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- Zhu, Meifeng, et al. Show all 13 Authors
- Biomaterials 2018 v.183 pp. 306-318
- aorta; biodegradability; cytokines; deformation; extracellular matrix; macrophages; mechanical properties; medicine; polymers; rats; tissue repair
- ... Implanted grafts, including vascular substitutes, inevitably experience remodeling by host cells. The design of grafts capable of promoting constructive remodeling remains a challenge within regenerative medicine. Here, we used a biodegradable elastic polymer, poly (l-lactide-co-ε-caprolactone) (PLCL), to develop a vascular graft with circumferentially aligned microfibers. The grafts exhibited exc ...
- Zhu, Meifeng, et al. Show all 10 Authors
- Biomaterials 2018 v.181 pp. 1-14
- absorption; adsorption; biocompatibility; blood platelets; cell adhesion; endothelial cells; fibrinogen; hemorrhage; low density lipoprotein; models; nanofibers; nitric oxide; topography
- ... Formation of a continuous endothelial cell (EC) monolayer inside the luminal surface with enhanced hemocompatibility, is a promising solution for improving performance and overall patency of small-diameter vascular grafts. There has been much debate regarding the ideal substrate surface topography to achieve this. Here, we investigated different polycaprolactone (PCL)-derived substrate surfaces fa ...