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1. A review on application of graphene‐based microfluidics

Author:
Chen, Xueye; Zhang, Shuai; Han, Wenbo; Wu, Zhongli; Chen, Yao; Wang, Shouxin
Source:
Journal of chemical technology and biotechnology 2018 v.93 no.12 pp. 3353-3363
ISSN:
0268-2575
Subject:
microfluidic technology,   etc   ; glucose; graphene; proteins; viruses;     Show all 5 Subjects
Abstract:
... This review reports on the progress of recent developments in graphene‐based microfluidics. The applications of graphene‐based microfluidics that are the focus of this work are illustrated and discussed mainly with examples from detection of viruses and disease, detection of proteins and glucose, detection of contaminants, and applications in sensors and material preparation. A variety of microflu ...
DOI:
10.1002/jctb.5710

2. Quantitative Variations with pH of Actin Depolymerizing Factor/Cofilin’s Multiple Actions on Actin Filaments

Author:
Wioland, Hugo; Jegou, Antoine; Romet-Lemonne, Guillaume
Source:
Biochemistry 2018 v.58 no.1 pp. 40-47
ISSN:
1520-4995
Subject:
microfluidic technology,   etc   ; actin; depolymerization; microfilaments; pH;     Show all 5 Subjects
Abstract:
... Actin depolymerizing factor (ADF)/cofilin is the main protein family promoting the disassembly of actin filaments, which is essential for numerous cellular functions. ADF/cofilin proteins disassemble actin filaments through different reactions, as they bind to their sides, sever them, and promote the depolymerization of the resulting ADF/cofilin-saturated filaments. Moreover, the efficiency of ADF ...
DOI:
10.1021/acs.biochem.8b01001

3. New strategies based on microfluidics for the synthesis of metal–organic frameworks and their membranes

Author:
Echaide-Górriz, Carlos; Clément, Coralie; Cacho-Bailo, Fernando; Téllez, Carlos; Coronas, Joaquín
Source:
Journal of materials chemistry 2018 v.6 no.14 pp. 5485-5506
ISSN:
2050-7496
Subject:
microfluidic technology,   etc   ; chemistry; coordination polymers; ligands;     Show all 4 Subjects
Abstract:
... Metal–organic frameworks (MOFs) are highly porous crystalline materials formed by the coordination of organic ligands with metal clusters. Despite the significant progress in their development over the last few years and their applications in various classic and emerging fields, the control of their shape and size remains a challenge, in particular the search for more efficient and environmentally ...
DOI:
10.1039/c8ta01232f

4. Fluorescence-based kinetic analysis of miniaturized protein microarrays

Author:
Ramiya Ramesh Babu, Heman Kumar; Gheber, Levi A.
Source:
Biosensors & bioelectronics 2018 v.122 pp. 290-299
ISSN:
0956-5663
Subject:
microfluidic technology,   etc   ; biosensors; fluorescence; kinetics; monitoring; protein microarrays;     Show all 6 Subjects
Abstract:
... Ideal monitoring devices should enjoy a combination of characteristics, e.g. high sensitivity, multiplexing, portability, short time-to-result (TTR). Typically, no device meets all of these demands since some of them are contradictory, to some extent. Herein, we present a miniaturized platform based on fluorescent detection, which is sensitive, readily allows multiplexing, and allows real-time mon ...
DOI:
10.1016/j.bios.2018.09.051

5. The influence of cell morphology on microfluidic single cell analysis

Author:
Zhang, Xuxin; Li, Yanzhao; Fang, Hanshu; Wei, Hongquan; Mu, Ying; Lang, Ming-Fei; Sun, Jing
Source:
RSC advances 2018 v.9 no.1 pp. 139-144
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; glioblastoma; image analysis; protein synthesis; proteins; signal transduction;     Show all 6 Subjects
Abstract:
... Microfluidics has been widely used in single cell analysis. Current protocols allow either spread or round cells to be analyzed. However, the contribution of cell morphology to single cell analysis has not been noted. In this study, four proteins (EGFR, PTEN, pAKT, and pS6) in the EGFR signaling pathway are measured simultaneously using microfluidic image cytometry (MIC) in glioblastoma cells U87. ...
DOI:
10.1039/c8ra08303g

6. Applications of Acoustofluidics in Bioanalytical Chemistry

Author:
Li, Peng; Huang, Tony Jun
Source:
Analytical chemistry 2018 v.91 no.1 pp. 757-767
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; acoustics; analytical chemistry; flow cytometry; ultrasonography;     Show all 5 Subjects
Abstract:
... Acoustics has a broad spectrum of applications, ranging from noise cancelation to ultrasonic imaging. In the past decade, there has been increasing interest in developing acoustic-based methods for biological and biomedical applications. This Perspective summarizes the recent progress in applying acoustofluidic methods (i.e., the fusion of acoustics and microfluidics) to bioanalytical chemistry. W ...
DOI:
10.1021/acs.analchem.8b03786

7. Correction: Indirect fabrication of versatile 3D microfluidic device by a rotating plate combined 3D printing system

Author:
Ha, Dong-Heon; Ko, Dong-Hyeon; Kim, Jin-Oh; Im, Do Jin; Kim, Byoung Soo; Park, Soo-Young; Park, Steve; Kim, Dong-Pyo; Cho, Dong-Woo
Source:
RSC advances 2018 v.8 no.71 pp. 40597
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; equipment design; equipment performance; processing technology;     Show all 4 Subjects
Abstract:
... Correction for ‘Indirect fabrication of versatile 3D microfluidic device by a rotating plate combined 3D printing system’ by Dong-Heon Ha et al., RSC Adv., 2018, 8, 37693–37699. ...
DOI:
10.1039/c8ra90091d

8. Engineering Surface Patterns with Shape Memory Polymers: Multiple Design Dimensions for Diverse and Hierarchical Structures

Author:
Zhao, Lingyu; Zhang, Liangpei; Zhao, Jun; Shi, Jidong; Dai, Zhaohe; Wang, Guorui; Zhang, Cheng; Li, Bo; Feng, Xiqiao; Zhang, Hui; Zhang, Jin; Zhang, Zhong
Source:
ACS applied materials & interfaces 2018 v.11 no.1 pp. 1563-1570
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; crosslinking; deformation; electronics; engineering; gold; polyethylene; thermal stability;     Show all 8 Subjects
Abstract:
... Deterministic design of surface patterns has seen a surge of interests because of their wide applications in flexible and stretchable electronics, microfluidics, and optical devices. Recently, instability of bilayer systems has been extensively utilized by which micro-/nano-patterns of a film can be easily achieved through macroscopically deforming the underlying substrate. For a bilayer system wi ...
DOI:
10.1021/acsami.8b15535

9. Capillary Scale Admittance and Conductance Detection

Author:
Huang, Weixiong; Chouhan, Bikash; Dasgupta, Purnendu K.
Source:
Analytical chemistry 2018 v.90 no.24 pp. 14561-14568
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; B-lymphocytes; electrodes; geometry; ion exchange chromatography; liquids;     Show all 6 Subjects
Abstract:
... Admittance detection, more commonly called capacitively coupled contactless conductivity detection, is widely used. While the true conductance of a solution is linear with concentration up to ∼1 mequiv/L, the admittance signal is nonlinear. In small-bore capillaries and highly resistive solutions, such as in suppressed open tubular ion chromatography (SOTIC), the admittance signal is exponentially ...
DOI:
10.1021/acs.analchem.8b04561

10. Transient binding promotes molecule penetration into mucin hydrogels by enhancing molecular partitioning

Author:
MarczynskiEqual contribution., Matthias; Käsdorf, Benjamin T.; Altaner, Bernhard; Wenzler, Andreas; Gerland, Ulrich; Lieleg, Oliver
Source:
Biomaterials science 2018 v.6 no.12 pp. 3373-3387
ISSN:
2047-4849
Subject:
microfluidic technology,   etc   ; biopolymers; equations; hydrogels; liquids; models; mucins; mucus;     Show all 8 Subjects
Abstract:
... Here, we present a microfluidics chip platform which allows for studying the charge-dependent transport of molecules across the interface of acidic mucin gels. With this setup, we demonstrate a selective accumulation of molecules at the liquid/gel interface of mucin hydrogels that occurs as a function of the molecule charge: this phenomenon is strongly pronounced for cationic molecules, weakly pro ...
DOI:
10.1039/c8bm00664d

11. Reinventing (Bio)chemical Analysis with Paper

Author:
Salentijn, G. IJ.; Grajewski, M.; Verpoorte, E.
Source:
Analytical chemistry 2018 v.90 no.23 pp. 13815-13825
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; blood; chemical analysis; chromatography; filtration; ionization; paper;     Show all 7 Subjects
Abstract:
... This paper focuses on one of the most commonly encountered materials in our society, namely paper. Paper is an inherently complex material, yet its use provides for chemical analysis approaches that are elegant in their simplicity of execution. In the first half of the previous century, paper in scientific research was used mainly for filtration and chromatographic separation. While its use decrea ...
DOI:
10.1021/acs.analchem.8b04825

12. Indirect fabrication of versatile 3D microfluidic device by a rotating plate combined 3D printing system

Author:
Ha, Dong-Heon; Ko, Dong-Hyeon; Kim, Jin-oh; Im, Do Jin; Kim, Byoung Soo; Park, Soo-Young; Park, Steve; Kim, Dong-Pyo; Cho, Dong-Woo
Source:
RSC advances 2018 v.8 no.66 pp. 37693-37699
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; catalytic activity; convection; durability; hydrogels; medicine; photochemical reactions;     Show all 7 Subjects
Abstract:
... In the past decade, 3D-printing technology has been applied in the field of microfluidics to fabricate microfluidic devices for wide-ranging areas of study including chemistry, biology, medicine, and others. However, these methods face several limitations such as insufficient resolution and long fabrication time. In this study, versatile microfluidic devices with different functions were indirectl ...
DOI:
10.1039/c8ra08465c

13. Simulation before fabrication: a case study on the utilization of simulators for the design of droplet microfluidic networks

Author:
Grimmer, Andreas; Chen, Xiaoming; Hamidović, Medina; Haselmayr, Werner; Ren, Carolyn L.; Wille, Robert
Source:
RSC advances 2018 v.8 no.60 pp. 34733-34742
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; case studies; droplets; hydrodynamics; models; prototypes;     Show all 6 Subjects
Abstract:
... The functional performance of passively operated droplet microfluidics is sensitive with respect to the dimensions of the channel network, the fabrication precision as well as the applied pressure because the entire network is coupled together. Especially, the local and global hydrodynamic resistance changes caused by droplets make the task to develop a robust microfluidic design challenging as pl ...
DOI:
10.1039/c8ra05531a

14. Re-entrant Cavities Enhance Resilience to the Cassie-to-Wenzel State Transition on Superhydrophobic Surfaces during Electrowetting

Author:
Roy, Rishav; Weibel, Justin A.; Garimella, Suresh V.
Source:
Langmuir 2018 v.34 no.43 pp. 12787-12793
ISSN:
1520-5827
Subject:
microfluidic technology,   etc   ; microstructure; mushrooms; models; adhesion; hydrophobicity; droplets;     Show all 7 Subjects
Abstract:
... Electrowetting-based droplet actuation has applications in digital microfluidics. Mobility of droplets on surfaces can be enhanced using structured superhydrophobic surfaces that offer inherently low adhesion to droplets in the Cassie state. However, these surfaces must be designed to prevent transition to the Wenzel state (in which droplets are immobile) at high electrowetting actuation voltages. ...
DOI:
10.1021/acs.langmuir.8b02675

15. Microfluidic Control Board for High-Pressure Flow, Composition, and Relative Permittivity

Author:
Andersson, Martin; Svensson, Karolina; Klintberg, Lena; Hjort, Klas
Source:
Analytical chemistry 2018 v.90 no.21 pp. 12601-12608
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; carbon dioxide; chromatography; heaters; methanol; mixing;     Show all 6 Subjects
Abstract:
... Flow control is central to microfluidics and chromatography. With decreasing dimensions and high pressures, precise fluid flows are often needed. In this paper, a high-pressure flow control system is presented, allowing for the miniaturization of chromatographic systems and the increased performance of microfluidic setups by controlling flow, composition, and relative permittivity of two-component ...
DOI:
10.1021/acs.analchem.8b02758

16. Microfluidic fabrication of microparticles for biomedical applications

Author:
LiThese authors contributed equally to this work., Wen; Zhang, Liyuan; Ge, Xuehui; Xu, Biyi; Zhang, Weixia; Qu, Liangliang; Choi, Chang-Hyung; Xu, Jianhong; Zhang, Afang; Lee, Hyomin; Weitz, David A.
Source:
Chemical Society reviews 2018 v.47 no.15 pp. 5646-5683
ISSN:
1460-4744
Subject:
microfluidic technology,   etc   ; artificial cells; biosensors; droplets; drugs; encapsulation; microparticles;     Show all 7 Subjects
Abstract:
... Droplet microfluidics offers exquisite control over the flows of multiple fluids in microscale, enabling fabrication of advanced microparticles with precisely tunable structures and compositions in a high throughput manner. The combination of these remarkable features with proper materials and fabrication methods has enabled high efficiency, direct encapsulation of actives in microparticles whose ...
DOI:
10.1039/c7cs00263g

17. Wetting of ferrofluids: Phenomena and control

Author:
Latikka, Mika; Backholm, Matilda; Timonen, Jaakko V.I.; Ras, Robin H.A.
Source:
Current opinion in colloid & interface science 2018 v.36 pp. 118-129
ISSN:
1359-0294
Subject:
microfluidic technology,   etc   ; contact angle; deformation; magnetic fields; nanoparticles;     Show all 5 Subjects
Abstract:
... Ferrofluids are liquids exhibiting remarkably strong response to magnetic fields, which leads to fascinating properties useful in various applications. Understanding the wetting properties and spreading of ferrofluids is important for their use in microfluidics and magnetic actuation. However, this is challenging as magnetically induced deformation of the ferrofluid surface can affect contact angl ...
DOI:
10.1016/j.cocis.2018.04.003

18. A microfluidic method to measure bulging heights for bulge testing of polydimethylsiloxane (PDMS) and polyurethane (PU) elastomeric membranes

Author:
Huang, Jen-Huang; Haffey, Kiersten; Arefin, Ayesha; Akhadov, Leyla E.; Harris, Jennifer F.; Iyer, Rashi; Nath, Pulak
Source:
RSC advances 2018 v.8 no.38 pp. 21133-21138
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; coatings; organ-on-a-chip; polydimethylsiloxane; polyurethanes;     Show all 5 Subjects
Abstract:
... Thin and flexible elastomeric membranes are frequently used in many microfluidic applications including microfluidic valves and organs-on-a-chip. The elastic properties of these membranes play an important role in the design of such microfluidic devices. Bulge testing, which is a common method to characterize the elastic behavior of these membranes, involves direct observation of the changes in th ...
DOI:
10.1039/c8ra01256c

19. Microfluidics for food science and engineering

Author:
Gunes, Deniz Z
Source:
Current opinion in food science 2018 v.21 pp. 57-65
ISSN:
2214-7993
Subject:
microfluidic technology,   etc   ; analytical methods; emulsions; engineering; foams; food technology; microstructure;     Show all 7 Subjects
Abstract:
... The advent of microfluidics as a research field radiating towards all other material science disciplines triggered a number of paradigm shifts, which changed visibly the research horizon in food science. Food engineering as a discipline, which was sometimes criticized for the conservatism of its approaches and aspirations, started finding some important benefits from using microfluidics as a resea ...
DOI:
10.1016/j.cofs.2018.06.002

20. Click chemistry approaches to expand the repertoire of PEG-based fluorinated surfactants for droplet microfluidics

Author:
Scanga, Randall; Chrastecka, Lucie; Mohammad, Ridhwan; Meadows, Austin; Quan, Phenix-Lan; Brouzes, Eric
Source:
RSC advances 2018 v.8 no.23 pp. 12960-12974
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; biocompatibility; cycloaddition reactions; droplets; emulsions; glycerol; oils; surfactants;     Show all 8 Subjects
Abstract:
... We report the novel and simplified synthesis of fluorinated surfactants for droplet microfluidics. The range of applications of droplet microfluidics has greatly expanded during the last decade thanks to its ability to manipulate and process tiny amount of sample and reagents at high throughput in independent reactors. A critical component of the technology is the formulation of the immiscible oil ...
DOI:
10.1039/c8ra01254g

21. Micro-optics for microfluidic analytical applications

Author:
Yang, Hui; Gijs, Martin A. M.
Source:
Chemical Society reviews 2018 v.47 no.4 pp. 1391-1458
ISSN:
1460-4744
Subject:
microfluidic technology,   etc   ; automation; cell biology; chemical analysis; nucleic acids;     Show all 5 Subjects
Abstract:
... This critical review summarizes the developments in the integration of micro-optical elements with microfluidic platforms for facilitating detection and automation of bio-analytical applications. Micro-optical elements, made by a variety of microfabrication techniques, advantageously contribute to the performance of an analytical system, especially when the latter has microfluidic features. Indeed ...
DOI:
10.1039/c5cs00649j

22. Microfluidic synthesis and on-chip enrichment application of two-dimensional hollow sandwich-like mesoporous silica nanosheet with water ripple-like surface

Author:
Hao, Nanjing; Nie, Yuan; Closson, Andrew B.; Zhang, John X.J.
Source:
Journal of colloid and interface science 2018
ISSN:
0021-9797
Subject:
microfluidic technology,   etc   ; adsorption; drugs; dyes; engineering; mass transfer; nanosheets; porous media; silica;     Show all 9 Subjects
Abstract:
... The merits of microfluidics bring new opportunities for engineering of nanomaterials with well controlled chemical, physical and biological properties for a variety of applications. Herein, using a two-run spiral-shaped microfluidic device, we first develop a facile and straightforward flow synthesis strategy to create two-dimensional mesoporous silica nanosheet (MSN). Such MSN exhibits typical ho ...
DOI:
10.1016/j.jcis.2018.12.040

23. Milk carton with integrated paper‐based microfluidics for milk quality rapid test

Author:
Fan, Yiqiang; Wang, Hongliang; Liu, Shicheng; Zhang, Boyang; Zhang, Yajun
Source:
Journal of food safety 2018 v.38 no.6 pp. e12548
ISSN:
0149-6085
Subject:
microfluidic technology,   etc   ; food industry; milk; milk quality; mobile telephones; packaging; paper;     Show all 7 Subjects
Abstract:
... This study integrated paper‐based microfluidic device on a milk carton for a rapid milk quality check. The microfluidic device was printed on the outer surface of milk carton using commercial wax printer. The testing process is fully automatic, after apply one drop of milk on the loading point, milk was driven by capillary force in the porous paper fiber in wax‐defined microchannels to reach the p ...
DOI:
10.1111/jfs.12548

24. SCOPE-Seq: a scalable technology for linking live cell imaging and single-cell RNA sequencing

Author:
Yuan, Jinzhou; Sheng, Jenny; Sims, Peter A.
Source:
Genome biology 2018 v.19 no.1 pp. 227
ISSN:
1474-760X
Subject:
microfluidic technology,   etc   ; DNA barcoding; biochemical compounds; fluorescence; image analysis; microarray technology; phenotype;     Show all 7 Subjects
Abstract:
... Optically decodable beads link the identity of a sample to a measurement through an optical barcode, enabling libraries of biomolecules to be captured on beads in solution and decoded by fluorescence. This approach has been foundational to microarray, sequencing, and flow-based expression profiling technologies. We combine microfluidics with optically decodable beads and show that phenotypic analy ...
DOI:
10.1186/s13059-018-1607-x

25. Preparation of Hollow Cu and CuOₓ Microspheres with a Hierarchical Structure for Heterogeneous Catalysis

Author:
Ding, Yunzhe; Yan, Ying; Wang, Hanwen; Wang, Xinkui; Hu, Tao; Tao, Shengyang; Li, Guangtao
Source:
ACS applied materials & interfaces 2018 v.10 no.48 pp. 41793-41801
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; catalysts; catalytic activity; copper; hydrogenation; mass transfer; mathematical models; microparticles;     Show all 8 Subjects
Abstract:
... Diffusion is one of the most critical factors which affect the performance of porous catalysts in heterogeneous reactions. Hollow spheres with a hierarchical structure could significantly improve the mass transfer in the spherical catalyst. Therefore, preparation of such kind of microspheres is an important work in the field of inorganic synthesis. Herein, we combine microfluidic technology and el ...
DOI:
10.1021/acsami.8b16246

26. Water and Oil Insoluble PEGDA-Based Microcapsule: Biocompatible and Multicomponent Encapsulation

Author:
Nam, Changwoo; Yoon, Jongsun; Ryu, Sang A; Choi, Chang-Hyung; Lee, Hyomin
Source:
ACS applied materials & interfaces 2018 v.10 no.47 pp. 40366-40371
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; biochemical compounds; droplets; encapsulation; hydrophilicity; hydrophobicity; molecular weight; oils; polyethylene glycol; solubility;     Show all 10 Subjects
Abstract:
... Despite the recent development in various materials capable of encapsulating biomolecules, there exist limited reports on multicomponent encapsulation in biocompatible microcapsules. In this letter, we utilize the molecular weight dependent solubility of poly(ethylene glycol) diacrylate (PEGDA) and droplet microfluidics to achieve direct encapsulation of both hydrophilic and hydrophobic cargoes in ...
DOI:
10.1021/acsami.8b16876

27. Mask-Free Laser Lithography for Rapid and Low-Cost Microfluidic Device Fabrication

Author:
Trantidou, Tatiana; Friddin, Mark S.; Gan, Kin B.; Han, Luyao; Bolognesi, Guido; Brooks, Nicholas J.; Ces, Oscar
Source:
Analytical chemistry 2018 v.90 no.23 pp. 13915-13921
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; X-radiation; byproducts; chemical reactions; droplets; engineering; generators (equipment); oils;     Show all 8 Subjects
Abstract:
... Microfluidics has become recognized as a powerful platform technology associated with a constantly increasing array of applications across the life sciences. This surge of interest over recent years has led to an increased demand for microfluidic chips, resulting in more time being spent in the cleanroom fabricating devices using soft lithography—a slow and expensive process that requires extensiv ...
DOI:
10.1021/acs.analchem.8b03169

28. Towards Three-Dimensional Dynamic Regulation and In Situ Characterization of Single Stem Cell Phenotype Using Microfluidics

Author:
Sart, Sébastien; Agathos, Spiros N.
Source:
Molecular biotechnology 2018 v.60 no.11 pp. 843-861
ISSN:
1073-6085
Subject:
microfluidic technology,   etc   ; bioreactors; drugs; evolution; mesenchymal stromal cells; monitoring; phenotype; screening; stem cells; therapeutics; tissue engineering;     Show all 11 Subjects
Abstract:
... Mesenchymal stem cells and pluripotent stem cells are recognized as promising tools for tissue engineering, cell therapy, and drug screening. Their use in therapy requires the production of a sufficient number of cells committed to functional regenerative phenotypes. Time- and magnitude-controlled application of mechanical and biochemical cues is required to appropriately control the evolution of ...
DOI:
10.1007/s12033-018-0113-4

29. One-Step Photochemical Generation of Biofunctionalized Hydrogel Particles via Two-Phase Flow

Author:
Schönberg, Jan-Niklas; Zinggeler, Marc; Fosso, Patrick; Brandstetter, Thomas; Rühe, Jürgen
Source:
ACS applied materials & interfaces 2018 v.10 no.46 pp. 39411-39416
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; DNA; chemical reactions; crosslinking; diagnostic techniques; hydrogels; photochemistry; polymers; proteins;     Show all 9 Subjects
Abstract:
... Biofunctional hydrogel particles have become increasingly popular in medical diagnostics; however, their generation is time-consuming and typically requires several process steps. We report on a new method for the simple, fast, and reproducible one-step generation of monodisperse hydrogel particles equipped with biofunctional molecules such as proteins or DNA. Key to the approach is the simultaneo ...
DOI:
10.1021/acsami.8b11757

30. Rapid Recovery Hydrogel Actuators in Air with Bionic Large-Ranged Gradient Structure

Author:
Tan, Yun; Wang, Di; Xu, Huaxiu; Yang, Yang; Wang, Xiong-Lei; Tian, Fei; Xu, Pingping; An, Wenli; Zhao, Xu; Xu, Shimei
Source:
ACS applied materials & interfaces 2018 v.10 no.46 pp. 40125-40131
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; actuators; air; copolymerization; deformation; electrophoresis; hydrogels; hydrophilicity; laponite; muscles; robots; temperature;     Show all 12 Subjects
Abstract:
... Fast recovery in a nonaqueous environment is a big challenge for hydrogel actuators. In this work, a temperature-responsive hydrogel actuator with outstandingly rapid recovery in air was reported. The hydrogel with bionic large-ranged gradient structure was fabricated by copolymerization of hydrophilic monomer hydroxyethyl acrylate (HEA) and N-isopropylacrylamide in the dispersion of Laponite util ...
DOI:
10.1021/acsami.8b13235

31. The crossing and integration between microfluidic technology and 3D printing for organ-on-chips

Author:
MiThese authors contributed equally to this work., Shengli; Du, Zhichang; Xu, Yuanyuan; Sun, Wei
Source:
Journal of materials chemistry 2018 v.6 no.39 pp. 6191-6206
ISSN:
2050-7518
Subject:
microfluidic technology,   etc   ; biocompatible materials; chemistry; extracellular matrix; manufacturing; organ-on-a-chip;     Show all 6 Subjects
Abstract:
... Organ-on-chips were designed to simulate the real tissue or organ microenvironment by precise control of the cells, the extracellular matrix and other micro-environmental factors to clarify physiological or pathological mechanisms. The organ chip is mainly based on the poly(dimethylsiloxane) (PDMS) microfluidic devices, whereas the conventional soft lithography requires a cumbersome manufacturing ...
DOI:
10.1039/c8tb01661e

32. Methane Hydrate Intrinsic Dissociation Kinetics Measured in a Microfluidic System by Means of in Situ Raman Spectroscopy

Author:
Chen, Weiqi; Hartman, Ryan L.
Source:
Energy & fuels 2018 v.32 no.11 pp. 11761-11771
ISSN:
1520-5029
Subject:
microfluidic technology,   etc   ; Raman spectroscopy; dissociation; energy; fuels; heat transfer; laboratory techniques; methane; temperature; theoretical models;     Show all 10 Subjects
Abstract:
... The present work investigates the dissociation kinetics of methane (sI) hydrate in a thermoelectrically cooled microfluidic system with in situ Raman spectroscopy. The dissociation profile of methane (sI) hydrate was measured under different Reynolds numbers (0.42–4.16), pressures (60.2 to 80.1 bar), and temperature driving force ([Tₑq – 0.1 K] to [Tₑq + 0.3 K]). A theoretical model was derived fr ...
DOI:
10.1021/acs.energyfuels.8b02833

33. UV-Responsive Behavior of Multistate and Multiscale Self-Assemblies Constructed by Gemini Surfactant 12-3-12·2Br– and trans-o-Methoxy-cinnamate

Author:
Tu, Yan; Ye, Zhicheng; Lian, Cheng; Shang, Yazhuo; Teng, Hongni; Liu, Honglai
Source:
Langmuir 2018 v.34 no.43 pp. 12990-12999
ISSN:
1520-5827
Subject:
microfluidic technology,   etc   ; anisotropy; drugs; hydrophobicity; irradiation; liquid crystals; micelles; photoisomerization; separation; surfactants; ultraviolet radiation; viscosity;     Show all 12 Subjects
Abstract:
... Photoresponsive systems with adjustable self-assembly morphologies and tunable rheological properties have aroused widespread concern of researchers in recent years because of their prospect applications in controlled release, microfluidics, sensors, and so forth. In this paper, we combine a cationic Gemini surfactant 12-3-12·2Br– and trans-2-methoxy-cinnamate (trans-OMCA) together to create a rep ...
DOI:
10.1021/acs.langmuir.8b02914

34. High-Throughput Enzyme Kinetics with 3D Microfluidics and Imaging SAMDI Mass Spectrometry

Author:
Grant, Jennifer; Goudarzi, Sohrab Habibi; Mrksich, Milan
Source:
Analytical chemistry 2018 v.90 no.21 pp. 13096-13103
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; bioassays; desorption; enzymatic reactions; enzyme kinetics; fluorescence; image analysis; mass spectrometry;     Show all 8 Subjects
Abstract:
... Microfluidic systems are important for performing precise reagent manipulations and reducing material consumption in biological assays. However, optical detection methods limit analyses to fluorescent or UV-active compounds and traditional 2D fluidic designs have limited degrees of freedom. This article describes a microfluidic device that has three inputs and performs 2592 distinct enzyme reactio ...
DOI:
10.1021/acs.analchem.8b04391

35. Surface-Enhanced Raman Scattering Based Microfluidics for Single-Cell Analysis

Author:
Willner, Marjorie R.; McMillan, Kay S.; Graham, Duncan; Vikesland, Peter J.; Zagnoni, Michele
Source:
Analytical chemistry 2018 v.90 no.20 pp. 12004-12010
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; Raman spectroscopy; droplets; nanoparticles; neoplasm cells; prostatic neoplasms; screening; spectral analysis; wheat germ;     Show all 9 Subjects
Abstract:
... The integration of surface-enhanced Raman scattering (SERS) with droplet microfluidics has the potential to improve our understanding of cellular systems. Herein, we present the first application of SERS droplet microfluidics for single-cell analysis. A microfluidic device was used to encapsulate single prostate cancer cells and wheat germ agglutin (WGA)-functionalized SERS nanoprobes in water-in- ...
DOI:
10.1021/acs.analchem.8b02636

36. Composite Multifunctional Micromotors from Droplet Microfluidics

Author:
Zou, Minhan; Wang, Jie; Yu, Yunru; Sun, Lingyu; Wang, Huan; Xu, Hua; Zhao, Yuanjin
Source:
ACS applied materials & interfaces 2018 v.10 no.40 pp. 34618-34624
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; bubbles; droplets; energy; equipment; hydrogels; hydrogen peroxide; iron oxides; magnetism; platinum; polymers;     Show all 11 Subjects
Abstract:
... Inspired by natural biological machines, lots of effort has been invested in developing artificially functional micromotors which can convert energy into movement for carrying out tasks in diverse areas. Here, we present a capillary microfluidic system with dual inner injections for one-step generation of composite structured polymer micromotors with two distinct cores of platinum (Pt) nanoparticl ...
DOI:
10.1021/acsami.8b11976

37. Microfluidic Study on the Attachment of Crude Oil Droplets to Gas Bubbles

Author:
Dudek, Marcin; Øye, Gisle
Source:
Energy & fuels 2018 v.32 no.10 pp. 10513-10521
ISSN:
1520-5029
Subject:
microfluidic technology,   etc   ; bubbles; droplets; electrostatic interactions; gases; methane; nitrogen; oil fields; oils; pH; petroleum; salinity;     Show all 12 Subjects
Abstract:
... Gas flotation is often used during treatment of the oilfield produced water. It relies on the generation of gas bubbles and their attachment to oil drops, for example, by forming an oil film on the surface of a gas bubble. In this paper, we present a microfluidic technique for investigating the attachment of crude oil drops to gas bubbles through the spreading mechanism. The developed method allow ...
DOI:
10.1021/acs.energyfuels.8b02236

38. Microfluidics in coagulation monitoring devices: a mini review

Author:
Harris, Leanne F.; Killard, Anthony J.
Source:
Analytical methods 2018 v.10 no.30 pp. 3714-3719
ISSN:
1759-9679
Subject:
microfluidic technology,   etc   ; analytical methods; coagulation; decision making; hemorrhage; hemostasis; monitoring; mortality; patient care;     Show all 9 Subjects
Abstract:
... Diagnosis and monitoring of disorders of coagulation and disturbances in haemostasis has been around for many years. Thrombotic and bleeding disorders are amongst the leading causes of mortality in the developed world, thus driving research in this area. The simplicity with which miniaturised devices operate and their application to the study of coagulation and haemostasis offer potential advantag ...
DOI:
10.1039/c8ay01230j

39. Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

Author:
Yang, Qian; Li, Jinhua; Wang, Xiaoyan; Peng, Hailong; Xiong, Hua; Chen, Lingxin
Source:
Biosensors & bioelectronics 2018 v.112 pp. 54-71
ISSN:
0956-5663
Subject:
microfluidic technology,   etc   ; binding sites; biosensors; fluorescence; point-of-care systems; polymers; porous media; signal transduction;     Show all 8 Subjects
Abstract:
... One pressing concern today is to construct sensors that can withstand various disturbances for highly selective and sensitive detecting trace analytes in complicated samples. Molecularly imprinted polymers (MIPs) with tailor-made binding sites are preferred to be recognition elements in sensors for effective targets detection, and fluorescence measurement assists in highly sensitive detection and ...
DOI:
10.1016/j.bios.2018.04.028

40. Dielectrowetting: The past, present and future

Author:
Edwards, A.M.J.; Brown, C.V.; Newton, M.I.; McHale, G.
Source:
Current opinion in colloid & interface science 2018 v.36 pp. 28-36
ISSN:
1359-0294
Subject:
microfluidic technology,   etc   ; dielectrophoresis; droplets; electric field; electric potential difference; electrodes; energy balance; liquids; statics;     Show all 9 Subjects
Abstract:
... Liquid dielectrophoresis is a bulk force acting on dipoles within a dielectric liquid inside a non-uniform electric field. When the driving electrodes are interdigitated, bulk liquid dielectrophoresis is converted to an interface-localised form capable of modifying the energy balance at an interface. When the interface is a solid-liquid one, the wetting properties of a surface are modified and thi ...
DOI:
10.1016/j.cocis.2017.11.005

41. Bioprinting of 3D tissues/organs combined with microfluidics

Author:
Ma, Jingyun; Wang, Yachen; Liu, Jing
Source:
RSC advances 2018 v.8 no.39 pp. 21712-21727
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; biochemical compounds; biocompatibility; biocompatible materials; biomimetics; bioprinting; cellular microenvironment; manufacturing; morphogenesis; precision medicine; tissues;     Show all 11 Subjects
Abstract:
... Accompanied by the increasing demand for organ transplants and personalized medicine, recent years have witnessed great developments in the regeneration of tissues/organs, which has benefited from various manufacturing technologies, especially 3D bioprinting. In 3D bioprinting, according to the morphogenesis, cellular microenvironment, and biological functions of the native tissues/organs, cells a ...
DOI:
10.1039/c8ra03022g

42. Liquid metals: fundamentals and applications in chemistry

Author:
Daeneke, T.; Khoshmanesh, K.; Mahmood, N.; de Castro, I. A.; Esrafilzadeh, D.; Barrow, S. J.; Dickey, M. D.; Kalantar-zadeh, K.
Source:
Chemical Society reviews 2018 v.47 no.11 pp. 4073-4111
ISSN:
1460-4744
Subject:
microfluidic technology,   etc   ; alloys; ambient temperature; catalytic activity; drugs; electronics; liquids; melting point; physical chemistry;     Show all 9 Subjects
Abstract:
... Post-transition elements, together with zinc-group metals and their alloys belong to an emerging class of materials with fascinating characteristics originating from their simultaneous metallic and liquid natures. These metals and alloys are characterised by having low melting points (i.e. between room temperature and 300 °C), making their liquid state accessible to practical applications in vario ...
DOI:
10.1039/c7cs00043j

43. (Bio)Analytical chemistry enabled by 3D printing: Sensors and biosensors

Author:
Manzanares Palenzuela, C. Lorena; Pumera, Martin
Source:
Trends in analytical chemistry 2018 v.103 pp. 110-118
ISSN:
0165-9936
Subject:
microfluidic technology,   etc   ; analytical chemistry; biosensors; explosives; genotoxicity; geometry; manufacturing; metabolites; nerve agents; pharmacokinetics; screening;     Show all 11 Subjects
Abstract:
... 3D printing has revolutionized the concept of object manufacturing, making an enormous impact on industry and economy. The technology has found a niche in countless fields, including scientific research. It has rendered practical solutions to scientific problems by offering tailored-shaped devices with exquisite control in design and geometry and through the versatility of printable materials. App ...
DOI:
10.1016/j.trac.2018.03.016

44. Highly transparent and flexible circuits through patterning silver nanowires into microfluidic channels

Author:
Sun, Jing; Zhou, Wenhui; Yang, Haibo; Zhen, Xue; Ma, Longfei; Williams, Dirk; Sun, Xudong; Lang, Ming-Fei
Source:
Chemical communications 2018 v.54 no.39 pp. 4923-4926
ISSN:
1364-548X
Subject:
microfluidic technology,   etc   ; chemical reactions; coatings; electronic equipment; labor; medical equipment; nanosilver; nanowires; polydimethylsiloxane; silver;     Show all 10 Subjects
Abstract:
... The development of flexible and transparent devices requires completely transparent and flexible circuits (TFCs). To overcome the disadvantages of the previously reported TFCs that are partially transparent, lacking pattern control, or labor consuming, we achieve true TFCs via a facile process with precise pattern control, exhibiting concurrent high transparency, conductivity, flexibility, stretch ...
DOI:
10.1039/c8cc01438h

45. A gemini surfactant-containing system with abundant self-assembly morphology and rheological behaviors tunable by photoinduction

Author:
Tu, Yan; Gao, Mengge; Teng, Hongni; Shang, Yazhuo; Fang, Bo; Liu, Honglai
Source:
RSC advances 2018 v.8 no.29 pp. 16004-16012
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; drugs; irradiation; materials science; micelles; photoisomerization; photosensitivity; surfactants; ultraviolet radiation; viscosity;     Show all 10 Subjects
Abstract:
... Photoresponsive micellar systems with adjustable aggregate morphologies and rheological properties may be useful in a number of fields such as in microfluidics, controlled release, and sensors. However, the complexity and great difficulty of synthesising photosensitive molecules hamper their practical applications to a significant degree. In this study, we constructed a novel photoinduced self-ass ...
DOI:
10.1039/c8ra01070f

46. A review of centrifugal microfluidics in environmental monitoring

Author:
Maguire, I.; O'Kennedy, R.; Ducrée, J.; Regan, F.
Source:
Analytical methods 2018 v.10 no.13 pp. 1497-1515
ISSN:
1759-9679
Subject:
microfluidic technology,   etc   ; analytical methods; automation; cost effectiveness; electrochemistry; environmental monitoring; manufacturing; mixing;     Show all 8 Subjects
Abstract:
... There is currently a gap in the use of centrifugal microfluidics in the field of environmental sensing. This review provides theoretical perspectives that have been demonstrated for applications in other domains and recommends adaptations for environmental sensing. Current approaches of centrifugal systems reported are primarily in the area of biosensing and electrochemical detection. In the case ...
DOI:
10.1039/c8ay00361k

47. Selective separation of microalgae cells using inertial microfluidics

Author:
Syed, Maira S.; Rafeie, Mehdi; Vandamme, Dries; Asadnia, Mohsen; Henderson, Rita; Taylor, Robert A.; Warkiani, Majid E.
Source:
Bioresource technology 2018 v.252 pp. 91-99
ISSN:
0960-8524
Subject:
microfluidic technology,   etc   ; Phaeodactylum tricornutum; Tetraselmis suecica; bacteria; biomass production; cell viability; fluorescence; microalgae; water quality analysis;     Show all 9 Subjects
Abstract:
... Microalgae represent the most promising new source of biomass for the world’s growing demands. However, the biomass productivity and quality is significantly decreased by the presence of bacteria or other invading microalgae species in the cultures. We therefore report a low-cost spiral-microchannel that can effectively separate and purify Tetraselmis suecica (lipid-rich microalgae) cultures from ...
DOI:
10.1016/j.biortech.2017.12.065

48. Active droplet-array (ADA) microfluidics enables multiplexed complex bioassays for point of care testing

Author:
ShuThe authors Bowen Shu and Zhujun Li contributed equally and share the first authorship., Bowen; Li, Zhujun; Yang, Xiao; Xiao, Feng; Lin, Dongguo; Lei, Xiuxia; Xu, Banglao; Liu, Dayu
Source:
Chemical communications 2018 v.54 no.18 pp. 2232-2235
ISSN:
1364-548X
Subject:
microfluidic technology,   etc   ; analytical methods; bioassays; chemical compounds; chemical reactions; droplets; energy; point-of-care testing;     Show all 8 Subjects
Abstract:
... We introduce a novel and versatile microfluidic technology that allows parallel and multi-step bioanalytical procedures to be simply implemented by switching reagent-containing droplet arrays among alternative interaction zones for intended mass or energy transport in a programmable manner. This enables multiplexed complex bioassays for point-of-care testing. ...
DOI:
10.1039/c7cc09377b

49. Fabrication of a microfluidic chip based on the pure polypropylene material

Author:
Liang, Fupeng; Qiao, Yi; Duan, Mengqin; Ju, An; Lu, Na; Li, Junji; Tu, Jing; Lu, Zuhong
Source:
RSC advances 2018 v.8 no.16 pp. 8732-8738
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; adsorption; chemical reactions; manufacturing; organ-on-a-chip; polymerase chain reaction; polypropylenes; rapid methods;     Show all 8 Subjects
Abstract:
... Polypropylene (PP) material has been widely used in the biomedical field for decades due to its high reliability in biochemical reactions. However, a pure PP material microfluidic chip has rarely been reported. Herein, a simple and rapid method has been developed to fabricate a pure PP microfluidic chip by a thermal bonding process using a PP film and PP substrate. An experiment for two-temperatur ...
DOI:
10.1039/c7ra13334k

50. Effect of lubricant viscosity on the self-healing properties and electrically driven sliding of droplets on anisotropic slippery surfaces

Author:
Wang, Zubin; Heng, Liping; Jiang, Lei
Source:
Journal of materials chemistry 2018 v.6 no.8 pp. 3414-3421
ISSN:
2050-7496
Subject:
microfluidic technology,   etc   ; Nepenthes; anisotropy; droplets; electric potential difference; liquids; lubricants; microchip technology; oils; silicone; viscosity;     Show all 11 Subjects
Abstract:
... The emerging slippery liquid-infused porous surfaces inspired by Nepenthes pitcher plants have attracted considerable attention because of their excellent self-cleaning properties and potential applications in novel microfluidics, microchips, and liquid transportation and liquid manipulation technologies. However, the development of anisotropic slippery surfaces is in its infancy. Although some in ...
DOI:
10.1039/c7ta10439a

51. Configurable 2D nano-flows in mesoporous films using paper patches

Author:
Mercuri, M.; Gimenez, R.; Berli, C. L. A.; Bellino, M. G.
Source:
RSC advances 2018 v.8 no.12 pp. 6414-6418
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; chemical reactions; engineering; filtration; imbibition; nanoparticles; paper; porous media;     Show all 8 Subjects
Abstract:
... Designing and controlling spontaneous imbibition is becoming a key requirement for advanced devices, presenting a substantial scientific and engineering challenge. Here we describe an approach that allows directional imbibition into designed geometries. A set of custom domains based on paper microfluidics mold nano-imbibition in user-defined shapes such as curvatures, corners, and vertices into me ...
DOI:
10.1039/c7ra13691a

52. Generation of controllable gaseous H₂S concentrations using microfluidics

Author:
Christoforidis, Theodore; Driver, Tom G.; Rehman, Jalees; Eddington, David T.
Source:
RSC advances 2018 v.8 no.8 pp. 4078-4083
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; ex vivo studies; hydrogen sulfide; in vitro studies; permeability; polydimethylsiloxane; sensors (equipment);     Show all 7 Subjects
Abstract:
... Hydrogen sulfide (H₂S) plays an important role as an intercellular and intracellular signaling molecule, yet its targets are not well understood. As a molecule it easily evaporates and it is hard to acquire stable concentration for in vitro studies, constituting a major problem for the field to identify its downstream targets and function. Here we develop a microfluidic system that can provide con ...
DOI:
10.1039/c7ra12220a

53. Microfluidic formation of proteinosomes

Author:
Ugrinic, Martina; Zambrano, Adrian; Berger, Simon; Mann, Stephen; Tang, T.-Y. Dora; deMello, Andrew
Source:
Chemical communications 2018 v.54 no.3 pp. 287-290
ISSN:
1364-548X
Subject:
microfluidic technology,   etc   ; bovine serum albumin; chemical compounds; chemical reactions; droplets; enzyme activity; glucose oxidase; oils;     Show all 8 Subjects
Abstract:
... Herein we describe a novel microfluidic method for the generation of proteinosome micro-droplets, based on bovine serum albumin and glucose oxidase conjugated to PNIPAAm chains. The size of such water-in-oil droplets is regulated via control of the input reagent flow rate, with generated proteinosome populations exhibiting narrower size distributions than those observed when using standard bulk me ...
DOI:
10.1039/c7cc08466h

54. Use of microfluidics to sort stallion sperm for intracytoplasmic sperm injection

Author:
Gonzalez-Castro, Raul A.; Carnevale, Elaine M.
Source:
Animal reproduction science 2018
ISSN:
0378-4320
Subject:
microfluidic technology,   etc   ; DNA; blastocyst; centrifugation; embryogenesis; freeze-thaw cycles; intracytoplasmic sperm injection; population characteristics; spermatozoa; stallions; viability;     Show all 11 Subjects
Abstract:
... We determined if microfluidic sorting (MF) of frozen-thawed stallion sperm improves sperm population characteristics and results in embryo development after intracytoplasmic sperm injection (ICSI). The efficiency and efficacy of MF sperm separation was evaluated by comparing pre- and post-separation sperm population variables. Procedural comparisons were performed after sorting with MF, single-lay ...
DOI:
10.1016/j.anireprosci.2018.12.012

55. Quantum-dot-encapsulated core–shell barcode particles from droplet microfluidics

Author:
Bian, Feika; Wang, Huan; Sun, Lingyu; Liu, Yuxiao; Zhao, Yuanjin
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7257-7262
ISSN:
2050-7518
Subject:
microfluidic technology,   etc   ; barcoding; biochemical compounds; biocompatibility; droplets; emulsifying; emulsions; hydrogels; moieties; nanoparticles; polyethylene glycol; quantum dots; silica;     Show all 13 Subjects
Abstract:
... The development of robust quantum dot (QD) barcode particles with specific compositions and simple identification is important to meet the demand for high-throughput assays. Here, we present a multiple-inner phase channel capillary microfluidic approach to generate novel QD-encapsulated core–shell barcode particles with distinctive features for multiplexing analysis. By using different QD disperse ...
DOI:
10.1039/c8tb00946e

56. Patterning Bubbles by the Stick–Slip Motion of the Advancing Triple Phase Line on Nanostructures

Author:
Zhou, Haihua; Huang, Zhandong; Cai, Zheren; Zhang, Rui; Wang, Haiyan; Song, Yanlin; Reichmanis, Elsa
Source:
Langmuir 2018 v.34 no.51 pp. 15804-15811
ISSN:
1520-5827
Subject:
microfluidic technology,   etc   ; air; aluminum oxide; bubbles; coatings; droplets; emulsions; finite element analysis; hydrogen bonding; hydrophobicity; liquids; nanomaterials;     Show all 12 Subjects
Abstract:
... The stick–slip motion of the triple phase contact line (TCL) has wide applications in inkjet printing, surface coatings, functional material assembly, and device fabrication. Here, for the first time, we report that on an alumina substrate with nanostructures, the stick–slip motion of the advancing TCL during spreading of an emulsion droplet can serve as an effective nanopatterning process. Air en ...
DOI:
10.1021/acs.langmuir.8b03135

57. Using the Bacterial Ribosome as a Discovery Platform for Peptide-Based Antibiotics

Author:
Charon, Justine; Manteca, Aitor; Innis, C. Axel
Source:
Biochemistry 2018 v.58 no.2 pp. 75-84
ISSN:
1520-4995
Subject:
microfluidic technology,   etc   ; antibiotics; antimicrobial peptides; bacteria; directed evolution; drugs; multiple drug resistance; pathogens; pharmaceutical industry; public health; ribosomes;     Show all 11 Subjects
Abstract:
... The threat of bacteria resistant to multiple antibiotics poses a major public health problem requiring immediate and coordinated action worldwide. While infectious pathogens have become increasingly resistant to commercially available drugs, antibiotic discovery programs in major pharmaceutical companies have produced no new antibiotic scaffolds in 40 years. As a result, new strategies must be sou ...
DOI:
10.1021/acs.biochem.8b00927

58. Highly conductive and bendable gold networks attached on intertwined cellulose fibers for output controllable power paper

Author:
Zhang, Yan; Yang, Hongmei; Cui, Kang; Zhang, Lina; Xu, Jinmeng; Liu, Hong; Yu, Jinghua
Source:
Journal of materials chemistry 2018 v.6 no.40 pp. 19611-19620
ISSN:
2050-7496
Subject:
microfluidic technology,   etc   ; Internet; anodes; cathodes; cellulosic fibers; chemistry; electrochemiluminescence; electronics; energy; gold; magnesium; paper; polymers; porosity; pyrroles; renewable energy sources;     Show all 16 Subjects
Abstract:
... On-chip energy units are urgently required for the rapid development of the Internet of Things and flexible electronics. Herein, a flexible integrated platform by incorporating paper microfluidic technology with a pencil-drawing approach is presented for self-charging/recharging, self-powered electropolymerization and sensing. By adopting a double bottom-up growth strategy based on paper microflui ...
DOI:
10.1039/c8ta08293f

59. Peptide functionalized magneto-plasmonic nanoparticles obtained by microfluidics for inhibition of β-amyloid aggregation

Author:
Hassan, N.; Cordero, M. L.; Sierpe, R.; Almada, M.; Juárez, J.; Valdez, M.; Riveros, A.; Vargas, E.; Abou-Hassan, A.; Ruso, J. M.; Kogan, M. J.
Source:
Journal of materials chemistry 2018 v.6 no.31 pp. 5091-5099
ISSN:
2050-7518
Subject:
microfluidic technology,   etc   ; Alzheimer disease; cell viability; cetyltrimethylammonium bromide; chemistry; chitosan; cytotoxicity; gold; magnetic properties; magnetism; nanogold; nanoparticles; nanorods; peptides; surfactants;     Show all 15 Subjects
Abstract:
... In the present work, we report on the synthesis of peptide functionalized magneto-plasmonic nanoparticles in a simple microfluidic platform. Superparamagnetic nanoparticles and gold nanorods were selected for this study. Magnetic nanoparticles were functionalized with peptide D1, which can bind selectively to toxic aggregates of the β-amyloid peptide associated with Alzheimer's disease. Gold nanor ...
DOI:
10.1039/c8tb00206a

60. Use of 3D printing and modular microfluidics to integrate cell culture, injections and electrochemical analysis

Author:
Munshi, Akash S.; Chen, Chengpeng; Townsend, Alexandra D.; Martin, R. Scott
Source:
Analytical methods 2018 v.10 no.27 pp. 3364-3374
ISSN:
1759-9679
Subject:
microfluidic technology,   etc   ; adenosine triphosphate; analytical methods; cell culture; electrochemistry; electrodes; endothelial cells; gold; half life; nitric oxide; polystyrenes; vasodilation;     Show all 12 Subjects
Abstract:
... Fabrication of microchip-based devices using 3D printing technology offers a unique platform to create separate modules that can be put together when desired for analysis. A 3D printed module approach offers various advantages such as file sharing and the ability to easily replace, customize, and modify the individual modules. Here, we describe the use of a modular approach to electrochemically de ...
DOI:
10.1039/c8ay00829a

61. Integration of reconfigurable potentiometric electrochemical sensors into a digital microfluidic platform

Author:
Farzbod, Ali; Moon, Hyejin
Source:
Biosensors & bioelectronics 2018 v.106 pp. 37-42
ISSN:
0956-5663
Subject:
microfluidic technology,   etc   ; ionophores; ion channels; monitoring; silver chloride; cations; automation; silver; potassium; potassium chloride; oxidation; specific ion electrodes;     Show all 12 Subjects
Abstract:
... This paper presents the demonstration of on-chip fabrication of a potassium-selective sensor array enabled by electrowetting on dielectric digital microfluidics for the first time. This demonstration proves the concept that electrochemical sensors can be seamlessly integrated with sample preparation units in a digital microfluidic platform. More significantly, the successful on-chip fabrication of ...
DOI:
10.1016/j.bios.2018.01.048

62. Microfluidic determination of lymphocyte vascular deformability: effects of intracellular complexity and early immune activation

Author:
KangN. K. and Q. G. contributed equally to this paper and are co-first authors., Ning; Guo, Quan; Islamzada, Emel; Ma, Hongshen; Scott, Mark D.
Source:
Integrative biology 2018 v.10 no.4 pp. 207-217
ISSN:
1757-9708
Subject:
microfluidic technology,   etc   ; T-lymphocytes; biomarkers; humans; lymphocyte proliferation; mechanical properties; micropores; models; monocytes; natural killer cells; shear stress; viscosity;     Show all 12 Subjects
Abstract:
... Despite the critical importance of mechanical (rheological + extrudability) deformability in the vascular flow of lymphocytes, it has been poorly investigated due to the limitations of existing technological tools. Microfluidics analysis of leukocyte deformability offers significant advantages in that it offers high throughput, large sample population and the ability to analyze a heterogeneous pop ...
DOI:
10.1039/c7ib00191f

63. Isolation of circulating plasma cells from blood of patients diagnosed with clonal plasma cell disorders using cell selection microfluidics

Author:
Kamande, Joyce W.; Lindell, Maria A. M.; Witek, Małgorzata A.; Voorhees, Peter M.; Soper, Steven A.
Source:
Integrative biology 2018 v.10 no.2 pp. 82-91
ISSN:
1757-9708
Subject:
microfluidic technology,   etc   ; antibodies; blood sampling; bone marrow; chromosomes; fluorescence in situ hybridization; myeloma; patients; plasma cells; point mutation;     Show all 10 Subjects
Abstract:
... Blood samples from patients with plasma cell disorders were analysed for the presence of circulating plasma cells (CPCs) using a microfluidic device modified with monoclonal anti-CD138 antibodies. CPCs were immuno-phenotyped using a CD38/CD56/CD45 panel and identified in 78% of patients with monoclonal gammopathy of undetermined significance (MGUS), all patients with smouldering and symptomatic mu ...
DOI:
10.1039/c7ib00183e

64. Label-free mesenchymal stem cell enrichment from bone marrow samples by inertial microfluidics

Author:
Lee, Lap Man; Rosano, Jenna M.; Wang, Yi; Klarmann, George J.; Garson, Charles J.; Prabhakarpandian, Balabhaskar; Pant, Kapil; Alvarez, Luis M.; Lai, Eva
Source:
Analytical methods 2018 v.10 no.7 pp. 713-721
ISSN:
1759-9679
Subject:
microfluidic technology,   etc   ; analytical methods; bone marrow; bone marrow cells; cartilage; mesenchymal stromal cells; mice; orthopedics; stem cells; therapeutics; viability;     Show all 11 Subjects
Abstract:
... Isolation of pure populations of mesenchymal stem cells from bone marrow aspirate is a critical need in regenerative medicine such as orthopedic and cartilage reconstruction with important clinical and therapeutic implications. Currently available stem cell isolation systems mainly rely on intrusive immuno-labeling techniques. Mesenchymal stem cells in bone marrow samples are typically larger than ...
DOI:
10.1039/c7ay02500a

65. Microfluidic Platform for Multimodal Analysis of Enzyme Secretion in Nanoliter Droplet Arrays

Author:
Haidas, Dominik; Bachler, Simon; Köhler, Martin; Blank, Lars M.; Zenobi, Renato; Dittrich, Petra S.
Source:
Analytical chemistry 2018 v.91 no.3 pp. 2066-2073
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; droplets; feed additives; feeds; fluorescence microscopes; fluorescence microscopy; glass; light microscopy; mass spectrometry; phytases; phytic acid; proteins; screening; secretion; yeasts;     Show all 15 Subjects
Abstract:
... High-throughput screening of cell-secreted proteins is essential for various biotechnological applications. In this article, we show a microfluidic approach to perform the analysis of cell-secreted proteins in nanoliter droplet arrays by two complementary methods, fluorescence microscopy and mass spectrometry. We analyzed the secretion of the enzyme phytase, a phosphatase used as an animal feed ad ...
DOI:
10.1021/acs.analchem.8b04506

66. Patterning and Reversible Actuation of Liquid Gallium Alloys by Preventing Adhesion on Rough Surfaces

Author:
Joshipura, Ishan D.; Ayers, Hudson R.; Castillo, Gilbert A.; Ladd, Collin; Tabor, Christopher E.; Adams, Jacob J.; Dickey, Michael D.
Source:
ACS applied materials & interfaces 2018 v.10 no.51 pp. 44686-44695
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; acids; adhesion; air; alloys; chemical bases; coatings; electrodes; electronics; energy; gallium; hydrophilicity; hydrophobicity; liquids; metrology; nanoparticles; roughness; silica; silicone; spectroscopy; surface roughness; surface tension; topography;     Show all 23 Subjects
Abstract:
... This work reports a simple approach to form, study, and utilize rough coatings that prevent the adhesion of gallium-based liquid metal alloys. Typically, liquids with large interfacial tension do not wet nonreactive surfaces, regardless of surface topography. However, these alloys form a surface oxide “skin” that adheres to many substrates, even those with low surface energy. This work reports a s ...
DOI:
10.1021/acsami.8b13099

67. Microfluidic Nanoassembly of Bioengineered Chitosan-Modified FcRn-Targeted Porous Silicon Nanoparticles @ Hypromellose Acetate Succinate for Oral Delivery of Antidiabetic Peptides

Author:
Martins, João P.; Liu, Dongfei; Fontana, Flavia; Ferreira, Mónica P. A.; Correia, Alexandra; Valentino, Silvia; Kemell, Marianna; Moslova, Karina; Mäkilä, Ermei; Salonen, Jarno; Hirvonen, Jouni; Sarmento, Bruno; Santos, Hélder A.
Source:
ACS applied materials & interfaces 2018 v.10 no.51 pp. 44354-44367
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; acetates; bioadhesives; chitosan; drug delivery systems; glucagon-like peptide 1; hypoglycemic agents; immunoglobulin G; intestines; models; nanoparticles; oral administration; pH; peptides; permeability; silicon;     Show all 16 Subjects
Abstract:
... Microfluidics technology is emerging as a promising strategy in improving the oral delivery of proteins and peptides. Herein, a multistage drug delivery system is proposed as a step forward in the development of noninvasive therapies. Undecylenic acid-modified thermally hydrocarbonized porous silicon (UnPSi) nanoparticles (NPs) were functionalized with the Fc fragment of immunoglobulin G for targe ...
DOI:
10.1021/acsami.8b20821

68. Cryoprotectant-Free Freezing of Cells Using Liquid Marbles Filled with Hydrogel

Author:
Vadivelu, Raja; Kashaninejad, Navid; Sreejith, Kamalalayam Rajan; Bhattacharjee, Ripon; Cock, Ian; Nguyen, Nam-Trung
Source:
ACS applied materials & interfaces 2018 v.10 no.50 pp. 43439-43449
ISSN:
1944-8252
Subject:
microfluidic technology,   etc   ; agarose; cell adhesion; cell culture; cell viability; cryopreservation; cryoprotectants; fetal bovine serum; freeze-thaw cycles; freezing; hydrogels; liquids; materials science; mice; toxicity;     Show all 15 Subjects
Abstract:
... Cryopreservation without cryoprotectant remains a significant challenge for the re-establishment of cell culture after freeze–thaw. Thus, finding an alternative and a simple cryopreservation method is necessary. Liquid marble (LM)-based digital microfluidics is a promising approach for cryoprotectant-free cryopreservation. However, the use of this platform to efficiently preserve samples with low ...
DOI:
10.1021/acsami.8b16236

69. Nanoliter-Sized Microchamber/Microarray Microfluidic Platform for Antibiotic Susceptibility Testing

Author:
Azizi, Morteza; Zaferani, Meisam; Dogan, Belgin; Zhang, Shiying; Simpson, Kenneth W.; Abbaspourrad, Alireza
Source:
Analytical chemistry 2018 v.90 no.24 pp. 14137-14144
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; Enterococcus faecalis; Escherichia coli; Klebsiella pneumoniae; antibiotic resistance; antibiotics; bacterial growth; bacterial infections; fluorescence; microarray technology; minimum inhibitory concentration;     Show all 11 Subjects
Abstract:
... The rise of antimicrobial resistance is challenging for physicians in clinical practice to prescribe antibiotics that are effective against bacterial infections. Conventional antibiotic susceptibility testing (AST) is labor-intensive and time-consuming (18–24 h). Newly emerging technologies such as microfluidics may enable more rapid AST assay time. In this study, we utilize a nanoliter-sized micr ...
DOI:
10.1021/acs.analchem.8b03817

70. A multi-amplicon 16S rRNA sequencing and analysis method for improved taxonomic profiling of bacterial communities

Author:
Schriefer, Andrew E.; Cliften, Paul F.; Hibberd, Matthew C.; Sawyer, Christopher; Brown-Kennerly, Victoria; Burcea, Lauren; Klotz, Elliott; Crosby, Seth D.; Gordon, Jeffrey I.; Head, Richard D.
Source:
Journal of microbiological methods 2018 v.154 pp. 6-13
ISSN:
0167-7012
Subject:
microfluidic technology,   etc   ; DNA; algorithms; bacterial communities; computer software; genes; germ-free animals; habitats; high-throughput nucleotide sequencing; metagenomics; mice; phylogeny; polymerase chain reaction; ribosomal RNA;     Show all 14 Subjects
Abstract:
... Metagenomic sequencing of bacterial samples has become the gold standard for profiling microbial populations, but 16S rRNA profiling remains widely used due to advantages in sample throughput, cost, and sensitivity even though the approach is hampered by primer bias and lack of specificity. We hypothesized that a hybrid approach, that combined targeted PCR amplification with high-throughput sequen ...
DOI:
10.1016/j.mimet.2018.09.019

71. Synthesis and Self-Assembly of Xylan-Based Amphiphiles: From Bio-Based Vesicles to Antifungal Properties

Author:
Rosselgong, Julien; Chemin, Maud; Almada, Cédric Cabral; Hemery, Gauvin; Guigner, Jean-Michel; Chollet, Guillaume; Labat, Gilles; Da Silva Perez, Denilson; Ham-Pichavant, Frédérique; Grau, Etienne; Grelier, Stéphane; Lecommandoux, Sébastien; Cramail, Henri
Source:
Biomacromolecules 2018 v.20 no.1 pp. 118-129
ISSN:
1526-4602
Subject:
microfluidic technology,   etc   ; acid hydrolysis; alkynes; amination; antifungal properties; azides; biocompatible materials; extrusion; fatty acid methyl esters; hydrophilicity; hydrophobicity; micelles; moieties; propiconazole; rehydration; solubilization; surfactants; xylan; xylose;     Show all 19 Subjects
Abstract:
... This work aims at designing functional biomaterials through selective chemical modification of xylan from beechwood. Acidic hydrolysis of xylan led to well-defined oligomers with an average of six xylose units per chain and with an aldehyde group at the reductive end. Reductive amination was performed on this aldehyde end group to introduce an azide reactive group. “Click chemistry” was then appli ...
DOI:
10.1021/acs.biomac.8b01210

72. THz Spectroscopy for a Rapid and Label-Free Cell Viability Assay in a Microfluidic Chip Based on an Optical Clearing Agent

Author:
Yang, Ke; Yang, Xiang; Zhao, Xiang; Lamy de la Chapelle, Marc; Fu, Weiling
Source:
Analytical chemistry 2018 v.91 no.1 pp. 785-791
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; absorption; antineoplastic agents; biomedical research; breast neoplasms; cell viability; cytotoxicity; liquids; neoplasm cells; oils; organ-on-a-chip; screening; spectroscopy; toxicology; viability assays;     Show all 15 Subjects
Abstract:
... Simple, rapid, and efficient cell viability assays play a fundamental role in much of biomedical research, including cell toxicology investigations and antitumor drug screening. Here, we demonstrate for the first time a rapid and label-free cell viability assay using THz spectroscopy in combination with a new optical clearing agent (OCA) and microfluidic technology. This strategy uses a considerab ...
DOI:
10.1021/acs.analchem.8b03665

73. Automated screening of C. elegans neurodegeneration mutants enabled by microfluidics and image analysis algorithms

Author:
de Carlos CáceresEqually contributed., Ivan; Porto, Daniel A.; Gallotta, Ivan; Santonicola, Pamela; Rodríguez-Cordero, Josue; Di Schiavi, Elia; Lu, Hang
Source:
Integrative biology 2018 v.10 no.9 pp. 539-548
ISSN:
1757-9708
Subject:
microfluidic technology,   etc   ; Nematoda; algorithms; alleles; automation; computer software; death; humans; image analysis; infants; models; motor neurons; muscular atrophy; mutants; neurodegenerative diseases; phenotype; screening;     Show all 17 Subjects
Abstract:
... Spinal muscular atrophy (SMA) is a degenerative disorder that selectively deteriorates motor neurons due to a deficiency of survival motor neuron protein (SMN). The illness is the leading genetic cause of death in infants and is difficult to study in complex biological systems such as humans. A simpler model system, such as the nematode C. elegans, can be used to study potential mechanisms underly ...
DOI:
10.1039/c8ib00091c

74. Droplet microfluidics in thermoplastics: device fabrication, droplet generation, and content manipulation using integrated electric and magnetic fields

Author:
Sahore, Vishal; Doonan, Steven R.; Bailey, Ryan C.
Source:
Analytical methods 2018 v.10 no.35 pp. 4264-4274
ISSN:
1759-9679
Subject:
microfluidic technology,   etc   ; beta-galactosidase; chemical analysis; droplets; enzyme substrates; geometry; hydrophobicity; magnetic fields; olefin; polymethylmethacrylate; potassium channels; silicon; thermoplastics; washing; wastes;     Show all 15 Subjects
Abstract:
... We have developed droplet microfluidic devices in thermoplastics and demonstrated the integration of key functional components that not only facilitate droplet generation, but also include electric field-assisted reagent injection, droplet splitting, and magnetic field-assisted bead extraction. We manufactured devices in poly(methyl methacrylate) and cyclic olefin polymer using a hot-embossing pro ...
DOI:
10.1039/c8ay01474d

75. Real-Time Study of Rapid Spread of Antibiotic Resistance Plasmid in Biofilm Using Microfluidics

Author:
Li, Bing; Qiu, Yong; Zhang, Jing; Huang, Xia; Shi, Hanchang; Yin, Huabing
Source:
Environmental science & technology 2018 v.52 no.19 pp. 11132-11141
ISSN:
1520-5851
Subject:
microfluidic technology,   etc   ; Escherichia coli; Pseudomonas putida; activated sludge; animal pathogens; antibiotic resistance; antibiotic resistance genes; bacteria; biofilm; cell growth; gene transfer; horizontal gene transfer; image analysis; monitoring; plasmids;     Show all 15 Subjects
Abstract:
... Gene transfer in biofilms is known to play an important role in antibiotic resistance dissemination. However, the process remains poorly understood. In this study, microfluidics with time-lapse imaging was used for real-time monitoring of plasmid-mediated horizontal gene transfer (HGT) in biofilms. Pseudomonas putida KT2440 harboring an antibiotic resistance plasmid RP4 was chosen as the donor whi ...
DOI:
10.1021/acs.est.8b03281

76. Automated 4-sample protein immunoassays using 3D-printed microfluidics

Author:
Kadimisetty, Karteek; Spak, Andrew P.; Bhalerao, Ketki S.; Sharafeldin, Mohamed; Mosa, Islam M.; Lee, Norman H.; Rusling, James F.
Source:
Analytical methods 2018 v.10 no.32 pp. 4000-4006
ISSN:
1759-9679
Subject:
microfluidic technology,   etc   ; Internet; analytical methods; automation; blood serum; carbon nanotubes; detection limit; diagnostic techniques; enzyme-linked immunosorbent assay; graphene; liquids; nanoparticles; prostate-specific antigen; proteins; rapid methods;     Show all 15 Subjects
Abstract:
... Low cost, miniaturized assay platforms that work with small sample volumes, high sensitivity and rapid detection will have high value in future biomolecular diagnostics. Herein we report an automated, 3D printed electrochemiluminescent (ECL) immunoarray integrated with a nanostructured pyrolytic graphite sheet (PGS) microwell chip configured to detect 2 proteins simultaneously from complex liquid ...
DOI:
10.1039/c8ay01271g

77. Rapid detection of four mycotoxins in corn using a microfluidics and microarray-based immunoassay system

Author:
Chen, Yiqi; Meng, Xiangrui; Zhu, Yunzeng; Shen, Minjie; Lu, Ying; Cheng, Jing; Xu, Youchun
Source:
Talanta 2018 v.186 pp. 299-305
ISSN:
0039-9140
Subject:
microfluidic technology,   etc   ; T-2 toxin; aflatoxin B1; corn; detection limit; forage; human health; image analysis; immunoassays; ochratoxin A; protein microarrays; prototypes; rapid methods; zearalenone;     Show all 14 Subjects
Abstract:
... Mycotoxins threaten human health seriously because they usually exist in food, fodder and commodities. In this study, a rapid and sensitive immunoassay system for commonly encountered mycotoxins was established based on microfluidics and protein microarrays. Four mycotoxins (T-2 toxin, aflatoxin B1, ochratoxin A, and zearalenone) can be automatically detected in a custom-made microdevice within 30 ...
DOI:
10.1016/j.talanta.2018.04.064

78. Development of immunomagnetic droplet-based digital immuno-PCR for the quantification of prostate specific antigen

Author:
Zhou, Wenhan
Source:
Analytical methods 2018 v.10 no.29 pp. 3690-3695
ISSN:
1759-9679
Subject:
microfluidic technology,   etc   ; DNA; analytical methods; antigen-antibody reactions; antigens; blood serum; droplets; humans; immunoassays; magnetic fields; models; polymerase chain reaction; prostate-specific antigen; proteins; washing;     Show all 15 Subjects
Abstract:
... Immuno-PCR (IPCR) is an immunoassay that employs DNA as the signal generator and utilizes both the versatility of antigen–antibody interactions and the exponential amplification power of PCR. Droplet-based digital PCR (ddPCR) is the third and latest generation of PCR technology, and the integration of ddPCR into IPCR will hopefully enable the absolute quantification and highly sensitive detection ...
DOI:
10.1039/c8ay00921j

79. High-glucose 3D INS-1 cell model combined with a microfluidic circular concentration gradient generator for high throughput screening of drugs against type 2 diabetes

Author:
Luo, Yong; Zhang, Xiuli; Li, Yujiao; Deng, Jiu; Li, Xiaorui; Qu, Yueyang; Lu, Yao; Liu, Tingjiao; Gao, Zhigang; Lin, Bingcheng
Source:
RSC advances 2018 v.8 no.45 pp. 25409-25416
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; basement membrane; cell culture; cell lines; cell proliferation; gels; glipizide; glucose; hyperglycemia; hypoglycemic agents; insulin secretion; models; noninsulin-dependent diabetes mellitus; pharmaceutical industry; screening;     Show all 15 Subjects
Abstract:
... In vitro models for screening of drugs against type 2 diabetes are crucial for the pharmaceutical industry. This paper presents a new approach for integration of a three-dimensionally-cultured insulinoma cell line (INS-1 cell) incubated in a high concentration of glucose as a new model. In this model, INS-1 cells tended to aggregate in the 3D gel (basement membrane extractant, BME), in a similar w ...
DOI:
10.1039/c8ra04040k

80. Automatic smartphone-based microfluidic biosensor system at the point of care

Author:
Xu, Dandan; Huang, Xiwei; Guo, Jinhong; Ma, Xing
Source:
Biosensors & bioelectronics 2018 v.110 pp. 78-88
ISSN:
0956-5663
Subject:
microfluidic technology,   etc   ; DNA; analytical methods; antibodies; bacteria; biosensors; blood; blood glucose; humans; image analysis; immunoassays; mobile telephones; point-of-care testing; sensory system;     Show all 14 Subjects
Abstract:
... Point-of-care testing technique is increasingly important for healthcare management in human being's daily life. However, traditional biosensor systems for health care are relatively expensive, bulky and hard-to-handle, which largely limits their use in point of care testing. The problems mentioned above are successfully addressed with the popularization of smartphone and the development of microf ...
DOI:
10.1016/j.bios.2018.03.018

81. Porous micropillar structures for retaining low surface tension liquids

Author:
Agonafer, Damena D.; Lee, Hyoungsoon; Vasquez, Pablo A.; Won, Yoonjin; Jung, Ki Wook; Lingamneni, Srilakshmi; Ma, Binjian; Shan, Li; Shuai, Shuai; Du, Zichen; Maitra, Tanmoy; Palko, James W.; Goodson, Kenneth E.
Source:
Journal of colloid and interface science 2018 v.514 pp. 316-327
ISSN:
0021-9797
Subject:
microfluidic technology,   etc   ; Gibbs free energy; anisotropy; capillarity; deformation; geometry; heat exchangers; liquids; mathematical models; prediction; silicon; surface tension; theoretical models; viscosity;     Show all 14 Subjects
Abstract:
... The ability to manipulate fluid interfaces, e.g., to retain liquid behind or within porous structures, can be beneficial in multiple applications, including microfluidics, biochemical analysis, and the thermal management of electronic systems. While there are a variety of strategies for controlling the disposition of liquid water via capillarity, such as the use of chemically modified porous adhes ...
DOI:
10.1016/j.jcis.2017.12.011

82. InnOscent system: Advancing flavor analysis using an original gas chromatographic analytical device

Author:
Villière, A.; Le Roy, S.; Fillonneau, C.; Prost, C.
Source:
Journal of chromatography 2018 v.1535 pp. 129-140
ISSN:
0021-9673
Subject:
microfluidic technology,   etc   ; active ingredients; detectors; flame ionization; flavor; gas chromatography-mass spectrometry; grapes; models; odor compounds; odors; olfactometry; pyrazines; spectrometers; wines;     Show all 14 Subjects
Abstract:
... Despite continuous advances in analytical and physiological knowledge, the comprehension of an aroma is still a challenge. Gas chromatography coupled to olfactometry (GC-O) is an efficient method to identify and estimate individual potential of odorants, but there is a gap between this individual characterization and the effective contribution of compounds in the mixture, which is due to complex c ...
DOI:
10.1016/j.chroma.2017.12.053

83. Multiplexed Label-Free Fractionation of Peripheral Blood Mononuclear Cells for Identification of Monocyte–Platelet Aggregates

Author:
Tay, Hui Min; Yeap, Wei Hseun; Dalan, Rinkoo; Wong, Siew Cheng; Hou, Han Wei
Source:
Analytical chemistry 2018 v.90 no.24 pp. 14535-14542
ISSN:
1520-6882
Subject:
microfluidic technology,   etc   ; atherosclerosis; biomarkers; blood platelets; cell viability; detection limit; diabetes; flow cytometry; fluorescent antibody technique; fractionation; image analysis; immune response; lymphocytes; macrophages; magnetism; monitoring; monocytes; patients; phagocytosis; point-of-care systems; risk assessment; thrombosis;     Show all 22 Subjects
Abstract:
... Monocytes and platelets play key roles in atherosclerosis and thrombosis, and circulating monocyte–platelet aggregates (MPA) in blood have been widely proposed as surrogate biomarkers for cardiovascular risk stratification and monitoring antiplatelet therapies. However, conventional MPA characterization is based on whole-blood fixation and flow cytometry analysis which adversely affect cell viabil ...
DOI:
10.1021/acs.analchem.8b04415

84. A high-throughput microtissue platform to probe endothelial function in vitro

Author:
Crampton, Alexandra L.; Cummins, Katherine A.; Wood, David K.
Source:
Integrative biology 2018 v.10 no.9 pp. 555-565
ISSN:
1757-9708
Subject:
microfluidic technology,   etc   ; automation; basement membrane; blood; cell culture; collagen; droplets; endothelial cells; endothelium; equipment; extracellular matrix; image analysis; liquids; permeability; solutes; tight junctions; transforming growth factor beta; tumor necrosis factor-alpha;     Show all 18 Subjects
Abstract:
... A critical role of vascular endothelium is as a semi-permeable barrier, dynamically regulating the flux of solutes between blood and the surrounding tissue. Existing platforms that quantify endothelial function in vitro are either significantly throughput limited or overlook physiologically relevant extracellular matrix (ECM) interactions and thus do not recapitulate in vivo function. Leveraging d ...
DOI:
10.1039/c8ib00111a

85. Engineering docetaxel-loaded micelles for non-small cell lung cancer: a comparative study of microfluidic and bulk nanoparticle preparation

Author:
Bao, Yuchen; Deng, Qinfang; Li, Yongyong; Zhou, Songwen
Source:
RSC advances 2018 v.8 no.56 pp. 31950-31966
ISSN:
2046-2069
Subject:
microfluidic technology,   etc   ; antineoplastic agents; cell lines; cytotoxicity; dialysis; drug delivery systems; engineering; fluorescence; histology; image analysis; inhibitory concentration 50; lung neoplasms; mice; micelles; nanomedicine; nanoparticles; particle size; particle size distribution; physicochemical properties;     Show all 19 Subjects
Abstract:
... Bulk preparation of micelles has the drawbacks of facile formation of large aggregates and heterogeneous particle size distribution. Microfluidic technology has shown clear potential to address these challenges for robust nanomedicine applications. In this study, docetaxel-loaded PLGA-PEG-Mal-based micelles were prepared by microfluidics and dialysis methods and their physicochemical properties we ...
DOI:
10.1039/c8ra04512g