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- Chin, Young‐Won, et al. Show all 5 Authors
- Phytotherapy research 2018 v.32 no.6 pp. 1004-1013
- Houttuynia cordata; animal disease models; diabetes; ethanol; excretion; glycemic effect; humans; hypoglycemia; kidneys; liver; medicinal properties; metformin; organic cation transporters; pharmacokinetics; rats; renal function; synergism; therapeutics
- ... The synergistic activity of Houttuynia cordata ethanol extract (HCT) and metformin combination in diabetic rats has been previously reported, but the fundamental causes remain unsolved. Organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) transport metformin to the liver and kidneys. Therefore, pharmacological activity and systemic exposure of metformin in HCT–metf ...