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- Bou, Shorgan, et al. Show all 8 Authors
- In vitro cellular & developmental biology 2018 v.54 no.7 pp. 496-504
- DNA methylation; blastocyst; cell proliferation; cytotoxicity; embryogenesis; gene activation; gene expression; histones; in vitro studies; mammals
- ... SCNT technology has been successfully used to clone a variety of mammals, but the cloning efficiency is very low. This low efficiency is likely due to the incomplete reprogramming of SCNT embryos. Histone modification and DNA methylation may participate in these events. Thus, it would be interesting to attempt to improve the efficiency of SCNT by using a HDACi VPA. In order to guarantee the effect ...