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- Yang, Ying-Chen, et al. Show all 9 Authors
- Toxicology 2018 v.410 pp. 65-72
- Parkinson disease; agonists; apoptosis; beta catenin; brain; clinical trials; cytotoxicity; etiology; glycogen synthase kinases; humans; mitochondria; models; neoplasms; neurogenesis; neurons; paraquat; patients; therapeutics
- ... Paraquat (PQ) as an herbicide has been demonstrated to impair dopaminergic (DAergic) neurons and highly correlate with the etiology of Parkinson’s disease (PD). WNT/β-CATENIN signaling is known for the specification and neurogenesis of midbrain DAergic neurons and implicated as a therapeutic target in treating many diseases, such as cancer and degenerative diseases. LGK974, a WNT pathway inhibitor ...