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1. Characterization of the zinc metalloprotease of Streptococcus suis serotype 2

Author:
Dumesnil, Audrey; Auger, Jean-Philippe; Roy, David; Vötsch, Désirée; Willenborg, Maren; Valentin-Weigand, Peter; Park, Pyong Woo; Grenier, Daniel; Fittipaldi, Nahuel; Harel, Josée; Gottschalk, Marcelo
Source:
Veterinary research 2018 v.49 no.1 pp. 109
ISSN:
1297-9716
Subject:
Streptococcus pneumoniae; Streptococcus suis; enzyme activity; epithelial cells; humans; meningitis; metalloproteinases; mucins; mutants; pathogenesis; pathogens; phylogeny; respiratory system; septic shock; serotypes; swine; syndecans; teams; veterinary medicine; virulence
Abstract:
... Streptococcus suis is a swine pathogen and zoonotic agent responsible for meningitis and septic shock. Although several putative virulence factors have been described, the initial steps of the S. suis pathogenesis remain poorly understood. While controversial results have been reported for a S. suis serotype 2 zinc metalloprotease (Zmp) regarding its IgA protease activity, recent phylogenetic anal ...
DOI:
10.1186/s13567-018-0606-y
PubMed:
30373658
PubMed Central:
PMC6206940

2. Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains

Author:
Herrera-Uribe, Júber; Jiménez-Marín, Ángeles; Lacasta, Anna; Monteagudo, Paula L.; Pina-Pedrero, Sonia; Rodríguez, Fernando; Moreno, Ángela; Garrido, Juan J.
Source:
Veterinary research 2018 v.49 no.1 pp. 90
ISSN:
1297-9716
Subject:
African swine fever; African swine fever virus; apoptosis; autoantibodies; autoantigens; cytoskeleton; death; guanosinetriphosphatase; immunity; lymph nodes; pathogenesis; phosphopyruvate hydratase; proteomics; signal transduction; swine; vaccines; veterinary medicine; vimentin; virulence; virulent strains
Abstract:
... African swine fever (ASF) is a pathology of pigs against which there is no treatment or vaccine. Understanding the equilibrium between innate and adaptive protective responses and immune pathology might contribute to the development of strategies against ASFV. Here we compare, using a proteomic approach, the course of the in vivo infection caused by two homologous strains: the virulent E75 and the ...
DOI:
10.1186/s13567-018-0585-z
PubMed:
30208957
PubMed Central:
PMC6134756

3. Fructose-1,6-bisphosphate aldolase encoded by a core gene of Mycoplasma hyopneumoniae contributes to host cell adhesion

Author:
Yu, Yanfei; Liu, Maojun; Hua, Lizhong; Qiu, Mingjun; Zhang, Wei; Wei, Yanna; Gan, Yuan; Feng, Zhixin; Shao, Guoqing; Xiong, Qiyan
Source:
Veterinary research 2018 v.49 no.1 pp. 114
ISSN:
1297-9716
Subject:
Mycoplasma hyopneumoniae; Shiga toxin-producing Escherichia coli; adhesins; cell adhesion; epithelial cells; fibronectins; financial economics; flow cytometry; fructose-bisphosphate aldolase; gene expression; genes; genomics; pathogenesis; pathogens; protein-protein interactions; surface plasmon resonance; swine; two-dimensional gel electrophoresis; veterinary medicine; virulence
Abstract:
... Mycoplasma hyopneumoniae is an important respiratory pathogen that causes great economic losses to the pig industry worldwide. Although some putative virulence factors have been reported, pathogenesis remains poorly understood. Herein, we evaluated the relative abundance of proteins in virulent 168 (F107) and attenuated 168L (F380) M. hyopneumoniae strains to identify virulence-associated factors ...
DOI:
10.1186/s13567-018-0610-2
PubMed:
30454073
PubMed Central:
PMC6245935

4. Insights into the genome sequence of ovine Pasteurella multocida type A strain associated with pneumonic pasteurellosis

Author:
Sahay, Swati; Shome, Rajeswari; Sankarasubramanian, Jagadesan; Vishnu, Udayakumar S.; Prajapati, Awadhesh; Natesan, Krithiga; Shome, Bibek Ranjan; Rahman, Habibur; Rajendhran, Jeyaprakash
Source:
Small ruminant research 2018 v.169 pp. 167-175
ISSN:
0921-4488
Subject:
Pasteurella multocida; bacteriophages; cattle; genes; genomic islands; genomics; horizontal gene transfer; pathogenesis; pathogens; phylogeny; pneumonic pasteurellosis; sequence analysis; sheep; sheep diseases; swine; virulence; virulent strains
Abstract:
... Pasteurella multocida is a causative agent of pneumonic pasteurellosis in ruminants. Bovine and porcine strains of P. multocida have been sequenced and analyzed worldwide. However limited genomic information is available on ovine strains involved in causation of pneumonic pasteurellosis. Therefore, the present study focused on genome sequencing and analysis of a P. multocida type A isolate recover ...
DOI:
10.1016/j.smallrumres.2018.10.004

5. Identification of Pasteurella multocida transcribed genes in porcine lungs through RNAseq

Author:
Chitarra, Cristiane Silva; Oliveira Filho, João Xavier de; Morés, Nelson; Silva, Mayara Inácio Vincenzi da; Cândido, Stefhano Luis; Cezarino, Paula Gabriela; Nakazato, Luciano; Dutra, Valéria
Source:
Microbial pathogenesis 2018 v.122 pp. 180-183
ISSN:
0882-4010
Subject:
Pasteurella multocida; RNA; amino acid metabolism; bacteria; biochemical pathways; gene expression; gene expression regulation; genes; heat stress; iron; lungs; nitrogen; pathogenesis; pathogens; pneumonia; ribosomal proteins; statistical analysis; swine; transcription (genetics); transcriptome; translation (genetics); virulence
Abstract:
... Pasteurella multocida is one of the most important pathogen that causes pneumonia in swine. Although several virulence factors are known, the pathogenesis of this bacterium is not well-studied. Therefore, to study the pathogenesis of P. multocida infection in porcine lung, next-generation RNA sequencing was used to compare the transcriptomes of P. multocida grown in vivo and in vitro, respectively ...
DOI:
10.1016/j.micpath.2018.06.014

6. SBP1 is an adhesion-associated factor without the involvement of virulence in Streptococcus suis serotype 2

Author:
Qian, Yunyun; Zhang, Yuhang; Yu, Yanfei; Li, Quan; Guo, Genglin; Fu, Yang; Yao, Huochun; Lu, Chengping; Zhang, Wei
Source:
Microbial pathogenesis 2018 v.122 pp. 90-97
ISSN:
0882-4010
Subject:
Danio rerio; Streptococcus suis; Western blotting; bacterial adhesion; fluorescent antibody technique; homologous recombination; human cell lines; humans; mice; morbidity; mortality; mutants; pathogenesis; pathogens; phagocytosis; serotypes; swine; virulence
Abstract:
... Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that infects swine and humans with high mortality and morbidity. Although a number of virulence-associated factors have been reported, the understanding of the molecular mechanism underlying SS2 pathogenicity remains limited. Our previous studies revealed that srtBCD-associated protein 2’ (SBP2′) contributed to the pathogenesis ...
DOI:
10.1016/j.micpath.2018.06.008

7. Comprehensive evaluation of the host responses to infection with differentially virulent classical swine fever virus strains in pigs

Author:
Wang, Jinghan; Sun, Yuan; Meng, Xing-Yu; Li, Lian-Feng; Li, Yongfeng; Luo, Yuzi; Wang, Wenjing; Yu, Shaoxiong; Yin, Caixia; Li, Su; Qiu, Hua-Ji
Source:
Virus research 2018 v.255 pp. 68-76
ISSN:
0168-1702
Subject:
Classical swine fever virus; T-lymphocytes; apoptosis; avirulent strains; carrier state; death; fever; genome; histopathology; immune response; inflammation; interferon-alpha; interleukin-10; interleukin-2; interleukin-4; interleukin-6; leukopenia; pathogenesis; secretion; signs and symptoms (animals and humans); specific pathogen-free animals; swine; tissue tropism; tumor necrosis factor-alpha; virulence; virulent strains
Abstract:
... Classical swine fever virus (CSFV) infection causes most variable clinical syndromes from chronic or latent infection to acute death, and it is generally acknowledged that the course of disease is affected by both virus and host factors. To compare host immune responses to differentially virulent CSFV strains in pigs, fifteen 8-week-old specific-pathogen-free pigs were randomly divided into four g ...
DOI:
10.1016/j.virusres.2018.06.012

8. Actinobacillus pleuropneumoniae biofilms: Role in pathogenicity and potential impact for vaccination development

Author:
Hathroubi, Skander; Loera-Muro, Abraham; Guerrero-Barrera, Alma L.; Tremblay, Yannick D. N.; Jacques, Mario
Source:
Animal health research reviews 2018 v.19 no.1 pp. 17-30
ISSN:
1475-2654
Subject:
Actinobacillus pleuropneumoniae; Gram-negative bacteria; acute course; aerosols; biofilm; death; direct contact; disease control; etiological agents; farms; hemorrhage; infectious diseases; lungs; pathogenesis; pleuropneumonia; swine; vaccination; vaccines; virulence
Abstract:
... Actinobacillus pleuropneumoniae is a Gram-negative bacterium that belongs to the family Pasteurellaceae. It is the causative agent of porcine pleuropneumonia, a highly contagious respiratory disease that is responsible for major economic losses in the global pork industry. The disease may present itself as a chronic or an acute infection characterized by severe pathology, including hemorrhage, fib ...
DOI:
10.1017/S146625231700010X
PubMed:
29110751

9. Phylodynamics of classical swine fever virus with emphasis on Ecuadorian strains

Author:
Garrido Haro, A. D.; Barrera Valle, M.; Acosta, A.; J. Flores, F.
Source:
Transboundary and emerging diseases 2018 v.65 no.3 pp. 782-790
ISSN:
1865-1674
Subject:
Classical swine fever virus; codons; emerging diseases; evolution; genetic variation; glycoproteins; models; pathogenesis; swine; virulence; Ecuador; Latin America; North America
Abstract:
... Classic swine fever virus (CSFV) is a Pestivirus from the Flaviviridae family that affects pigs worldwide and is endemic in several Latin American countries. However, there are still some countries in the region, including Ecuador, for which CSFV molecular information is lacking. To better understand the epidemiology of CSFV in the Americas, sequences from CSFVs from Ecuador were generated and a p ...
DOI:
10.1111/tbed.12803

10. Porcine Response to a Multidrug-Resistant Salmonella enterica serovar I 4,[5],12:i:- Outbreak Isolate

Author:
Shippy, Daniel C.; Bearson, Bradley L.; Holman, Devin B.; Brunelle, Brian W.; Allen, Heather K.; Bearson, Shawn M.D.
Source:
Foodborne pathogens & disease 2018 v.15 no.5 pp. 253-261
ISSN:
1556-7125
Subject:
Salmonella Typhimurium; antibodies; bacterial motility; blood serum; diarrhea; feces; fever; flagellin; foodborne illness; genes; immune response; interferon-gamma; intestinal microorganisms; intestines; lipopolysaccharides; microbial communities; multiple drug resistance; nucleotide sequences; pathogenesis; pork; ribosomal RNA; serotypes; signs and symptoms (animals and humans); swine; swine diseases; virulence; water content
Abstract:
... Salmonella enterica serovar I 4,[5],12:i:- has emerged as a common nontyphoidal Salmonella serovar to cause human foodborne illness. An interesting trait of serovar I 4,[5],12:i:- is that it only expresses the fliC gene for bacterial motility (i.e., monophasic), while most Salmonella strains alternately express two flagellin genes (fliC and fljB). The goal of this study was to characterize the por ...
DOI:
10.1089/fpd.2017.2378

11. Porcine Response to a Multidrug-Resistant to a Multidrug-Resistan serovar l 4,[5],12:i;:-Outbreak Isolate serovar I 4,[5],12:i:- Outbreak Isolate

Author:
Shippy, Daniel C.; Bearson, Bradley L.; Holman, Devin B.; Brunelle, Brian; Allen, Heather K.; Bearson, Shawn M. D.
Source:
Foodborne pathogens & disease 2018 v.15 no.5 pp. 253-261
ISSN:
1535-3141
Subject:
Salmonella Typhimurium; antibodies; bacterial motility; blood serum; diarrhea; feces; fever; foodborne illness; genes; human diseases; immune response; interferon-gamma; intestinal microorganisms; intestines; lipopolysaccharides; microbial communities; multiple drug resistance; nucleotide sequences; pathogenesis; pork; ribosomal RNA; serotypes; signs and symptoms (animals and humans); swine; swine diseases; virulence; water content
Abstract:
... Salmonella enterica serovar I 4,[5],12:i:- has emerged as a common nontyphoidal Salmonella serovar to cause human foodborne illness. An interesting trait of serovar I 4,[5],12:i:- is that it only expresses the fliC gene for bacterial motility (i.e., monophasic), while most Salmonella strains alternately express two flagellin genes (fliC and fljB). The goal of this study was to characterize the porcine ...
DOI:
10.1089/fpd.2017.2378

12. Characterization and functional analysis of PnuC that is involved in the oxidative stress tolerance and virulence of Streptococcus suis serotype 2

Author:
Li, Quan; Zhang, Yuhang; Dechao, Du; Yanfei, Yu; Zhang, Wei
Source:
Veterinary microbiology 2018 v.216 pp. 198-206
ISSN:
0378-1135
Subject:
Danio rerio; Streptococcus suis; financial economics; gene deletion; hydrogen peroxide; mice; models; mutants; oxidative stress; pathogenesis; pathogens; phenotype; pork industry; serotypes; stress tolerance; swine; tissues; virulence; virulent strains
Abstract:
... Streptococcus suis, an important swine pathogen and a major zoonotic agent, is responsible for severe financial losses in the global swine industry. Although a multitude of virulence factors have been reported, the pathogenesis of S. suis infections remains poorly understood. In our previous work, we identified a potential virulence-associated protein, named PnuC, unique to virulent strains of S. ...
DOI:
10.1016/j.vetmic.2018.02.013