U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Subject term neuroprotective effect Remove constraint Subject term: neuroprotective effect
Start Over

Search

303  Search Results

« Previous | 1 - 20 of 303 |
Number of results to display per page

Search Results

1. 3H-1,2-dithiole-3-thione protects PC12 cells against amyloid beta 1–42 (Aβ1–42) induced apoptosis via activation of the ERK1/2 pathway

Author:
Chunyan Zhang; Linsen Xie; Fangxia Guan; Yuanbo Cui
Source:
Life sciences 2018 v.213 pp. 74-81
ISSN:
0024-3205
Subject:
Alzheimer disease; Western blotting; amyloid; apoptosis; calcium; caspase-3; cell viability; flow cytometry; lactate dehydrogenase; neurons; neuroprotective effect; phosphatidylinositol 3-kinase; protein content; protein kinases; rats; reactive oxygen species
Abstract:
... Increasing evidence displays that deposition of aggregated β-amyloid (Aβ) leads to neuronal cell apoptosis, thus aggravates the pathological progression of Alzheimer's disease (AD). 3H-1,2-dithiole-3-thione (D3T) has been proved to exert neuroprotective effects. However, the effect of D3T on protecting against Aβ-induced apoptosis and the underlying mechanism are unknown.MTT, DCFH-DA assay, LDH re ...
DOI:
10.1016/j.lfs.2018.10.025

2. Spirulina maxima Extract Reduces Obesity through Suppression of Adipogenesis and Activation of Browning in 3T3-L1 Cells and High-Fat Diet-Induced Obese Mice

Author:
Young-Jin Seo; Kui-Jin Kim; Jia Choi; Eun-Jeong Koh; Boo-Yong Lee
Source:
Nutrients 2018 v.10 no.6 pp. -
ISSN:
2072-6643
Subject:
Spirulina maxima; Western blotting; adipogenesis; animal disease models; antioxidants; atherosclerosis; blood lipids; chlorophyll; droplets; ethanol; high fat diet; lipid content; lipids; lipogenesis; metabolic syndrome; mice; microalgae; neuroprotective effect; noninsulin-dependent diabetes mellitus; obesity; peroxisome proliferator-activated receptor gamma; protein content; protein synthesis; staining
Abstract:
... Obesity predisposes animals towards the metabolic syndrome and diseases such as type 2 diabetes, atherosclerosis, and cardiovascular disease. Spirulina maxima is a microalga with anti-oxidant, anti-cancer, and neuroprotective activities, but the anti-obesity effect of Spirulina maxima 70% ethanol extract (SM70EE) has not yet been fully established. We investigated the effect of SM70EE on adipogene ...
DOI:
10.3390/nu10060712
PubMed:
29865208
PubMed Central:
PMC6024816

3. A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera

Author:
Saroopa P. Samaradivakara; Radhika Samarasekera; Shiroma M. Handunnetti; O. V. D. S. Jagathpriya Weerasena; Ayad A. Al-Hamashi; James T. Slama; William R. Taylor; Qasim Alhadidi; Zahoor A. Shah; Lalith Perera; L. M. Viranga Tillekeratne
Source:
Journal of natural products 2018 v.81 no.8 pp. 1693-1700
ISSN:
1520-6025
Subject:
Vateria; acetylcholinesterase; anti-inflammatory activity; antioxidant activity; bark; cell lines; chromatography; cytotoxicity; enzyme inhibition; fractionation; glucose; growth retardation; indigenous species; inhibitory concentration 50; neoplasm cells; neoplasms; neuroglia; neuroprotective effect; nitric oxide; oxygen; plants (botany); protons; resveratrol; spectral analysis
Abstract:
... A new resveratrol trimer, vateriferol (1), having four cis-oriented methine protons and constituting four contiguous stereocenters, was isolated from the bark extract of Vateria copallifera by bioassay-guided fractionation using a combination of normal, reversed phase, and size exclusion column chromatography. The structure was established based on its spectroscopic data. Vateriferol (1) was evalu ...
DOI:
10.1021/acs.jnatprod.7b00892
PubMed:
30040425
PubMed Central:
PMC7015271

4. A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice

Author:
Domenico Nuzzo; Antonella Amato; Pasquale Picone; Simona Terzo; Giacoma Galizzi; Francesco Paolo Bonina; Flavia Mulè; Marta Di Carlo
Source:
Nutrients 2018 v.10 no.9 pp. -
ISSN:
2072-6643
Subject:
Curcuma longa; anti-inflammatory activity; antioxidants; apoptosis; brain; chlorogenic acid; cholesterol; dietary supplements; fluorescent antibody technique; high fat diet; inflammation; insulin; insulin receptors; insulin resistance; interleukin-1beta; interleukin-6; inulin; lipid peroxidation; metabolic diseases; mice; neurodegenerative diseases; neuroprotective effect; nutrients; obesity; oxidative stress; risk factors; silymarin; transcription factor NF-kappa B
Abstract:
... Obesity and metabolic disorders can be risk factors for the onset and development of neurodegenerative diseases. The aim of the present study was to investigate the protective effects of a natural dietary supplement (NDS), containing Curcuma longa, silymarin, guggul, chlorogenic acid and inulin, on dysmetabolism and neurodegeneration in the brains of high fat diet (HFD)-fed mice. Decrease in the e ...
DOI:
10.3390/nu10091130
PubMed:
30134549
PubMed Central:
PMC6165339

5. A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis

Author:
Zi-Long Wang; Shuang Wang; Yi Kuang; Zhi-Min Hu; Xue Qiao; Min Ye
Source:
Pharmaceutical biology 2018 v.56 no.1 pp. 465-484
ISSN:
1744-5116
Subject:
Oriental traditional medicine; Scutellaria baicalensis; antioxidants; biochemical pathways; biosynthesis; chemical composition; databases; flavonoids; glycosides; medicinal plants; neuroprotective effect; polysaccharides; roots
Abstract:
... Context: Scutellaria baicalensis Georgi (Lamiaceae) is a popular medicinal plant. Its roots are used as the famous traditional Chinese medicine Huang-Qin, which is recorded in Chinese Pharmacopoeia, European Pharmacopoeia, and British Pharmacopoeia. Objective: This review comprehensively summarizes research progress in phytochemistry, pharmacology, and flavonoid biosynthesis of S. baicalensis. Met ...
DOI:
10.1080/13880209.2018.1492620
PubMed:
31070530
PubMed Central:
PMC6292351

6. A facile approach for synthesis of nano-CeO2 particles loaded co-polymer matrix and their colossal role for blood-brain barrier permeability in Cerebral Ischemia

Author:
Yongtao Gao; Xiaobing Chen; Honglin Liu
Source:
Journal of photochemistry and photobiology 2018 v.187 pp. 184-189
ISSN:
1011-1344
Subject:
animals; antioxidants; blood-brain barrier; brain; ceric oxide; composite polymers; cortex; drugs; edema; electrons; free radicals; ischemia; models; nanocomposites; nanoparticles; neuroprotective effect; neutralization; oxidation; permeability; spectroscopy; stroke
Abstract:
... A prospective resource of pharmacological treatment of ischemic brains stroke is rapid interference using potential neuroprotective materials. Cerium oxide nanoparticles have been shown to defend against blood brain barrier damage in cerebral ischemic brain stroke. While cerium oxide nanoparticles is highly permeable across the blood–brain barrier and also these nanoparticles are effective antioxi ...
DOI:
10.1016/j.jphotobiol.2018.05.003

7. A systematic review on the neuroprotective perspectives of beta‐caryophyllene

Author:
Keylla da Conceição Machado; Muhammad Torequl Islam; Eunüs S. Ali; Razina Rouf; Shaikh Jamal Uddin; Shrabanti Dev; Jamil A. Shilpi; Manik Chandra Shill; Hasan Mahmud Reza; Asish Kumar Das; Subrata Shaw; Mohammad S. Mubarak; Siddhartha Kumar Mishra; Ana Amelia de Carvalho Melo‐Cavalcante
Source:
Phytotherapy research 2018 v.32 no.12 pp. 2376-2388
ISSN:
0951-418X
Subject:
Alzheimer disease; alcohol abuse; antioxidant activity; anxiety; beta-caryophyllene; cannabinoid receptors; databases; essential oils; inflammation; mechanism of action; nephroprotective effect; nervous system; neuroprotective effect; oxidative stress; pain; systematic review
Abstract:
... Beta (β)‐caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils reported for several important pharmacological activities, including antioxidant, anti‐inflammatory, anticancer, cardioprotective, hepatoprotective, gastroprotective, nephroprotective, antimicrobial, and immune‐modulatory activity. Recent studies suggest that it also possesses neuroprotective effect. This study ...
DOI:
10.1002/ptr.6199

8. A time-of-flight mass spectrometry based strategy to fast screen triterpenoids in Xanthoceras sorbifolia Bunge husks for bioactive substances against Alzheimer's disease

Author:
Weiwei Rong; Kewen Ding; Sirui Guo; Ziyue Yuan; Qing Li; Kaishun Bi
Source:
RSC advances 2018 v.8 no.27 pp. 14732-14739
ISSN:
2046-2069
Subject:
Alzheimer disease; Xanthoceras sorbifolium; bioactive compounds; cell viability; cytotoxicity; hulls; mass spectrometry; neuroprotective effect; rats; traditional medicine; triterpenoids; China
Abstract:
... Xanthoceras sorbifolia Bunge is a folk medicine in China. Recently, the triterpenoids in its husks have attracted more and more attention for potential prevention against Alzheimer's disease. However, current studies on its bioactive substances were still insufficient. To reveal more bioactive substances, an efficient and practical strategy based on high resolution mass spectra coupled with multip ...
DOI:
10.1039/c8ra01765d

9. A urinary metabolomics (GC-MS) strategy to evaluate the antidepressant-like effect of chlorogenic acid in adrenocorticotropic hormone-treated rats

Author:
Le Zhao; Zixu Zhang; Mingmei Zhou; Xiaojun Gou; Yang Zeng; Jing Song; Weini Ma; Ying Xu
Source:
RSC advances 2018 v.8 no.17 pp. 9141-9151
ISSN:
2046-2069
Subject:
Eucommia ulmoides; amino acid metabolism; animal models; bark; biochemical pathways; bioinformatics; blood serum; chlorogenic acid; corticotropin; corticotropin-releasing hormone; diet; dopamine; drugs; energy metabolism; gas chromatography-mass spectrometry; human health; laboratory animals; males; memory; mental depression; metabolites; metabolomics; neuroprotective effect; neurotransmitters; polyphenols; rats; rearing; serotonin; sucrose
Abstract:
... Major depressive disorder (MDD) is a chronic recurring illness that seriously affects human health. Chlorogenic acid (CGA), an important polyphenol extracted from Eucommia ulmoides Oliver bark, has been reported to have anti-depression, neuroprotection, memory improvement and other pharmacological effects. However, little is known about the underlying mechanisms of CGA on the treatment of depressi ...
DOI:
10.1039/c8ra00074c

10. Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin

Author:
Qin-Mei Zhou; Ming-Hua Chen; Xiao-Hong Li; Cheng Peng; Da-Sheng Lin; Xiao-Nian Li; Yang He; Liang Xiong
Source:
Journal of natural products 2018 v.81 no.9 pp. 1919-1927
ISSN:
1520-6025
Subject:
Candida albicans; Pogostemon cablin; X-ray diffraction; antifungal properties; aorta; essential oils; median effective concentration; minimum inhibitory concentration; neuroprotective effect; rats; sesquiterpenoids; spectral analysis; vasodilator agents
Abstract:
... Seven novel guaiane sesquiterpenoids (1–7) and three known seco-guaianes were isolated from the volatile oil of Pogostemon cablin. Their structures including absolute configurations were determined by spectroscopic analyses, a modified Mosher’s method, and X-ray diffraction and ECD data. The results indicated that the ECD Cotton effects arising from one or two nonconjugated olefinic chromophores c ...
DOI:
10.1021/acs.jnatprod.7b00690

11. Acanthus ebracteatus leaf extract provides neuronal cell protection against oxidative stress injury induced by glutamate

Author:
Anchalee Prasansuklab; Tewin Tencomnao
Source:
BMC complementary and alternative medicine 2018 v.18 no.1 pp. 278
ISSN:
1472-6882
Subject:
Acanthus; alternative medicine; antioxidant activity; apoptosis; cell viability; gene expression; genes; glutathione; ingredients; leaf extracts; longevity; messenger RNA; mice; models; neurodegenerative diseases; neurons; neuroprotective effect; oxidative toxicity; protein content; reactive oxygen species; traditional medicine; Asia
Abstract:
... BACKGROUND: Acanthus ebracteatus (AE), an herb native to Asia, has been recognized in traditional folk medicine not only for its antioxidant properties and various pharmacological activities but also as an ingredient of longevity formulas. However, its anti-neurodegenerative potential is not yet clearly known. This work aimed to evaluate the protective effect of AE leaf extract against glutamate-i ...
DOI:
10.1186/s12906-018-2340-4
PubMed:
30326896
PubMed Central:
PMC6192065

12. Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents

Author:
Hao-Wen Jiang; Jing Lin; Gui-Min Wang; Jing-Jing Zhang; Shan-Shan Gu; Lei Cao; Yan Chen; Ling Wang; He Jiao; Wei-Liang Zhu; Hai-Yan Zhang; Wei-Min Zhao; Jin-Long Li
Source:
Phytochemistry letters 2018 v.24 pp. 179-183
ISSN:
1874-3900
Subject:
Cynanchum wilfordii; X-ray diffraction; acetophenones; bark; circular dichroism spectroscopy; enantiomers; neuroprotective effect; oligomerization; spectral analysis
Abstract:
... Seven new acetophenone derivatives, three couples of enantiomers (±)-cynwilforones D − F (1 − 3) together with cynwilforone G (4), were isolated form the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and X-ray crystallography. Each racemate was separated into individual enantiomers, and electronic circular dichroism (ECD) calculation ...
DOI:
10.1016/j.phytol.2018.02.002

13. Acid-base fractions separated from Streblus asper leaf ethanolic extract exhibited antibacterial, antioxidant, anti-acetylcholinesterase, and neuroprotective activities

Author:
Anchalee Prasansuklab; Atsadang Theerasri; Matthew Payne; Alison T. Ung; Tewin Tencomnao
Source:
BMC complementary and alternative medicine 2018 v.18 no.1 pp. 223
ISSN:
1472-6882
Subject:
2,2-diphenyl-1-picrylhydrazyl; Alzheimer disease; Gram-positive bacteria; Streblus asper; acetylcholinesterase; alternative medicine; antibacterial properties; antioxidant activity; antioxidants; cell lines; cell viability; chemical composition; chemical constituents of plants; ethanol; fatty acids; gas chromatography-mass spectrometry; leaf extracts; leaves; minimum inhibitory concentration; neurons; neuroprotective effect; plant hormones; steroids; terpenoids; thin layer chromatography; toxicity; South East Asia
Abstract:
... BACKGROUND: Streblus asper is a well-known plant native to Southeast Asia. Different parts of the plant have been traditionally used for various medicinal purposes. However, there is very little scientific evidence reporting its therapeutic benefits for potential treatment of Alzheimer’s disease (AD). The study aimed to evaluate antibacterial, antioxidant, acetylcholinesterase (AChE) inhibition, a ...
DOI:
10.1186/s12906-018-2288-4
PubMed:
30041641
PubMed Central:
PMC6057052

14. Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway

Author:
Maiquan Li; Fei Zhou; Tao Xu; Huaxin Song; Baiyi Lu
Source:
Food and chemical toxicology 2018 v.119 pp. 6-13
ISSN:
0278-6915
Subject:
Danio rerio; Parkinson disease; adults; blood-brain barrier; brain; cell death; intraperitoneal injection; locomotion; models; neurons; neuroprotective effect; oxidative stress; signal transduction; therapeutics; toxicology; tyrosine 3-monooxygenase
Abstract:
... Acteoside has been reported to have antioxidant and neuroprotective effect, which is a promising therapeutic way in prevention and treatment of Parkinson's disease. The present study was aimed to understand the neuroprotective effect of acteoside and to elucidate its underlying mechanism. 6-hydroxydopamine (6-OHDA)-induced neural damage in zebrafish model was used to study the protective effect of ...
DOI:
10.1016/j.fct.2018.06.018

15. Administration of Momordica charantia Enhances the Neuroprotection and Reduces the Side Effects of LiCl in the Treatment of Alzheimer’s Disease

Author:
Hei-Jen Huang; Shu-Ling Chen; Yen-Ting Chang; Jong-Ho Chyuan; Hsiu Mei Hsieh-Li
Source:
Nutrients 2018 v.10 no.12 pp. -
ISSN:
2072-6643
Subject:
Alzheimer disease; Momordica charantia; adverse effects; dietary supplements; drugs; females; hepatotoxicity; hyperglycemia; intraperitoneal injection; lithium chloride; males; memory disorders; mice; neurons; neuroprotective effect; ovariectomy; streptozotocin; survival rate
Abstract:
... Recently, the use of natural food supplements to reduce the side effects of chemical compounds used for the treatment of various diseases has become popular. Lithium chloride (LiCl) has some protective effects in neurological diseases, including Alzheimer’s disease (AD). However, its toxic effects on various systems and some relevant interactions with other drugs limit its broader use in cli ...
DOI:
10.3390/nu10121888
PubMed:
30513908
PubMed Central:
PMC6316175

16. Agathisflavone isolated from Anacardium occidentale suppresses SIRT1‐mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe‐transfected SH‐SY5Y cells

Author:
Ravikanth Velagapudi; Olusiji O. Ajileye; Uchechukwu Okorji; Priya Jain; Mutalib A. Aderogba; Olumayokun A. Olajide
Source:
Phytotherapy research 2018 v.32 no.10 pp. 1957-1966
ISSN:
0951-418X
Subject:
Anacardium occidentale; bioactive compounds; immunoblotting; inducible nitric oxide synthase; interleukin-1beta; interleukin-6; lipopolysaccharides; neuroglia; neurons; neuroprotective effect; neurotoxicity; nitric oxide; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha; viability
Abstract:
... Agathisflavone is a bioactive compound in Anacardium occidentale. In this study, we investigated inhibition neuroinflammation in BV2 microglia by agathisflavone. Neuroprotective activity of the compound was investigated in differentiated SH‐SY5Y cells. Experiments in lipopolysaccharide (LPS)‐activated BV2 microglia showed that pretreatment with agathisflavone (5–20 μM) produced significant reducti ...
DOI:
10.1002/ptr.6122

17. Agomelatine's effect on circadian locomotor rhythm alteration and depressive-like behavior in 6-OHDA lesioned rats

Author:
Leonardo C. Souza; Bruno J. Martynhak; Taysa B. Bassani; Joelle de M. Turnes; Meira M. Machado; Eric Moura; Roberto Andreatini; Maria A.B.F. Vital
Source:
Physiology & behavior 2018 v.188 pp. 298-310
ISSN:
0031-9384
Subject:
Parkinson disease; animal models; antidepressants; circadian rhythm; locomotion; neurons; neuroprotective effect; patients; rats; sucrose
Abstract:
... Parkinson's disease (PD) patients often suffer from circadian locomotor rhythms impairment and depression, important non-motor symptoms. It is known that toxin-based animal models of PD can reproduce these features. In a 6-hydroxydopamine (6-OHDA) intranigral model, we first investigated the possible disturbances on circadian rhythms of locomotor activity. The rats were divided into 6-OHDA and Sha ...
DOI:
10.1016/j.physbeh.2018.02.033

18. Akebia quinata Decaisne aqueous extract acts as a novel anti-fatigue agent in mice exposed to chronic restraint stress

Author:
Sun Haeng Park; Seol Jang; Si Woo Lee; Sun Dong Park; Yoon-Young Sung; Ho Kyoung Kim
Source:
Journal of ethnopharmacology 2018 v.222 pp. 270-279
ISSN:
0378-8741
Subject:
Akebia quinata; alanine transaminase; aspartate transaminase; blood serum; brain damage; cell death; chlorogenic acid; corticosterone; cyclic AMP; epinephrine; herbal medicines; hippocampus; histopathology; immunohistochemistry; liver; mice; neurons; neuroprotective effect; norepinephrine; oral administration; phosphorylation; serotonin; sucrose; swimming; traditional medicine; tropomyosins
Abstract:
... Akebia quinata Decaisne extract (AQE; Lardizabalaceae) is used in traditional herbal medicine for stress- and fatigue-related depression, improvement of fatigue, and mental relaxation.To clarify the effects of AQE on stress-induced fatigue, we investigated the neuroprotective pharmacological effects of A. quinata Decaisne in mice exposed to chronic restraint stress.Seven-week old C57BL/6 mice chro ...
DOI:
10.1016/j.jep.2018.04.010

19. Alkaloids with neuroprotective effects from the leaves of Isatis indigotica collected in the Anhui Province, China

Author:
Si-Fan Liu; Ying-Ying Zhang; Le Zhou; Bin Lin; Xiao-Xiao Huang; Xiao-Bo Wang; Shao-Jiang Song
Source:
Phytochemistry 2018 v.149 pp. 132-139
ISSN:
0031-9422
Subject:
Isatis tinctoria; alkaloids; apoptosis; circular dichroism spectroscopy; humans; leaves; models; neuroprotective effect; spectral analysis; staining; China
Abstract:
... Six undescribed alkaloids, indiforine A-F, together with four known ones, were isolated from the leaves of Isatis indigotica Fortune. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configurations of indiforine A and B were determined by comparison of the experimental and calculated electronic circular dichroism spectra, as well as experimental and c ...
DOI:
10.1016/j.phytochem.2018.02.016

20. Aloysia citrodora Paláu (Lemon verbena): A review of phytochemistry and pharmacology

Author:
Roodabeh Bahramsoltani; Pourouchista Rostamiasrabadi; Zahra Shahpiri; André M. Marques; Roja Rahimi; Mohammad Hosein Farzaei
Source:
Journal of ethnopharmacology 2018 v.222 pp. 34-51
ISSN:
0378-8741
Subject:
Aloysia citrodora; anesthetics; anticarcinogenic activity; antimicrobial properties; antioxidants; cell culture; common names; databases; diarrhea; essential oils; ethnobotany; flatulence; geranial; ingredients; medicinal plants; neral; neuroprotective effect; sedatives; sleep disorders; therapeutics; traditional medicine; tranquilizers; verbascoside; Europe; Northern Africa; South America
Abstract:
... Aloysia citrodora Paláu (Lippia citriodora Kunth), commonly known as "lemon verbena" is a medicinal plant native to South America, North Africa, and South of Europe which is used by native people for several indications such as diarrhea, flatulence, insomnia, and rheumatism.Despite the wide biological activities of lemon verbena, there is no current review summarizing medicinal properties of the p ...
DOI:
10.1016/j.jep.2018.04.021