaccines; cell lines; clinical trials; dendritic cells; equipment; glycolipids; humans; immune response; inflammation; mannose; messenger RNA; mice; models; neoplasms; ribonucleases; vaccination;     Show all 21 Subjects
Abstract:
... Clinical trials with direct administration of synthetic mRNAs encoding tumor antigens demonstrated safety and induction of tumor-specific immune responses. Their proper delivery to dendritic cells (DCs) requires their protection against RNase degradation and more specificity for dose reduction. Lipid-Polymer-RNA lipopolyplexes (LPR) are attractive mRNA delivery systems and their equipment with man ...
DOI:
10.1016/j.jconrel.2018.03.035

43. Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality

Author:
Kang, Ting; Huang, Yukun; Zhu, Qianqian; Cheng, Hao; Pei, Yuanyuan; Feng, Jingxian; Xu, Minjun; Jiang, Gan; Song, Qingxiang; Jiang, Tianze; Chen, Hongzhuan; Gao, Xiaoling; Chen, Jun
Source:
Biomaterials 2018 v.164 pp. 80-97
ISSN:
0142-9612
Subject:
lymph nodes,   etc   ; CD8-positive T-lymphocytes; adjuvants; antibodies; antigen presentation; antigens; biomimetics; bone marrow; dendritic cells; heat shock proteins; melanoma; membrane proteins; mice; models; nanotechnology; natural killer cells; neoplasm cells; phospholipids; remission; synergism; vaccination; vaccines;     Show all 22 Subjects
Abstract:
... Recent breakthroughs in cancer immunotherapy offer new paradigm-shifting therapeutic options for combating cancer. Personalized therapeutic anti-cancer vaccines training T cells to directly fight against tumor cells endogenously offer tremendous benefits in working synergistically with immune checkpoint inhibitors. Biomimetic nanotechnology offers a versatile platform to boost anticancer immunity ...
DOI:
10.1016/j.biomaterials.2018.02.033

44. Intranasal but not subcutaneous vaccination with LaAg allows rapid expansion of protective immunity against cutaneous leishmaniasis

Author:
Pereira Silva Bezerra, Izabella; Amaral Abib, Marina; Rossi-Bergmann, Bartira
Source:
Vaccine 2018 v.36 no.18 pp. 2480-2486
ISSN:
0264-410X
Subject:
lymph nodes,   etc   ; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; GATA transcription factors; Leishmania amazonensis; antigens; cutaneous leishmaniasis; hypersensitivity; immune response; interleukin-10; interleukin-12; mice; parasites; promastigotes; transforming growth factors; vaccination; vaccines;     Show all 17 Subjects
Abstract:
... Mucosal but not parenteral vaccination with whole Leishmania amazonensis promastigotes antigens (LaAg) is known to increase host resistance to infection by an as yet unknown immune mechanism. Since early immune responses are critical for infection establishment, in the present study the differential responses elicited by subcutaneous (s.c.) and intranasal (i.n.) vaccination with LaAg were investig ...
DOI:
10.1016/j.vaccine.2018.03.020

45. Injectable polypeptide hydrogel for dual-delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma

Author:
Song, Huijuan; Huang, Pingsheng; Niu, Jinfeng; Shi, Gaona; Zhang, Chuangnian; Kong, Deling; Wang, Weiwei
Source:
Biomaterials 2018 v.159 pp. 119-129
ISSN:
0142-9612
Subject:
lymph nodes,   etc   ; CD8-positive T-lymphocytes; Toll-like receptor 3; agonists; antigens; cell viability; cytotoxicity; dendritic cells; hydrogels; immune response; immunostimulants; immunotherapy; injection site; melanoma; mice; neoplasm cells; polypeptides; subcutaneous injection; vaccines; valine;     Show all 20 Subjects
Abstract:
... Transplantation of immune cells manipulated in vitro to dictate immune responses in the body is promising in cancer immunotherapy. However, this approach suffers from low cell survival after administration, insufficient cell homing to lymph nodes, and off-target. Here we demonstrate an injectable and self-assembled poly(l-valine) hydrogel as the delivery carrier of cargoes including antigen and im ...
DOI:
10.1016/j.biomaterials.2018.01.004

46. Milk basic protein supplementation exerts an anti-inflammatory effect in a food-allergic enteropathy model mouse

Author:
Ono-Ohmachi, Aiko; Nakajima-Adachi, Haruyo; Morita, Yoshikazu; Kato, Ken; Hachimura, Satoshi
Source:
Journal of dairy science 2018 v.101 no.3 pp. 1852-1863
ISSN:
0022-0302
Subject:
lymph nodes,   etc   ; CD4-positive T-lymphocytes; anti-inflammatory activity; autoimmune diseases; bone density; bone marrow; bone resorption; dendritic cells; digestive system diseases; femur; genes; hypersensitivity; immunoglobulin E; in vitro culture; inflammation; interleukin-4; intestines; mice; milk; models; ovalbumin; protein supplements;     Show all 22 Subjects
Abstract:
... To examine novel functions of milk basic protein (MBP) in T-cell-related inflammatory diseases, such as autoimmune diseases and allergies, we evaluated the effects of MBP on the causative responses of ovalbumin (OVA)-specific T cells in a food-allergic enteropathy model, OVA23–3 mice, which express an OVA-specific T-cell receptor gene. The OVA-specific CD4+ T cells of the mesenteric lymph nodes (M ...
DOI:
10.3168/jds.2017-13253

47. Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen‐induced allergic rhinitis in mice

Author:
Choi, S.‐P.; Oh, H.‐N.; Choi, C.‐Y.; Ahn, H.; Yun, H.S.; Chung, Y.M.; Kim, B.; Lee, S.J.; Chun, T.
Source:
Journal of applied microbiology 2018 v.124 no.3 pp. 821-828
ISSN:
1364-5072
Subject:
lymph nodes,   etc   ; secretion; interferon-gamma; rhinitis; Lactobacillus plantarum; lungs; pollen; oral administration; immunoglobulin G; interleukin-13; Betula; blood serum; nasal cavity; histology; mice; immunoglobulin E; immune response; interleukin-5; probiotics; animal models; interleukin-4;     Show all 21 Subjects
Abstract:
... AIMS: In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)‐induced allergic rhinitis. METHODS AND RESULTS: Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP‐induced allergic rhinitis by reducing airway hyperresponsiveness, and both the histological scores and the number of infiltrated cells ...
DOI:
10.1111/jam.13635

48. Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis

Author:
Liu, Yuanqi; Ren, Wei; Bai, Yang; Wan, Lihong; Sun, Xiaodong; Liu, Yin; Xiong, Wenbi; Zhang, Yuan-Yuan; Zhou, Liming
Source:
Natural medicines 2018 v.72 no.2 pp. 481-492
ISSN:
1340-3443
Subject:
lymph nodes,   etc   ; Western blotting; angiogenesis; antineoplastic activity; cell lines; cell proliferation; dose response; doxorubicin; feet; hepatoma; histology; males; metastasis; mice; models; resveratrol; vascular endothelial growth factor C; vascular endothelial growth factor receptor-3;     Show all 18 Subjects
Abstract:
... The purpose of this study was to investigate the effects and mechanisms of oxyresveratrol (Oxyres) on hepatocellular carcinoma (HCC) in vitro and in vivo. The MTT and Transwell assays were performed to investigate the effects of Oxyres on cell proliferation and migration of two HCC cell lines, QGY-7701 and SMMC-7721 cells. H22 cells were subcutaneously injected into hind foot pads of 70 male mice ...
DOI:
10.1007/s11418-018-1173-2

49. The octapetide NAP alleviates intestinal and extra-intestinal anti-inflammatory sequelae of acute experimental colitis

Author:
Heimesaat, Markus M.; Giladi, Eliezer; Kühl, Anja A.; Bereswill, Stefan; Gozes, Illana
Source:
Peptides 2018 v.101 pp. 1-9
ISSN:
0196-9781
Subject:
lymph nodes,   etc   ; Bifidobacterium; T-lymphocytes; anti-inflammatory activity; apoptosis; colitis; complications (disease); dextran sulfate; epithelial cells; humans; interferon-gamma; interleukin-10; interleukin-6; intestinal microorganisms; intestines; kidneys; mice; mucosa; neuroprotective effect; nitric oxide; secretion; sodium chloride; tumor necrosis factors;     Show all 23 Subjects
Abstract:
... The octapeptide NAP has been shown to exert neuroprotective properties and reduce neuro-inflammatory responses. The aim of the present study was to investigate if NAP provides anti-inflammatory effects in acute murine colitis. To address this, C57BL/6 j mice were challenged with 3.5% dextran sulfate sodium from day 0 until day 6 to induce colitis, either treated intraperitoneally with NAP or place ...
DOI:
10.1016/j.peptides.2017.12.023

50. Use of Immunohistochemistry to Demonstrate In Vivo Expression of the Burkholderia mallei Virulence Factor BpaB During Experimental Glanders

Author:
Zimmerman, Shawn M.; Long, Mackenzie E.; Dyke, Jeremy S.; Jelesijevic, Tomislav P.; Michel, Frank; Lafontaine, Eric R.; Hogan, Robert J.
ISSN:
1544-2217
Subject:
lymph nodes,   etc   ; Burkholderia mallei; Callitrichidae; animal models; animal pathology; antibiotics; bacteria; biofilm; breathing; epithelial cells; glanders; humans; immunohistochemistry; macrophages; mice; neutrophils; pathogenesis; pneumonia; sepsis (infection); therapeutics; tissues; vaccines; virulence; zoonoses;     Show all 24 Subjects
Abstract:
... Burkholderia mallei causes the highly contagious and debilitating zoonosis glanders, which infects via inhalation or percutaneous inoculation and often culminates in life-threatening pneumonia and sepsis. In humans, glanders is difficult to diagnose and requires prolonged antibiotic therapy with low success rates. No vaccine exists to protect against B. mallei, and there is concern regarding its u ...
DOI:
10.1177/0300985817736113

51. Vaccine potential of antigen cocktails composed of recombinant Toxoplasma gondii TgPI-1, ROP2 and GRA4 proteins against chronic toxoplasmosis in C3H mice

Author:
Picchio, Mariano S.; Sánchez, Vanesa R.; Arcon, Nadia; Soto, Ariadna S.; Perrone Sibilia, Matías; Aldirico, María de los Angeles; Urrutia, Mariela; Moretta, Rosalía; Fenoy, Ignacio M.; Goldman, Alejandra; Martin, Valentina
Source:
Experimental parasitology 2018 v.185 pp. 62-70
ISSN:
0014-4894
Subject:
lymph nodes,   etc   ; Toxoplasma gondii; antibodies; antigens; blood serum; brain; cell proliferation; cytokines; humoral immunity; immunization; immunoglobulin A; intestines; mice; mucosal immunity; parasites; protective effect; recombinant proteins; secretion; serine proteinases; toxoplasmosis; vaccines;     Show all 21 Subjects
Abstract:
... The development of an effective and safe vaccine to prevent Toxoplasma gondii infection is an important aim due to the great clinical and economic impact of this parasitosis. We have previously demonstrated that immunization with the serine protease inhibitor-1 (TgPI-1) confers partial protection to C3H/HeN and C57BL/6 mice. In order to improve the level of protection, in this work, we combined th ...
DOI:
10.1016/j.exppara.2018.01.006

52. Experimental infection of mice with noncytopathic bovine viral diarrhea virus 2 increases the number of megakaryocytes in bone marrow

Author:
Lee, Kyung-Hyun; Han, Du-Gyeong; Kim, Suhee; Choi, Eun-Jin; Choi, Kyoung-Seong
Source:
Virology journal 2018 v.15 no.1 pp. 115
ISSN:
1743-422X
Subject:
lymph nodes,   etc   ; immunosuppression; oral administration; immunohistochemistry; lymphocytes; thrombocytopenia; tissue distribution; cattle industry; financial economics; bone marrow; spleen; pathogenesis; antigen detection; herds; Bovine viral diarrhea virus 2; mice; leukopenia; histopathology; viral antigens; reverse transcriptase polymerase chain reaction; animal models; Bovine viral diarrhea virus 1; megakaryocytes; RNA; signs and symptoms (animals and humans);     Show all 25 Subjects
Abstract:
... BACKGROUND: Bovine viral diarrhea virus (BVDV) causes significant economic losses worldwide in the cattle industry through decrease in productive performance and immunosuppression of animals in herds. Recent studies conducted by our group showed that mice can be infected with BVDV-1 by the oral route. The purpose of this study was to assess the clinical signs, hematological changes, histopathologi ...
DOI:
10.1186/s12985-018-1030-7

53. Indirubin ameliorates imiquimod-induced psoriasis-like skin lesions in mice by inhibiting inflammatory responses mediated by IL-17A-producing γδ T cells

Author:
Xie, Xiang-jiang; Di, Ting-ting; Wang, Yan; Wang, Ming-xing; Meng, Yu-jiao; Lin, Yan; Xu, Xiao-long; Li, Ping; Zhao, Jing-xia
Source:
Molecular immunology 2018 v.101 pp. 386-395
ISSN:
0161-5890
Subject:
lymph nodes,   etc   ; Oriental traditional medicine; T-lymphocytes; autoimmune diseases; dermatitis; flow cytometry; gene expression; immunomodulation; in vitro culture; indigo; inflammation; interleukin-17; interleukin-6; keratinocytes; leaves; messenger RNA; methotrexate; mice; models; neutrophils; protein synthesis; proteins; psoriasis; secretion; skin lesions; spleen; therapeutics;     Show all 27 Subjects
Abstract:
... Indirubin (IR) is a bisindole compound extracted from the leaves of Chinese herb Indigo Naturalis. Indigo Naturalis has been widely used in traditional Chinese medicine to treat inflammatory and autoimmune diseases. Psoriasis is a chronic immune-mediated inflammatory skin disease in which γδ T cells play an important role. This study aims to determine the immunoregulatory effects and the underlyin ...
DOI:
10.1016/j.molimm.2018.07.011

54. Anti-Inflammatory Effects of a Mixture of Lactic Acid Bacteria and Sodium Butyrate in Atopic Dermatitis Murine Model

Author:
Kim, Jeong A.; Kim, Sung-Hak; Kim, In Sung; Yu, Da Yoon; Kim, Sung Chan; Lee, Seung Ho; Lee, Sang Suk; Yun, Cheol-Heui; Choi, In Soon; Cho, Kwang Keun
Source:
Journal of medicinal food 2018 v.21 no.7 pp. 716-725
ISSN:
1557-7600
Subject:
lymph nodes,   etc   ; Bacteroidetes; Bifidobacterium animalis subsp. lactis; Lactobacillus casei; Lactobacillus plantarum; Lactobacillus rhamnosus; T-lymphocytes; animal models; anti-inflammatory activity; atopic dermatitis; blood serum; cell differentiation; ears; histamine; interleukin-10; intestinal microorganisms; intestines; lactic acid bacteria; mice; probiotics; quantitative polymerase chain reaction; sequence analysis; sodium butyrate; species identification; spleen; tissues; whey protein;     Show all 27 Subjects
Abstract:
... Atopic dermatitis is a chronic and recurrent inflammatory skin disease. Recently, probiotics have been shown to suppress allergic symptoms through immunomodulatory responses. In the present study, combinatorial effects on allergic symptoms were identified in BALB/c mice fed with a mixture of four species of probiotics, Bifidobacterium lactis, Lactobacillus casei, Lactobacillus rhamnosus, and Lacto ...
DOI:
10.1089/jmf.2017.4116

55. A lentiviral vaccine expressing KMP11-HASPB fusion protein increases immune response to Leishmania major in BALB/C

Author:
Mortazavidehkordi, Nahid; Fallah, Ali; Abdollahi, Abbas; Kia, Vahid; Khanahmad, Hossein; Najafabadi, ZahraGhayour; Hashemi, Nooshin; Estiri, Bahareh; Roudbari, Zahra; Najafi, Ali; Farjadfar, Akbar; Hejazi, SeyedHossein
Source:
Parasitology research 2018 v.117 no.7 pp. 2265-2273
ISSN:
0932-0113
Subject:
lymph nodes,   etc   ; Leishmania major; Lentivirus; Western blotting; amastigotes; antibodies; antigens; cell-mediated immunity; enzyme-linked immunosorbent assay; hydrophilicity; immune response; immunoglobulin G; interferon-gamma; interleukin-10; leishmaniasis; macrophages; membrane proteins; mice; parasite load; promastigotes; recombinant vaccines; reverse transcriptase polymerase chain reaction; spleen; surface proteins; vaccination; vaccine development;     Show all 26 Subjects
Abstract:
... Hydrophilic acylated surface protein B (HASPB) is an immunogenic Leishmania-specific protein that antibodies are produced against it in the sera of Leishmania-infected individuals. Kinetoplastid membrane protein 11 (KMP11) is another Leishmania antigen and considered as the suitable candidate for vaccine development Leishmaniasis. It is a highly conserved surface protein expressed in both promasti ...
DOI:
10.1007/s00436-018-5915-6

56. Effectiveness of the sesquiterpene (-)-α-bisabolol in dogs with naturally acquired canine leishmaniosis: an exploratory clinical trial

Author:
Corpas-López, V.; Merino-Espinosa, G.; Acedo-Sánchez, C.; Díaz-Sáez, V.; Navarro-Moll, M.C.; Morillas-Márquez, F.; Martín-Sánchez, J.
Source:
Veterinary research communications 2018 v.42 no.2 pp. 121-130
ISSN:
0165-7380
Subject:
lymph nodes,   etc   ; Leishmania; antibodies; blood; bone marrow; clinical trials; cytokines; dog diseases; dogs; drugs; fluorescent antibody technique; gastrointestinal system; humans; immune response; interferon-gamma; mice; models; parasite load; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sesquiterpenoids; toxicity; veterinary medicine; visceral leishmaniasis;     Show all 24 Subjects
Abstract:
... The use of natural products is a promising approach for treating visceral leishmaniosis. (-)-α-Bisabolol is a sesquiterpene that have been proved active in vivo on Leishmania infantum-infected mice without showing toxicity. A single-centre, parallel-group, randomized, exploratory study was designed to assess its efficacy in a canine leishmaniosis model involving naturally infected dogs. In this cl ...
DOI:
10.1007/s11259-018-9714-4

57. Antigenicity, immunogenicity and protective efficacy of a conserved Leishmania hypothetical protein against visceral leishmaniasis

Author:
Dias, Daniel S.; Martins, Vívian T.; Ribeiro, Patrícia A. F.; Ramos, Fernanda F.; Lage, Daniela P.; Tavares, Grasiele S. V.; Mendonça, Débora V. C.; Chávez-Fumagalli, Miguel A.; Oliveira, Jamil S.; Silva, Eduardo S.; Gomes, Dawidson A.; Rodrigues, Michele A.; Duarte, Mariana C.; Galdino, Alexsandro S.; Menezes-Souza, Daniel; Coelho, Eduardo A. F.
Source:
Parasitology 2018 v.145 no.6 pp. 740-751
ISSN:
1469-8161
Subject:
lymph nodes,   etc   ; Leishmania infantum; antibodies; bone marrow; dogs; enzyme-linked immunosorbent assay; granulocyte-macrophage colony-stimulating factor; humans; immunogenicity; immunoglobulin G; interferon-gamma; interleukin-10; interleukin-12; interleukin-4; liver; mice; mononuclear leukocytes; nitrites; parasite load; parasites; patients; promastigotes; recombinant proteins; saponins; spleen; vaccines; visceral leishmaniasis;     Show all 27 Subjects
Abstract:
... In this study, a Leishmania hypothetical protein, LiHyS, was evaluated regarding its antigenicity, immunogenicity and protective efficacy against visceral leishmaniasis (VL). Regarding antigenicity, immunoblottings and an enzyme-linked immunosorbent assay using human and canine sera showed high sensitivity and specificity values for the recombinant protein (rLiHyS) in the diagnosis of VL. When eva ...
DOI:
10.1017/S0031182017001731
PubMed:
29113597

58. Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice

Author:
Wang, Junpeng; Qi, Ying; Niu, Xinli; Tang, Hua; Meydani, Simin Nikbin; Wu, Dayong
Source:
The Journal of nutritional biochemistry 2018 v.54 pp. 130-139
ISSN:
0955-2863
Subject:
lymph nodes,   etc   ; CD4-positive T-lymphocytes; adverse effects; animal models; antioxidant activity; autoimmune diseases; autoimmunity; cell proliferation; chemokine CXCL10; citrus fruits; encephalitis; gene expression; humans; inflammation; interleukin-6; ligands; messenger RNA; mice; naringenin; nutrition; sclerosis; spinal cord; transcription factors; tumor necrosis factor-alpha; vascular cell adhesion molecules;     Show all 25 Subjects
Abstract:
... Autoimmune disease is highly prevalent in humans. Since conventional therapies have limited efficacy and often come with significant side effects, nutrition may provide an alternative and complementary approach to improving autoimmune disorders. Naringenin, a flavonoid found in citrus fruits, has been shown to have anti-inflammatory and antioxidant properties. Using the experimental autoimmune enc ...
DOI:
10.1016/j.jnutbio.2017.12.004

59. Mechanism of Antibacterial Activities of a Rice Hull Smoke Extract (RHSE) Against Multidrug‐Resistant Salmonella Typhimurium In Vitro and in Mice

Author:
Kim, Sung Phil; Lee, Sang Jong; Nam, Seok Hyun; Friedman, Mendel
Source:
Journal of food science 2018 v.83 no.2 pp. 440-445
ISSN:
0022-1147
Subject:
lymph nodes,   etc   ; DNA; Salmonella Typhimurium; agarose; animal models; antibacterial properties; antibiotic resistance; bacteria; cecum; cell death; cell membranes; excretion; feces; feeds; flavor; food additives; foods; gastroenteritis; gels; health promotion; in vitro studies; liquid smoke; liver; mice; minimum inhibitory concentration; multiple drug resistance; pathogens; protein composition; rice hulls; scanning electron microscopy; smoke; sodium dodecyl sulfate; spleen;     Show all 33 Subjects
Abstract:
... The present study tested antibacterial activity of a rice hull smoke extract (RHSE) against a multidrug‐resistant strain of Salmonella Typhimurium and examined its mode of suppressive action in vitro and in mice. In vitro studies showed that the minimum inhibitory concentration (MIC) value of RHSE was 1.29% (v/v). The inactivation was confirmed by complete loss of cell viability in the range of 10 ...
DOI:
10.1111/1750-3841.14020

60. Anti-allergic effects of the ethanol extract of Syzygium formosum (Wall.) Masam leaves and its immunoregulatory mechanisms

Author:
Nguyen, Thi Minh Nguyet; Lomunova, Maria; Vu, Thi Phuong Duyen; Le, Ba Vinh; Kim, Young Ho; Kang, Jong Seong; Hwang, Inkyu
Source:
Journal of ethnopharmacology 2018 v.211 pp. 171-179
ISSN:
0378-8741
Subject:
lymph nodes,   etc   ; Syzygium; T-lymphocytes; Vietnamese people; alum; anaphylaxis; animal models; anti-allergic agents; body temperature; body weight; chickens; cytokines; dermatitis; diarrhea; dose response; eosinophils; ethanol; food allergies; immune response; immunization; leaf extracts; leaves; mast cells; mice; ovalbumin; small intestine; traditional medicine; Vietnam;     Show all 28 Subjects
Abstract:
... As documented in a Vietnamese traditional medical encyclopedia, Syzygium formosum (Wall.) Masam leaves have been routinely used among indigenous Vietnamese people for treatment of various allergy-like symptoms including dermatitis and rhinitis.Anti-allergic activity of S. formosum leaves was examined with a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and mechanisms underlying the ...
DOI:
10.1016/j.jep.2017.09.026

61. Synthetic Polymeric Mixed Micelles Targeting Lymph Nodes Trigger Enhanced Cellular and Humoral Immune Responses

Author:
Li, Chenxi; Zhang, Xiaoxu; Chen, Qing; Zhang, Jiulong; Li, Wenpan; Hu, Haiyang; Zhao, Xiuli; Qiao, Mingxi; Chen, Dawei
Source:
ACS applied materials & interfaces 2018 v.10 no.3 pp. 2874-2889
ISSN:
1944-8252
Subject:
lymph nodes,   etc   ; T-lymphocytes; Toll-like receptor 7; agonists; antibodies; antigen presentation; antigens; cancer vaccines; composite polymers; cytokines; cytotoxicity; dendritic cells; encapsulation; endosomes; humoral immunity; immune response; immunization; immunoglobulin G; lysosomes; major histocompatibility complex; mice; micelles; neoplasms; ovalbumin; secretion; subcutaneous injection;     Show all 26 Subjects
Abstract:
... It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines because antigen presentation and initiation of T-cell-mediated immune responses occur primarily at these locations. In this study, amphiphilic diblock copolymer poly(2-ethyl-2-oxazoline)-poly(d,l-lactide) (PEOz-PLA) combined with carboxylterminated-Pluronic F127 was used to construct mixed micelles [carboxyl ...
DOI:
10.1021/acsami.7b14004

62. Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice

Author:
Lee, Shih-Chieh; Wang, Shih-Yun; Li, Chien-Chun; Liu, Cheng-Tzu
Source:
Yàowù shípǐn fēnxī 2018 v.26 no.1 pp. 211-220
ISSN:
1021-9498
Subject:
lymph nodes,   etc   ; Cinnamomum osmophloeum; Toll-like receptor 4; animal disease models; anti-inflammatory activity; body weight changes; caspase-1; chemical composition; chemotypes; cinnamon; cooking; corn oil; diabetes; drugs; endotoxins; essential oils; genes; indigenous species; interferon-gamma; interleukin-18; interleukin-1beta; leaves; linalool; mice; nitrates; nitrites; nucleoproteins; people; plants (botany); rats; signal transduction; spleen; therapeutics; tumor necrosis factor-alpha;     Show all 34 Subjects
Abstract:
... Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demonstrated the chemical composition and anti-inflammatory effect of leaf essential oil of Cinnamomum osmophloeum Kanehira of linalool chemotype in strept ...
DOI:
10.1016/j.jfda.2017.03.006

63. Newly designed hemagglutinin-Der p 2 chimera is a potential candidate for allergen specific immunotherapy

Author:
Mrkić, Ivan; Minić, Rajna; Popović, Dragan; Živković, Irena; Gavrović-Jankulović, Marija
Source:
Life sciences 2018
ISSN:
0024-3205
Subject:
lymph nodes,   etc   ; Escherichia coli; Orthomyxoviridae; Western blotting; affinity chromatography; allergens; circular dichroism spectroscopy; enzyme-linked immunosorbent assay; epitopes; genetic engineering; hemagglutinins; hypersensitivity; immune response; immunization; immunogenicity; immunoglobulin E; inclusion bodies; interleukin-10; leukocytes; mice; mites; people; phenotype; recombinant antigens; recombinant proteins; species abundance; spleen; splenocytes; two-dimensional gel electrophoresis; urea;     Show all 30 Subjects
Abstract:
... AimTo investigate the immunomodulatory potential of a chimera composed of the receptor-binding domain of hemagglutinin 1 (H1s) from Influenza virus and Der p 2 (D2) allergen for allergen-specific immunotherapy of house-dust mite allergy (HDM).H1sD2 chimera and D2 allergen were produced by genetic engineering in E. coli. Recombinant antigens were extracted from inclusion bodies by urea, then refold ...
DOI:
10.1016/j.lfs.2018.10.036

64. The composition of a bioprocessed shiitake (Lentinus edodes) mushroom mycelia and rice bran formulation and its antimicrobial effects against Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 in macrophage cells and in mice

Author:
Kim, Sung Phil; Lee, Sang Jong; Nam, Seok Hyun; Friedman, Mendel
Source:
BMC complementary and alternative medicine 2018 v.18 no.1 pp. 322
ISSN:
1472-6882
Subject:
lymph nodes,   etc   ; Lentinula edodes; Salmonella Typhimurium; alternative medicine; antibacterial properties; antibiotic resistance; antibiotics; autophagy; bacteria; biomarkers; bioprocessing; cecum; cytokines; eggs; enzyme-linked immunosorbent assay; excretion; feces; food safety; gas chromatography; human diseases; inducible nitric oxide synthase; interferon-beta; intestinal mucosa; liver; macrophages; mass spectrometry; meat products; medicine; messenger RNA; mice; mushrooms; mycelium; nitric oxide; novel foods; protein synthesis; rice bran; rice bran oil; salmonellosis; secretion; spleen;     Show all 40 Subjects
Abstract:
... BACKGROUND: Human infection by pathogenic Salmonella bacteria can be acquired by consuming of undercooked meat products and eggs. Antimicrobial resistance against antibiotics used in medicine is also a major concern. To help overcome these harmful effects on microbial food safety and human health, we are developing novel antimicrobial food-compatible formulations, one of which is described in the ...
DOI:
10.1186/s12906-018-2365-8